Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not fibrosis

Radiotherapy and Oncology

Volumn 111, Issue 1, 2014, Pages 63-71

  Monceau, Virginie ^a,b   Llach, Anna ^c   Azria, David ^d   Bridier, André ^e   Petit, Benoît ^a,b   Mazevet, Marianne ^c   Strup Perrot, Carine ^f   To, Thi Hong Van ^a,b   Calmels, Lucie ^e   Germaini, Marie Michèle ^c   Gourgou, Sophie ^d   Fenoglietto, Pascal ^d   Bourgier, Céline ^a,d,e   Gomez, Ana Maria ^c   Escoubet, Brigitte ^g,h,i   Dörr, Wolfgang ^j,k   Haagen, Julia ^j   Deutsch, Eric ^a,b,e   Morel, Eric ^c   Vozenin, Marie Catherine ^a,b,l  

^a Institut Gustave Roussy   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c IPSIT   (France)

^d CENTRE VAL D AURELLE   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^g BICHAT HOSPITAL   (France)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ CENTRE DE RECHERCHE DES CORDELIERS   (France)

^j DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^k MEDICAL UNIVERSITY OF VIENNA   (Austria)

^l LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

more..

Author keywords

Amyloidosis; Cardiomyocyte; Epac1; Fibrosis; Heart; Hypertrophy; Radiotherapy

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; EXCHANGE PROTEIN ACTIVATED BY CAMP 1; GELATINASE A; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; CALCIUM; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAPGEF3 PROTEIN, HUMAN; ALPHA ACTIN; AMYLOID;

ANIMAL EXPERIMENT; ARTICLE; CANCER THERAPY; CARDIOTOXICITY; ECHOCARDIOGRAPHY; HEART AMYLOIDOSIS; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; PERICARDITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INDUCED PERICARDITIS; RADIOTHERAPY; AMYLOIDOSIS; ANIMAL; BREAST NEOPLASMS; C57BL MOUSE; CARDIOMEGALY; FEMALE; FIBROSIS; HEART; HEART MUSCLE CELL; HUMAN; MALE; METABOLISM; PATHOLOGY; RADIATION INJURIES; RADIATION RESPONSE; RAT; ADULT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CASE REPORT; CONTROLLED STUDY; HEART SIZE; IN VIVO STUDY; IRRADIATION; MIDDLE AGED; TRANSLATIONAL RESEARCH;

AMYLOIDOSIS; ANIMALS; BREAST NEOPLASMS; CALCIUM; CARDIOMEGALY; FEMALE; FIBROSIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEART; HUMANS; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; RADIATION INJURIES; RATS;

EID: 84902147971     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2014.01.025     Document Type: Article

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