Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 289-294

  Yokota, Shin Ichi ^a   Higashi, Eriko ^a   Fukami, Tatsuki ^a   Yokoi, Tsuyoshi ^a   Nakajima, Miki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Nuclear factor erythroid 2 related factor 2; Transcriptional regulation

Indexed keywords

CYTOCHROME P450 2A6; MESSENGER RNA; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL LEVEL; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MALE; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 78650178488     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.09.020     Document Type: Article

References (30)

1. C.H. Yun, T. Shimada, and F.P. Guengerich Purification and characterization of human liver microsomal cytochrome P-450 2A6 Mol Pharmacol 40 1991 679 685
2. M. Nakajima, T. Yamamoto, K. Nunoya, T. Yokoi, K. Nagashima, and K. Inoue Role of human cytochrome P4502A6 in C-oxidation of nicotine Drug Metab Dispos 24 1996 1212 1217 (Pubitemid 26423061)
3. M. Nakajima, T. Yamamoto, K. Nunoya, T. Yokoi, K. Nagashima, and K. Inoue Characterization of CYP2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes J Pharmacol Exp Ther 277 1996 1010 1015
4. H.F. Tiano, M. Hosokawa, P.C. Chulada, P.B. Smith, R.L. Wang, and F.J. Gonzalez Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone (NNK) Carcinogenesis 14 1993 1421 1427 (Pubitemid 23229690)
5. M. Nakajima Smoking behavior and related cancers: the role of CYP2A6 polymorphisms Curr Opin Mol Ther 9 2007 538 544 (Pubitemid 350182382)
6. A.A. Strasser, V. Malaiyandi, E. Hoffmann, R.F. Tyndale, and C. Lerman An association of CYP2A6 genotype and smoking topography Nicotine Tob Res 9 2007 511 518 (Pubitemid 46534464)
7. M. Fujieda, H. Yamazaki, T. Saito, K. Kiyotani, M.A. Gyamfi, and M. Sakurai Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers Carcinogenesis 25 2004 2451 2458 (Pubitemid 39625186)
8. M. Itoh, M. Nakajima, E. Higashi, R. Yoshida, K. Nagata, and Y. Yamazoe Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-γ coactivator 1α J Pharmacol Exp Ther 319 2006 693 702
9. E. Higashi, T. Fukami, M. Itoh, S. Kyo, M. Inoue, and T. Yokoi Human CYP2A6 is induced by estrogen via estrogen receptor Drug Metab Dispos 35 2007 1935 1941 (Pubitemid 47481589)
10. T. Onica, K. Nichols, M. Larin, L. Ng, A. Maslen, and Z. Dvorak Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter Mol Pharmacol 73 2008 451 460 (Pubitemid 351159215)
11. S. Satarug, M. Nishijo, P. Ujjin, Y. Vanavanitkun, J.R. Baker, and M.R. Moore Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects Toxicol Lett 148 2004 187 197 (Pubitemid 38369221)
12. A. Abu-Bakar, S. Satarug, G.C. Marks, M.A. Lang, and M.R. Moore Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2 Toxicol Lett 148 2004 199 210 (Pubitemid 38369222)
13. K. Itoh, T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, and Y. Katoh An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements Biochem Biophys Res Commun 236 1997 313 322 (Pubitemid 27373291)
14. N. Hakooz, and I. Hamdan Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers Curr Drug Metab 8 2007 9 15 (Pubitemid 46043888)
15. M. Nakajima, M. Itoh, H. Sakai, T. Fukami, M. Katoh, and H. Yamazaki CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl Int J Cancer 119 2006 2520 2526 (Pubitemid 44691304)
16. Y. Tsuchiya, M. Nakajima, S. Kyo, T. Kanaya, M. Inoue, and T. Yokoi Human CYP1B1 is regulated by estradiol via estrogen receptor Cancer Res 64 2004 3119 3125 (Pubitemid 38581412)
17. A. Nakamura, M. Nakajima, E. Higashi, H. Yamanaka, and T. Yokoi Genetic polymorphisms in the 5′-flanking region of human UDP- glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation Pharmacogenet Genomics 18 2008 709 720
18. E. Balogun, M. Hoque, P. Gong, E. Killeen, C.J. Green, and R. Foresti Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochem J 371 2003 887 895 (Pubitemid 36578887)
19. N.G. Innamorato, A.I. Rojo, A.J. García-Yagüe, M. Yamamoto, M.L. de Ceballos, and A. Cuadrado The transcription factor Nrf2 is a therapeutic target against brain inflammation J Immunol 181 2008 680 689
20. L. Kong, M. Tanito, Z. Huang, F. Li, X. Zhou, and A. Zaharia Delay of photoreceptor degeneration in tubby mouse by sulforaphane J Neurochem 101 2007 1041 1052 (Pubitemid 46683876)
21. A.C. Lee, and M. Murray Up-regulation of human CYP2J2 in HepG2 cells by butylated hydroxyanisole is mediated by c-Jun and Nrf2 Mol Pharmacol 77 2010 987 994
22. A. Abu-Bakar, V. Lämsä, S. Arpiainen, M.R. Moore, M.A. Lang, and J. Hakkola Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2 Drug Metab Dispos 35 2007 787 794 (Pubitemid 46641550)
23. C. Rodríguez-Antona, M. Niemi, J.T. Backman, L.I. Kajosaari, P.J. Neuvonen, and M. Robledo Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism Pharmacogenomics J 8 2008 268 277 (Pubitemid 352038306)
24. N.L. Benowitz Pharmacology of nicotine: addiction and therapeutics Annu Rev Pharmacol Toxicol 36 1996 597 613 (Pubitemid 26168710)
25. R.H. Hübner, J.D. Schwartz, P. De Bishnu, B. Ferris, L. Omberg, and J.G. Mezey Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking Mol Med 15 2009 203 219
26. A. Boutten, D. Goven, J. Boczkowski, and M. Bonay Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway Expert Opin Ther Targets 14 2010 329 346
27. J.I. Anetor, F. Ajose, G.O. Anetor, A.A. Iyanda, O.O. Babalola, and F.A. Adeniyi High cadmium/zinc ratio in cigarette smokers: potential implications as a biomarker of risk of prostate cancer Niger J Physiol Sci 23 2008 41 49
28. N.L. Benowitz, and P. Jacob III Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers Clin Pharmacol Ther 53 1993 316 323 (Pubitemid 23094374)
29. R.E. Poland, R.N. Pechnick, C.C. Cloak, Y.J. Wan, I. Nuccio, and K.M. Lin Effect of cigarette smoking on coumarin metabolism in humans Nicotine Tob Res 2 2000 351 354
30. K.A. Schoedel, E.M. Sellers, R. Palmour, and R.F. Tyndale Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration Mol Pharmacol 63 2003 96 104 (Pubitemid 36043813)