The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination

Osteoarthritis and Cartilage

Volumn 18, Issue 3, 2010, Pages 297-302

  Jackson, C G ^a   Plaas, A H ^b   Sandy, J D ^b   Hua, C ^c   Kim Rolands, S ^c   Barnhill, J G ^d,e   Harris, C L ^d   Clegg, D O ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d University of New Mexico   (United States)

^e UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Chondroitin sulfate; Glucosamine; Osteoarthritis; Pharmacokinetics; Therapeutics

Indexed keywords

CHONDROITIN SULFATE; DISACCHARIDE; GLUCOSAMINE;

ADULT; ANALGESIA; AREA UNDER THE CURVE; ARTICLE; CHROMATOGRAPHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; ELECTROPHORESIS; FEMALE; FLUOROPHORE ASSISTED CARBOHYDRATE ELECTROPHORESIS; HUMAN; KNEE PAIN; MALE; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ARTHRALGIA; CHONDROITIN SULFATES; CLINICAL TRIALS AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; GLUCOSAMINE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS; PAIN MEASUREMENT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 76549129482     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2009.10.013     Document Type: Article

References (23)

1. Lawrence R.C., Helmick C.G., Arnett F.C., Deyo R.A., Felson D.T., Giannini E.H., et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41 (1998) 778-799
2. McNair P.J., Simmonds M.A., Boocock M.G., and Larmer P.J. Exercise therapy for the management of osteoarthritis of the hip joint: a systematic review. Arthritis Res Ther 11 (2009) R98
3. Reichmann W.M., Katz J.N., Kessler C.L., Jordan J.M., and Losina E. Determinants of self-reported health status in a population-based sample of persons with radiographic knee osteoarthritis. Arthritis Rheum 61 (2009) 1046-1053
4. Corsinovi L., Martinelli E., Fonte G., Astengo M., Sona A., Gatti A., et al. Efficacy of oxycodone/acetaminophen and codeine/acetaminophen vs conventional therapy in elderly women with persistent, moderate to severe osteoarthritis-related pain. Arch Gerontol Geriatr (2009)
5. Hochberg M.C. Nutritional supplements for knee osteoarthritis-still no resolution. N Engl J Med 354 (2006) 858-860
6. Clegg D.O., Reda D.J., Harris C.L., Klein M.A., O'Dell J.R., Hooper M.M., et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354 (2006) 795-808
7. Laverty S., Sandy J.D., Celeste C., Vachon P., Marier J.F., and Plaas A.H. Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum 52 (2005) 181-191
8. Plaas A.H., West L., Midura R.J., and Hascall V.C. Disaccharide composition of hyaluronan and chondroitin/dermatan sulfate. Analysis with fluorophore-assisted carbohydrate electrophoresis. Methods Mol Biol 171 (2001) 117-128
9. Zhong S., Zhong D., and Chen X. Improved and simplified liquid chromatography/electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 854 (2007) 291-298
10. Persiani S., Rotini R., Trisolino G., Rovati L.C., Locatelli M., Paganini D., et al. Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose. Osteoarthritis Cartilage 15 (2007) 764-772
11. Meulyzer M., Vachon P., Beaudry F., Vinardell T., Richard H., Beauchamp G., et al. Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthritis Cartilage 16 (2008) 973-979
12. Myers A.L., Upreti V.V., Khurana M., and Eddington N.D. Characterization of total plasma glycosaminoglycan levels in healthy volunteers following oral administration of a novel antithrombotic odiparcil with aspirin or enoxaparin. J Clin Pharmacol 48 (2008) 1158-1170
13. Zinellu A., Pisanu S., Zinellu E., Lepedda A.J., Cherchi G.M., Sotgia S., et al. A novel LIF-CE method for the separation of hyaluronan- and chondroitin sulfate-derived disaccharides: application to structural and quantitative analyses of human plasma low- and high-charged chondroitin sulfate isomers. Electrophoresis 28 (2007) 2439-2447
14. Fox B.A., and Stephens M.M. Glucosamine/chondroitin/primorine combination therapy for osteoarthritis. Drugs Today (Barc) 45 (2009) 21-31
15. Vangsness Jr. C.T., Spiker W., and Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy 25 (2009) 86-94
16. Tat S.K., Pelletier J.P., Verges J., Lajeunesse D., Montell E., Fahmi H., et al. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther 9 (2007) R117
17. Theodosakis J. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 31 (2004) 826 author reply 826-827
18. Volpi N. HPLC and on-line MS detection for the analysis of chondroitin sulfates/hyaluronan disaccharides derivatized with 2-aminoacridone. Anal Biochem (2009)
19. Matsuzaki H., Kobayashi H., Yagyu T., Wakahara K., Kondo T., Kurita N., et al. Plasma bikunin as a favorable prognostic factor in ovarian cancer. J Clin Oncol 23 (2005) 1463-1472
20. Zhuo L., Salustri A., and Kimata K. A physiological function of serum proteoglycan bikunin: the chondroitin sulfate moiety plays a central role. Glycoconj J 19 (2002) 241-247
21. Boudry G., Cheeseman C.I., and Perdue M.H. Psychological stress impairs Na+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane. Am J Physiol Regul Integr Comp Physiol 292 (2007) R862-867
22. Petersen S.G., Saxne T., Heinegard D., Hansen M., Holm L., Koskinen S., et al. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage 18 (2010) 34-40
23. Block J.A., Oegema T.R., Sandy J.D., and Plaas A. The effects of oral glucosamine on joint health: is a change in research approach needed?. Osteoarthritis Cartilage 18 (2010) 5-11