Hydroxyl radical (•OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 12, 2012, Pages 2148-2159

  Yu, Yang ^a   Fan, Si Miao ^a   Song, Jun Ke ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Autophagy; Hydroxyl radical; Oridonin; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 8; CATALASE; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GLUTATHIONE; HYDROXYL RADICAL; ORIDONIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; FENTON'S REAGENT; HYDROGEN PEROXIDE; IRON; KAURANE DERIVATIVE; PLANT EXTRACT; PROTEIN TYROSINE KINASE; SCAVENGER;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UPREGULATION; WESTERN BLOTTING; CHEMISTRY; DOSE RESPONSE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PHYTOTHERAPY; RABDOSIA; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN-TYROSINE KINASES; RABDOSIA; SIGNAL TRANSDUCTION;

EID: 84871538807     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00405     Document Type: Article

References (38)

1. Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med., 38, 1433-1444 (2005).
2. Baran CP, Zeigler MM, Tridandapani S, Marsh CB. The role of ROS and RNS in regulating life and death of blood monocytes. Curr. Pharm. Des., 10, 855-866 (2004).
3. Fiers W, Beyaert R, Declercq W, Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene, 18, 7719-7730 (1999).
4. Choi WY, Kim GY, Lee WH, Choi YH. Sanguinarine, a benzo-phenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway. Chemotherapy, 54, 279-287 (2008).
5. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell, 116, 205-219 (2004).
6. Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer, 4, 592-603 (2004).
7. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science, 281, 1305-1308 (1998).
8. Esposito E, Cuzzocrea S. New therapeutic strategy for Parkinson's and Alzheimer's disease. Curr. Med. Chem., 17, 2764-2774 (2010).
9. Salvador N, Aguado C, Horst M, Knecht E. Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. J. Biol. Chem., 275, 27447-27456 (2000).
10. 2. Cell Growth Differ., 11, 49-61 (2000).
11. Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death. Acta Med. Okayama, 59, 261-270 (2005).
12. Ikezoe T, Yang Y, Bandobashi K, Saito T, Takemoto S, Machida H, Togitani K, Koeffler HP, Taguchi H. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways. Mol. Cancer Ther., 4, 578-586 (2005).
13. Zhang CL, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. Biol. Pharm. Bull., 27, 1527-1531 (2004).
14. Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells. Biol. Pharm. Bull., 30, 254-260 (2007).
15. Cheng Y, Qiu F, Ye YC, Tashiro S, Onodera S, Ikejima T. Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch. Biochem. Biophys., 490, 70-75 (2009).
16. Szumiel I. Autophagy, reactive oxygen species and the fate of mammalian cells. Free Radic. Res., 45, 253-265 (2011).
17. Morgan MJ, Liu ZG. Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol. Cells, 30, 1-12 (2010).
18. Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. J. Asian Nat. Prod. Res., 10, 77-87 (2008).
19. Li D, Cui Q, Chen SG, Wu LJ, Tashiro S, Onodera S, Ikejima T. Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. J. Pharmacol. Sci., 105, 22-33 (2007).
20. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol., 8, 741-752 (2007).
21. Ohtani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, Kondo S, Atkinson EN, Minna JD, Roth JA, Ji L. Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy. Cancer Res., 67, 6293-6303 (2007).
22. Tilak JC, Boloor KK, Sane Ketaki S, Ghaskadbi Saroj S, Lele RD. Free radicals and antioxidants in human health: current status and future prospects. J. Assoc. Physicians India, 52, 794-804 (2004).
23. Jiang F, Zhang Y, Dusting GJ. NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol. Rev., 63, 218-242 (2011).
24. Gao X, Deeb D, Liu P, Liu Y, Arbab-Ali S, Dulchavsky SA, Gautam SC. Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells. J. Exp. Ther. Oncol., 9, 119-127 (2011).
25. Zhang YH, Wu YL, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells. Acta Pharmacol. Sin., 32, 1266-1275 (2011).
26. Kang N, Zhang JH, Qiu F, Tashiro S, Onodera S, Ikejima T. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett., 294, 147-158 (2010).
27. Chuang YC, Su WH, Lei HY, Lin YS, Liu HS, Chang CP, Yeh TM. Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation. PLoS ONE, 7, e37613 (2012).
28. Zeng R, Chen Y, Zhao S, Cui GH. Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. Acta Pharmacol. Sin., 33, 91-100 (2012).
29. Chen G, Zhang X, Zhao M, Wang Y, Cheng X, Wang D, Xu Y, Du Z, Yu X. Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. BMC Cancer, 11, 170 (2011).
30. Xie X, Le L, Fan Y, Lv L, Zhang J. Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. Autophagy, 8 [Epub ahead of print] (2012).
31. Lin RZ, Wang TP, Hung RJ, Chuang YJ, Chien CC, Chang HY. Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species. J. Cell. Physiol., 226, 1750-1762 (2011).
32. Tanner EA, Blute TA, Brachmann CB, McCall K. Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. Development, 138, 327-338 (2011).
33. Waldbaum S, Patel M. Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy? J. Bioenerg. Biomembr., 42, 449-455 (2010).
34. Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis, 5, 415-418 (2000).
35. Duan W, Jin X, Li Q, Tashiro S, Onodera S, Ikejima T. Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. J. Pharmacol. Sci., 113, 48-56 (2010).
36. Kang N, Zhang JH, Qiu F, Chen S, Tashiro S, Onodera S, Ikejima T. Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells. J. Nat. Prod., 73, 1058-1063 (2010).
37. Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J. Pharmacol. Sci., 107, 370-379 (2008).
38. Bazsó-Dombi E, Oravecz K, Jeney F, Nagy K, Zs-Nagy I. On the useful role of OH′ free radicals in differentiation of cultured human fibroblasts. Arch. Gerontol. Geriatr., 31, 233-242 (2000).