Epac-1 activator 8-O-cAMP augments renoprotective effects of allogeneic murine EPCs in acute ischemic kidney injury

American Journal of Physiology - Renal Physiology

Volumn 298, Issue 1, 2010, Pages

  Patschan, D ^a   Patschan, S ^a   Wessels, J T ^a,b   Becker, J U ^c   David, S ^c   Henze, E ^a   Goligorsky, M S ^d   Muller G A ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UMG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Acute renal failure; Endothelial progenitor cells; Exchange protein directly activated by cAMP; Stem cells

Indexed keywords

ANTIPORTER; BETA INTEGRIN; BETA INTEGRIN 1; CYCLIC AMP; CYCLIC ARGINYLGLYCYLASPARGININE PEPTIDE; ENCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP 1; INTEGRIN RECEPTOR; PEPTIDE; UNCLASSIFIED DRUG; 8 (4 CHLORO PHENYLTHIO) 2' O METHYLADENOSINE 3' 5' CYCLIC MONOPHOSPHATE; 8-(4-CHLORO-PHENYLTHIO)-2'-O-METHYLADENOSINE-3'-5'-CYCLIC MONOPHOSPHATE; CYCLIC ARGININE GLYCINE ASPARTIC ACID PEPTIDE; CYCLIC ARGININE-GLYCINE-ASPARTIC ACID PEPTIDE; CYCLOPEPTIDE; DRUG DERIVATIVE; EPAC PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CLAMP; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOFLUORESCENCE; ISOLATION PROCEDURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL ARTERY; RENAL PROTECTION; STEM CELL TRANSPLANTATION; UNINEPHRECTOMY; ALLOTRANSPLANTATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; KIDNEY; METABOLISM; METHODOLOGY; NEPHRECTOMY; PATHOLOGY; REPERFUSION INJURY; STEM CELL; TRANSPLANTATION; VASCULARIZATION;

ANIMALS; CYCLIC AMP; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INTEGRIN BETA CHAINS; KIDNEY; KIDNEY FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL; NEPHRECTOMY; PEPTIDES, CYCLIC; REPERFUSION INJURY; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 74049152405     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00485.2009     Document Type: Article

References (26)

1. Adams V, Lenk K, Linke A, Lenz D, Erbs S, Sandri M, Tarnok A, Gielen S, Emmrich F, Schuler G, Hambrecht R. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol 24: 684-690, 2004.
2. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, Isner JM. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85: 221-228, 1999.
3. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275: 964-967, 1997.
4. Assmus B, Honold J, Schachinger V, Britten M, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali N, Tonn T, Dimmeler S, Zeiher A. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355: 1222-1232, 2006.
5. Bos JL. Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 31: 680-686, 2006.
6. Carmona G, Chavakis E, Koehl U, Zeiher A, Dimmeler S. Activation of Epac stimulates integrin-dependent homing of progenitor cells. Blood 111: 2640-2646, 2008.
7. Case J, Mead LE, Bessler WK, Prater D, White HA, Saadatzadeh MR, Bhavsar JR, Yoder MC, Haneline LS, Ingram DA. Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 35: 1109-1118, 2007.
8. De Groot K, Bahlmann FH, Sowa J, Koenig J, Menne J, Haller H, Fliser D. Uremia causes endothelial progenitor cell deficiency. Kidney Int 66: 641-646, 2004.
9. Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood 102: 1340-1346, 2003.
10. Hiasa K, Ishibashi M, Ohtani K, Inoue S, Zhao Q, Kitamoto S, Sata M, Ichiki T, Takeshita A, Egashira K. Gene transfer of stromal cellderived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation 109: 2454-2461, 2004.
11. Karlberg L, Norlen BJ, Ojteg G, Wolgast M. Impaired medullary circulation in postischemic acute renal failure. Acta Physiol Scand 118: 11-17, 1983.
12. Khakoo AY, Finkel T. Endothelial progenitor cells. Annu Rev Med 56: 79-101, 2005.
13. Lange C, Tögel F, Ittrich H, Clayton F, Nolte-Ernsting C, Zander AR, Westenfelder C. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int 68: 1613-1617, 2005.
14. Leaf A. Cell swelling. A factor in ischemic tissue injury. Circulation 48: 455-458, 1973.
15. Nguyen K, Sylvain NR, Bunnell SC. T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28: 810-821, 2008.
16. Patschan D, Krupincza K, Patschan S, Zhang Z, Hamby C, Goligorsky MS. Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning. Am J Physiol Renal Physiol 291: F176-F185, 2006.
17. Patschan D, Patschan S, Gobe G, Chintala S, Goligorsky M. Uric acid heralds ischemic tissue injury to mobilize endothelial progenitor cells. J Am Soc Nephrol 18: 1516-1524, 2007.
18. Patschan D, Plotkin M, Goligorsky MS. Therapeutic use of stem and endothelial progenitor cells in acute renal injury: ça ira. Curr Opin Pharmacol 6: 176-183, 2006.
19. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 9: 702-712, 2003.
20. Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107: 1164-1169, 2003.
21. Schuster MD, Kocher AA, Seki T, Martens TP, Xiang G, Homma S, Itescu S. Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration. Am J Physiol Heart Circ Physiol 287: H525-H532, 2004.
22. Tögel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 289: F31-F42, 2005.
23. Urbich C, Dimmeler S. Endothelial progenitor cells functional characterization. Trends Cardiovasc Med 14: 318-322, 2004.
24. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 95: 343-353, 2004.
25. Yoder MC, Mead LE, Prater D, Krier TR, Mroueh KN, Li F, Krasich R, Temm CJ, Prchal JT, Ingram DA. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109: 1801-1809, 2007.
26. Zhang W, Zhang G, Jin H, Hu R. Characteristics of bone marrowderived endothelial progenitor cells in aged mice. Biochem Biophys Res Commun 348: 1018-1023, 2006.