Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats

Journal of Hepatology

Volumn 51, Issue 1, 2009, Pages 102-113

  Hu, Ping Fang ^a   Chen, Han ^a   Zhong, Wei ^a   Lin, Yong ^a   Zhang, Xin ^b   Chen, Yue Xiang ^a   Xie, Wei Fen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Adenovirus; Hepatic fibrosis; Plasminogen activator inhibitor 1 (PAI 1); RNA interference (RNAi)

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGENASE 3; DIMETHYLNITROSAMINE; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SHORT HAIRPIN RNA; SMAD3 PROTEIN; SMAD7 PROTEIN; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; UPREGULATION;

ACTINS; ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL PROLIFERATION; COLLAGEN TYPE I; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS, EXPERIMENTAL; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RNA, SMALL INTERFERING; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 67349254116     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.02.025     Document Type: Article

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