Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms

Biological Psychiatry

Volumn 76, Issue 1, 2014, Pages 47-56

  Jayanthi, Subramaniam ^a   McCoy, Michael T ^a   Chen, Billy ^b   Britt, Jonathan P ^b   Kourrich, Saïd ^b   Yau, Hau Jie ^b   Ladenheim, Bruce ^a   Krasnova, Irina N ^a   Bonci, Antonello ^b   Cadet, Jean Lud ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b U S DEPARTMENT OF HEALTH AND HUMAN SERVICES   (United States)

Author keywords

Addiction; AMPAR; CoREST; HDAC2; MeCP2; NMDAR; REST; valproic acid

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; AMPA RECEPTOR; COREPRESSOR PROTEIN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GENOMIC DNA; GLUA1 AMPA RECEPTOR; GLUA2 AMPA RECEPTOR; GLUN1 N METHYL DEXTRO ASPARTIC ACID RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR N1; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE H4; IMMUNOGLOBULIN G; MESSENGER RNA; METHAMPHETAMINE; METHYL CPG BINDING PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR COREPRESSOR 1; SIRTUIN 1; SIRTUIN 2; UNCLASSIFIED DRUG; VALPROIC ACID; DNA BINDING PROTEIN; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; HDAC1 PROTEIN, RAT; HDAC2 PROTEIN, RAT; HISTONE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL FRACTIONATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORPUS STRIATUM; DNA HYDROXYMETHYLATION; DNA METHYLATION; DNA SEQUENCE; DOWN REGULATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EXPOSURE; ELECTROPHYSIOLOGY; EPIGENETICS; EX VIVO STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE EXPRESSION; GENE INTERACTION; GENE REPRESSION; GENE SEQUENCE; HISTONE ACETYLATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIMIT OF QUANTITATION; LONG TERM EXPOSURE; MALE; NERVE CELL PLASTICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SYNAPTIC TRANSMISSION; TRANSCRIPTION INITIATION SITE; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY;

ACETYLATION; ANIMALS; CORPUS STRIATUM; DNA METHYLATION; DNA-BINDING PROTEINS; DOWN-REGULATION; EPIGENESIS, GENETIC; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONES; MALE; METHAMPHETAMINE; NEURONS; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; REPRESSOR PROTEINS; SIRTUIN 1; SIRTUIN 2; VALPROIC ACID;

EID: 84902282655     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.09.034     Document Type: Article

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