β-adrenergic receptor number in human lymphocytes is inversely correlated with aerobic capacity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 6 37-6, 1998, Pages

  Fujii, Nobuharu ^a   Homma, Sachiko ^b   Yamazaki, Fumio ^c   Sone, Ryoko ^d   Shibata, Takeshi ^a   Ikegami, Haruo ^e   Murakami, Kazuo ^a   Miyazaki, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JAPAN WOMEN'S COLLEGE OF PHYSICAL EDUCATION   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d YAMAGUCHI UNIVERSITY   (Japan)

^e International Budo University   (Japan)

Author keywords

Catecholamine; Competitive reverse transcription polymerase chain reaction; Downregulation

Indexed keywords

BETA ADRENERGIC RECEPTOR;

ADULT; AEROBIC METABOLISM; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TRAINING;

EID: 0031832020     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.6.e1106     Document Type: Article

References (35)

1. Bertin, B., P. Mansier, I. Makeh, P. Briand, W. Rostene, B. Swynghedauw, and A. D. Strosberg. Specific atrial overexpression of G protein coupled human beta 1 adrenoceptors in transgenic mice. Cardiovasc. Res. 27: 1606-1612, 1993.
2. Bøyum, A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Lab. Invest. 21, Suppl. 97: 77-89, 1968.
3. Bristow, M. R., R. Ginsburg, V. Umans, M. Fowler, W. Minobe, R. Rasmussen, P. Zera, R. Menlove, P. Shah, and S. Jamieson. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ. Res. 59: 297-309, 1986.
4. Brodde, O.-E., R. Kretsch, K. Ikezono, H.-R. Zerkowski, and J. C. Reidemeister. Human β-adrenoceptors; relation of myocardial and lymphocyte β-adrenoceptor density. Science 231: 1584-1585, 1986.
5. Butler, J., M. O'Brien, K. O'Malley, and J. G. Kelly. Relationship of β-adrenoceptor density to fitness in athletes. Nature 298: 60-62, 1982.
6. Chomeczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
7. Cousineau, D., R. J. Ferguson, J. Dechamplain, P. Gauthier, P. Cote, and M. Bourassa. Catecholamines in coronary sinus during exercise in man before and after training. J. Appl. Physiol. 43: 801-806, 1977.
8. Davis, J. A., M. H. Frank, B. J. Wipp, and K. Wasserman. Anaerobic threshold alterations caused by endurance training in middle-aged men. J. Appl. Physiol. 46: 1039-1046, 1979.
9. Dela, F., K. J. Mikines, M. Von Linstow, and H. Galbo. Heart rate and plasma catecholamines during 24 h of everyday life in trained and untrained men. J. Appl. Physiol. 73: 2389-2395, 1992.
10. Frey, M. J., D. Mancini, D. Fischberg, J. R. Wilson, and P. B. Molinoff. Effect of exercise duration on density and coupling of β-adrenergic receptor on human mononuclear cells. J. Appl. Physiol. 66: 1494-1500, 1989.
11. Fujii, N., T. Shibata, S. Homma, H. Ikegami, K. Murakami, and H. Miyazaki. Exercise-induced changes in β-adrenergic receptor mRNA level measured by competitive RT-PCR. J. Appl. Physiol. 82: 1926-1931, 1997.
12. Fujii, N., M. Tanaka, J. Ohnishi, K. Yukawa, E. Takimoto, S. Shimada, M. Naruse, F. Sugiyama, K. Yagami, K. Murakami, and H. Miyazaki. Alterations of angiotensin II receptor contents in hypertrophied hearts. Biochem. Biophys. Res. Commun. 212: 326-333, 1995.
13. Goldstein, D. S., G. Fuersteing, J. L. Izzo, I. J. Kopin, and H. R. Keiser. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man. Life Sci. 28: 467-473, 1981.
14. Hadcock, J. R., and C. C. Malbon. Down-regulation of β-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc. Natl. Acad. Sci. USA 85: 5021-5025, 1988.
15. Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J. 4: 2881-2889, 1990.
16. Horn, E. M., S. J. Corwin, S. F. Steinberg, Y. K. Chow, G. W. Neuberg, P. J. Cannon, E. R. Powers, and J. P. Bilezikian. Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and beta adrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy. Circulation 78: 1373-1379, 1988.
17. Jost, J., M. Weiss, and H. Weicker. Sympathoadrenergic regulation and the adrenoceptor system. J. Appl. Physiol. 68: 897-904, 1990.
18. Kajiura, J. S., J. D. MacDougall, P. B. Ernst, and E. V. Younglai. Immune response to changes in training intensity and volume in runners. Med. Sci. Sports Exerc. 27: 1111-1117, 1995.
19. Khan, M. M., P. Sansoni, E. D. Silverman, E. G. Engleman, and K. L. Melmon. Beta-adrenergic receptors on human suppressor, helper, and cytolytic lymphocytes. Biochem. Pharmacol. 35: 1137-1142, 1986.
20. Lehmann, M., H. H. Dickhuth, P. Schmid, H. Porzig, and J. Keul. Plasma catecholamines, β-adrenergic receptors, and isoproterenol sensitivity in endurance trained and non-endurance trained volunteers. Eur. J. Appl. Physiol. 52: 362-369, 1982.
21. 2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 90: 10798-10802, 1993.
22. Mäki, T., K. Kontula, and M. Härkönen. The beta-adrenergic system in man: physiological and pathophysiological response. Regulation of receptor density and functioning. Scand. J. Clin. Lab. Invest. 50, Suppl. 201: 25-43, 1990.
23. Mäki, T., K. Kontula, P. Myllunen, and M. Härkönen. β-Adrenergic receptors of human lymphocytes in physically active and immobilized subjects: characterization by a polyethylene glycol precipitation assay. Scand. J. Clin. Lab. Invest. 47: 261-267, 1987.
24. Michel, M. C., J. J. Beckeringh, K. Ikezono, R. Kretsch, and O. E. Brodde. Lymphocyte beta 2-adrenoceptors mirror precisely beta 2-adrenoceptor, but poorly beta 1-adrenoceptor changes in the human heart. J. Hypertens. 4: S215-S218, 1986.
25. 2-adrenergic receptors. Science 264: 582-586, 1994.
26. Motulsky, H. J., E. M. S. Cunningham, A. DeBlasi, and P. A. Insel. Agonist-induced redistribution of beta-adrenergic receptors on intact human mononuclear leukocytes. Redistributed receptors are nonfunctional. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E583-E590, 1986.
27. Nieman, D. C., D. Brendle, D. A. Henson, J. Suttles, V. D. Cook, B. J. Warren, D. E. Butterworth, O. R. Fagoaga, and S. L. Nehlsen-Cannarella. Immune function in athletes versus nonathletes. Int. J. Sports Med. 16: 329-333, 1995.
28. Nieman, D. C., K. S. Buckley, D. A. Henson, B. J. Warren, J. Suttles, J. C. Ahle, S. Simandle, O. R. Fagoaga, and S. L. Nehlsen-Cannarella. Immune function in marathon runners versus sedentary controls. Med. Sci. Sports Exerc. 27: 986-992, 1995.
29. Ohman, E. M., J. Butler, J. G. Kelly, J. Horgan, and K. O'Malley. Beta-adrenoceptor adaptation to endurance training. J. Cardiovasc. Pharmacol. 10: 728-731, 1987.
30. Plourde, G., S. Rousseau-Migneron, and A. Nadeau. β-Adrenoceptor adenylate cyclase system adaptation to physical training in rat ventricular tissue. J. Appl. Physiol. 70: 1633-1638, 1991.
31. Rhind, S. G., P. N. Shek, S. Shinkai, and R. J. Shephard. Differential expression of interleukin-2 receptor alpha and beta chains in relation to natural killer cell subsets and aerobic exercise. Int. J. Sports Med. 15: 911-918, 1994.
32. Scatchard, G. The attraction of proteins for small molecules and ions. Ann. NY Acad. Sci. 51: 660-672, 1949.
33. Tipton, C. M. Training and bradycardia in rats. Am. J. Physiol. 209: 1089-1094, 1965.
34. Verde, T. J., S. G. Thomas, R. W. Moore, P. Shek, and R. J. Shephard. Immune responses and increased training of the elite athlete. J. Appl. Physiol. 73: 1494-1499, 1992.
35. Yu, S. S., R. J. Lefkowitz, and W. P. Hausdorff. β-Adrenergic receptor sequestration: a potential mechanism of receptor resensitization. J. Biol. Chem. 268: 337-341, 1993.