3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1 β interferes with mature IL-1 β signaling

Journal of Biological Chemistry

Volumn 289, Issue 23, 2014, Pages 16214-16222

  Davaro, Facundo ^a,c   Forde, Sorcha D ^a   Garfield, Mark ^b   Jiang, Zhaozhao ^a   Halmen, Kristen ^a   Tamburro, Nelsy Depaula ^a   Kurt Jones, Evelyn ^a   Fitzgerald, Katherine A ^a   Golenbock, Douglas T ^a   Wang, Donghai ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION;

ANTI-INFLAMMATORY EFFECTS; CLINICAL TRIAL; INFLAMMATORY RESPONSE; INTERLEUKIN-1; MOLECULAR MECHANISM; PROINFLAMMATORY CYTOKINES; REDUCTASE INHIBITORS; SIGNALING PATHWAYS;

MEDICAL APPLICATIONS;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; RAC1 PROTEIN; RAC2 PROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ATHEROSCLEROSIS; CASPASE; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; INTERLEUKIN;

ANIMALS; CELLS, CULTURED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION;

EID: 84902169305     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.571505     Document Type: Article

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