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TGF-β receptors and TGF-β binding proteoglycans: Recent progress in identifying their functional properties
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Massagué J, Cheifetz S, Boyd FT, Andres JL. TGF-β receptors and TGF-β binding proteoglycans: recent progress in identifying their functional properties. Ann NY Acad Sci. 593:1990;59-72.
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Massagué, J.1
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TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
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Moses HL, Yang E, Pietenpol JA. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell. 63:1990;245-247.
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TGF-β receptor-mediated signaling
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Derynck R. TGF-β receptor-mediated signaling. Trends Biochem Sci. 19:1994;548-553.
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Derynck, R.1
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5
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0029117276
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Cloning and characterization of a human type II receptor for bone morphogenetic proteins
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Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, Ten Dijke P, Heldin CH, Miyazono K. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci USA. 92:1995;7632-7636.
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Rosenzweig, B.L.1
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Yamashita, H.5
Ten Dijke, P.6
Heldin, C.H.7
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6
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0028180315
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The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
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Kingsley DM. The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8:1994;133-146.
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Kingsley, D.M.1
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7
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Pattern specific expression of the dpp gene in imaginal discs is regulated by 3' cis-regulatory elements
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Masucci JD, Miltenberger RJ, Hoffmann FM. Pattern specific expression of the dpp gene in imaginal discs is regulated by 3' cis-regulatory elements. Genes Dev. 4:1990;2011-2023.
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Masucci, J.D.1
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Hoffmann, F.M.3
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8
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0028981461
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Shortsighted acts in the decapentaplegic pathway in Drosophile eye development and has homology to a mouse TGF-β responsive gene
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of outstanding interest. The identification of a Drosophila homolog of mammalian TSC-22, short-sighted (shs), is described. This report provides genetic evidence suggesting shs is required in Dpp signaling. This is a good example of how Drosophila genetics can be used to examine the role of TGF-βs in the differentiation of specific tissues.
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Treisman JE, Lai ZC, Rubin GM. shortsighted acts in the decapentaplegic pathway in Drosophile eye development and has homology to a mouse TGF-β responsive gene. of outstanding interest Development. 121:1995;2835-2845 The identification of a Drosophila homolog of mammalian TSC-22, short-sighted (shs), is described. This report provides genetic evidence suggesting shs is required in Dpp signaling. This is a good example of how Drosophila genetics can be used to examine the role of TGF-βs in the differentiation of specific tissues.
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(1995)
Development
, vol.121
, pp. 2835-2845
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Treisman, J.E.1
Lai, Z.C.2
Rubin, G.M.3
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9
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0026670791
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Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor β1 and other growth factors
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Shibanuma M, Kuroki T, Nose K. Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor β1 and other growth factors. J Biol Chem. 267:1992;10219-10224.
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J Biol Chem
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Shibanuma, M.1
Kuroki, T.2
Nose, K.3
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10
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0028299339
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Glial growth factor restricts mammalian neural crest stem cells to a glial fate
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Shah NM, Marchionni MA, Isaacs I, Stroobant PW, Anderson DJ. Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell. 77:1994;349-360.
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Shah, N.M.1
Marchionni, M.A.2
Isaacs, I.3
Stroobant, P.W.4
Anderson, D.J.5
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11
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0029897371
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Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members
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of outstanding interest. Signals by members of the TGF-β superfamily promote instructively rather than selectively alternative fates to neural crest stem cells. These data provide an important model for the generation of diverse cell fates from multi-potent progenitor cells in early embryogenesis.
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Shah NM, Groves AK, Anderson DJ. Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members. of outstanding interest Cell. 85:1996;331-343 Signals by members of the TGF-β superfamily promote instructively rather than selectively alternative fates to neural crest stem cells. These data provide an important model for the generation of diverse cell fates from multi-potent progenitor cells in early embryogenesis.
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(1996)
Cell
, vol.85
, pp. 331-343
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Shah, N.M.1
Groves, A.K.2
Anderson, D.J.3
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12
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0000481399
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Development of peripheral nerve fibers
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P.J. Dyck, P.K. Thomas, J. Griffin, P.A. Low, Poduslo J.F. edn 3 Philadelphia, PA: WB Saunders Co
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Webster HD. Development of peripheral nerve fibers. Dyck PJ, Thomas PK, Griffin J, Low PA, Poduslo JF. edn 3 Peripheral Neuropathy. 1992;243-266 WB Saunders Co, Philadelphia, PA.
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Peripheral Neuropathy
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Webster, H.D.1
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13
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0027503180
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Plasticity of developing and adult dorsal root ganglion neurons as revealed
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Deirée P, Ribbens C, Martin D, Rogister B, Lefebvre PP, Rigo JM, Leprince P, Schoenen J, Moonen G. Plasticity of developing and adult dorsal root ganglion neurons as revealed. in vitro. Brain Res Bull. 30:1993;231-237.
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In vitro. Brain Res Bull
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Deirée, P.1
Ribbens, C.2
Martin, D.3
Rogister, B.4
Lefebvre, P.P.5
Rigo, J.M.6
Leprince, P.7
Schoenen, J.8
Moonen, G.9
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14
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0025800595
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Localization and actions of transforming growth factor-βs in the embryonic nervous system
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Flanders KC, Ludecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K. Localization and actions of transforming growth factor-βs in the embryonic nervous system. Development. 113:1991;183-191.
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Development
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Flanders, K.C.1
Ludecke, G.2
Engels, S.3
Cissel, D.S.4
Roberts, A.B.5
Kondaiah, P.6
Lafyatis, R.7
Sporn, M.B.8
Unsicker, K.9
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15
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0025776477
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Tranforming growth factor-β isoforms in the adult rat central and peripheral nervous system
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Unsicker K, Flanders KC, Cissel DS, Lafyatis R, Sporn MB. Tranforming growth factor-β isoforms in the adult rat central and peripheral nervous system. Neuroscience. 44:1991;613-625.
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Neuroscience
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Unsicker, K.1
Flanders, K.C.2
Cissel, D.S.3
Lafyatis, R.4
Sporn, M.B.5
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16
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0027395241
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Transforming growth factor β as a neuronoglial signal during peripheral nervous system response to injury
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Rogister B, Delrée P, Leprince P, Martin D, Sadzot C, Malgrange B, Munaut C, Rigo JM, Lefebvre PP, Octave JN, et al. Transforming growth factor β as a neuronoglial signal during peripheral nervous system response to injury. J Neurosci Res. 34:1993;32-43.
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J Neurosci Res
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Rogister, B.1
Delrée, P.2
Leprince, P.3
Martin, D.4
Sadzot, C.5
Malgrange, B.6
Munaut, C.7
Rigo, J.M.8
Lefebvre, P.P.9
Octave, J.N.10
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17
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0028986744
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Transforming growth factor-β1 regulates axon/Schwann cell interactions
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of special interest. TGF-β1 promotes the premyelinating or nonmyelinating Schwann cell phenotype. These data provide a model for the role of TGF-β in development of the peripheral nervous system and in repair after injury in the adult.
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Einheber S, Hannocks M-J, Metz CN, Rifkin DB, Salzer JL. Transforming growth factor-β1 regulates axon/Schwann cell interactions. of special interest J Cell Biol. 129:1995;443-458 TGF-β1 promotes the premyelinating or nonmyelinating Schwann cell phenotype. These data provide a model for the role of TGF-β in development of the peripheral nervous system and in repair after injury in the adult.
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J Cell Biol
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Einheber, S.1
Hannocks M-J2
Metz, C.N.3
Rifkin, D.B.4
Salzer, J.L.5
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18
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0029137658
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Transforming growth factor-β blocks myelination but no ensheathment of axons by Schwann cells in vitro
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of special interest. This set of experiments tests the effects of TGF-β on the ensheathment and myelination of dorsal root ganglion neurons by Scwhann cells in vitro. TGF-β blocks Schwann cell myelination in neuron/Schwann cell co-cultures. This report provides a model of the role of TGF-β1 in peripheral nerve regeneration.
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Guénard V, Gwynn LA, Wood PM. Transforming growth factor-β blocks myelination but no ensheathment of axons by Schwann cells in vitro. of special interest J Neurosci. 15:1995;419-428 This set of experiments tests the effects of TGF-β on the ensheathment and myelination of dorsal root ganglion neurons by Scwhann cells in vitro. TGF-β blocks Schwann cell myelination in neuron/Schwann cell co-cultures. This report provides a model of the role of TGF-β1 in peripheral nerve regeneration.
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(1995)
J Neurosci
, vol.15
, pp. 419-428
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Guénard, V.1
Gwynn, L.A.2
Wood, P.M.3
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19
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0027645607
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Axons modulate the expression of tranforming growth factor-βs in Schwann cells
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Scherer SS, Kamholz J, Jakowlew SB. Axons modulate the expression of tranforming growth factor-βs in Schwann cells. Glia. 8:1993;265-276.
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Glia
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Scherer, S.S.1
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0026493347
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Peptide growth factors and their interactions during chondrogenesis
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Hill DJ, Logan A. Peptide growth factors and their interactions during chondrogenesis. Prog Growth Factor Res. 4:1992;45-68.
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Prog Growth Factor Res
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Hill, D.J.1
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23
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0029033910
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Independent changes in type I and type II receptors for TGF-β induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype
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of outstanding interest. This report provides a possible mechanism for the stepwise actions of TGFβ like proteins in skeletal development. Changes imprinted by BMP-2 on the TGF-β receptor profile in osteoblasts after responsiveness to TGF-β and allow further osteoblast differentiation.
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Centrella M, Casinghino S, Kim J, Pham T, Rosen V, Wozney J, McCarthy TL. Independent changes in type I and type II receptors for TGF-β induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. of outstanding interest Mol Cell Biol. 15:1995;3273-3281 This report provides a possible mechanism for the stepwise actions of TGFβ like proteins in skeletal development. Changes imprinted by BMP-2 on the TGF-β receptor profile in osteoblasts after responsiveness to TGF-β and allow further osteoblast differentiation.
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Mol Cell Biol
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Centrella, M.1
Casinghino, S.2
Kim, J.3
Pham, T.4
Rosen, V.5
Wozney, J.6
McCarthy, T.L.7
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24
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0025857671
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Recombinant bone morphogenetic protein 2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
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Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S. Recombinant bone morphogenetic protein 2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol. 113:1991;681-687.
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J Cell Biol
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Yamaguchi, A.1
Katagiri, T.2
Ikeda, T.3
Wozney, J.M.4
Rosen, V.5
Wang, E.A.6
Kahn, A.J.7
Suda, T.8
Yoshiki, S.9
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25
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0025789151
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Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor β1 and β2
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Chen P, Carrington JL, Hammonds RG, Reddi AH. Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor β1 and β2. Exp Cell Res. 195:1991;509-515.
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Chen, P.1
Carrington, J.L.2
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Reddi, A.H.4
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26
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0028179081
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Transforming growth factor-β and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in in vitro
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Roark EF, Greer K. Transforming growth factor-β and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in in vitro. Dev Dyn. 200:1994;103-116.
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Roark, E.F.1
Greer, K.2
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27
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0029065505
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Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells
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of special interest. Evidence for the stepwise actions of members of the TGF-β superfamily in osteoblast differentiation is presented here. The data suggest that TGF-β1 acts prior to BMP-6 during osteoblast differentiation.
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Gitelman SE, Kirk M, Ye J-Q, Filvaroff EH, Kahn AJ, Derynck R. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. of special interest Cell Growth Differ. 6:1995;827-836 Evidence for the stepwise actions of members of the TGF-β superfamily in osteoblast differentiation is presented here. The data suggest that TGF-β1 acts prior to BMP-6 during osteoblast differentiation.
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Cell Growth Differ
, vol.6
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Gitelman, S.E.1
Kirk, M.2
Ye J-Q3
Filvaroff, E.H.4
Kahn, A.J.5
Derynck, R.6
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28
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0027409133
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Modulation of expression and cell surface binding of members of the transforming growth factor-β superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells
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Gazit D, Ebner R, Kahn AJ, Derynck R. Modulation of expression and cell surface binding of members of the transforming growth factor-β superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol Endocrinol. 7:1993;189-198.
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Mol Endocrinol
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Gazit, D.1
Ebner, R.2
Kahn, A.J.3
Derynck, R.4
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29
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0026440993
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The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-β superfamily
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Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-β superfamily. Cell. 71:1992;399-410.
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Cell
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Kingsley, D.M.1
Bland, A.E.2
Grubber, J.M.3
Marker, P.C.4
Russell, L.B.5
Copeland, N.G.6
Jenkins, N.A.7
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30
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0028232724
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Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily
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Storm EE, Huynh TV, Copeland NG, Jenkins NA, Kingsley DM, Lee S-J. Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily. Nature. 368:1994;639-643.
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Nature
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Storm, E.E.1
Huynh, T.V.2
Copeland, N.G.3
Jenkins, N.A.4
Kingsley, D.M.5
Lee S-J6
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31
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0029936784
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A human chondrodysplasia due to a mutation in a TGF-β superfamily member
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of outstanding interest. Demonstration that a mutation in the human CDMP-1 gene (homologous to mouse Gdf-5) is associated with a recessive human chondrodysplasia. This represents the first human disorder attributable to a mutation in the TGF-β superfamily.
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Thomas JT, Lin KM, Nandedkar M, Camargo M, Cervenka A, Luyten FP. A human chondrodysplasia due to a mutation in a TGF-β superfamily member. of outstanding interest Nat Genet. 12:1996;315-317 Demonstration that a mutation in the human CDMP-1 gene (homologous to mouse Gdf-5) is associated with a recessive human chondrodysplasia. This represents the first human disorder attributable to a mutation in the TGF-β superfamily.
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Nat Genet
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Thomas, J.T.1
Lin, K.M.2
Nandedkar, M.3
Camargo, M.4
Cervenka, A.5
Luyten, F.P.6
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32
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0029100688
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Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with TGF-β1
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Denker AE, Nicoll SB, Tuan RS. Formation of cartilage-like spheroids by micromass cultures of murine C3H10T 1 2 cells upon treatment with TGF-β1. Differentiation. 59:1994;25-34.
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Denker, A.E.1
Nicoll, S.B.2
Tuan, R.S.3
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33
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0029670126
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TGF-β and basement membrane matrigel stimulate the chondrogenic phenotype in osteoblastic cells derived from fetal rat calvaria
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Basic N, Basic V, Bulic K, Grgic M, Kleinman HK, Luyten FP, Vukicevic S. TGF-β and basement membrane matrigel stimulate the chondrogenic phenotype in osteoblastic cells derived from fetal rat calvaria. J Bone Miner Res. 11:1996;384-391.
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J Bone Miner Res
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Basic, N.1
Basic, V.2
Bulic, K.3
Grgic, M.4
Kleinman, H.K.5
Luyten, F.P.6
Vukicevic, S.7
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34
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0028284846
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Opposite effects of osteogenic protein and TGF-β on chondrogenesis in cultured long bone rudiments
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Dieudonne SC, Semeins CM, Goei SW, Vukicevic S, Nulen JK, Smapath TK, Helder M, Burger EH. Opposite effects of osteogenic protein and TGF-β on chondrogenesis in cultured long bone rudiments. J Bone Miner Res. 9:1994;771-780.
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Dieudonne, S.C.1
Semeins, C.M.2
Goei, S.W.3
Vukicevic, S.4
Nulen, J.K.5
Smapath, T.K.6
Helder, M.7
Burger, E.H.8
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35
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0141979839
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Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: Regulation by transforming growth factor-β and serum factors
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Kato Y, Iwamoto M, Koike T, Suzuki F, Takano Y. Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor-β and serum factors. Proc Natl Acad Sci USA. 85:1988;9552-9556.
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Kato, Y.1
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Takano, Y.5
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36
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0027209267
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TGF-β1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases
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Ballock RT, Heydemann A, Wakefield LM, Flanders KC, Roberts AB, Sporn MB. TGF-β1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev Biol. 158:1993;414-429.
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Ballock, R.T.1
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Flanders, K.C.4
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Interplay between proliferation and differentiation within the myogenic lineage
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Olson EN. Interplay between proliferation and differentiation within the myogenic lineage. Dev Biol. 154:1992;261-272.
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0028980337
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Ras p21VAL inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors
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Kong Y, Johnson SE, Taparowsky EJ, Konieczny SF. Ras p21VAL inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors. Mol Cell Biol. 115:1995;5205-5213.
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Kong, Y.1
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Taparowsky, E.J.3
Konieczny, S.F.4
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0025909860
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TGF-β represses the action of myogenin through a mechanism independent of DNA binding
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Brennen TJ, Edmondson DG, Li L, Olson EN. TGF-β represses the action of myogenin through a mechanism independent of DNA binding. Proc Natl Acad Sci USA. 88:1991;3822-3826.
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Proc Natl Acad Sci USA
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Brennen, T.J.1
Edmondson, D.G.2
Li, L.3
Olson, E.N.4
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MyoD induces growth arrest independent of differentiation in normal and transformed cells
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Crescenzi M, Fleming TP, Lassar AB, Weintraub H, Aaronson SA. MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc Natl Acad Sci USA. 87:1990;8442-8446.
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Crescenzi, M.1
Fleming, T.P.2
Lassar, A.B.3
Weintraub, H.4
Aaronson, S.A.5
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41
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0025277030
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Cell proliferation inhibited by MyoD1 independently of myogenic differentiation
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Sorrentino V, Pepperkok R, Davis RL, Ansorge W, Philipson L. Cell proliferation inhibited by MyoD1 independently of myogenic differentiation. Nature. 345:1990;813-815.
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Nature
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42
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0027499060
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Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
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Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell. 72:1993;309-324.
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Gu, W.1
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43
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0028926433
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Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor β
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of special interest. This report demonstrates that cyclin D1 expression is upregulated by TGF-β1, an inhibitor of myoblast differentiation. Stable overexpression of cyclin D1 also blocks myoblast differentiation, suggesting that upregulation of cyclin D1 expression may play a role in the inhibition of myoblast differentiation by TGF-β1.
-
Rao SS, Kohtz DS. Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor β of special interest J Biol Chem. 270:1995;4093-4100 This report demonstrates that cyclin D1 expression is upregulated by TGF-β1, an inhibitor of myoblast differentiation. Stable overexpression of cyclin D1 also blocks myoblast differentiation, suggesting that upregulation of cyclin D1 expression may play a role in the inhibition of myoblast differentiation by TGF-β1.
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(1995)
J Biol Chem
, vol.270
, pp. 4093-4100
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Rao, S.S.1
Kohtz, D.S.2
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44
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0028145332
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Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators
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Rao SS, Chu C, Kohtz DS. Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. Mol Cell Biol. 14:1994;5259-5267.
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(1994)
Mol Cell Biol
, vol.14
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Rao, S.S.1
Chu, C.2
Kohtz, D.S.3
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45
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0026600982
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Transforming growth factor-β a bidirectional regulator for hematopoietic cell growth
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Keller JR, Jacobsen SEW, Dubois CM, Hestdal K, Ruscetti FW. Transforming growth factor-β a bidirectional regulator for hematopoietic cell growth. Int J Cell Clon. 10:1992;2-11.
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(1992)
Int J Cell Clon
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Keller, J.R.1
Jacobsen, S.E.W.2
Dubois, C.M.3
Hestdal, K.4
Ruscetti, F.W.5
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46
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0028952955
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Transforming growth factor β1 inhibits expression of the gene products for steel factor and its receptor (c-kit)
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Heinrich MC, Dooley DC, Keeble WW. Transforming growth factor β1 inhibits expression of the gene products for steel factor and its receptor (c-kit). Blood. 85:1995;1769-1780.
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(1995)
Blood
, vol.85
, pp. 1769-1780
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Heinrich, M.C.1
Dooley, D.C.2
Keeble, W.W.3
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47
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0029074681
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Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock-out mice
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of outstanding interest. This report examines the cause of perinatal lethality in 50% of TGF-β1 null embryos and provides evidence that the primary effect of loss of TGF-β1 in vivo is defective yolk sac hematopoiesis and endothelial differentiation. This report is important because it determines the role of TGF-β1 in a mammalian system in vivo using a loss-of-function mutation.
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Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ. Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock-out mice. of outstanding interest Development. 121:1995;1845-1854 This report examines the cause of perinatal lethality in 50% of TGF-β1 null embryos and provides evidence that the primary effect of loss of TGF-β1 in vivo is defective yolk sac hematopoiesis and endothelial differentiation. This report is important because it determines the role of TGF-β1 in a mammalian system in vivo using a loss-of-function mutation.
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(1995)
Development
, vol.121
, pp. 1845-1854
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Dickson, M.C.1
Martin, J.S.2
Cousins, F.M.3
Kulkarni, A.B.4
Karlsson, S.5
Akhurst, R.J.6
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48
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0027510447
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Expression and function of c-kit in fetal hematopoietic progenitor cells: Transition from early c-kit independent to the late c-kit dependent wave of hematopoiesis in the murine embryo
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Ogawa M, Nishikawa S, Yoshingaga K, Hayashi S, Kunisada T, Nakao J, Kina T, Sudo T, Kodama H. Expression and function of c-kit in fetal hematopoietic progenitor cells: transition from early c-kit independent to the late c-kit dependent wave of hematopoiesis in the murine embryo. Development. 117:1993;1089-1098.
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(1993)
Development
, vol.117
, pp. 1089-1098
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Ogawa, M.1
Nishikawa, S.2
Yoshingaga, K.3
Hayashi, S.4
Kunisada, T.5
Nakao, J.6
Kina, T.7
Sudo, T.8
Kodama, H.9
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49
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0023389935
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Inhibitory action of transforming growth factor-β on endothelial cells
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Muller G, Behrens J, Nussbaumer T, Bohlen P, Birchmeier W. Inhibitory action of transforming growth factor-β on endothelial cells. Proc Natl Acad Sci USA. 84:1987;5600-5604.
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(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5600-5604
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Muller, G.1
Behrens, J.2
Nussbaumer, T.3
Bohlen, P.4
Birchmeier, W.5
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50
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0027379724
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Defects in mesoderm, neural tube, and vascular development in mouse embryos lacking fibronectin
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George EL, Georges-Labousse EN, Patel-King RS, Raybourn H, Hynes RO. Defects in mesoderm, neural tube, and vascular development in mouse embryos lacking fibronectin. Development. 119:1993;1079-1091.
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(1993)
Development
, vol.119
, pp. 1079-1091
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George, E.L.1
Georges-Labousse, E.N.2
Patel-King, R.S.3
Raybourn, H.4
Hynes, R.O.5
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51
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0029980518
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Modulation of transforming growth factor-β receptor levels on microvascular endothelial cells during in vitro angiogenesis
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of outstanding interest. This report provides evidence that alterations in responsiveness to TGF-β as a result of culture conditions or differentiation status correlates with receptor profile. Experimental evidence is also provided for the hypothesis that type 1 and type II receptors can mediate distinct responses.
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Sankar S, Mahooti-Brooks N, Bensen L, McCarthy TL, Centrella M, Madri JA. Modulation of transforming growth factor-β receptor levels on microvascular endothelial cells during in vitro angiogenesis. of outstanding interest J Clin Invest. 97:1996;1436-1446 This report provides evidence that alterations in responsiveness to TGF-β as a result of culture conditions or differentiation status correlates with receptor profile. Experimental evidence is also provided for the hypothesis that type 1 and type II receptors can mediate distinct responses.
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(1996)
J Clin Invest
, vol.97
, pp. 1436-1446
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Sankar, S.1
Mahooti-Brooks, N.2
Bensen, L.3
McCarthy, T.L.4
Centrella, M.5
Madri, J.A.6
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52
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0024446721
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Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-β
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Kulyk WM, Rodgers BJ, Greer K, Kosher RA. Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-β Dev Biol. 135:1989;424-430.
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(1989)
Dev Biol
, vol.135
, pp. 424-430
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Kulyk, W.M.1
Rodgers, B.J.2
Greer, K.3
Kosher, R.A.4
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53
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0028990126
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Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
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of special interest. Genetic data from Drosophila, implicating a role for the mammalian transcription factor PRDII-BF1 in signaling by members of the TGF-β superfamily.
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Grieder NC, Nellen D, Burke R, Basler K, Affolter M. schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. of special interest Cell. 81:1995;791-800 Genetic data from Drosophila, implicating a role for the mammalian transcription factor PRDII-BF1 in signaling by members of the TGF-β superfamily.
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(1995)
Cell
, vol.81
, pp. 791-800
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Grieder, N.C.1
Nellen, D.2
Burke, R.3
Basler, K.4
Affolter, M.5
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54
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0029072998
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The Drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family
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of special interest. Identification of a Drosophila gene schnurri, which is homologous to human major histocompatibility complex-binding proteins and involved in Dpp signaling.
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Arora K, Dai H, Kazuko SG, Jamal J, O'Connor MB, Letsou A, Warrior R. The Drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family. of special interest Cell. 81:1995;781-790 Identification of a Drosophila gene schnurri, which is homologous to human major histocompatibility complex-binding proteins and involved in Dpp signaling.
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(1995)
Cell
, vol.81
, pp. 781-790
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Arora, K.1
Dai, H.2
Kazuko, S.G.3
Jamal, J.4
O'Connor, M.B.5
Letsou, A.6
Warrior, R.7
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55
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0030593038
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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
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of special interest. Identification of a novel tumor suppressor gene DPC4 (deleted in pancreatic cancer) with sequence homology to a Drosophila gene Mothers against decapentaplegic that is implicated in a TGF-β like signaling pathway. This report demonstrates how the identification and characterization of TGF-β signaling components in Drosophila can have significance for the understanding of the human disease.
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Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, Da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. of special interest Science. 271:1996;350-353 Identification of a novel tumor suppressor gene DPC4 (deleted in pancreatic cancer) with sequence homology to a Drosophila gene Mothers against decapentaplegic that is implicated in a TGF-β like signaling pathway. This report demonstrates how the identification and characterization of TGF-β signaling components in Drosophila can have significance for the understanding of the human disease.
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(1996)
Science
, vol.271
, pp. 350-353
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Hahn, S.A.1
Schutte, M.2
Hoque, A.T.M.S.3
Moskaluk, C.A.4
Da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
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56
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0029952544
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Arrested lung morphogenesis in transgenic mice bearing an SP-C TGF-β1 chimetic gene
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of special interest. This report examines the effects of TGF-β1 on the differentiation of distal lung epithelium in vivo.
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Zhou L, Dey CR, Wert SE, Whitsett JA. Arrested lung morphogenesis in transgenic mice bearing an SP-C TGF-β1 chimetic gene. of special interest Dev Biol. 175:1996;227-238 This report examines the effects of TGF-β1 on the differentiation of distal lung epithelium in vivo.
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(1996)
Dev Biol
, vol.175
, pp. 227-238
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Zhou, L.1
Dey, C.R.2
Wert, S.E.3
Whitsett, J.A.4
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57
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0029671373
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Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype
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of special interest. This report characterizes the effect of TGF-β2 on mature bone. Despite the fact that TGF-β2 increases osteoblast function in vitro, transgenic mice demonstrate an osteoporosis-like phenotype resulting from deregulation of the bone remodeling cycle. These results demonstrate the complex nature of the effects of TGF-βs in vivo.
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Erlebacher A, Derynck R. Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype. of special interest J Cell Biol. 132:1996;195-210 This report characterizes the effect of TGF-β2 on mature bone. Despite the fact that TGF-β2 increases osteoblast function in vitro, transgenic mice demonstrate an osteoporosis-like phenotype resulting from deregulation of the bone remodeling cycle. These results demonstrate the complex nature of the effects of TGF-βs in vivo.
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(1996)
J Cell Biol
, vol.132
, pp. 195-210
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Erlebacher, A.1
Derynck, R.2
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58
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0030027895
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Requirement of transforming growth factor-β (TGF-β) type II receptor for TGF-β induced proliferation and growth
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Zhao Y, Young SL. Requirement of transforming growth factor-β (TGF-β) type II receptor for TGF-β induced proliferation and growth. J Biol Chem. 271:1996;2369-2372.
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(1996)
J Biol Chem
, vol.271
, pp. 2369-2372
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Zhao, Y.1
Young, S.L.2
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59
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0029098259
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Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors
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Choi ME, Ballermann BJ. Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors. J Biol Chem. 270:1995;21144-21150.
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(1995)
J Biol Chem
, vol.270
, pp. 21144-21150
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Choi, M.E.1
Ballermann, B.J.2
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60
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0028910192
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Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription
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Brand T, Schneider MD. Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription. J Biol Chem. 270:1995;8274-8284.
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(1995)
J Biol Chem
, vol.270
, pp. 8274-8284
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Brand, T.1
Schneider, M.D.2
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61
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0027250810
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Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities
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Chen R-H, Ebner R, Derynck R. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science. 260:1993;1335-1338.
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(1993)
Science
, vol.260
, pp. 1335-1338
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Chen R-H1
Ebner, R.2
Derynck, R.3
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