The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet?

Brain, Behavior, and Immunity

Volumn 26, Issue 2, 2012, Pages 195-200

  Sanders, Virginia M ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antibody; B cell; Beta2 adrenergic receptor; CD4+ T cell; CD86; Cytokine; Immune system; Norepinephrine; Sympathetic nervous system; Th1 cell; Th2 cell

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CD86 ANTIGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 4; NORADRENALIN; TRANSCRIPTION FACTOR;

ADRENERGIC SYSTEM; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHOLINERGIC SYSTEM; DNA METHYLATION; EPIGENETICS; IMMUNOREGULATION; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; UPREGULATION;

ANIMALS; ANTIGENS, CD86; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, BETA-2; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 84856003167     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.08.001     Document Type: Article

References (21)

1. Ader R., Felten D., Cohen N. Interactions between the brain and the immune system. Ann. Rev. Pharmacol. Toxicol. 1990, 30:561-602.
2. Besedovsky H., Del Rey A., Sorkin E., Da Prada M., Burri R., Honegger C. The immune response evokes changes in brain noradrenergic neurons. Science 1983, 221:564-566.
3. Felten D.L., Felten S.Y., Carlson S.L., Olschowka J.A., Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J. Immunol. 1985, 135(2):755s-765s.
4. Kasprowicz D.J., Kohm A.P., Berton M.T., Chruscinski A.J., Sharpe A.H., Sanders V.M. Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. J. Immunol. 2000, 165:680-690.
5. Kin N.W., Sanders V.M. CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C{gamma}2/protein kinase C{alpha}beta signaling pathways. J. Immunol. 2006, 176:6727-6735.
6. Kin N., Sanders V. CD86 regulates IgG1 production via a CD19-dependent mechanism. J. Immunol. 2007, 179:1516-1523.
7. Kohm A.P., Sanders V.M. Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo. J. Immunol. 1999, 162:5299-5308.
8. Kohm A.P., Sanders V.M. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol. Rev. 2001, 53:487-525.
9. Kohm A.P., Mozaffarian A., Sanders V.M. B cell receptor- and beta-2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells. J. Immunol. 2002, 168:6314-6322.
10. Mathews J.A., Gibb D.R., Chen B.H., Scherle P., Conrad D.H. CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes. J. Biol. Chem. 2010, 285:37531-37541.
11. McAlees J.W., Sanders V.M. Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. Mol. Cell Biol. 2009, 29:675-686.
12. Nance D.M., Sanders V.M. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav. Immun. 2007, 21:736-745.
13. Podojil J.R., Sanders V.M. Selective regulation of mature IgG1 transcription by CD86 and beta2-adrenergic receptor stimulation. J. Immunol. 2003, 170:5143-5151.
14. Podojil J.R., Kin N.W., Sanders V.M. CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B expression and binding to the 3'-IgH enhancer in B cells. J. Biol. Chem 2004, 279:23394-23404.
15. Pongratz G., McAlees J.W., Conrad D.H., Erbe R.S., Haas K.M., Sanders V.M. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J. Immunol. 2006, 177:2926-2938.
16. Ramer-Quinn D.S., Baker R.A., Sanders V.M. Activated Th1 and Th2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of Th1 cell cytokine production. J. Immunol. 1997, 159:4857-4867.
17. Ramer-Quinn D.S., Swanson M.A., Lee W.T., Sanders V.M. Cytokine production by naive and primary effector CD4(+) T cells exposed to norepinephrine. Brain Behav. Immun. 2000, 14:239-255.
18. Sanders V.M., Baker R.A., Ramer-Quinn D.S., Kasprowicz D.J., Fuchs B.A., Street N.E. Differential expression of the beta-2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J. Immunol. 1997, 158:4200-4210.
19. Sanders V.M., Kasprowicz D.J., Kohm A.P., Swanson M.A. Neurotransmitter receptors on lymphocytes and other lymphoid cells 2001, 161-196. Psychoneuroimmunology Academic Press, San Diego, CA. R. Ader, D. Felten, N. Cohen (Eds.).
20. Serpe C.J., Coers S., Sanders V.M., Jones K.J. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav. Immun. 2003, 17:393-402.
21. Swanson M.A., Lee W.T., Sanders V.M. IFN-gamma production by Th1 cells generated from naive CD4(+) T cells exposed to norepinephrine. J. Immunol. 2001, 166:232-240.