Role of glucosamine in the treatment for osteoarthritis

Rheumatology International

Volumn 32, Issue 10, 2012, Pages 2959-2967

  Reginster, Jean Yves ^a,c   Neuprez, Audrey ^a   Lecart, Marie Paule ^b   Sarlet, Nathalie ^b   Bruyere, Olivier ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Policliniques L BRULL Quai Godefroid Kurth   (Belgium)

Author keywords

Glucosamine; Osteoarthritis; Structure; Symptoms; Treatment

Indexed keywords

CELECOXIB; CHONDROITIN SULFATE; GLUCOSAMINE; GLUCOSAMINE SULFATE; IBUPROFEN; MANGANESE ASCORBATE; MANGANESE DERIVATIVE; PARACETAMOL; PIROXICAM; PLACEBO; UNCLASSIFIED DRUG;

CHRONIC PAIN; COST EFFECTIVENESS ANALYSIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; HEALTH ECONOMICS; HUMAN; INTENTION TO TREAT ANALYSIS; KNEE OSTEOARTHRITIS; LONG TERM CARE; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SYMPTOM; TEMPOROMANDIBULAR JOINT; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOMECHANICS; COST-BENEFIT ANALYSIS; DIETARY SUPPLEMENTS; DRUG COSTS; GLUCOSAMINE; HUMANS; KNEE JOINT; OSTEOARTHRITIS, KNEE; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 84867894359     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2416-2     Document Type: Review

References (58)

1. Setnikar I, Cereda R, Pacini MA, Revel L (1991) Antireactive properties of glucosamine sulfate. Arzneimittelforschung 41(2):157-161
2. Reginster JY, Bruyere O, Fraikin G, Henrotin Y (2005) Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bull Hosp Jt Dis 63(1-2):31-36
3. Largo R, Alvarez-Soria MA, Diez-Ortego I, Calvo E, Sanchez-Pernaute O, Egido J, Herrero-Beaumont G (2003) Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthr Cartil 11(4):290-298
4. Alvarez-Soria MA, Largo R, Calvo E, Herrero-Beaumont G (2005) Differential anticatabolic profile of glucosamine sulfate versus other anti-osteoarthritic drugs on human osteoarthritic chondrocytes and synovial fibroblasts in culture. Osteoarthr Cartil 13:S153
5. Uitterlinden EJ, Jahr H, Koevoet JL, Jenniskens YM, Bierma-Zeinstra SM, Degroot J, Verhaar JA, Weinans H, van Osch GJ (2006) Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthr Cartil 14(3):250-257. doi: 10.1016/j.joca.2005.10.001
6. Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M (2011) Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs. J Orthop Res. doi: 10.1002/jor.22003
7. Imagawa K, de Andres MC, Hashimoto K, Pitt D, Itoi E, Goldring MB, Roach HI, Oreffo RO (2011) The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes-implications for osteoarthritis. Biochem Biophys Res Commun 405(3):362-367. doi: 10.1016/j.bbrc.2011.01.007
8. Altman RD, Abramson S, Bruyere O, Clegg D, Herrero-Beaumont G, Maheu E, Moskowitz R, Pavelka K, Reginster JY (2006) Commentary: osteoarthritis of the knee and glucosamine. Osteoarthr Cartil 14(10):963-966. doi: 10.1016/j.joca.2006.06.010
9. Reginster JY, Bruyere O, Neuprez A (2007) Current role of glucosamine in the treatment of osteoarthritis. Rheumatology (Oxford) 46(5):731-735. doi: 10.1093/rheumatology/kem026
10. Reichelt A, Forster KK, Fischer M, Rovati LC, Setnikar I (1994) Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. Arzneimittelforschung 44(1):75-80
11. Setnikar I, Palumbo R, Canali S, Zanolo G (1993) Pharmacokinetics of glucosamine in man. Arzneimittelforschung 43(10):1109-1113
12. Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD (1999) Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med 164(2):85-91
13. Rovati L (1997) Clinical development of glucosamine sulfate as selective drug in osteoarthritis. Rheumatol Eur 26:70
14. Houpt JB, McMillan R, Wein C, Paget-Dellio SD (1999) Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 26(11):2423-2430
15. Rovati L (1993) Clinical efficacy of glucosamine sulfate in osteoarthritis of the spine. Rev Esp Reumatol 20(S1):325
16. Muller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I (1994) Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthr Cartil 2(1):61-69
17. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I (1998) Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 48(5):469-474
18. Rovati L (1997) The clinical profile of glucosamine sulfate as a selective symptom modifying drug in osteoarhtritis: current data and perspective. Osteoarthr Cartil 5(SA):72
19. Thie NM, Prasad NG, Major PW (2001) Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol 28(6):1347-1355
20. Cohen M, Wolfe R, Mai T, Lewis D (2003) A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 30(3):523-528
21. Hughes R, Carr A (2002) A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford) 41(3):279-284
22. Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola G (2000) Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 172(2):91-94
23. McAlindon T (2003) Why are clinical trials of glucosamine no longer uniformly positive? Rheum Dis Clin N Am 29(4):789-801
24. Zeisel SH (1999) Regulation of nutraceuticals. Science 285(5435):1853-1855
25. McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K (2004) Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med 117(9):643-649. doi: 10.1016/j.amjmed.2004.06.023
26. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354(8):795-808. doi: 10.1056/NEJMoa052771
27. Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martin-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araujo D, Figueroa M, Branco J (2007) Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 56(2):555-567. doi: 10.1002/art.22371
28. Russell AS, Aghazadeh-Habashi A, Jamali F (2002) Active ingredient consistency of commercially available glucosamine sulfate products. J Rheumatol 29(11):2407-2409
29. Hoffer LJ, Kaplan LN, Hamadeh MJ, Grigoriu AC, Baron M (2001) Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 50(7):767-770. doi: 10.1053/meta.2001.24201
30. Cordoba F, Nimni ME (2003) Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulfur amino acids. Osteoarthr Cartil 11(3):228-230
31. Laverty S, Sandy JD, Celeste C, Vachon P, Marier JF, Plaas AH (2005) Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum 52(1):181-191. doi: 10.1002/art.20762
32. Pham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, Simon L, Strand V, Woodworth T, Dougados M (2004) OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthr Cartil 12(5):389-399. doi: 10.1016/j.joca.2004.02.001
33. Reginster JY (2007) The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. Arthritis Rheum 56(7):2105-2110. doi: 10.1002/art.22852
34. Leeb BF, Schweitzer H, Montag K, Smolen JS (2000) A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis. J Rheumatol 27(1):205-211
35. McAlindon TE, LaValley MP, Gulin JP, Felson DT (2000) Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283(11):1469-1475
36. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY (2003) Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Int Med 163(13):1514-1522. doi: 10.1001/archinte.163.13.1514
37. Towheed TE, Anastassiades TP (1999) Glucosamine therapy for osteoarthritis. J Rheumatol 26(11):2294-2297
38. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G (2005) Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev (2):CD002946. doi: 10.1002/14651858.CD002946.pub2
39. Bruyere O, Burlet N, Delmas PD, Rizzoli R, Cooper C, Reginster JY (2008) Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. BMC Musculoskelet Disord 9:165. doi: 10.1186/1471-2474-9-165
40. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C (2001) Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 357(9252):251-256. doi: 10.1016/S0140-6736(00)03610-2
41. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC (2002) Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Int Med 162(18):2113-2123
42. Bruyere O, Honore A, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY (2002) Radiologic features poorly predict clinical outcomes in knee osteoarthritis. Scand J Rheumatol 31(1):13-16
43. Bruyere O, Honore A, Ethgen O, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY (2003) Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthr Cartil 11(1):1-5
44. Christgau S, Henrotin Y, Tanko LB, Rovati LC, Collette J, Bruyere O, Deroisy R, Reginster JY (2004) Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol 22(1):36-42
45. Mazzuca SA, Brandt KD, Lane KA, Katz BP (2002) Knee pain reduces joint space width in conventional standing anteroposterior radiographs of osteoarthritic knees. Arthritis Rheum 46(5):1223-1227. doi: 10.1002/art.10256
46. Pavelka K, Bruyere O, Rovati LC, Olejarova M, Giacovelli G, Reginster JY (2003) Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials. Osteoarthr Cartil 11(10):730-737
47. Bruyere O, Pavelka K, Rovati LC, Gatterova J, Giacovelli G, Olejarova M, Deroisy R, Reginster JY (2008) Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthr Cartil 16(2):254-260. doi: 10.1016/j.joca.2007.06.011
48. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO 3rd, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO (2008) The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 58(10):3183-3191. doi: 10.1002/art.23973
49. Bruyere O (2011) Large review finds no clinically important effect of glucosamine or chondroitin on pain in people with osteoarthritis of the knee or hip but results are questionable and likely due to heterogeneity. Evid Based Med 16(2):52-53. doi: 10.1136/ebm1164
50. Aghazadeh-Habashi A, Jamali F (2011) The glucosamine controversy; a pharmacokinetic issue. J Pharm Pharm Sci 14(2):264-273
51. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG (2010) Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int 30(3):357-363. doi: 10.1007/s00296-009-0969-5
52. Tapadinhas MJ, Rivera IC, Bignamini AA (1982) Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 3(3):157-168
53. Adams ME (1999) Hype about glucosamine. Lancet 354(9176):353-354. doi: 10.1016/S0140-6736(99)90040-5
54. Rovati LC, Annefeld M, Giacovelli G, Schmid K, Setnikar I (1999) Glucosamine in osteoarthritis. Lancet 354 (9190):1640; author reply 1641-1642
55. AbdelFatah W, Hammad T (2001) Chondroitin sulfate and glucosamine: a review to their safety profile. JAMA 3:17-24
56. Matheson AJ, Perry CM (2003) Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging 20(14):1041-1060
57. Tannis AJ, Barban J, Conquer JA (2004) Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthr Cartil 12(6):506-511. doi: 10.1016/j.joca.2004.03.001
58. Scholtissen S, Bruyere O, Neuprez A, Severens JL, Herrero-Beaumont G, Rovati L, Hiligsmann M, Reginster JY (2010) Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol. Int J Clin Pract 64(6):756-762. doi: 10.1111/j.1742-1241.2010. 02362.x