Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis

Carbohydrate Polymers

Volumn 109, Issue , 2014, Pages 126-138

  Bottegoni, Carlo ^a   Muzzarelli, Riccardo A A ^a   Giovannini, Francesca ^a   Busilacchi, Alberto ^a   Gigante, Antonio ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Chondroitin sulphate; d Glucosamine; Nutraceuticals; Oral chondroprotection; Osteoarthritis

Indexed keywords

DRUG THERAPY; JOINTS (ANATOMY); REPAIR;

CHONDROITIN SULPHATE; D-GLUCOSAMINE; NUTRACEUTICALS; ORAL CHONDROPROTECTION; OSTEOARTHRITIS;

SULFUR COMPOUNDS;

ANTIINFLAMMATORY AGENT; CHONDROITIN SULFATE; GLUCOSAMINE;

ANIMAL; CARTILAGE; CARTILAGE CELL; DIET SUPPLEMENTATION; DRUG EFFECTS; HUMAN; ORAL DRUG ADMINISTRATION; OSTEOARTHRITIS; PATHOLOGY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARTILAGE; CHONDROCYTES; CHONDROITIN SULFATES; DIETARY SUPPLEMENTS; GLUCOSAMINE; HUMANS; OSTEOARTHRITIS;

EID: 84902157288     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2014.03.033     Document Type: Review

References (177)

1. A. Aghazadeh-Habashi, and F. Jamali The glucosamine controversy; a pharmacokinetic issue Journal of Pharmacy and Pharmaceutical Sciences 14 2011 264 273
2. A.R. Ajadi, S.G. Oladele, B.O. Ebenezer, and B.K. Olajide Evaluation of glucosamine and snail mucin on the progression of experimental knee osteoarthritis in dogs International Journal of Morphology 31 2013 280 286
3. J.W. Anderson, R.J. Nicolosi, and J.F. Borzelleca Glucosamine effects in humans, a review of effects on glucose metabolism, side effects, safety considerations and efficacy Food Chemistry and Toxicology 43 2005 187 201
4. N.M.S. Arafa, H.M. Hamuda, S.T. Melek, and S.K. Darwish The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model Toxicology and Industrial Health 29 2013 187 201
5. S. Artamonova, and F.F. Sharnina Isolation of D-glucosamine from chitin-glucan complexes Applied Biochemistry and Microbiology 49 2013 426 431
6. J.P. Bali, H. Cousse, and E. Neuzil Biochemical basis of the pharmacologic action of chondroitin sulphates on the osteoarticular system Seminars of Arthritis Rheumatology 31 2001 58 68
7. K. Bauerova, S. Ponist, V. Kuncirova, D. Mihalova, E. Paulovicova, and N. Volpi Protective effect of chondroitin sulfate on induced arthritis in rats Osteoarthritis and Cartilage 19 2011 1373 1379
8. G.A. Bell, E.D. Kantor, J.W. Lampe, D.D. Shen, and E. White Use of glucosamine and chondroiitin in relation to mortality European Journal of Epidemiology 27 2012 593 603
9. B.A. Biggee, C.M. Blinn, T.E. McAlindon, M. Nuite, and J.E. Silbert Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness Annals of the Rheumatic Diseases 65 2006 222 226
10. C. Black, C. Clar, R. Henderson, C. MacEachern, P. McNamee, and Z. Quayyum et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee, a systematic review and economic evaluation Health Technology Assessment 13 2009 1 148
11. J.A. Block, T.R. Oegema, J.D. Sandy, and A. Plaas The effects of oral glucosamine on joint health, is a change in research approach needed? Osteoarthritis and Cartilage 18 2010 5 11
12. A.J. Bollet, and J.L. Nance Biochemical findings in normal and osteoarthritic articular cartilage. II. Chondroitin sulfate concentration and chain length, water and ash content Journal of Clinical Investigations 45 1966 1170 1177
13. R.G. Boot, E.F. Blommaart, E. Swart, K. Ghauharali-van der Vlugt, N. Bijl, and C. Moe et al. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase Journal of Biological Chemistry 276 2001 6770 6778
14. R.G. Boot, G.H. Renkema, A. Strijland, A.J. Zonneveld, and J.M.F.G. Aerts Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages Journal of Biological Chemistry 270 1995 26252 26256
15. O. Bruyere, and J.Y. Reginster Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis Drugs & Aging 24 2007 573 580
16. O. Bruyere, N. Burlet, P.D. Delmas, R. Rizzoli, C. Cooper, and J.Y. Reginster Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system BMC Musculoskeletal Disorders 9 2008 article 165
17. O. Bruyère, S. Scholtissen, A. Neuprez, M. Hiligsmann, A. Toukouki, and J.Y. Reginster Impact of chondroitin sulphate on health utility in patients with knee osteoarthritis, towards economic analysis Journal of Medicinal Economy 12 2009 356 360
18. A. Busilacchi, A. Gigante, M. Mattioli-Belmonte, S. Manzotti, and R.A.A. Muzzarelli Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration Carbohydrate Polymers 98 2013 665 676
19. V. Calamia, L. Lourido, P. Fernandez-Puente, J. Mateos, B. Rocha, and E. Montell et al. Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties Arthritis Research & Therapy 2012 14
20. G.M. Campo, A. Avenoso, S. Campo, A. D'Ascola, P. Traina, and A. Calatroni Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice Osteoarthritis and Cartilage 16 2008 1474 1483
21. G.M. Campo, A. Avenoso, S. Campo, P. Traina, A. D'Ascola, and A. Calatroni Glycosaminoglycans reduced inflammatory response by modulating toll-like receptor-4 in LPS-stimulated chondrocytes Archives of Biochemistry and Biophysics 491 2009 7 15
22. N. Canas, R. Gorina, A.M. Planas, J. Vergés, E. Montell, and A.G. García et al. Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation Neuroscience 19 2010 872 879
23. X. Chen, L. Liu, J.H. Li, G.C. Du, and J. Chen Improved glucosamine and N-acetylglucosamine production by an engineered Escherichia coli via step-wise regulation of dissolved oxygen level Bioresource Technology 110 2012 534 538
24. R. Chiusaroli, T. Piepoli, and T. Zanelli et al. Experimental pharmacology of glucosamine sulfate International Journal of Rheumatology 2011 2011 8 Article ID 939265, doi: 10.1155/2011/939265
25. P.M. Collins Carbohydrates 1987 Chapman & Hall London
26. T. Conrozier Chondroitin sulfates (CS 4&6), practical applications and economic impact Presse Medicale 27 1998 1866 1868
27. G.V. Coppa, F. Maccari, L. Zampini, L. Santoro, T. Galeazzi, and O. Gabrielli et al. Structural characterisation of chondroitin sulphate from Italian cheese Parmigiano-Reggiano Food Chemistry 134 2012 195 199
28. S. Dahmer, and R.M. Schiller Glucosamine American Family Physician 78 2008 471 476
29. A. Das Jr., and T.A. Hammad Efficacy of a combination of FCHG49 (TM) glucosamine hydrochloride, TRH122 (TM) low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis Osteoarthritis and Cartilage 8 2000 343 350
30. S. Das, R. Sen, and D. Roy Enzymatic processing of chitinaceous wastes for N-acetyl-D-glucosamine production, an example of green and efficient environmental management Environmental Engineering and Management Journal 11 2012 1849 1855
31. C.L. David, J. Orpiszewski, X.C. Zhu, K.J. Reissner, and D.W. Aswad Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain Journal of Biological Chemistry 273 1998 32063 32070
32. G. David, V. Lories, A. Heremans, B. Van der Schueren, J.J. Cassiman, and H. Van den Berghe Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts Journal of Cell Biology 108 1989 1165 1173
33. M. David-Raoudi, B. Deschrevel, S. Leclercq, P. Galéra, K. Boumediene, and J.P. Pujol Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases. Role of p38 and Akt Arthritis and Rheumatism 60 2009 760 770
34. P.S.E. Davies, S.M. Graham, R.J. MacFarlane, A. Leonidou, A. Mantalaris, and E. Tsiridis Disease-modifying osteoarthritis drugs, in vitro and in vivo data on the development of DMOADs under investigation Expert Opinion on Investigational Drugs 22 2013 423 441
35. C.L. Deal, and R.W. Moskowitz Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitine sulphate, and collagen hydrolysate Rheumatic Diseases Clinic of North America 25 1999 379 395
36. A. Derfoul, A.D. Miyoshi, D.E. Freeman, and R.S. Tuan Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation Osteoarthritis and Cartilage 15 2007 646 655
37. S. Dumitriu Polysaccharides in medicinal applications 1996 Marcel Dekker New York 696
38. D. Durmus, G. Alaly, Y. Aliyazicioglu, O. Buyukakincak, and F. Canturk Effects of glucosamine sulfate and exercise therapy on serum leptin levels in patients with knee osteoarthritis, preliminary results of randomized controlled clinical trial Rheumatology International 33 2013 593 599
39. J.M. Erickson, and T.M. Messer Glucosamine and chondroitin sulfate treatment of hand osteoarthritis Journal of Hand Surgery-American Volume 38A 2013 1638 1640
40. A.J. Fosang Aggrecanase and cartilage proteoglycan degradation K.M.K. Bottomley, D. Bradshaw, J.S. Nixon, Metalloproteinases as targets for anti-inflammatory drugs 1999 Birkhauser Basel 117 144
41. A.J. Fosang, and F. Beier Emerging frontiers in cartilage and chondrocyte biology Best Practice & Research Clinical Rheumatology 25 2011 751 766
42. A.J. Fosang, and F.M. Rogerson Identifying the human aggrecanase Osteoarthritis and Cartilage 18 2010 1109 1116
43. C. Gabay, C. Medinger-Sadowski, D. Gascon, F. Kolo, and A. Finckh Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis, a randomized, double-blind, placebo-controlled clinical trial at a single center Arthritis and Rheumatism 63 2011 3383 3391
44. A. Geraci, D. Zatta, C. Stazzabosco, G. Tomasello, G. Alongi, and M. Genovese et al. The clinical effectiveness of glucosamine sulfate, chondroiitin sulfate, hydrolyzed collagen type II, hydrolyzed hyaluronic acid and L carnitine supplement in patients with osteoarthritis of the knee, a multi center randomized double blind controlled clinical trial Minerva Ortopedica e Traumatologica 63 2012 9 17
45. M.H. Gilzad-Kohan, and F. Jamali Glucosamine and adjuvant arthritis, a pharmacokinetic and pharmacodynamic study European Journal of Pharmaceutical Sciences 47 2012 387 393
46. S.H. Goldberg, J.M. Von Feldt, and J.H. Lonner Pharmacologic therapy for osteoarthritis American Journal of Orthopedy 12 2002 673 680
47. J.N. Gouze, K. Bordji, and S. Gulberti et al. Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis, influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes Arthritis and Rheumatism 44 2001 351 360
48. G.F. Grant, and R.W. Gracy Therapeutic nutraceutical treatments for osteoarthritis and ischaemia Expert Opinion on Therapeutic Patents 10 2000 39 48
49. H. Greenlee, K.D. Crew, T. Shao, G. Kranwinkel, K. Kalinsky, and M. Maurer et al. Phase II study of glucosamine with chondroiitin on aromatase inhibitor-associated joint symptoms in women with breast cancer Supportive Care in Cancer 21 2013 1077 1087
50. O. Habuchi Diversity and functions of glycosaminoglycan sulfotransferases Biochimica Biophysica Acta 1474 2000 115 127
51. J. Han, X. Guo, Y.X. Lei, B.S. Dennis, S.X. Wu, and C.Y. Wu Synthesis and characterization of selenium-chondroiitin sulfate nanoparticles Carbohydrate Polymers 90 2012 122 126
52. R.S. Harlan, R.C. Haut, and M.W. Orth The effect of glucosamine and chondroitin on stressed equine cartilage explants Journal of Equine Veterinary Science 32 2012 12 14
53. J.N. Hathcock, and A. Shao Risk assessment for glucosamine and chondroitin sulfate Regulatory Toxicology and Pharmacology 47 2007 78 83
54. Y. Henrotin, and C. Lambert Chondroitin and glucosamine in the management of osteoarthritis: An update Current Rheumatology Reports 15 10 2013 10.1007/s11926-013-0361-z
55. Y. Henrotin, M. Mathy, C. Sanchez, and C. Lambert Chondroitin sulfate in the treatment of osteoarthritis: From in vitro studies to clinical recommendations Therapeutic Advances in Musculoskeletal Diseases 2 2010 335 348
56. G. Herrero-Beaumont, and L.C. Rovati Use of crystalline glucosamine sulfate in osteoarthritis Future Medicine 1 2006 397 414
57. M. Hochberg, X. Chevalier, Y. Henrotin, D.J. Hunter, and D. Uebelhart Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: What's the evidence? Current Medical Research and Opinion 29 2013 259 267
58. M.C. Hochberg, and D.O. Clegg Potential effects of chondroitin sulfate on joint swelling, a GAIT report Osteoarthritis and Cartilage 16 2008 S22 S24
59. M.C. Hochberg Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: An updated meta-analysis of randomized placebo-controlled trials of 2-year duration Osteoarthritis and Cartilage 18 2010 S28 S31
60. J. Hua, K. Sakamoto, and I. Nagaoka Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils Journal of Leukocyte Biology 71 2002 632 640
61. E.C. Huskisson Glucosamine and chondroitin for osteoarthritis Journal of International Medical Research 36 2008 1161 1179
62. A. Ibrahim, M.H. Gilzad-Kohan, A. Aghazadeh-Habashi, and F. Jamali Absorption and bioavailability of glucosamine in the rat Journal of Pharmaceutical Sciences 101 2012 2574 2583
63. K. Imagawa, M.C. DeAndres, K. Hashimoto, D. Pitt, E. Itoi, and M.B. Goldring et al. The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes-implications for osteoarthritis Biochemical Biophysical Research Communications 405 2011 362 367
64. C.G. Jackson, A.H. Plaas, J.D. Sandy, C. Hua, S. Kim-Rolands, and J.G. Barnhill et al. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination Osteoarthritis and Cartilage 19 2010 297 302
65. K.M. Jordan, N.K. Arden, M. Doherty, B. Bannwarth, J.W. Bijlsma, and P. Dieppe et al. EULAR Recommendations 2003, an evidence based approach to the management of knee osteoarthritis, Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) Annals of the Rheumatic Diseases 62 2003 1145 1155
66. T. Kamarul, S. Ab-Rahim, M. Tumin, L. Selvaratnam, and T.S. Ahmad A preliminary study of the effects of glucosamine sulphate and chondroitin sulphate on surgically treated and untreated focal cartilage damage European Cells & Materials 21 2011 259 271
67. E.D. Kantor, J.W. Lampe, T.L. Vaughan, U. Peters, C.D. Rehm, and E. White Association between use of special dietary supplements and C-reactive protein concentrations American Journal of Epidemiology 176 2012 1002 1013
68. N. Kanzaki, K. Saito, A. Maeda, Y. Kitagawa, Y. Kiso, and K. Watanabe et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroiitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis, a randomized, double-blind, placebo-controlled study Journal of the Science of Food and Agriculture 92 2012 862 869
69. T. Kean, and M. Thanou Biodegradation, biodistribution and toxicity of chitosan Advances in Drug Delivery Reviews 62 2010 3 11
70. J.F. Kennedy, and C.A. White Bioactive carbohydrates 1983 Ellis Horwood Chichester 216
71. I.M. Khan, S.J. Gilbert, S.K. Singhrao, V.C. Duance, and C.W. Archer Cartilage integration, evaluation of the reasons for failure of integration during cartilage repair. A review European Cells and Materials 16 2008 26 39
72. M.M. Kim, E. Mendis, N. Rajapakse, and S.K. Kim Glucosamine sulfate promotes osteoblastic differentiation of MG-63 cells via anti-inflammatory effect Bioorganic & Medicinal Chemistry Letters 17 2007 1938 1942
73. S.K. Kim Chitin, chitosan, oligosaccharides and their derivatives 2011 CRC Press London
74. S.K. Kim Marine nutraceuticals: Prospects and perspectives 2013 CRC Press London
75. K. Kimata, M. Okayama, A. Ooira, and S. Suzuki Heterogeneity of proteochondroitin sulfates produced by chondrocytes at different stages of cytodifferentiation Journal of Biological Chemistry 249 1974 1646 1653
76. S.G. Kirkham, and R.K. Samarasinghe Review article, glucosamine Journal of Orthopaedic Surgery (Hong Kong) 17 2009 72 76
77. M. Kubo, K. Ando, T. Mimura, Y. Matsusue, and K. Mori Chondroitin sulfate for the treatment of hip and knee osteoarthritis. Current status and future trends Life Sciences 85 2009 477 483
78. R. Largo, M.A. Alvarez-Soria, I. Diez-Ortego, E. Calvo, O. Sanchez-Pernaute, and J. Egido et al. Glucosamine inhibits IL-1beta-induced NFkB activation in human osteoarthritic chondrocytes Osteoarthritis and Cartilage 11 2003 290 298
79. R.M. Lauder Chondroitin sulphate, a complex molecule with potential impacts on a wide range of biological systems Complement Therapy Medicine 17 2009 56 62
80. S. Laverty, J.D. Sandy, C. Celeste, P. Vachon, J.F. Marier, and A.H. Plaas Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses Arthritis & Rheumatism 52 2005 181 191
81. Y.H. Lee, J.H. Woo, S.J. Choi, J.D. Ji, and G.G. Song Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression, a meta-analysis Rheumatology International 30 2010 357 363
82. B.F. Leeb, H. Schweitzer, K. Montag, and J.S. Smolen A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis Journal of Rheumatology 27 2000 205 211
83. C.T. Leffler, A.F. Philippi, S.G. Leffler, J.C. Mosure, and P.D. Kim Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back, a randomized, double-blind, placebo-controlled pilot study Military Medicine 164 1999 85 91
84. L. Lippiello Glucosamine and chondroitin sulfate, biological response modifiers of chondrocytes under simulated conditions of joint stress Osteoarthritis and Cartilage 11 2003 335 342
85. L. Liu, Y.F. Liu, H.D. Shin, R. Chen, J.H. Li, and G.C. Du et al. Microbial production of glucosamine and N-acetylglucosamine, advances and perspectives Applied Microbiology and Biotechnology 97 2013 6149 6158
86. F. Luttosch, and C. Baerwald Pharmacological treatment of osteoarthrosis Aktuelle Rheumatologie 37 2012 366 370
87. M.S. Martin, S. Van Sell, and J. Danter Glucosamine and chondroiitin an appropriate adjunct treatment of symptomatic osteoarthritis of the knee Orthopaedic Nursing 31 2012 160 166
88. A.J. Matheson, and C.M. Perry Glucosamine - A review of its use in the management of osteoarthritis Drugs & Aging 20 2003 1041 1060
89. B.F. Matthews Composition of articular cartilage in osteoarthritis British Medical Journal 2 1953 660
90. B. Mazières, M. Hucher, M. Zaim, and P. Garnero Effect of chondroitin sulphate in symptomatic knee osteoarthritis, a multicentre, randomised, double-blind, placebo-controlled study Annals of the Rheumatic Diseases 66 2007 639 645
91. T.E. McAlindon, M.P. LaValley, J.P. Gulin, and D.T. Felson Glucosamine and chondroitin for treatment of osteoarthritis, a systematic quality assessment and meta-analysis Journal of the American Medical Association 283 2000 1469 1475
92. C.J. Meininger, K.A. Kelly, H. Li, T.E. Haynes, and G.Y. Wu Glucosamine inhibits inducible nitric oxide synthesis Biochemical and Biophysical Research Communications 279 2000 234 239
93. I. Möller, M. Pérez, J. Monfort, P. Benito, J. Cuevas, and C. Perna et al. Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis, a randomized, double-blind, placebo-controlled study Osteoarthritis and Cartilage 18 Suppl 1 2010 S32 S40
94. R. Momomura, K. Naito, M. Igarashi, T. Watari, A. Terakado, and S. Oike et al. Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers Molecular Medicine Reports 7 2013 742 746
95. R.A.A. Muzzarelli Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone Carbohydrate Polymers 76 2009 167 182
96. R.A.A. Muzzarelli Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers Marine Drugs 8 2010 292 312
97. R.A.A. Muzzarelli Nanochitins and nanochitosans, paving the way to eco-friendly and energy-saving exploitation of marine resources K. Matyjaszewski, M. Möller, Polymer science, a comprehensive reference Vol. 10 2012 Elsevier BV Amsterdam 153 164
98. R.A.A. Muzzarelli, and C. Muzzarelli Chitosan, a dietary supplement and a food technology commodity C.G. Biliaderis, M.S. Izydorczyk, Functional food carbohydrates 2006 Francis and Taylor Orlando, USA 215 248
99. R.A.A. Muzzarelli, J. Boudrant, D. Meyer, N. Manno, M. DeMarchis, and M.G. Paoletti Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin, A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial Carbohydrate Polymers 87 2012 b 995 1012
100. R.A.A. Muzzarelli, F. Greco, A. Busilacchi, V. Sollazzo, and A. Gigante Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration, a review Carbohydrate Polymers 89 2012 723 739
101. R.A.A. Muzzarelli, F. Orlandini, D. Pacetti, E. Boselli, N.G. Frega, and G. Tosi et al. Chitosan taurocholate capacity to bind lipids and to undergo enzymatic hydrolysis, An in vitro model Carbohydrate Polymers 66 2006 363 371
102. R.A.A. Muzzarelli, V. Stanic, and V. Ramos Enzymatic depolymerization of chitins and chitosans C. Bucke, Methods in biotechnology, carbohydrate biotechnology protocols 1999 Humana Press Totowa 197 211
103. H. Nakamura Application of glucosamine on human disease: osteoarthritis Carbohydrate Polymers 84 2011 835 839
104. T. Nakano, Z. Pietrasik, L. Ozimek, and M. Betti Extraction, isolation and analysis of chondroitin sulfate from broiler chicken biomass Process Biochemistry 47 2012 1909 1918
105. Y. Nakayama, T. Narita, A. Mori, S. Uesaka, K. Miyazaki, and H. Ito The effects of age and sex on chondroitin sulfates in normal synovial fluid Arthritis and Rheumatology 46 2002 2105 2108
106. Natural Standard, Chondroitin sulfate, Natural Standard Monographs, 2007.
107. W. Noack, M. Fischer, K.K. Forster, L.C. Rovati, and I. Setnikar Glucosamine sulfate in osteoarthritis of the knee Osteoarthritis and Cartilage 2 1994 51 59
108. S.M. Noskov, A.A. Lavrukhina, K.Y. Shirokova, and A.A. Pryanichnikova Strategy for the use of chondroprotectors in osteoarthrosi Terapevticheskii Arkhiv 85 2013 92 94
109. A. Oohira, R. Katoh-Semba, E. Watanabe, and F. Matsui Brain development and multiple molecular species of proteoglycan Neuroscience Research 20 1994 195 207
110. L. Palmieri, A. Conte, L. Giovannini, P. Lualdi, and G. Ronca Metabolic fate of exogenous chondroitin sulfate in the experimental animal Arzneimittel-Forschung/Drug Research 40 1990 319 323
111. K. Pavelka, J. Gatterova, M. Olejarova, S. Machacek, G. Giacovelli, and L.C. Rovati Glucosamine sulfate use and delay of progression of knee osteoarthritis, a 3-year, randomized, placebo-controlled, double-blind study Archives of Internal Medicine 162 2002 2113 2123
112. I.M. Pecly, N.M. Melo-Filho, and P.A. Mourao Effects of molecular size and chemical structure on renal and hepatic removal of exogenously administered chondroitin sulfate in rats Biochimica Biophysica Acta 1760 2006 865 876
113. V.H. Pomin, A.A. Piquet, M.S. Pereira, and P.A.S. Mourão Residual keratan sulfate in chondroitin sulfate formulations for oral administration Carbohydrate Polymers 90 2012 839 846
114. N. Poolsup, S. Suthisisang, P. Channark, and W. Kittikulsuth Glucosamine long-term treatment and the progression of knee osteoarthritis, systematic review of randomized controlled trials Annals of Pharmacotherapy 39 2005 1080 1087
115. K. Prydz, and K.T. Dalen Synthesis and sorting of proteoglycans Journal of Cell Sciences 113 2000 193 205
116. S. Qian, Q.Z. Zhang, Y.F. Wang, B. Lee, G.V. Betageri, and M.S.S. Chow et al. Bioavailability enhancement of glucosamine hydrochloride by chitosan International Journal of Pharmaceutics 455 2013 365 373
117. G.X. Qiu, S.N. Gao, G. Giacovelli, L. Rovati, and I. Setnikar Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis Arzneimittel-Forschung/Drug Research 48 1998 469 474
118. R.L. Ragle, and A.D. Sawitzke Nutraceuticals in the management of osteoarthritis Drugs and Aging 29 2012 717 731
119. N. Rajapakse, E. Mendis, M.M. Kim, and S.K. Kim Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells Bioorganic and Medicinal Chemistry 15 2007 4891 4896
120. M.N.V. Ravi Kumar, R.A.A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A.J. Domb Chitosan chemistry and pharmaceutical perspectives Chemical Reviews 104 2004 6017 6084
121. A.D. Recklies, C. White, and H. Ling The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase beta-mediated signalling pathways Biochemical Journal 365 2002 119 126
122. J. Reginster, and E. Tajana Single oral dose of (1200 mg) sachet of chondroitin 4&6 sulfate (Chondrosulf®) relieves pain and improves function. Results of a double blind study, versus placebo and an active treatment in knee OA patients Osteoarthritis and Cartilage 19 S1 2011 S53 S236
123. J.Y. Reginster, O. Bruyere, and A. Neuprez Current role of glucosamine in the treatment of osteoarthritis Rheumatology 46 2007 731 735
124. J.Y. Reginster, R. Deroisy, L.C. Rovati, R.L. Lee, E. Lejeune, and O. Bruyere et al. Long-term effects of glucosamine sulphate on osteoarthritis progression, a randomised, placebo-controlled clinical trial Lancet 357 2001 251 256
125. J.Y. Reginster, A. Neuprez, M.P. Lecart, N. Sarlet, and O. Bruyere Role of glucosamine in the treatment of osteoarthritis Rheumatology International 32 2012 2959 2967
126. S. Reichenbach, R. Sterchi, M. Scherer, S. Trelle, E. Burgi, and U. Burgi et al. Meta-analysis, chondroitin for osteoarthritis of the knee or hip Annals of Internal Medicine 146 2007 580 590
127. N.S. Remya, and P.D. Nair Engineering cartilage tissue interfaces using a natural glycosaminoglycan hydrogel matrix. An in vitro study Materials Science & Engineering C-33 2013 575 582
128. F. Richy, O. Bruyere, O. Ethgen, M. Chucherat, Y. Henrotin, and J.Y. Reginster Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis, a comprehensive meta-analysis Archives of Internal Medicine 163 2003 1514 1522
129. G. Ronca, and A. Conte Metabolic fate of partially depolymerized shark chondroitin sulfate in man International Journal of Clinical Pharmacology Research 13 1993 27 34
130. C. Rubio-Terrés An economic evaluation of chondroitin sulfate and non-steroidal anti-inflammatory drugs for the treatment of osteoarthritis. Data from the VECTRA study Reumatologic Clinics 6 2010 187 195
131. D.R. Runkel, and M.J. Cupp Glucosamine sulfate use in osteoarthritis American Journal of Health & Systematic Pharmacy 56 1999 267 269
132. S.C. Sahoo, A. Tharalekshmy, S.W. Ng, and P. Naumov Glucosamine salts, resolving ambiguities over the market-based compositions Crystal Growth & Design 12 2012 5148 5154
133. A. Sanches-Silva, T. Ribeiro, T.G. Albuquerque, P. Paseiro, R. Sendon, and A.B. de Quiros et al. Ultra-high pressure LC determination of glucosamine in shrimp by-products and migration tests of chitosan films Journal of Separation Science 35 2012 633 640
134. J.D. Sandy, D. Gamett, V. Thompson, and C. Verscharen Chondrocyte-mediated catabolism of aggrecan, aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine Biochemical Journal 335 1998 59 66
135. A.D. Sawitzke, H. Shi, and M.F. Finco et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis, a report from the glucosamine/chondroitin arthritis intervention trial Arthritis & Rheumatism 58 2008 3183 3191
136. T. Selvan, K. Rajiah, M.S.M. Nainar, and E.M. Mathew A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis Scientific World Journal 2012 1 5
137. H.J. Seo, Y.K. Sung, C.B. Choi, E.B. Lee, C. Cheong, and S.Y. Kim et al. Prevalence and factors affecting glucosamine use in Korea, a survey-based study Rheumatology International 33 2013 1627 1631
138. D. Sibbritt, J. Adams, C.W. Lui, A. Broom, and J. Wardle Who uses Glucosamine and why?. A study of 266,848 Australians aged 45 years and older PLoS One 7 2012 NIL-285 NIL-290
139. R.R. Simon, V. Marks, A.R. Leeds, and J.W. Anderson A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals Diabetes Metabolism Research Reviews 27 2011 14 27
140. A.B. Sitanggang, H.S. Wu, S.S. Wang, and Y.C. Ho Effect of pellet size and stimulating factor on the glucosamine production using Aspergillus sp BCRC 31742 Bioresource Technology 101 2010 3595 3601
141. D. Stoppoloni, L. Politi, P. Dalla Vedova, M. Messano, A. Koverech, and R. Scandurra et al. L-Carnitine enhances extracellular matrix synthesis in human primary chondrocytes Rheumatology International 33 2013 2399 2403
142. K.M. Surapaneni, and G. Venkataramana Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis Indian Journal of Medical Sciences 61 2007 9 14
143. M. Suzuki, W. Fujimoto, M. Goto, M. Morimatsu, M. Syuto, and T. Iwanaga Cellular expression of gut chitinase mRNA in the gastrointestinal tract of mice and chickens Histochemistry and Cytochemistry 8 2002 1081 1089
144. J.M. Talent, and R.W. Gracy Pilot-study of oral polymeric N-acetyl-d-glucosamine as a potential treatment for patients with osteoarthritis Clinical Therapy 18 1996 1184 1190
145. Y. Tamai, K. Miyatake, Y. Okamoto, Y. Takamori, H. Sakamoto, and S. Minami Enhanced healing of cartilaginous injuries by glucosamine hydrochloride Carbohydrate Polymers 48 2002 369 378
146. S. Taniguchi, J. Ryu, M. Seki, T. Sumino, Y. Tokuhashi, and M.J. Esumi Orthopedic Research 30 2012 673 678
147. S.K. Tat, J.-P. Pelletier, F. Mineau, N. Duval, and J. Martel-Pelletier Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes. Relevance of purity and production process Journal of Rheumatology 37 2010 656 664
148. M.M. Temple, W.C. Bae, M.Q. Chen, M. Lotz, D. Amiel, and R.D. Coutts et al. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle Osteoarthritis and Cartilage 15 2007 1042 1052
149. M.L. Tiku, H. Narla, M. Jain, and P. Yalamanchili Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation Arthritis Research & Therapy 9 4 2007 article R76
150. T.E. Towheed Current status of glucosamine therapy in osteoarthritis Arthritis and Rheumathism 49 2003 601 604
151. T.E. Towheed, L. Maxwell, T.P. Anastassiades, B. Shea, J. Houpt, and V. Robinson Glucosamine therapy for treating osteoarthritis (Cochrane review) The Cochrane Library, Issue 3 2006 Chichester UK
152. D. Uebelhart Clinical review of chondroitin sulfate in osteoarthritis Osteoarthritis and Cartilage 16 2008 S19 S21
153. D. Uebelhart, R. Knols, E.D. de Bruin, and G. Verbruggen Chondroitin sulfate as a structure-modifying agent Chondroitin sulfate, structure, role and pharmacological activity 2006 Elsevier Inc Amsterdam
154. E.J. Uitterlinden, J.L. Koevoet, and C.F. Verkoelen et al. Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants BMC Musculoskeletal Disorders 9 2008 article 120
155. E. Vaclavikova, and F. Kvasnincka Isotachophoretic determination of glucosamine and chondroitin sulfate in dietary supplements Czech Journal of Food Sciences 31 2013 55 65
156. C. Valvason, E. Musacchio, and A. Pozzuoli et al. Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes, effects on HO-1, p22Phox and iNOS expression Rheumatology 47 2008 31 35
157. C.T. Vangsness Jr., W. Spiker, and J. Erickson A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis Arthroscopy - The Journal of Arthroscopic and Related Surgery 25 2009 86 94
158. S. Varghese, P. Theprungsirikul, and S. Sahani et al. Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression Osteoarthritis and Cartilage 15 2007 59 68
159. J.A. Vazquez, I. Rodriguez-Amado, M.I. Montemayor, J. Fraguas, M.D. Gonzales, and M.A. Murado Chondroitin sulfate, hyaluronic acid and chitin/chitosan production using marine waste sources, characteristics, applications and eco-friendly processes. A review Marine Drugs 11 2013 747 774
160. N. Volpi Oral bioavailability of chondroitin sulfate (Condrosulf) and its
161. N. Volpi Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers Osteoarthritis and Cartilage 11 6 2003 433 441
162. N. Volpi Analytical aspects of pharmaceutical grade chondroitin sulfates Journal of Pharmaceutical Sciences 96 2007 3168 3180
163. N. Volpi Quality of different chondroitin sulfate preparations in relation to their therapeutic activity Pharmacy & Pharmacology 61 2009 1271 1280
164. N. Volpi About oral absorption and human pharamacokinetics of chondroitin sulphate Osteoarthritis and Cartilage 18 2010 1104 1105
165. N. Volpi Anti-inflammatory activity of chondroitin sulphate, New functions from an old natural macromolecule Inflammopharmacology 19 2011 299 306
166. A. Walsh, M. Sweeney, T. Bahar, and B.J.V. O'Doherty Multi-functional roles of chitosan as a potential protective agent against obesity PLoS One 8 2013 10.1371/journal.pone.0053828
167. Y. Wang, L.F. Prentice, L. Vitetta, A.E. Wluka, and F.M. Cicuttini The effect of nutritional supplements on osteoarthritis Alternative Medicine Review 9 2004 275 296
168. C.A. Welch, G.D. Potter, P.G. Gibbs, and E.M. Eller Plasma concentration of glucosamine and chondroitin sulfate in horses after an oral dose Journal of Equine Veterinary Science 32 2012 60 64
169. L.M. Wildi, J.P. Raynauld, J. Martel-Pelletier, A. Beaulieu, L. Bessette, and F. Morin et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy, a randomised, double-blind, placebo-controlled pilot study using MRI Annals of Rheumatic Diseases 70 2011 982 989
170. H. Wu, M. Liu, S. Wang, H. Zhao, W. Yao, and W. Feng et al. Comparative fasting bioavailability and pharmacokinetics properties of 2 formulations of glucosamine hydrochloride in healthy Chinese adult male volunteers Arzneimittelforschung-Drug Research 62 2012 367 371
171. Y. Yamagishi, M. Igarashi, A. Suzuki, S. Suguro, S.I. Hirano, and I. Nagaoka Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats Experimental and Therapeutic Medicine 4 2012 640 644
172. J. Yue, M. Yang, S. Yi, B. Dong, W. Li, and Z. Yang et al. Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease, a cluster-randomized, placebo-condrolled study Osteoarthritis and Cartilage 20 2012 622 629
173. J. Zaia, B. Liu, R. Boynton, and F. Barry Structural analysis of cartilage proteoglycans and glycoproteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Analytical Biochemistry 277 2000 94 103
174. M. Zako, T. Shinomura, O. Miyaishi, M. Iwaki, and K. Kimata Transient expression of PG-M/versican, a large chondroitin sulfate proteoglycan in developing chicken retina Journal of Neurochemistry 69 1997 2155 2161
175. B. Zegels, P. Crozes, D. Uebelhart, O. Bruyere, and J.Y. Reginster Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroiitin 4&6 sulfate in patients with knee osteoarthritis. Results of a randomized double blind placebo controlled study Osteoarthritis and Cartilage 21 2013 22 27
176. J.X. Zhang, L. Liu, J.H. Li, G.C. Du, and J. Chen Enhanced glucosamine production by Aspergillus sp BCRC 31742 based on the time-variant kinetics analysis of dissolved oxygen level Bioresource Technology 111 2012 507 511
177. W. Zhang, M. Doherty, B.F. Leeb, L. Alekseeva, N.K. Arden, and J.W. Bijlsma et al. EULAR evidence based recommendations for the management of hand osteoarthritis, report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) Annals of Rheumatic Diseases 66 2007 377 388