HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

Journal of Leukocyte Biology

Volumn 93, Issue 2, 2013, Pages 289-299

  Liao, Yi Hsiang ^a,b   Lin, Yi Chieh ^a   Tsao, Shih Ting ^a   Lin, Ying Cing ^a   Yang, Ai Jen ^a   Huang, Chen Tsung ^a   Huang, Kuo Chin ^c   Lin, Wan Wan ^a,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Il 1; Inflammasome; Isoprenoids; Mevalonate kinase deficiency; Statins

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE TRIPHOSPHATE; CATHEPSIN B INHIBITOR; CRYOPYRIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MEVINOLIN; P2X7 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; LYSOSOME; MOLECULAR MECHANICS; MONOCYTE; PRIORITY JOURNAL; PROTEIN SECRETION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CASPASE 1; CELL LINE; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOBLOTTING; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MONOCYTES; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84873312422     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0812409     Document Type: Article

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