Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes

Journal of Molecular and Cellular Cardiology

Volumn 53, Issue 5, 2012, Pages 617-625

  Ruiz Hurtado, Gema ^a   Domínguez Rodríguez, Alejandro ^a   Pereira, Laetitia ^b   Fernández Velasco, María ^c   Cassan, Cécile ^d   Lezoualc'h, Frank ^e   Benitah, Jean Pierre ^a   Gómez, Ana M ^a  

^a Universite Paris Sud   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d UNIVERSITY OF MONTPELLIER   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Arrhythmia; Calcium signaling; Calmodulin; Epac; Excitation contraction coupling; Heart

Indexed keywords

CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ISOLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXCITATION TRANSCRIPTION COUPLING; EXTRACELLULAR CALCIUM; HEART ARRHYTHMIA; HEART HYPERTROPHY; HEART MUSCLE CELL; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; CAFFEINE; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALMODULIN; CARDIOMEGALY; CELLS, CULTURED; CYCLIC AMP; ENZYME ACTIVATION; ENZYME ACTIVATORS; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MALE; MICROSCOPY, CONFOCAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION;

RATTUS;

EID: 84867405630     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.08.004     Document Type: Article

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