Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

Biochemical Pharmacology

Volumn 82, Issue 5, 2011, Pages 453-463

  Hoffmann, Ruth ^a   Von Schwarzenberg, Karin ^a   López Antón, Nancy ^a   Rudy, Anita ^a   Wanner, Gerhard ^a   Dirsch, Verena M ^b   Vollmar, Angelika M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Autophagy; Chemoresistance; ER stress; Sesquiterpene lactone

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOSOME; CASPASE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HELENALIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE OMI; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CELL CLONE; CELL DEATH; CELL STRAIN MCF 7; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN FUNCTION; SOLID TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELLS, CULTURED; CYTOPROTECTION; ENDOPLASMIC RETICULUM; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 79960915931     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.029     Document Type: Article

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