Benefit of physical fitness against inflammation in obesity: Role of beta adrenergic receptors

Brain, Behavior, and Immunity

Volumn 39, Issue , 2014, Pages 113-120

  Hong, Suzi ^a   Dimitrov, Stoyan ^a   Pruitt, Christopher ^a   Shaikh, Farah ^a   Beg, Nuzhat ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Beta adrenergic receptor; LPS stimulated TNF production; Monocytes; Obesity; Physical fitness; Sensitivity to isoproterenol

Indexed keywords

BETA ADRENERGIC RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPRENALINE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOPULMONARY FUNCTION; CYTOKINE PRODUCTION; DEMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FITNESS; FLOW CYTOMETRY; HUMAN; INFLAMMATION; LEISURE; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MONOCYTE; OBESITY; OXYGEN CONSUMPTION; PATHOGENESIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEPTOR BINDING; RECEPTOR SENSITIVITY; TREADMILL EXERCISE; WAIST CIRCUMFERENCE; ADOLESCENT; BLOOD; COMPLICATION; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MIDDLE AGED; MONOCYTES; OBESITY; PHYSICAL FITNESS; RECEPTORS, ADRENERGIC, BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902356128     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2013.12.009     Document Type: Article

References (57)

1. An J., Ribeiro R.C., Webb P., Gustafsson J.A., Kushner P.J., Baxter J.D., Leitman D.C. Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc. Natl. Acad. Sci. USA 1999, 96:15161-15166.
2. Balducci S., Zanuso S., Cardelli P., Salvi L., Mazzitelli G., Bazuro A., Iacobini C., Nicolucci A., Pugliese G. Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES). Diabetes Care 2012, 35:1347-1354.
3. Bellinger D.L., Millar B.A., Perez S., Carter J., Wood C., Thyagarajan S., Molinaro C., Lubahn C., Lorton D. Sympathetic modulation of immunity: relevance to disease. Cell Immunol. 2008, 252:27-56.
4. Borg G. Perceived exertion as an indicator of somatic stress. Scand. J. Rehabil. Med. 1970, 2:92-98.
5. Brodde O.E., Daul A., O'Hara N., Bock K.D. Increased density and responsiveness of alpha 2 and beta-adrenoceptors in circulating blood cells of essential hypertensive patients. J. Hypertens. Suppl. 1984, 2:S111-S114.
6. Butler J., O'Brien M., O'Malley K., Kelly J.G. Relationship of beta-adrenoreceptor density to fitness in athletes. Nature 1982, 298:60-62.
7. Cartier A., Cote M., Lemieux I., Perusse L., Tremblay A., Bouchard C., Despres J.P. Sex differences in inflammatory markers: what is the contribution of visceral adiposity?. Am. J. Clin. Nutr. 2009, 89:1307-1314.
8. Davison K., Bircher S., Hill A., Coates A.M., Howe P.R., Buckley J.D. Relationships between obesity, cardiorespiratory fitness, and cardiovascular function. J. Obes. 2010, 2010:191253.
9. Dimitrov S., Shaikh F., Pruitt C., Green M., Wilson K., Beg N., Hong S. Differential TNF production by monocyte subsets under physical stress: blunted mobilization of proinflammatory monocytes in prehypertensive individuals. Brain Behav. Immun. 2013, 27:101-108.
10. Dimsdale J.E., Moss J. Plasma catecholamines in stress and exercise. JAMA 1980, 243:340-342.
11. Eikelis N., Esler M. The neurobiology of human obesity. Exp. Physiol. 2005, 90:673-682.
12. Eisenhut M. Inflammation-induced desensitization of beta-receptors in acute lung injury. Am. J. Respir. Crit. Care Med. 2012, 185:894-895.
13. Elenkov I.J., Wilder R.L., Chrousos G.P., Vizi E.S. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 2000, 52:595-638.
14. Ershler W.B., Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 2000, 51:245-270.
15. Euteneuer F., Mills P.J., Rief W., Ziegler M.G., Dimsdale J.E. Association of in vivo beta-adrenergic receptor sensitivity with inflammatory markers in healthy subjects. Psychosom. Med. 2012, 74:271-277.
16. Eysmann S.B., Gervino E., Vatner D.E., Katz S.E., Decker L., Douglas P.S. Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans. J. Appl. Physiol. 1996, 80:616-622.
17. Feldman R.D., Limbird L.E., Nadeau J., Robertson D., Wood A.J. Leukocyte beta-receptor alterations in hypertensive subjects. J. Clin. Invest. 1984, 73:648-653.
18. Fogelholm M. Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes. Rev. 2010, 11:202-221.
19. Frey M.J., Mancini D., Fischberg D., Wilson J.R., Molinoff P.B. Effect of exercise duration on density and coupling of beta-adrenergic receptors on human mononuclear cells. J. Appl. Physiol. 1989, 66:1494-1500.
20. Fujii N., Homma S., Yamazaki F., Sone R., Shibata T., Ikegami H., Murakami K., Miyazaki H. Beta-adrenergic receptor number in human lymphocytes is inversely correlated with aerobic capacity. Am. J. Physiol. 1998, 274:E1106-E1112.
21. Hamer M. The relative influences of fitness and fatness on inflammatory factors. Prev. Med. 2007, 44:3-11.
22. Hautala A.J., Kiviniemi A.M., Makikallio T.H., Tiinanen S., Seppanen T., Huikuri H.V., Tulppo M.P. Muscle sympathetic nerve activity at rest compared to exercise tolerance. Eur. J. Appl. Physiol. 2008, 102:533-538.
23. Hong S., Farag N.H., Nelesen R.A., Ziegler M.G., Mills P.J. Effects of regular exercise on lymphocyte subsets and CD62L after psychological vs. physical stress. J. Psychosom. Res. 2004, 56:363-370.
24. Hong S., Johnson T.A., Farag N.H., Guy H.J., Matthews S.C., Ziegler M.G., Mills P.J. Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals. J. Appl. Physiol. 2005, 98:1057-1063.
25. Kizaki T., Takemasa T., Sakurai T., Izawa T., Hanawa T., Kamiya S., Haga S., Imaizumi K., Ohno H. Adaptation of macrophages to exercise training improves innate immunity. Biochem. Biophys. Res. Commun. 2008, 372:152-156.
26. Landmann R. Beta-adrenergic receptors in human leukocyte subpopulations. Eur. J. Clin. Invest. 1992, 22(Suppl. 1):30-36.
27. Lehmann M., Dickhuth H.H., Schmid P., Porzig H., Keul J. Plasma catecholamines, beta-adrenergic receptors, and isoproterenol sensitivity in endurance trained and non-endurance trained volunteers. Eur. J. Appl. Physiol. Occup. Physiol. 1984, 52:362-369.
28. Leosco D., Rengo G., Iaccarino G., Filippelli A., Lymperopoulos A., Zincarelli C., Fortunato F., Golino L., Marchese M., Esposito G., Rapacciuolo A., Rinaldi B., Ferrara N., Koch W.J., Rengo F. Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H1596-H1603.
29. Lohse M.J., Engelhardt S., Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure?. Circ. Res. 2003, 93:896-906.
30. Maisel A.S., Fowler P., Rearden A., Motulsky H.J., Michel M.C. A new method for isolation of human lymphocyte subsets reveals differential regulation of beta-adrenergic receptors by terbutaline treatment. Clin. Pharmacol. Ther. 1989, 46:429-439.
31. Maisel A.S., Harris T., Rearden C.A., Michel M.C. Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure. Circulation 1990, 82:2003-2010.
32. Maki T., Kontula K., Myllynen P., Harkonen M. Beta-adrenergic receptors of human lymphocytes in physically active and immobilized subjects: characterization by a polyethylene glycol precipitation assay. Scand. J. Clin. Lab Invest. 1987, 47:261-267.
33. McAllister R.G., Love D.W., Guthrie G.P., Dominic J.A., Kotchen T.A. Peripheral beta-receptor responsiveness in patients with essential hypertension. Arch. Intern. Med. 1979, 139:879-881.
34. Michel M.C., Brodde O.E., Insel P.A. Peripheral adrenergic receptors in hypertension. Hypertension 1990, 16:107-120.
35. Mills P.J., Yu H., Ziegler M.G., Patterson T., Grant I. Vulnerable caregivers of patients with Alzheimer's disease have a deficit in circulating C. Psychosom. Med. 1999, 61:168-174.
36. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
37. Mueller P.J. Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity. Clin. Exp. Pharmacol. Physiol. 2007, 34:377-384.
38. Nicklas B.J., You T., Pahor M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. CMAJ 2005, 172:1199-1209.
39. O'Connor M.F., Bower J.E., Cho H.J., Creswell J.D., Dimitrov S., Hamby M.E., Hoyt M.A., Martin J.L., Robles T.F., Sloan E.K., Thomas K.S., Irwin M.R. To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain Behav. Immun. 2009, 23:887-897.
40. Pedersen B.K. Body mass index-independent effect of fitness and physical activity for all-cause mortality. Scand. J. Med. Sci. Sports 2007, 17:196-204.
41. Petersen A.M., Pedersen B.K. The role of IL-6 in mediating the anti-inflammatory effects of exercise. J. Physiol. Pharmacol. 2006, 57(Suppl. 10):43-51.
42. Plourde G., Rousseau-Migneron S., Nadeau A. Beta-adrenoceptor adenylate cyclase system adaptation to physical training in rat ventricular tissue. J. Appl. Physiol. 1991, 70:1633-1638.
43. Poirier P., Giles T.D., Bray G.A., Hong Y., Stern J.S., Pi-Sunyer F.X., Eckel R.H. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006, 113:898-918.
44. Rahmouni K. Obesity, sympathetic overdrive, and hypertension: the leptin connection. Hypertension 2010, 55:844-845.
45. Rief W., Mills P.J., ncoli-Israel S., Ziegler M.G., Pung M.A., Dimsdale J.E. Overnight changes of immune parameters and catecholamines are associated with mood and stress. Psychosom. Med. 2010, 72:755-762.
46. Sanders V.M. The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet?. Brain Behav. Immun. 2012, 26:195-200.
47. Severn A., Rapson N.T., Hunter C.A., Liew F.Y. Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists. J. Immunol. 1992, 148:3441-3445.
48. Shaw K., Gennat H., O'Rourke P., Del M.C. Exercise for overweight or obesity. Cochrane. Database Syst. Rev. 2006, CD003817.
49. Starkie R., Ostrowski S.R., Jauffred S., Febbraio M., Pedersen B.K. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J. 2003, 17:884-886.
50. Straznicky N.E., Eikelis N., Lambert E.A., Esler M.D. Mediators of sympathetic activation in metabolic syndrome obesity. Curr. Hypertens. Rep. 2008, 10:440-447.
51. Sui X., LaMonte M.J., Laditka J.N., Hardin J.W., Chase N., Hooker S.P., Blair S.N. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA 2007, 298:2507-2516.
52. Sylvestre-Gervais L., Nadeau A., Nguyen M.H., Tancrede G., Rousseau-Migneron S. Effects of physical training on beta-adrenergic receptors in rat myocardial tissue. Cardiovasc. Res. 1982, 16:530-534.
53. van der Poll T., Coyle S.M., Barbosa K., Braxton C.C., Lowry S.F. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. J. Clin. Invest. 1996, 97:713-719.
54. Van Tits L.J., Michel M.C., Grosse-Wilde H., Happel M., Eigler F.W., Soliman A., Brodde O.E. Catecholamines increase lymphocyte beta 2-adrenergic receptors via a beta 2-adrenergic, spleen-dependent process. Am. J. Physiol. 1990, 258:E191-E202.
55. Werle E.O., Strobel G., Weicker H. Decrease in rat cardiac beta 1- and beta 2-adrenoceptors by training and endurance exercise. Life Sci. 1990, 46:9-17.
56. You T., Nicklas B.J. Chronic inflammation: role of adipose tissue and modulation by weight loss. Curr. Diabetes Rev. 2006, 2:29-37.
57. Zanesco A., Antunes E. Effects of exercise training on the cardiovascular system: pharmacological approaches. Pharmacol. Ther. 2007, 114:307-317.