Glucosamine

American Family Physician

Volumn 78, Issue 4, 2008, Pages

  Dahmer, Stephen ^a,c   Schiller, Robert M ^b  

^a Beth Israel Center for Health and Healing   (United States)

^b Institute for Urban Family Health   (United States)

^c Beth Israel Department of Family Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CHONDROITIN; GLUCOSAMINE; GLUCOSAMINE SULFATE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; WARFARIN; CHONDROITIN SULFATE; NON PRESCRIPTION DRUG;

ANTINOCICEPTION; ASTHMA; CLINICAL TRIAL; DIARRHEA; DIET SUPPLEMENTATION; DISEASE COURSE; DRUG COST; DRUG EFFICACY; DRUG INFORMATION; DRUG USE; DYSPNEA; EPIGASTRIC PAIN; FOOD ALLERGY; HEARTBURN; HUMAN; HYPERSENSITIVITY REACTION; KNEE OSTEOARTHRITIS; NAUSEA; PAIN ASSESSMENT; PATIENT EDUCATION; REVIEW; RHEUMATOID ARTHRITIS; SELF EVALUATION; TEMPOROMANDIBULAR JOINT DISORDER; THERAPY EFFECT; TREATMENT CONTRAINDICATION; TREATMENT RESPONSE; VISUAL ANALOG SCALE; DRUG COMBINATION; DRUG CONTRAINDICATION; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

CHONDROITIN SULFATES; DRUG THERAPY, COMBINATION; DRUGS, NON-PRESCRIPTION; GLUCOSAMINE; HUMANS; OSTEOARTHRITIS, KNEE; PRACTICE GUIDELINES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 52049122906     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Kolata G. Supplements fail to stop arthritis pain, study says. The New York Times. February 23, 2006: A23. http://www.nytimes.com/2006/02/23/health/ 23arthritis.html?-r=1&ei=5094&en=0b447ab268a67ac3&hp=&ex= 1140757200&partner=homepage&pagewanted=all&oref=slogin. Accessed January 11, 2008.
2. Limited meta-analysis doesn't represent reality of population with osteoarthritis [news release]. Washington, DC: Council for Responsible Nutrition; April 16, 2007. http://www.crnusa.org/prpdfs/CRNPR07-AIM-chondroitin- 041607.pdf. Accessed April 14, 2008.
3. Gregory PJ, Sperry M, Wilson AF. Dietary supplements for osteoarthritis. Am Fam Physician. 2008;77(2):177-185. (Pubitemid 351162302)
4. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251-256. (Pubitemid 32120855)
5. Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002;162(18):2113-2123. (Pubitemid 35168220)
6. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354(8):795-808. (Pubitemid 43290918)
7. Lippiello L, Woodward J, Karpman R, Hammad TA. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res. 2000;(381):229-240.
8. Lippiello L, Karpman RR, Hammad T. Synergistic effect of glucosamine HCL and chondroitin sulfate on in vitro proteoglycan synthesis by bovine chondrocytes. Paper presented at: American Academy of Orthopaedic Surgeons 67th Annual Meeting; March 15-19, 2000; Rosemont, Ill. http://www.med.nyu.edu/ patientcare/library/article.html?ChunkIID=21661. Accessed January 11, 2008.
9. Runkel DR, Cupp MJ. Glucosamine sulfate use in osteoarthritis. Am J Health Syst Pharm. 1999;56(3):267-269. (Pubitemid 29076206)
10. Setnikar I, Palumbo R, Canali S, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneimittelforschung. 1993;43(10):1109-1113. (Pubitemid 23311890)
11. Towheed TE, Maxwell L, Anastassiades TP, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005;(2):CD002946.
12. Qiu GX, Weng XS, Zhang K, et al. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis [in Chinese]. Zhonghua Yi Xue Za Zhi. 2005;85(43):3067-3070. (Pubitemid 43140894)
13. Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999;164(2):85-91. (Pubitemid 29096040)
14. Reichelt A, Förster KK, Fischer M, Rovati LC, Setnikar I. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee: a randomised, placebo-controlled, double-blind study. Arzneimittelforschung. 1994;44(1):75-80. (Pubitemid 24036884)
15. D'Ambrosio E, Casa B, Bompani R, Scali G, Scali M. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica. 1981;2(8):504-508. (Pubitemid 11143940)
16. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Effi- cacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998;48(5):469-474. (Pubitemid 28247632)
17. Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage. 1994;2(1):61-69. (Pubitemid 24159681)
18. Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol. 2001;28(6):1347-1355. (Pubitemid 32510508)
19. Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola G. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med. 2000;172(2):91-94.
20. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol. 1999;26(11):2423-2430. (Pubitemid 29528986)
21. Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford). 2002;41(3):279-284. (Pubitemid 34546007)
22. McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med. 2004;117(9):643-649. (Pubitemid 40288170)
23. Messier SP, Mihalko S, Loeser RF, et al. Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study. Osteoarthritis Cartilage. 2007;15(11):1256-1266. (Pubitemid 350029043)
24. Vlad SC, LaValley MP, McAlindon TE, Felson DT. Glucosamine for pain in osteoarthritis: why do trial results differ? Arthritis Rheum. 2007;56(7):2267-2277. (Pubitemid 47173575)
25. Kolasinski S. Glucosamine and chondroitin: update 2006. Altern Med Alert. 2006;9(7):73-78.
26. Hochberg MC. Nutritional supplements for knee osteoarthritis - still no resolution. N Engl J Med. 2006;354(8):858-860. (Pubitemid 43290926)
27. Rozendaal RM, Koes BW, van Osch GJ, et al. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med. 2008;148(4):268-277. (Pubitemid 351665485)
28. Theodosakis J. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol. 2004;31(4):826. (Pubitemid 38451283)
29. Cohen M, Wolfe R, Mai T, Lewis D. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee [published correction appears in J Rheumatol. 2003;30(11):2512]. J Rheumatol. 2003;30(3):523-528. (Pubitemid 36301945)
30. Tallarida RJ, Cowan A, Raffa RB. Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice. J Pharmacol Exp Ther. 2003;307(2):699-704. (Pubitemid 37310686)
31. Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev. 1998;3(1):27-39. (Pubitemid 128709601)
32. Nakamura H, Masuko K, Yudoh K, Kato T, Kamada T, Kawahara T. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int. 2007;27(3):213-218. (Pubitemid 46088250)
33. Gray HC. Hutcheson PS, Slavin RG. Is glucosamine sulfate safe in patients with seafood allergy? [letter]. J Allergy Clin Immunol. 2004;114(2)459-460. (Pubitemid 39119056)
34. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm. 2004;61(3):306-307. (Pubitemid 39004631)
35. Matheu V, Gracia Bara MT, Pelta R, Vivas E, Rubio M. Immediate- hypersensitivity reaction to glucosamine sulfate. Allergy. 1999;54(6):643. (Pubitemid 29301825)
36. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica. 1982;3(3):157-168. (Pubitemid 13242759)
37. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract. 2002;15(6):481-484. (Pubitemid 44872685)
38. Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med. 2003;163(13):1587-1590. (Pubitemid 36835104)
39. Arthritis Foundation. Glucosamine and chondroitin sulfate. http://www.arthritis.org/conditions/alttherapies/glucosamine.asp. Accessed January 11, 2008.
40. Joint rememdies (glucosamine and chondroitin supplements). Consumer Reports. 2002;67(1)18-21.
41. Vital Nutrients recalls Joint Ease & Verified Quality Brand Joint Comfort Complex because of adverse health risk associated with aristolochic acid [news release]. Middletown, Conn.: Vital Nutrients/RHG & Co., Inc.; May 24, 2001. http://www.fda.gov/oc/po/firmrecalls/vital5-01.html. Accessed April 14, 2008.