Exercise training and β-blocker treatment ameliorate age-dependent impairment of β-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 3, 2007, Pages

  Leosco, Dario ^a   Rengo, Giuseppe ^b,c   Iaccarino, Guido ^a   Filippelli, Amelia ^d   Lymperopoulos, Anastasios ^b   Zincarelli, Carmela ^a,b   Fortunato, Francesca ^a   Golino, Luca ^a   Marchese, Massimo ^a   Esposito, Giovanni ^a   Rapacciuolo, Antonio ^a   Rinaldi, Barbara ^d   Ferrara, Nicola ^c,e   Koch, Walter J ^b   Rengo, Franco ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c IRCCS   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e UNIVERSITY OF MOLISE   (Italy)

Author keywords

adrenergic receptor desensitization; Aging; G protein coupled receptor kinase 2; Heart failure

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ISOPRENALINE; METOPROLOL;

ADRENERGIC STIMULATION; AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EXERCISE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; AGING; ANIMALS; BLOOD PRESSURE; HEART; HEART RATE; ISOPROTERENOL; MALE; METOPROLOL; MYOCARDIAL CONTRACTION; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; VENTRICULAR FUNCTION, LEFT;

EID: 34548461690     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00308.2007     Document Type: Article

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