-
1
-
-
84860287080
-
Epidemiology of viral hepatitis and hepatocellular carcinoma
-
El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012;142:1264-73.
-
(2012)
Gastroenterology
, vol.142
, pp. 1264-1273
-
-
El-Serag, H.B.1
-
2
-
-
14944375587
-
Immunology of hepatitis B virus and hepatitis C virus infection
-
DOI 10.1038/nri1573
-
Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005;5:215-29. (Pubitemid 40364823)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.3
, pp. 215-229
-
-
Rehermann, B.1
Nascimbeni, M.2
-
3
-
-
38049044476
-
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
-
Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol. 2008;48:335-52.
-
(2008)
J Hepatol
, vol.48
, pp. 335-352
-
-
Fattovich, G.1
Bortolotti, F.2
Donato, F.3
-
4
-
-
33644863680
-
Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality
-
DOI 10.1053/j.gastro.2006.01.032, PII S0016508506000382
-
Tanaka Y, Kurbanov F, Mano S, et al. Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality. Gastroenterology. 2006;130: 703-14. (Pubitemid 43374521)
-
(2006)
Gastroenterology
, vol.130
, Issue.3
, pp. 703-714
-
-
Tanaka, Y.1
Kurbanov, F.2
Mano, S.3
Orito, E.4
Vargas, V.5
Esteban, J.I.6
Yuen, M.7
Lai, C.8
Kramvis, A.9
Kew, M.C.10
Smuts, H.E.11
Netesov, S.V.12
Alter, H.J.13
Mizokami, M.14
-
5
-
-
77955472579
-
Evolving challenges in hepatic fibrosis
-
Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 2010;7:425-36.
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 425-436
-
-
Friedman, S.L.1
-
6
-
-
84873020277
-
Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
-
Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer. 2013;13:123-35.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 123-135
-
-
Arzumanyan, A.1
Reis, H.M.2
Feitelson, M.A.3
-
7
-
-
84859441977
-
Smad phosphoisoform signals in acute and chronic liver injury: Similarities and differences between epithelial and mesenchymal cells
-
Matsuzaki K. Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells. Cell Tissue Res. 2012;347:225-43.
-
(2012)
Cell Tissue Res
, vol.347
, pp. 225-243
-
-
Matsuzaki, K.1
-
8
-
-
17144455384
-
Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
-
Shiratori Y, Imazeki F, Moriyama M, et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med. 2000;132:517-24. (Pubitemid 30171890)
-
(2000)
Annals of Internal Medicine
, vol.132
, Issue.7
, pp. 517-524
-
-
Shiratori, Y.1
Imazeki, F.2
Moriyama, M.3
Yano, M.4
Arakawa, Y.5
Yokosuka, O.6
Kuroki, T.7
Nishiguchi, S.8
Sata, M.9
Yamada, G.10
Fujiyama, S.11
Yoshida, H.12
Omata, M.13
-
9
-
-
0033520109
-
Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan
-
Yoshida H, Shiratori Y, Moriyama M, et al. Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy. Ann Intern Med. 1999;131:174-81. (Pubitemid 29364999)
-
(1999)
Annals of Internal Medicine
, vol.131
, Issue.3
, pp. 174-181
-
-
Yoshida, H.1
Shiratori, Y.2
Moriyama, M.3
Arakawa, Y.4
Ide, T.5
Sata, M.6
Inoue, O.7
Yano, M.8
Tanaka, M.9
Fujiyama, S.10
Nishiguchi, S.11
Kuroki, T.12
Imazeki, F.13
Yokosuka, O.14
Kinoyama, S.15
Yamada, G.16
Omata, M.17
-
10
-
-
77956635697
-
Outcome of sustained virological responders with histologically advanced chronic hepatitis C
-
HALT-C Trial Group
-
Morgan TR, Ghany MG, Kim HY, HALT-C Trial Group, et al. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology. 2010;52:833-44.
-
(2010)
Hepatology
, vol.52
, pp. 833-844
-
-
Morgan, T.R.1
Ghany, M.G.2
Kim, H.Y.3
-
11
-
-
34247570948
-
Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: A multicenter, retrospective cohort study of 1124 patients
-
DOI 10.1111/j.1478-3231.2006.01406.x
-
Kobayashi S, Takeda T, Enomoto M, et al. Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients. Liver Int. 2007;27:186-91. (Pubitemid 46680721)
-
(2007)
Liver International
, vol.27
, Issue.2
, pp. 186-191
-
-
Kobayashi, S.1
Takeda, T.2
Enomoto, M.3
Tamori, A.4
Kawada, N.5
Habu, D.6
Sakaguchi, H.7
Kuroda, T.8
Kioka, K.9
Kim, S.R.10
Kanno, T.11
Ueda, T.12
Hirano, M.13
Fujimoto, S.14
Jomura, H.15
Nishiguchi, S.16
Seki, S.17
-
12
-
-
0036699940
-
Molecular pathogenesis of human hepatocellular carcinoma
-
DOI 10.1038/ng0802-339
-
Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002;31:339-46. (Pubitemid 35154440)
-
(2002)
Nature Genetics
, vol.31
, Issue.4
, pp. 339-346
-
-
Thorgeirsson, S.S.1
Grisham, J.W.2
-
13
-
-
0030271736
-
Regulation of differentiation by TGF-β
-
Moses HL, Serra R. Regulation of differentiation by TGF-β. Curr Opin Genet Dev. 1996;6:581-6.
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 581-586
-
-
Moses, H.L.1
Serra, R.2
-
14
-
-
84866742560
-
TGF-β signalling in context
-
Massagué J. TGF-β signalling in context. Nat Rev Mol Cell Biol. 2012;13:616-30.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 616-630
-
-
Massagué, J.1
-
15
-
-
0034163388
-
Autocrine stimulatory mechanism by transforming growth factor β in human hepatocellular carcinoma
-
Matsuzaki K, Date M, Furukawa F, et al. Autocrine stimulatory mechanism by transforming growth factor β in human hepatocellular carcinoma. Cancer Res. 2000;60:1394-402. (Pubitemid 30152013)
-
(2000)
Cancer Research
, vol.60
, Issue.5
, pp. 1394-1402
-
-
Matsuzaki, K.1
Date, M.2
Furukawa, F.3
Tahashi, Y.4
Matsushita, M.5
Sakitani, K.6
Yamashiki, N.7
Seki, T.8
Saito, H.9
Nishizawa, M.10
Fujisawa, J.11
Inoue, K.12
-
16
-
-
0033865273
-
Regulatory mechanisms for transforming growth factor β as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of smads in its growth
-
Matsuzaki K, Date M, Furukawa F, et al. Regulatory mechanisms for transforming growth factor β as an autocrine inhibitor in human hepatocellular carcinoma: implications for roles of Smads in its growth. Hepatology. 2000;32:218-27. (Pubitemid 30614653)
-
(2000)
Hepatology
, vol.32
, Issue.2
, pp. 218-227
-
-
Matsuzaki, K.1
Date, M.2
Furukawa, F.3
Tahashi, Y.4
Matsushita, M.5
Sugano, Y.6
Yamashiki, N.7
Nakagawa, T.8
Seki, T.9
Nishizawa, M.10
Fujisawa, J.11
Inoue, K.12
-
17
-
-
84868157852
-
TGF-β signaling in onset and progression of hepatocellular carcinoma
-
Meindl-Beinker NM, Matsuzaki K, Dooley S. TGF-β signaling in onset and progression of hepatocellular carcinoma. Dig Dis. 2012;30:514-23.
-
(2012)
Dig Dis
, vol.30
, pp. 514-523
-
-
Meindl-Beinker, N.M.1
Matsuzaki, K.2
Dooley, S.3
-
18
-
-
0000116653
-
The transforming growth factor-βs
-
Sporn MB, Roberts AB, editors. Berlin: Springer
-
Roberts AB, Sporn MB. The transforming growth factor-βs. In: Sporn MB, Roberts AB, editors. Peptide growth factors and their receptors. Berlin: Springer; 1990. p. 419-72.
-
(1990)
Peptide Growth Factors and Their Receptors
, pp. 419-472
-
-
Roberts, A.B.1
Sporn, M.B.2
-
19
-
-
0031438047
-
TGF-β signalling from cell membrane to nucleus through SMAD proteins
-
DOI 10.1038/37284
-
Heldin CH, Miyazono K, ten Dijke P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390: 465-71. (Pubitemid 28013118)
-
(1997)
Nature
, vol.390
, Issue.6659
, pp. 465-471
-
-
Heldin, C.-H.1
Miyazono, K.2
Ten, D.P.3
-
21
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
DOI 10.1038/nature02650
-
Matsuura I, Denissova NG, Wang G, et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature. 2004;430:226-31. (Pubitemid 38902433)
-
(2004)
Nature
, vol.430
, Issue.6996
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
22
-
-
65649084845
-
Transforming growth factor-β-inducible phosphorylation of Smad3
-
Wang G, Matsuura I, He D, et al. Transforming growth factor-β- inducible phosphorylation of Smad3. J Biol Chem. 2009;284:9663-73.
-
(2009)
J Biol Chem
, vol.284
, pp. 9663-9673
-
-
Wang, G.1
Matsuura, I.2
He, D.3
-
23
-
-
67650466368
-
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-b signal in later stages of human colorectal cancer
-
Matsuzaki K, Kitano C, Murata M, et al. Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-b signal in later stages of human colorectal cancer. Cancer Res. 2009;69:5321-30.
-
(2009)
Cancer Res
, vol.69
, pp. 5321-5330
-
-
Matsuzaki, K.1
Kitano, C.2
Murata, M.3
-
24
-
-
70350780570
-
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-βpathways
-
Alarcón C, Zaromytidou AI, Xi Q, et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-βpathways. Cell. 2009;139:757-69.
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcón, C.1
Zaromytidou, A.I.2
Xi, Q.3
-
25
-
-
70350785179
-
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-b signaling
-
Gao S, Alarcón C, Sapkota G, et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-b signaling. Mol Cell. 2009;36:457-68.
-
(2009)
Mol Cell
, vol.36
, pp. 457-468
-
-
Gao, S.1
Alarcón, C.2
Sapkota, G.3
-
26
-
-
24944439828
-
Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3
-
Matsuura I, Wang G, He D, et al. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry. 2005;44:12546-53.
-
(2005)
Biochemistry
, vol.44
, pp. 12546-12553
-
-
Matsuura, I.1
Wang, G.2
He, D.3
-
27
-
-
6044261233
-
TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions
-
DOI 10.1038/sj.onc.1207981
-
Mori S, Matsuzaki K, Yoshida K, et al. TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Oncogene. 2004;23:7416-29. (Pubitemid 39382144)
-
(2004)
Oncogene
, vol.23
, Issue.44
, pp. 7416-7429
-
-
Mori, S.1
Matsuzaki, K.2
Yoshida, K.3
Furukawa, F.4
Tahashi, Y.5
Yamagata, H.6
Sekimoto, G.7
Seki, T.8
Matsui, H.9
Nishizawa, M.10
Fujisawa, J.-I.11
Okazaki, K.12
-
28
-
-
34347235524
-
Reversible Smad-dependent signaling between tumor suppression and oncogenesis
-
DOI 10.1158/0008-5472.CAN-06-4629
-
Sekimoto G, Matsuzaki K, Yoshida K, et al. Reversible Smaddependent signaling between tumor suppression and oncogenesis. Cancer Res. 2007;67:5090-6. (Pubitemid 46997243)
-
(2007)
Cancer Research
, vol.67
, Issue.11
, pp. 5090-5096
-
-
Sekimoto, G.1
Matsuzaki, K.2
Yoshida, K.3
Mori, S.4
Murata, M.5
Seki, T.6
Matsui, H.7
Fujisawa, J.-I.8
Okazaki, K.9
-
29
-
-
79953761687
-
c-Jun N-terminal kinase 1 promotes TGF-β1-induced epithelial to mesenchymaltransition via control of linker phosphorylation and transcriptional activity of Smad3
-
van der Velden JL, Alarcón JF, Guala AS, et al. c-Jun N-terminal kinase 1 promotes TGF-β1-induced epithelial to mesenchymaltransition via control of linker phosphorylation and transcriptional activity of Smad3. Am J Respir Cell Mol Biol. 2011;44:571-81.
-
(2011)
Am J Respir Cell Mol Biol
, vol.44
, pp. 571-581
-
-
Van Der Velden, J.L.1
Alarcón, J.F.2
Guala, A.S.3
-
30
-
-
84874234780
-
An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by micro RNAs in lung cancer cells
-
Saito A, Suzuki HI, Horie M, et al. An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by micro RNAs in lung cancer cells. PLoS ONE. 2013;8:e56587.
-
(2013)
PLoS ONE
, vol.8
-
-
Saito, A.1
Suzuki, H.I.2
Horie, M.3
-
31
-
-
84877705727
-
TGF-β-activated kinase 1(Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crestderived cells
-
Yumoto K, Thomas PS, Lane J, et al. TGF-β-activated kinase 1(Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crestderived cells. J Biol Chem. 2013;288:13467-80.
-
(2013)
J Biol Chem
, vol.288
, pp. 13467-13480
-
-
Yumoto, K.1
Thomas, P.S.2
Lane, J.3
-
32
-
-
0141866937
-
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts
-
DOI 10.1053/jhep.2003.50384
-
Furukawa F, Matsuzaki K, Mori S, et al. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology. 2003;38:879-89. (Pubitemid 37221671)
-
(2003)
Hepatology
, vol.38
, Issue.4
, pp. 879-889
-
-
Furukawa, F.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yoshida, K.5
Sugano, Y.6
Yamagata, H.7
Matsushita, M.8
Seki, T.9
Inagaki, Y.10
Nishizawa, M.11
Fujisawa, J.12
Inoue, K.13
-
33
-
-
12544257249
-
Role of Rho/ROCK and p38 map kinase pathways in transforming growth factor β mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo
-
Kamaraju AK, Roberts AB. Role of Rho/ROCK and p38 map kinase pathways in transforming growth factor β mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem. 2005;280:1024-36.
-
(2005)
J Biol Chem
, vol.280
, pp. 1024-1036
-
-
Kamaraju, A.K.1
Roberts, A.B.2
-
34
-
-
67749106488
-
A negative feedback control of transforming growth factor-β signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204
-
Millet C, Yamashita M, Heller M, et al. A negative feedback control of transforming growth factor-β signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204. J Biol Chem. 2009;284:19808-16.
-
(2009)
J Biol Chem
, vol.284
, pp. 19808-19816
-
-
Millet, C.1
Yamashita, M.2
Heller, M.3
-
35
-
-
38149054804
-
Axin and GSK3-b control Smad3 protein stability and modulate TGF-β signaling
-
Guo X, Ramirez A, Waddell DS, et al. Axin and GSK3-b control Smad3 protein stability and modulate TGF-β signaling. Genes Dev. 2008;22:106-20.
-
(2008)
Genes Dev
, vol.22
, pp. 106-120
-
-
Guo, X.1
Ramirez, A.2
Waddell, D.S.3
-
36
-
-
84867413455
-
Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
-
Abushahba W, Olabisi OO, Jeong BS, et al. Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma. PLoS ONE. 2012;7:e47312.
-
(2012)
PLoS ONE
, vol.7
-
-
Abushahba, W.1
Olabisi, O.O.2
Jeong, B.S.3
-
37
-
-
84883811151
-
Smad phospho-isoforms direct context-dependent TGF-b signaling
-
Matsuzaki K. Smad phospho-isoforms direct context-dependent TGF-b signaling. Cytokine Growth Factor Rev. 2013;24:385-99.
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, pp. 385-399
-
-
Matsuzaki, K.1
-
38
-
-
30944436222
-
Smad3 phosphorylation by cyclin-dependent kinases
-
DOI 10.1016/j.cytogfr.2005.09.010, PII S1359610105001140
-
Liu F. Smad3 phosphorylation by cyclin-dependent kinases. Cytokine Growth Factor Rev. 2006;17:9-17. (Pubitemid 43117512)
-
(2006)
Cytokine and Growth Factor Reviews
, vol.17
, Issue.1-2
, pp. 9-17
-
-
Liu, F.1
-
39
-
-
58149239730
-
Phospho-control of TGF-βsuperfamily signaling
-
Wrighton KH, Lin X, Feng X-H. Phospho-control of TGF-βsuperfamily signaling. Cell Res. 2009;19:8-20.
-
(2009)
Cell Res
, vol.19
, pp. 8-20
-
-
Wrighton, K.H.1
Lin, X.2
Feng, X.-H.3
-
40
-
-
80755187843
-
Smad phosphoisoform signaling specificity: The right place at the right time
-
Matsuzaki K. Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis. 2011;32:1578-88.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1578-1588
-
-
Matsuzaki, K.1
-
41
-
-
58149213801
-
Non-Smad pathways in TGF-β signaling
-
Zhang YE. Non-Smad pathways in TGF-β signaling. Cell Res. 2009;19:128-39.
-
(2009)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
42
-
-
24944497786
-
Non-Smad TGF-β signals
-
Moustakas A, Heldin CH. Non-Smad TGF-β signals. J Cell Sci. 2005;118:3573-84.
-
(2005)
J Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
43
-
-
19944427463
-
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation
-
DOI 10.1074/jbc.M410144200
-
Yamanaka M, Shegogue D, Pei H, et al. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation. J Biol Chem. 2004;279:53994-4001. (Pubitemid 40053131)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.52
, pp. 53994-54001
-
-
Yamanaka, M.1
Shegogue, D.2
Pei, H.3
Bu, S.4
Bielawska, A.5
Bielawski, J.6
Pettus, B.7
Hannun, Y.A.8
Obeid, L.9
Trojanowska, M.10
-
44
-
-
25444479744
-
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
-
DOI 10.1073/pnas.0506517102
-
Kang Y, He W, Tulley S, et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA. 2005;102:13909-14. (Pubitemid 41377677)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.39
, pp. 13909-13914
-
-
Kang, Y.1
He, W.2
Tulley, S.3
Gupta, G.P.4
Serganova, I.5
Chen, C.-R.6
Manova-Todorova, K.7
Blasberg, R.8
Gerald, W.L.9
Massague, J.10
-
45
-
-
0036304111
-
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
-
Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol. 2002;4:487-94. (Pubitemid 34752433)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.7
, pp. 487-494
-
-
Oft, M.1
Akhurst, R.J.2
Balmain, A.3
-
46
-
-
70350497349
-
Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
-
Ikushima H, Todo T, Ino Y, et al. Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell. 2009;5:504-14.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 504-514
-
-
Ikushima, H.1
Todo, T.2
Ino, Y.3
-
47
-
-
20244376914
-
Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury
-
Yoshida K, Matsuzaki K, Mori S, et al. Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol. 2005;166:1029-39. (Pubitemid 40524428)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.4
, pp. 1029-1039
-
-
Yoshida, K.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yamagata, H.5
Furukawa, F.6
Seki, T.7
Nishizawa, M.8
Fujisawa, J.9
Okazaki, K.10
-
49
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883-99.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
50
-
-
34347232205
-
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma
-
DOI 10.1002/hep.21672
-
Matsuzaki K, Murata M, Yoshida K, et al. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology. 2007;46:48-57. (Pubitemid 47171920)
-
(2007)
Hepatology
, vol.46
, Issue.1
, pp. 48-57
-
-
Matsuzaki, K.1
Murata, M.2
Yoshida, K.3
Sekimoto, G.4
Uemura, Y.5
Sakaida, N.6
Kaibori, M.7
Kamiyama, Y.8
Nishizawa, M.9
Fujisawa, J.10
Okazaki, K.11
Seki, T.12
-
51
-
-
65449159717
-
Hepatitis B virus X protein shifts human hepatic TGF-β signaling from tumor-suppression to oncogenesis in early chronic hepatitis B
-
Murata M, Matsuzaki K, Yoshida K, et al. Hepatitis B virus X protein shifts human hepatic TGF-β signaling from tumor-suppression to oncogenesis in early chronic hepatitis B. Hepatology. 2009;49:1203-17.
-
(2009)
Hepatology
, vol.49
, pp. 1203-1217
-
-
Murata, M.1
Matsuzaki, K.2
Yoshida, K.3
-
52
-
-
67650377329
-
Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor-suppression in rat hepatocellular carcinoma
-
Nagata H, Hatano E, Tada M, et al. Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor-suppression in rat hepatocellular carcinoma. Hepatology. 2009;49:1944-53.
-
(2009)
Hepatology
, vol.49
, pp. 1944-1953
-
-
Nagata, H.1
Hatano, E.2
Tada, M.3
-
53
-
-
79951626443
-
Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis
-
Kawamata S, Matsuzaki K, Murata M, et al. Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis. Inflamm Bowel Dis. 2011;17:683-95.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 683-695
-
-
Kawamata, S.1
Matsuzaki, K.2
Murata, M.3
-
54
-
-
0031596719
-
4 administration
-
DOI 10.1016/S0168-8278(98)80280-8
-
Date M, Matsuzaki K, Matsushita M, et al. Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4 administration. J Hepatol. 1998;28:572-81. (Pubitemid 28167994)
-
(1998)
Journal of Hepatology
, vol.28
, Issue.4
, pp. 572-581
-
-
Date, M.1
Matsuzaki, K.2
Matsushita, M.3
Sakitani, K.4
Shibano, K.5
Okajima, A.6
Yamamoto7
Ogata, N.8
Okumura, T.9
Seki, T.10
Kubota, Y.11
Kan, M.12
McKeehan, W.L.13
Inoue, K.14
-
55
-
-
0034023752
-
Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury
-
DOI 10.1136/gut.46.5.719
-
Date M, Matsuzaki K, Matsushita M, et al. Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury. Gut. 2000;46:719-24. (Pubitemid 30305793)
-
(2000)
Gut
, vol.46
, Issue.5
, pp. 719-724
-
-
Date, M.1
Matsuzaki, K.2
Matsushita, M.3
Tahashi, Y.4
Furukawa, F.5
Inoue, K.6
-
56
-
-
84897111988
-
Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats
-
Epub ahead of print
-
Kaji K, Yoshiji H, Ikenaka Y, et al. Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats. J Gastroenterol. 2013 (Epub ahead of print).
-
(2013)
J Gastroenterol
-
-
Kaji, K.1
Yoshiji, H.2
Ikenaka, Y.3
-
57
-
-
84880983644
-
Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress
-
Szuster-Ciesielska A, Mizerska-Dudka M, Daniluk J, et al. Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress. J Gastroenterol. 2013;48:222-37.
-
(2013)
J Gastroenterol
, vol.48
, pp. 222-237
-
-
Szuster-Ciesielska, A.1
Mizerska-Dudka, M.2
Daniluk, J.3
-
59
-
-
72249114470
-
Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition
-
Kluwe J, Pradere JP, Gwak GY, et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology. 2010;138:347-59.
-
(2010)
Gastroenterology
, vol.138
, pp. 347-359
-
-
Kluwe, J.1
Pradere, J.P.2
Gwak, G.Y.3
-
60
-
-
84877955035
-
TGF-β signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells
-
Mu X, Lin S, Yang J, et al. TGF-β signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells. PLoS ONE. 2013;8:e63436.
-
(2013)
PLoS ONE
, vol.8
-
-
Mu, X.1
Lin, S.2
Yang, J.3
-
61
-
-
0029784067
-
1 arrest, p53, and Rb
-
Glick AB, Weinberg WC, Wu IH, et al. Transforming growth factor β 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb. Cancer Res. 1996;56:3645-50. (Pubitemid 26272005)
-
(1996)
Cancer Research
, vol.56
, Issue.16
, pp. 3645-3650
-
-
Glick, A.B.1
Weinberg, W.C.2
Wu, I.-H.3
Quan, W.4
Yuspa, S.H.5
-
62
-
-
0034704916
-
Defects in TGFβ signaling overcome senescence of mouse keratinocytes expressing v-ras(Ha)
-
Tremain R, Marko M, Kinnimulki V, et al. Defects in TGF-β signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene. 2000;19:1698-709. (Pubitemid 30200972)
-
(2000)
Oncogene
, vol.19
, Issue.13
, pp. 1698-1709
-
-
Tremain, R.1
Marko, M.2
Kinnimulki, V.3
Ueno, H.4
Bottinger, E.5
Glick, A.6
-
63
-
-
0035126895
-
Autocrine transforming growth factor β suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells
-
Yang H, Kyo S, Takatura M, et al. Autocrine transforming growth factor β suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. Cell Growth Differ. 2001;12:119-27. (Pubitemid 32194901)
-
(2001)
Cell Growth and Differentiation
, vol.12
, Issue.2
, pp. 119-127
-
-
Yang, H.1
Kyo, S.2
Takatura, M.3
Sun, L.4
-
65
-
-
84883814284
-
Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C
-
Epub ahead of print
-
Yamaguchi T, Matsuzaki K, Inokuchi R, et al. Phosphorylated Smad2 and Smad3 signaling: shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C. Hepatol Res. 2013 (Epub ahead of print).
-
(2013)
Hepatol Res
-
-
Yamaguchi, T.1
Matsuzaki, K.2
Inokuchi, R.3
-
66
-
-
0030054203
-
Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
-
Eitzman DT, McCoy RD, Zheng X, et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest. 1996;97:232-7. (Pubitemid 26021713)
-
(1996)
Journal of Clinical Investigation
, vol.97
, Issue.1
, pp. 232-237
-
-
Eitzman, D.T.1
McCoy, R.D.2
Zheng, X.3
Fay, W.P.4
Shen, T.5
Ginsburg, D.6
Simon, R.H.7
-
67
-
-
67349254116
-
Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats
-
Hu PF, Chen H, Zhong W, et al. Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats. J Hepatol. 2009;51:102-13.
-
(2009)
J Hepatol
, vol.51
, pp. 102-113
-
-
Hu, P.F.1
Chen, H.2
Zhong, W.3
-
68
-
-
0028301747
-
Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma: Comparison with chronic liver diseases
-
Shirai Y, Kawata S, Tamura S, et al. Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma: comparison with chronic liver diseases. Cancer. 1994;73:2275-9. (Pubitemid 24129108)
-
(1994)
Cancer
, vol.73
, Issue.9
, pp. 2275-2279
-
-
Shirai, Y.1
Kawata, S.2
Tamura, S.3
Ito, N.4
Tsushima, H.5
Takaishi, K.6
Kiso, S.7
Matsuzawa, Y.8
-
69
-
-
33749627330
-
How to modulate inflammatory cytokines in liver diseases
-
DOI 10.1111/j.1478-3231.2006.01339.x
-
Tilg H, Kaser A, Moschen AR. How to modulate inflammatory cytokines in liver diseases. Liver Int. 2006;26:1029-39. (Pubitemid 44541743)
-
(2006)
Liver International
, vol.26
, Issue.9
, pp. 1029-1039
-
-
Tilg, H.1
Kaser, A.2
Moschen, A.R.3
-
70
-
-
0037656524
-
Distortion of autocrine transforming growth factor β signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells
-
DOI 10.1038/sj.onc.1206305
-
Sugano Y, Matsuzaki K, Tahashi Y, et al. Distortion of autocrine transforming growth factor β signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells. Oncogene. 2003;22:2309-21. (Pubitemid 36566786)
-
(2003)
Oncogene
, vol.22
, Issue.15
, pp. 2309-2321
-
-
Sugano, Y.1
Matsuzaki, K.2
Tahashi, Y.3
Furukawa, F.4
Mori, S.5
Yamagata, H.6
Yoshida, K.7
Matsushita, M.8
Nishizawa, M.9
Fujisawa, J.10
Inoue, K.11
-
71
-
-
84655161582
-
Effects of 1-year administration of olmesartan on portal pressure and TGF-b1 in selected patients with cirrhosis: A randomized controlled trial
-
Hidaka H, Nakazawa T, Shibuya A, et al. Effects of 1-year administration of olmesartan on portal pressure and TGF-b1 in selected patients with cirrhosis: a randomized controlled trial. J Gastroenterol. 2011;46:1316-23.
-
(2011)
J Gastroenterol
, vol.46
, pp. 1316-1323
-
-
Hidaka, H.1
Nakazawa, T.2
Shibuya, A.3
-
72
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
73
-
-
29944436855
-
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA Level
-
DOI 10.1001/jama.295.1.65
-
Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295:65-73. (Pubitemid 43042691)
-
(2006)
Journal of the American Medical Association
, vol.295
, Issue.1
, pp. 65-73
-
-
Chen, C.-J.1
Yang, H.-I.2
Su, J.3
Jen, C.-L.4
You, S.-L.5
Lu, S.-N.6
Huang, G.-T.7
Iloeje, U.H.8
-
74
-
-
7044260782
-
Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms
-
DOI 10.1053/j.gastro.2004.09.016, PII S0016508504015951
-
Bréchot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology. 2004;127:S56-61. (Pubitemid 39423370)
-
(2004)
Gastroenterology
, vol.127
, Issue.SUPPL.
-
-
Brechot, C.1
-
75
-
-
0025907983
-
HBx gene of hepatitis B virus induces liver cancer in transgenic mice
-
Kim CM, Koike K, Saito I, et al. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991;351:317-20. (Pubitemid 21896589)
-
(1991)
Nature
, vol.351
, Issue.6324
, pp. 317-320
-
-
Kim, C.-M.1
Koike, K.2
Saito, I.3
Miyamura, T.4
Jay, G.5
-
76
-
-
0035084167
-
Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
-
DOI 10.1128/JVI.75.8.3851-3858.2001
-
Madden CR, Finegold MJ, Slagle BL. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol. 2001;75:3851-8. (Pubitemid 32246394)
-
(2001)
Journal of Virology
, vol.75
, Issue.8
, pp. 3851-3858
-
-
Madden, C.R.1
Finegold, M.J.2
Slagle, B.L.3
-
77
-
-
0031712813
-
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
-
DOI 10.1038/2053
-
Moriya K, Fujie H, Shintani Y, et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med. 1998;4:1065-7. (Pubitemid 28417341)
-
(1998)
Nature Medicine
, vol.4
, Issue.9
, pp. 1065-1067
-
-
Moriya, K.1
Fujie, H.2
Shintani, Y.3
Yotsuyanagi, H.4
Tsutsumi, T.5
Ishibashi, K.6
Matsuuras, Y.7
Kimura, S.8
Miyamura, T.9
Koike, K.10
-
78
-
-
36348973582
-
Altered innate immunity in chronic hepatitis C infection: Cause or effect?
-
DOI 10.1002/hep.21938
-
Szabo G, Chang S, Dolganiuc A. Altered innate immunity in chronic hepatitis C infection: cause or effect? Hepatology. 2007;46:1279-90. (Pubitemid 350144792)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1279-1290
-
-
Szabo, G.1
Chang, S.2
Dolganiuc, A.3
-
79
-
-
0037180757
-
Inflammation and cancer
-
DOI 10.1038/nature01322
-
Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860-7. (Pubitemid 36019639)
-
(2002)
Nature
, vol.420
, Issue.6917
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
80
-
-
73949157586
-
Modulation of the transforming growth factor-β1-induced Smad phosphorylation by theextracellular matrix receptor b1-integrin
-
Hamajima H, Ozaki I, Zhang H, et al. Modulation of the transforming growth factor-β1-induced Smad phosphorylation by theextracellular matrix receptor b1-integrin. Int J Oncol.2009;35:1441-7.
-
(2009)
Int J Oncol
, vol.35
, pp. 1441-1447
-
-
Hamajima, H.1
Ozaki, I.2
Zhang, H.3
-
81
-
-
70350102906
-
SKI knockdown inhibits human melanoma tumor growth in vivo
-
Chen D, Lin Q, Box N, et al. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell Melanoma Res. 2009;22:761-72.
-
(2009)
Pigment Cell Melanoma Res
, vol.22
, pp. 761-772
-
-
Chen, D.1
Lin, Q.2
Box, N.3
-
82
-
-
0037221907
-
Histological outcome during long-term lamivudine therapy
-
DOI 10.1053/gast.2003.50013
-
Dienstag JL, Goldin RD, Heathcote EJ, et al. Histological outcome during long-term lamivudine therapy. Gastroenterology. 2003;124:105-17. (Pubitemid 36055344)
-
(2003)
Gastroenterology
, vol.124
, Issue.1
, pp. 105-117
-
-
Dienstag, J.L.1
Goldin, R.D.2
Heathcote, E.J.3
Hann, H.W.L.4
Woessner, M.5
Stephenson, S.L.6
Gardner, S.7
Gray, D.F.8
Schiff, E.R.9
-
83
-
-
33845671388
-
Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years
-
DOI 10.1053/j.gastro.2006.09.020, PII S0016508506020804
-
Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology. 2006;131:1743-51. (Pubitemid 44958517)
-
(2006)
Gastroenterology
, vol.131
, Issue.6
, pp. 1743-1751
-
-
Hadziyannis, S.J.1
Tassopoulos, N.C.2
Heathcote, E.J.3
Chang, T.4
Kitis, G.5
Rizzetto, M.6
Marcellin, P.7
Lim, S.G.8
Goodman, Z.9
Ma, J.10
Brosgart, C.L.11
Borroto-Esoda, K.12
Arterburn, S.13
Chuck, S.L.14
-
84
-
-
77956639159
-
Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
-
Chang TT, Liaw YF, Wu SS, et al. Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology. 2010;52:886-93.
-
(2010)
Hepatology
, vol.52
, pp. 886-893
-
-
Chang, T.T.1
Liaw, Y.F.2
Wu, S.S.3
-
85
-
-
79955433548
-
Targeted therapies for hepatocellular carcinoma
-
Villanueva A, Llovet JM. Targeted therapies for hepatocellular carcinoma. Gastroenterology. 2011;140:1410-26.
-
(2011)
Gastroenterology
, vol.140
, pp. 1410-1426
-
-
Villanueva, A.1
Llovet, J.M.2
-
86
-
-
77953119545
-
Risk assessment for the development of hepatocellular carcinoma: According to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease
-
Eun JR, Lee HJ, Kim TN, et al. Risk assessment for the development of hepatocellular carcinoma: according to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease. J Hepatol. 2010;53:118-25.
-
(2010)
J Hepatol
, vol.53
, pp. 118-125
-
-
Eun, J.R.1
Lee, H.J.2
Kim, T.N.3
-
87
-
-
79960302035
-
Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: Results of the nationwide HEPNET. Greece cohort study
-
Papatheodoridis GV, Manolakopoulos S, Touloumi G, et al. Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: results of the nationwide HEPNET. Greece cohort study. Gut. 2011;60:1109-16.
-
(2011)
Gut
, vol.60
, pp. 1109-1116
-
-
Papatheodoridis, G.V.1
Manolakopoulos, S.2
Touloumi, G.3
-
88
-
-
33745532794
-
Genetics of hepatocellular tumors
-
DOI 10.1038/sj.onc.1209547, PII 1209547
-
Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene. 2006;25:3778-86. (Pubitemid 43980473)
-
(2006)
Oncogene
, vol.25
, Issue.27
, pp. 3778-3786
-
-
Laurent-Puig, P.1
Zucman-Rossi, J.2
|