Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway

Biochemical Pharmacology

Volumn 90, Issue 2, 2014, Pages 135-144

  Jiang, Xinwei ^a,b   Tang, Xilan ^b   Zhang, Peiwen ^b   Liu, Guoling ^a   Guo, Honghui ^a  

^a SHAOGUAN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Anthocyanin; Apoptosis; Hyperglycemia; Mitochondrial dysfunction; Oxidative stress

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CYANIDIN 3 GLUCOSIDE; CYANIDIN 3 ORTHO BETA GLUCOSIDE; CYTOCHROME C; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME INACTIVATION; HYPERGLYCEMIA; LIPID DIET; LIVER CELL; LIVER PROTECTION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANTHOCYANIN; APOPTOSIS; CYANIDIN-3-O-Β-GLUCOSIDE; GLUCOSE; HYPERGLYCEMIA; LY294002; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; PD98059; SB203580; SP600125;

ANIMALS; ANTHOCYANINS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CYTOCHROMES C; DIET, HIGH-FAT; DIETARY FATS; FATTY LIVER; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSIDES; HEPATOCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASE; PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84902264334     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.04.018     Document Type: Article

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