Distortion of autocrine transforming growth factor β signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells

Oncogene

Volumn 22, Issue 15, 2003, Pages 2309-2321

  Sugano, Yasushi ^a   Matsuzaki, Koichi ^a   Tahashi, Yoshiya ^a   Furukawa, Fukiko ^a   Mori, Shigeo ^a   Yamagata, Hideo ^a   Yoshida, Katsunori ^a   Matsushita, Masanori ^a   Nishizawa, Mikio ^b   Fujisawa, Junichi ^c   Inoue, Kyoichi ^a  

^a Kansai Medical University   (Japan)

^b Department of Medical Chemistry ^*  (Japan)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

HCC; PAI 1; Smad; TGF ; VEGF

Indexed keywords

ALANINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER GROWTH; CELL GROWTH; GENE FUNCTION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ALPHA-FETOPROTEINS; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; AUTOCRINE COMMUNICATION; CARCINOMA, HEPATOCELLULAR; DISEASE PROGRESSION; DNA REPLICATION; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; LYMPHOKINES; MACROMOLECULAR SUBSTANCES; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037656524     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206305     Document Type: Article

References (36)

1. Abelev GI. (1971). Adv. Cancer Res., 14, 295-358.
2. Bajou K, Noël A, Gerard RD, Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig NE, Carmeliet P, Collen D and Foidart JM. (1998). Nat. Med., 4, 923-928.
3. Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS and Skriver L. (1985). Adv. Cancer Res., 44, 139-266.
4. Date M, Matsuzaki K, Matsushita M, Sakitani K, Shibano K, Okajima A, Yamamoto C, Ogata N, Okumura T, Seki T, Kubota Y, Kan M, McKeehan WL and Inoue K (1998). J. Hepatol., 28, 572-581.
5. de Caestecker MP, Piek E and Roberts AB. (2000). J. Natl. Cancer Inst., 92, 1388-1402.
6. Derynck R, Zhang Y and Feng X-H. (1998). Cell, 95, 737-740.
7. Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, Van de Water L and Senger DR. (1991). J. Exp. Med., 174, 1275-1278.
8. Engel ME, Datta PK and Moses HL. (1998). J. Cell. Biochem. Suppl., 30/31, 111-122.
9. Fan G, Ma X, Kren BT and Steer CJ. (1996). Oncogene, 12, 1909-1919.
10. Feng X-H, Lin X and Derynck R. (2000). EMBO J., 19, 5178-5193.
11. Ferrara N. (1999). Curr. Top. Microbiol. Immunol., 237, 1-30.
12. Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA and Castellino FJ. (2000). Cancer Res., 60, 5839-5847.
13. Healy AM and Gelehrter TD. (1994). J. Biol. Chem., 269, 19095-19100.
14. Hua X, Liu X, Ansari DO and Lodish HF. (1998). Genes Dev., 12, 3084-3095.
15. Kim S-J, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M and Roberts AB. (1990). Mol. Cell. Biol., 10, 1492-1497.
16. Macías-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L and Wrana JL. (1996). Cell, 87, 1215-1224.
17. Massagué J. (1998). Annu. Rev. Biochem., 67, 753-791.
18. Matsuzaki K, Date M, Furukawa F, Tahashi Y, Matsushita M, Sakitani K, Yamashiki N, Seki T, Saito H, Nishizawa M, Fujisawa J and Inoue K. (2000a). Cancer Res., 60, 1394-1402.
19. Matsuzaki K, Date M, Furukawa F, Tahashi Y, Matsushita M, Sugano Y, Yamashiki N, Nakagawa T, Seki T, Nishizawa M, Fujisawa J and Inoue K. (2000b). Hepatology, 32, 218-227.
20. Matsuzaki K, Yoshitake Y, Miyagiwa M, Minemura M, Tanaka M, Sasaki H and Nishikawa K. (1990). Jpn. J. Cancer Res., 81, 345-354.
21. Mise M, Arii S, Higashituji H, Furutani M, Niwano M, Harada T, Ishigami S, Toda Y, Nakayama H, Fukumoto M, Fujita J and Imamura M. (1996). Hepatology, 23, 455-464.
22. Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, Hishima T, Koike M, Shitara N, Iwama T, Utsunomiya J, Kuroki T and Mori T. (1999). Oncogene, 18, 3098-3103.
23. Miyazono K, Kusanagi K and Inoue H. (2001). J. Cell Physiol., 187, 265-276.
24. Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin N-E, Heldin C-H and ten Dijke P. (1997). Nature, 389, 631-635.
25. Pedersen H, Brünner N, Francis D, Østerlind K, Ronne E, Hansen HH, Danø K and Grøndahl-Hansen J. (1994a). Cancer Res., 54, 4671-4675.
26. Pedersen H, Grøndahl-Hansen J, Francis D, Østerlind K, Hansen HH, Danø K and Brünner N. (1994b). Cancer Res., 54, 120-123.
27. Piek E and Roberts AB. (2001). Adv. Cancer Res., 83, 1-54.
28. Prunier C, Ferrand N, Frottier B, Pessah M and Atfi A. (2001). Mol. Cell. Biol., 21, 3302-3313.
29. Riggins GJ, Kinzler KW, Vogelstein B and Thiagalingam S. (1997). Cancer Res., 57, 2578-2580.
30. Schwarte-Waldhoff I, Volpert OV, Bouck NP, Sipos B, Hahn SA, Klein-Scory S, Lüttges J, Kölppel G, Graeven U, Eilert-Micus C, Hintelmann A and Schmiegel W. (2000). Proc. Natl. Acad. Sci. USA, 97, 9624-9629.
31. Shirai Y, Kawata S, Tamura S, Ito N, Tsusima H, Takaishi K, Kiso S and Matsuzawa Y. (1994). Cancer, 73, 2275-2279.
32. Wrana JL. (2000). Cell, 100, 189-192.
33. Yakicier MC, Irmak MB, Romano A, Kew M and Ozturk M. (1999). Oncogene, 18, 4879-4883.
34. Yamanaka N, Okamoto E, Toyosaka A, Mitunobu M, Fujihara S, Kato T, Fujimoto J, Oriyama T, Furukawa K and Kawamura E. (1990). Cancer, 65, 1104-1110.
35. Zhang Y and Derynck R. (1999). Trends Cell Biol., 9, 274-279.
36. Zhou L, Hayashi Y, Itoh T, Wang W, an Rui J and Itoh H. (2000). Pathol. Int., 50, 392-397.