Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor nrf2 in liver

Chemical Research in Toxicology

Volumn 23, Issue 5, 2010, Pages 977-985

  Lämsä, Virpi ^a   Levonen, Anna Liisa ^b   Leinonen, Hanna ^b   Ylä Herttuala, Seppo ^b   Yamamoto, Masayuki ^c   Hakkola, Jukka ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2A5; HEAVY METAL; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LEAD CHLORIDE; METHYLMERCURIC CHLORIDE; PHENETHYL ISOTHIOCYANATE; PROTEIN; PROTEIN BACH1; PROTEIN HMOX1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME REGULATION; GENE CONTROL; LIVER; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; GENE KNOCKDOWN TECHNIQUES; HEME OXYGENASE-1; HEPATOCYTES; MEMBRANE PROTEINS; METALS, HEAVY; MICE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; UP-REGULATION;

ANIMALIA;

EID: 77952332154     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100084c     Document Type: Article

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