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Volumn 95, Issue 3, 2009, Pages 252-258

Radiation induced heart disease

Author keywords

[No Author keywords available]

Indexed keywords

AORTA STENOSIS; AORTA VALVE REGURGITATION; ARTICLE; HEART ARRHYTHMIA; HEART MUSCLE FIBROSIS; HODGKIN DISEASE; HUMAN; IRRADIATION; ISCHEMIC HEART DISEASE; MEDIASTINAL IRRADIATION; PERICARDITIS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INDUCED HEART DISEASE; TREATMENT DURATION;

EID: 62149087421     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2008.149088     Document Type: Article
Times cited : (137)

References (20)
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    • Morton DL, Glancy DL, Joseph WL, et al. Management of patients with radiation-induced pericarditis with effusion: a note on the development of aortic regurgitation in two of them. Chest 1973;64:291-7. ▶ Discusses the notion that pericardiectomy effectively relieves cardiac tamponade and probably prevents development of constrictive pericarditis. In 17 patients with radiation induced pericardial effusions and in whom subtotal pericardiectomy was performed, 12 were living and well without evidence of significant cardiac dysfunction up to 3 years after operation.
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    • Asymptomatic cardiac disease following mediastinal irradiation
    • This study was designed to evaluate the utility of screening previously irradiated patients with echocardiography. The results demonstrated a high prevalence of asymptomatic heart disease and aortic valvular disease, ▶
    • Heidenreich PA, Hancock SL, Lee BK, et al. Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol 2003;42:743-9. ▶ This study was designed to evaluate the utility of screening previously irradiated patients with echocardiography. The results demonstrated a high prevalence of asymptomatic heart disease and aortic valvular disease.
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    • Diastolic dysfunction after mediastinal irradiation
    • The study sought to determine the prevalence of diastolic dysfunction and its associated prognosis in asymptomatic patients after irradiation. Results demonstrated that there is a high prevalence of diastolic dysfunction, and its presence is associated with stress induced ischaemia and a worse prognosis, ▶
    • Heidenreich PA, Hancock SL, Vagelos RH, et al. Diastolic dysfunction after mediastinal irradiation. Am Heart J 2005;150:977-82. ▶ The study sought to determine the prevalence of diastolic dysfunction and its associated prognosis in asymptomatic patients after irradiation. Results demonstrated that there is a high prevalence of diastolic dysfunction, and its presence is associated with stress induced ischaemia and a worse prognosis.
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    • This report describes the cases of three young patients with evidence of significant valvular disease following mediastinal irradiation and provides a review of the literature, ▶
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    • Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA 1993;270:1949-55. ▶ This retrospective study assessed the risk of cardiovascular mortality after treatment in 2232 Hodgkin's disease patients. Mediastinal irradiation increased the risk of cardiovascular death. Risk was found to be higher with increasing irradiation doses, minimal blocking, young age, and increasing duration of follow-up.
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    • van Son JA, Noyez L, van Asten WN. Use of internal mammary artery in myocardial revascularization after mediastinal irradiation. J Thorac Cardiovasc Surg 1992;104:1539-44. ▶ This study evaluated use of the internal mammary artery versus vein grafts in patients with radiation associated proximal coronary artery disease. Based on the findings, the authors conclude that the internal mammary artery should be considered as a viable conduit for revascularisation when preoperative assessment shows patency.
    • van Son JA, Noyez L, van Asten WN. Use of internal mammary artery in myocardial revascularization after mediastinal irradiation. J Thorac Cardiovasc Surg 1992;104:1539-44. ▶ This study evaluated use of the internal mammary artery versus vein grafts in patients with radiation associated proximal coronary artery disease. Based on the findings, the authors conclude that the internal mammary artery should be considered as a viable conduit for revascularisation when preoperative assessment shows patency.
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    • Handa N, McGregor CG, Danielson GK, et al. Coronary artery bypass grafting in patients with previous mediastinal radiation therapy. J Thorac Cardiovasc Surg 1999;117:1136-42. ▶ This is a retrospective review of patients undergoing coronary artery bypass surgery after mediastinal irradiation. While early results of surgery were good, late survival was limited by malignancy and the development of heart failure. Notably, a number of patients were later diagnosed with valve disease and required valve surgery.
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    • Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol 2007;25:43-9. ▶ In a study of 294 outpatients, the authors evaluated whether stress imaging could identify unsuspected coronary stenoses in patients with a history of mediastinal irradiation for Hodgkin's disease. The authors concluded that stress induced signs of ischaemia and significant coronary artery disease were highly prevalent after mediastinal irradiation in young patients, and stress testing identified asymptomatic individuals at high risk for acute myocardial infarction or sudden cardiac death.
    • Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol 2007;25:43-9. ▶ In a study of 294 outpatients, the authors evaluated whether stress imaging could identify unsuspected coronary stenoses in patients with a history of mediastinal irradiation for Hodgkin's disease. The authors concluded that stress induced signs of ischaemia and significant coronary artery disease were highly prevalent after mediastinal irradiation in young patients, and stress testing identified asymptomatic individuals at high risk for acute myocardial infarction or sudden cardiac death.


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