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Volumn 112, Issue 15, 2004, Pages 1512-1518

Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers

Author keywords

2 microglobulin; Cadmium; Coumarin; Cytochrome P450 2A6; Drug metabolizing enzyme; Environmental exposure; Lead; Liver drug metabolism; N acetyl D glucosaminidase; Nicotine; Nicotine C oxidase; Proteinuria; Zinc

Indexed keywords

BIOLOGICAL MARKER; CADMIUM; CREATININE; CYTOCHROME P450 2A6; LEAD; N ACETYL BETA GLUCOSAMINIDASE; ZINC;

EID: 8744262844     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7192     Document Type: Article
Times cited : (26)

References (57)
  • 1
    • 1642271442 scopus 로고    scopus 로고
    • Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: Involvement of the transcription factor Nrf2
    • Abu-Bakar A, Satarug S, Marks G, Lang MA, Moore MR. 2004. Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of the transcription factor Nrf2. Toxicol Lett 148:199-210.
    • (2004) Toxicol. Lett. , vol.148 , pp. 199-210
    • Abu-Bakar, A.1    Satarug, S.2    Marks, G.3    Lang, M.A.4    Moore, M.R.5
  • 2
    • 0024516371 scopus 로고
    • Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells
    • Alam J, Shibahara S, Smith A. 1989. Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells. J Biol Chem 264:6371-6375.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6371-6375
    • Alam, J.1    Shibahara, S.2    Smith, A.3
  • 3
    • 0034623211 scopus 로고    scopus 로고
    • Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells
    • Alam J, Wicks C, Stewart D, Gong P, Touchard C, Otterbein S. 2000. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. J Biol Chem 275:27694-27702.
    • (2000) J. Biol. Chem. , vol.275 , pp. 27694-27702
    • Alam, J.1    Wicks, C.2    Stewart, D.3    Gong, P.4    Touchard, C.5    Otterbein, S.6
  • 4
    • 0035885280 scopus 로고    scopus 로고
    • Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples
    • Baker JR, Satarug S, Reilly PEB, Edward RJ, Ariyoshi N, Kamataki T, et al. 2001. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. Biochem Pharmacol 62:713-721.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 713-721
    • Baker, J.R.1    Satarug, S.2    Reilly, P.E.B.3    Edward, R.J.4    Ariyoshi, N.5    Kamataki, T.6
  • 5
    • 0037085045 scopus 로고    scopus 로고
    • Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein
    • Baker JR, Satarug S, Urbenjapol S, Edward RJ, Williams DJ, Moore MR, et al. 2002. Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein. Biochem Pharmacol 63:693-696.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 693-696
    • Baker, J.R.1    Satarug, S.2    Urbenjapol, S.3    Edward, R.J.4    Williams, D.J.5    Moore, M.R.6
  • 7
    • 0035016501 scopus 로고    scopus 로고
    • Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants
    • Bartosiewicz MJ, Jenkins D, Penn S, Emery J, Buckpitt A. 2001. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther 297:895-905.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 895-905
    • Bartosiewicz, M.J.1    Jenkins, D.2    Penn, S.3    Emery, J.4    Buckpitt, A.5
  • 9
    • 0942276504 scopus 로고    scopus 로고
    • Cardiovascular pathophysiology of environmental pollutants
    • Bhatnagar A. 2004. Cardiovascular pathophysiology of environmental pollutants. Am J Physiol Heart Circ Physiol 286:H497-H485.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Bhatnagar, A.1
  • 13
    • 0017748544 scopus 로고
    • Lead intoxication among demolition workers: The effect of lead on the hepatic cytochrome P-450 system in humans
    • Fischbein A, Alvares AP, Anderson KE, Sassa S, Kappas A. 1977. Lead intoxication among demolition workers: the effect of lead on the hepatic cytochrome P-450 system in humans. J Toxicol Environ Health 3:431-437.
    • (1977) J. Toxicol. Environ. Health , vol.3 , pp. 431-437
    • Fischbein, A.1    Alvares, A.P.2    Anderson, K.E.3    Sassa, S.4    Kappas, A.5
  • 14
    • 0031241088 scopus 로고    scopus 로고
    • Molecular mechanism of heme biosynthesis
    • Fujita H. 1997. Molecular mechanism of heme biosynthesis. Tohoku J Exp Med 183:83-99.
    • (1997) Tohoku J. Exp. Med. , vol.183 , pp. 83-99
    • Fujita, H.1
  • 15
    • 0036755603 scopus 로고    scopus 로고
    • Can nutrition affect chemical toxicity?
    • Furst A. 2002. Can nutrition affect chemical toxicity? Intl J Toxicol 21:419-424.
    • (2002) Intl. J. Toxicol. , vol.21 , pp. 419-424
    • Furst, A.1
  • 16
    • 0027477577 scopus 로고
    • Dietary intake, levels in food and estimated intake of lead, cadmium and mercury
    • Galal-Gorchev H. 1993. Dietary intake, levels in food and estimated intake of lead, cadmium and mercury. Food Addit Contam 10:115-128.
    • (1993) Food Addit. Contam. , vol.10 , pp. 115-128
    • Galal-Gorchev, H.1
  • 17
    • 0030753968 scopus 로고    scopus 로고
    • Toxic and essential metal interactions
    • Goyer RA. 1997. Toxic and essential metal interactions. Annu Rev Nutr 17:37-50.
    • (1997) Annu. Rev. Nutr. , vol.17 , pp. 37-50
    • Goyer, R.A.1
  • 19
    • 33044489103 scopus 로고
    • Cadmium
    • IPCS (International Programme on Chemical Safety). Geneva:World Health Organization
    • IPCS (International Programme on Chemical Safety). 1992. Cadmium. Environmental Health Criteria 134. Geneva:World Health Organization.
    • (1992) Environmental Health Criteria , vol.134
  • 20
    • 0036225268 scopus 로고    scopus 로고
    • Cadmium overload and toxicity
    • Jarup L. 2002. Cadmium overload and toxicity. Nephrol Dial Transplant 17(suppl 2):35-39.
    • (2002) Nephrol. Dial. Transplant , vol.17 , Issue.SUPPL. 2 , pp. 35-39
    • Jarup, L.1
  • 22
    • 18644367143 scopus 로고    scopus 로고
    • Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad)
    • Jin T, Nordberg M, Frech W, Dumont X, Bernard A, Ye T, et al. 2002. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals 15:397-410.
    • (2002) Biometals , vol.15 , pp. 397-410
    • Jin, T.1    Nordberg, M.2    Frech, W.3    Dumont, X.4    Bernard, A.5    Ye, T.6
  • 23
    • 0025999673 scopus 로고
    • Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity
    • Kraul H, Truckenbrodt J, Huster A, Topfer R, Hoffman A. 1991. Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity. Eur J Clin Pharmacol 4:475-480.
    • (1991) Eur. J. Clin. Pharmacol. , vol.4 , pp. 475-480
    • Kraul, H.1    Truckenbrodt, J.2    Huster, A.3    Topfer, R.4    Hoffman, A.5
  • 24
    • 0028304752 scopus 로고
    • Cadmium: Exposure markers as predictors of nephrotoxic effects
    • Lauwerys RR, Bernard AM, Roels HA, Buchet JP. 1994. Cadmium: exposure markers as predictors of nephrotoxic effects. Clin Chem 40(7):1391-1394.
    • (1994) Clin. Chem. , vol.40 , Issue.7 , pp. 1391-1394
    • Lauwerys, R.R.1    Bernard, A.M.2    Roels, H.A.3    Buchet, J.P.4
  • 25
    • 0034091885 scopus 로고    scopus 로고
    • Mechanisms of nephrotoxicity from metal combinations: A review
    • Madden EF, Fowler BA. 2000. Mechanisms of nephrotoxicity from metal combinations: a review. Drug Chem Toxicol 23:1-12.
    • (2000) Drug Chem. Toxicol. , vol.23 , pp. 1-12
    • Madden, E.F.1    Fowler, B.A.2
  • 26
    • 0017752397 scopus 로고
    • The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation
    • Meredith PA, Campbell BC, Moore MR, Goldberg A. 1977. The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation. Eur J Clin Pharmacol 12:235-239.
    • (1977) Eur. J. Clin. Pharmacol. , vol.12 , pp. 235-239
    • Meredith, P.A.1    Campbell, B.C.2    Moore, M.R.3    Goldberg, A.4
  • 27
    • 0030885491 scopus 로고    scopus 로고
    • A major role for CYHP2A6 in nicotine C-oxidation by human liver microsome
    • Messina ES, Tyndale RF, Sellers EM. 1997. A major role for CYHP2A6 in nicotine C-oxidation by human liver microsome. J Pharmacol Exp Ther 282:1608-1614.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 1608-1614
    • Messina, E.S.1    Tyndale, R.F.2    Sellers, E.M.3
  • 28
    • 1642359157 scopus 로고    scopus 로고
    • A commentary on the impacts of metals and metalloids in the environment upon the metabolism of drugs and chemicals
    • Moore MR. 2004. A commentary on the impacts of metals and metalloids in the environment upon the metabolism of drugs and chemicals. Toxicol Lett 148:153-158.
    • (2004) Toxicol. Lett. , vol.148 , pp. 153-158
    • Moore, M.R.1
  • 29
    • 0023638393 scopus 로고
    • Lead effects on the heme biosynthetic pathway. Relationship to toxicity
    • Moore R, Goldberg A, Yeung-Laiwah AA. 1987. Lead effects on the heme biosynthetic pathway. Relationship to toxicity. Ann NY Acad Sci 514:191-203.
    • (1987) Ann. NY Acad. Sci. , vol.514 , pp. 191-203
    • Moore, R.1    Goldberg, A.2    Yeung-Laiwah, A.A.3
  • 30
    • 0034880245 scopus 로고    scopus 로고
    • Study of lead exposure from automobile exhaust as a risk for nephrotoxicity among traffic policemen
    • Mortada WI, Sobh MA, El-Defrawy MM, Farahat SE. 2001. Study of lead exposure from automobile exhaust as a risk for nephrotoxicity among traffic policemen. Am J Nephrol 21:274-279.
    • (2001) Am. J. Nephrol. , vol.21 , pp. 274-279
    • Mortada, W.I.1    Sobh, M.A.2    El-Defrawy, M.M.3    Farahat, S.E.4
  • 31
    • 0031846115 scopus 로고    scopus 로고
    • New approaches for detecting thresholds of human nephrotoxicity using cadmium as an example
    • Mueller PW, Price RG, Finn WF. 1998. New approaches for detecting thresholds of human nephrotoxicity using cadmium as an example. Environ Health Perspect 106:227-230.
    • (1998) Environ. Health Perspect. , vol.106 , pp. 227-230
    • Mueller, P.W.1    Price, R.G.2    Finn, W.F.3
  • 33
    • 0742324327 scopus 로고    scopus 로고
    • The gender differences in health effects of environmental cadmium exposure and potential mechanisms
    • Nishijo M, Satarug S, Honda R, Tsuritani I, Aoshima K. 2004. The gender differences in health effects of environmental cadmium exposure and potential mechanisms. Mol Cell Biochem 255:87-92.
    • (2004) Mol. Cell Biochem. , vol.255 , pp. 87-92
    • Nishijo, M.1    Satarug, S.2    Honda, R.3    Tsuritani, I.4    Aoshima, K.5
  • 35
    • 0342313759 scopus 로고    scopus 로고
    • Renal effects of cadmium intake in a Japanese general population in two areas unpolluted by cadmium
    • Oo YK, Kobayashi E, Nogawa K, Kubo Y, Suwazono Y, Kido T, et al. 2000. Renal effects of cadmium intake in a Japanese general population in two areas unpolluted by cadmium. Arch Environ Health 55:98-103.
    • (2000) Arch. Environ. Health , vol.55 , pp. 98-103
    • Oo, Y.K.1    Kobayashi, E.2    Nogawa, K.3    Kubo, Y.4    Suwazono, Y.5    Kido, T.6
  • 36
    • 0035154274 scopus 로고    scopus 로고
    • Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism
    • Oscarson M. 2001. Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism. Drug Metab Dispos 29:91-95.
    • (2001) Drug Metab Dispos. , vol.29 , pp. 91-95
    • Oscarson, M.1
  • 40
    • 0026934672 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
    • Rautio A, Kraul H, Kojo A, Salmela E, Pelkonen O. 1992. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics 2:227-233.
    • (1992) Pharmacogenetics , vol.2 , pp. 227-233
    • Rautio, A.1    Kraul, H.2    Kojo, A.3    Salmela, E.4    Pelkonen, O.5
  • 41
    • 0025760161 scopus 로고
    • Induction of heme oxygenase in the small intestinal epithelium: A response to oral cadmium exposure
    • Rosenberg DW, Kappas A. 1991. Induction of heme oxygenase in the small intestinal epithelium: a response to oral cadmium exposure. Toxicology 67:199-210.
    • (1991) Toxicology , vol.67 , pp. 199-210
    • Rosenberg, D.W.1    Kappas, A.2
  • 42
    • 0034986767 scopus 로고    scopus 로고
    • Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium
    • Satarug S, Baker JR, Reilly PEB, Moore MR, Williams DJ. 2001. Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium. Hum Exp Toxicol 20(4):205-213.
    • (2001) Hum. Exp. Toxicol. , vol.20 , Issue.4 , pp. 205-213
    • Satarug, S.1    Baker, J.R.2    Reilly, P.E.B.3    Moore, M.R.4    Williams, D.J.5
  • 43
    • 0036283062 scopus 로고    scopus 로고
    • Cadmium levels in the lung, liver, kidney cortex and urine samples from Australians without occupational exposure to metals
    • Satarug S, Baker JR, Reilly PEB, Moore MR, Williams DJ. 2002. Cadmium levels in the lung, liver, kidney cortex and urine samples from Australians without occupational exposure to metals. Arch Environ Health 57:69-77.
    • (2002) Arch. Environ. Health , vol.57 , pp. 69-77
    • Satarug, S.1    Baker, J.R.2    Reilly, P.E.B.3    Moore, M.R.4    Williams, D.J.5
  • 44
    • 0034490142 scopus 로고    scopus 로고
    • Safe levels of cadmium intake to prevent renal toxicity in human subjects
    • Satarug S, Haswell-Elkins MR, Moore MR. 2000. Safe levels of cadmium intake to prevent renal toxicity in human subjects. Br J Nutr 84:791-802.
    • (2000) Br. J. Nutr. , vol.84 , pp. 791-802
    • Satarug, S.1    Haswell-Elkins, M.R.2    Moore, M.R.3
  • 46
    • 1642383654 scopus 로고    scopus 로고
    • Effects of chronic exposure to low-level cadmium on renal function and CYP2A6-mediated coumarin metabolism in human subjects
    • Satarug S, Nishijo M, Ujjin P, Vanavanitkun Y, Baker JR, Moore MR. 2004a. Effects of chronic exposure to low-level cadmium on renal function and CYP2A6-mediated coumarin metabolism in human subjects. Toxicol Lett 148:187-197.
    • (2004) Toxicol. Lett. , vol.148 , pp. 187-197
    • Satarug, S.1    Nishijo, M.2    Ujjin, P.3    Vanavanitkun, Y.4    Baker, J.R.5    Moore, M.R.6
  • 47
    • 1642297362 scopus 로고    scopus 로고
    • Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai men and women
    • Satarug S, Ujjin P, Vanavanitkun Y, Baker JR, Moore MR. 2004b. Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai men and women. Toxicol Lett 148:177-185.
    • (2004) Toxicol. Lett. , vol.148 , pp. 177-185
    • Satarug, S.1    Ujjin, P.2    Vanavanitkun, Y.3    Baker, J.R.4    Moore, M.R.5
  • 48
    • 4544381751 scopus 로고    scopus 로고
    • Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men
    • Satarug S, Ujjin P, Vanavanitkun Y, Mishijo M, Baker JR, Moore MR. 2004c. Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men. Toxicology 204(2-3):161-173.
    • (2004) Toxicology , vol.204 , Issue.2-3 , pp. 161-173
    • Satarug, S.1    Ujjin, P.2    Vanavanitkun, Y.3    Mishijo, M.4    Baker, J.R.5    Moore, M.R.6
  • 49
    • 0037222167 scopus 로고    scopus 로고
    • Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration
    • Schoedel KA, Sellers EM, Palmour R, Tyndale RF. 2003. Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Mol Pharmacol 63:96-104.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 96-104
    • Schoedel, K.A.1    Sellers, E.M.2    Palmour, R.3    Tyndale, R.F.4
  • 50
    • 0028900559 scopus 로고
    • CYP3A4 and CYP2A6 activities marked by the metabolism of ligocaine and coumarin in patients with liver and kidney diseases and epileptic patients
    • Sotaniemi EA, Raunio A, Backstrom M, Arvela P, Pelkonen O. 1995. CYP3A4 and CYP2A6 activities marked by the metabolism of ligocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol 39:71-76.
    • (1995) Br. J. Clin. Pharmacol. , vol.39 , pp. 71-76
    • Sotaniemi, E.A.1    Raunio, A.2    Backstrom, M.3    Arvela, P.4    Pelkonen, O.5
  • 51
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
    • Tenhunen R, Marver HS, Schmid R. 1968. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 61:748-755.
    • (1968) Proc. Natl. Acad. Sci. USA , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 52
    • 0037291512 scopus 로고    scopus 로고
    • Nicotine metabolism, human drug metabolism polymorphisms, and smoking behavior
    • Tricker AR. 2003. Nicotine metabolism, human drug metabolism polymorphisms, and smoking behavior. Toxicology 183:151-173.
    • (2003) Toxicology , vol.183 , pp. 151-173
    • Tricker, A.R.1
  • 53
    • 0036260293 scopus 로고    scopus 로고
    • Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females
    • Ujjin P, Satarug S, Vanavanitkun Y, Daigo S, Ariyoshi N, Yamazaki H, et al. 2002. Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. Pharmacogenetics 12:241-249.
    • (2002) Pharmacogenetics , vol.12 , pp. 241-249
    • Ujjin, P.1    Satarug, S.2    Vanavanitkun, Y.3    Daigo, S.4    Ariyoshi, N.5    Yamazaki, H.6
  • 54
    • 1642351981 scopus 로고    scopus 로고
    • Induction of the liver CYP2A5 in female BALB/c mice exposed to cadmium
    • [Abstract]
    • Urbenjapol S, Satarug S, Noller B, Moore MR. 2001. Induction of the liver CYP2A5 in female BALB/c mice exposed to cadmium [Abstract]. Toxicology 164:62.
    • (2001) Toxicology , vol.164 , pp. 62
    • Urbenjapol, S.1    Satarug, S.2    Noller, B.3    Moore, M.R.4
  • 56
    • 0019164964 scopus 로고
    • High performance liquid chromatography of coumarin and its metabolites
    • Walters DG, Lake BG, Cottrell RC. 1980. High performance liquid chromatography of coumarin and its metabolites. J Chromatogr 196:501-505.
    • (1980) J. Chromatogr. , vol.196 , pp. 501-505
    • Walters, D.G.1    Lake, B.G.2    Cottrell, R.C.3
  • 57
    • 0003391968 scopus 로고
    • World Health Organization WHO Technical Report Series No. Geneva:World Health Organization
    • World Health Organization, 1989. Evaluation of Certain Food Additives and Contaminants. WHO Technical Report Series No. 776. Geneva:World Health Organization.
    • (1989) Evaluation of Certain Food Additives and Contaminants , Issue.776


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