Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES)

Diabetes Care

Volumn 35, Issue 6, 2012, Pages 1347-1354

  Balducci, Stefano ^a,b,c   Zanuso, Silvano ^d   Cardelli, Patrizia ^a,b   Salvi, Laura ^a,b   Mazzitelli, Giulia ^a,b   Bazuro, Alessandra ^a,b   Iacobini, Carla ^a,c   Nicolucci, Antonio ^e   Pugliese, Giuseppe ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Metabolic Fitness Association   (Italy)

^d UNIVERSITY OF GREENWICH   (United Kingdom)

^e Consorzio Mario Negri Sud S Maria Imbaro ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AEROBIC EXERCISE; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORONARY HEART DISEASE RISK SCORE; COUNSELING; DISEASE DURATION; FEMALE; FITNESS; HEMOGLOBIN BLOOD LEVEL; HIP FLEXIBILITY; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTERMETHOD COMPARISON; LIFESTYLE MODIFICATION; LOWER BODY MUSCLE STRENGTH; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); MUSCLE STRENGTH; MUSCULOSKELETAL SYSTEM PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESISTANCE TRAINING; SCORING SYSTEM; SEDENTARY LIFESTYLE; TRUNK FLEXIBILITY; UPPER BODY MUSCLE STRENGTH; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

BODY MASS INDEX; C-REACTIVE PROTEIN; CALORIMETRY, INDIRECT; COHORT STUDIES; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIRECTIVE COUNSELING; EXERCISE; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; ITALY; MALE; MIDDLE AGED; OBESITY; PHYSICAL FITNESS; RESISTANCE TRAINING; RISK FACTORS; SEDENTARY LIFESTYLE; WAIST CIRCUMFERENCE; WEIGHT LOSS;

EID: 84861789102     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-1859     Document Type: Article

References (40)

1. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 1986;314:605-613 (Pubitemid 16132724)
2. Manson JE, Greenland P, LaCroix AZ, et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002;347:716-725 (Pubitemid 35203902)
3. Hu G, Eriksson J, Barengo NC, et al. Occupational, commuting, and leisure-time physical activity in relation to total and cardiovascular mortality among Finnish subjects with type 2 diabetes. Circulation 2004;110:666-673 (Pubitemid 39056264)
4. Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KM. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med 2003;163:1440-1447 (Pubitemid 36758916)
5. Umpierre D, Ribeiro PA, Kramer CK, et al. Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. JAMA 2011;305:1790-1799
6. Sigal RJ, Kenny GP, Boulé NG, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007;147:357-369 (Pubitemid 351664536)
7. Church TS, Blair SN, Cocreham S, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010;304:2253-2262
8. Balducci S, Zanuso S, Nicolucci A, et al.; Italian Diabetes Exercise Study (IDES) Investigators. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in type 2 diabetic subjects: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med 2010;170:1794-1803
9. Nicolucci A, Balducci S, Cardelli P, Zanuso S, Pugliese G.; Italian Diabetes Exercise Study (IDES) Investigators. Improvement of quality of life with supervised exercise training in subjects with type 2 diabetes mellitus. Arch Intern Med 2011;171:1951-1953
10. Cauza E, Hanusch-Enserer U, Strasser B, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil 2005;86:1527-1533 (Pubitemid 41115812)
11. Larose J, Sigal RJ, Boulé NG, et al. Effect of exercise training on physical fitness in type II diabetes mellitus. Med Sci Sports Exerc 2010;42:1439-1447
12. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 2002;346:793-801 (Pubitemid 34987553)
13. Ruiz JR, Sui X, Lobelo F, et al. Association between muscular strength and mortality in men: prospective cohort study. BMJ 2008;337:a439
14. Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality inmen with type 2 diabetes. Ann Intern Med 2000;132:605-611 (Pubitemid 30217552)
15. Tanasescu M, Leitzmann MF, Rimm EB, Hu FB. Physical activity in relation to cardiovascular disease and total mortality among men with type 2 diabetes. Circulation 2003;107:2435-2439 (Pubitemid 36605225)
16. Church TS, Cheng YJ, Earnest CP, et al. Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care 2004;27:83-88 (Pubitemid 38196714)
17. Church TS, LaMonte MJ, Barlow CE, Blair SN. Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 2005;165:2114-2120 (Pubitemid 41434586)
18. Pedersen BK. Body mass index-independent effect of fitness and physical activity for allcause mortality. Scand J Med Sci Sports 2007;17:196-204
19. Fogelholm M. Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev 2010;11:202-221
20. Balducci S, Zanuso S, Massarini M, et al.; Italian Diabetes Exercise Study (IDES) Group. The Italian Diabetes and Exercise Study (IDES): design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome. Nutr Metab Cardiovasc Dis 2008;18:585-595
21. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20:1183-1197
22. Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005;366:1059-1062 (Pubitemid 41338752)
23. Di Loreto C, Fanelli C, Lucidi P, et al. Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects. Diabetes Care 2003;26:404-408 (Pubitemid 36929063)
24. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care 2006;29:1433-1438 (Pubitemid 44125954)
25. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 7th ed. Philadelphia, PA, Lippincott Williams & Wilkins, 2005
26. Folsom AR, Jacobs DR Jr, Caspersen CJ, Gomez-Marin O, Knudsen J. Test-retest reliability of the Minnesota leisure time physical activity questionnaire. J Chronic Dis 1986;39:505-511 (Pubitemid 16070695)
27. Zanuso S, Balducci S, Gutierrez AJ, Bergamin M, Pugliese G. Similar energy expenditure from resistance training at moderate and vigorous intensity in subjects with type 2 diabetes. Diabetes Res Clin Pract 2009;85:e40-e41
28. Stevens RJ, Kothari V, Adler AI, Stratton IM; United Kingdom Prospective Diabetes Study (UKPDS) Group. The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56). Clin Sci (Lond) 2001;101:671-679 (Pubitemid 33135349)
29. Balke B, Ware RW. An experimental study of physical fitness of Air Force personnel. U S Armed Forces Med J 1959;10:675-688
30. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-381 (Pubitemid 13215050)
31. Brzycki M. Strength testing - predicting a one-rep max from reps to fatigue. J Phys Educ, Recreat Dance 1993;64:88-90
32. Boulé NG, Kenny GP, Haddad E, Wells GA, Sigal RJ. Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus. Diabetologia 2003;46:1071-1081 (Pubitemid 37041237)
33. 1(c) in type 2 diabetes mellitus. Diabetologia 2011;54:93-102
34. Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol 2007;27:996-1003 (Pubitemid 46641984)
35. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 1999;130:89-96 (Pubitemid 29045356)
36. Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA. Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 2002;25:1612-1618 (Pubitemid 41071120)
37. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006;295:1412-1419
38. Stevens J, Evenson KR, Thomas O, Cai J, Thomas R. Associations of fitness and fatness with mortality in Russian and American men in the lipids research clinics study. Int J Obes Relat Metab Disord 2004;28:1463-1470 (Pubitemid 39481851)
39. Pedersen BK. The diseasome of physical inactivity - and the role of myokines in muscledfat cross talk. J Physiol 2009;587:5559-5568
40. Church T. The low-fitness phenotype as a risk factor: more than just being sedentary? Obesity (Silver Spring) 2009;17(Suppl. 3):S39-S42