Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: A possible therapeutic approach to preeclampsia

Placenta

Volumn 35, Issue 7, 2014, Pages 476-482

  Zhao, Y ^a   Zheng, Y F ^a   Luo, Q Q ^a   Yan, T ^a   Liu, X X ^a   Han, L ^a   Zou, L ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Edaravone; Hypoxia; Preeclampsia; Soluble Fms like tyrosine kinase 1 (sFlt 1); Trophoblasts

Indexed keywords

COBALT CHLORIDE; MESSENGER RNA; NORPHENAZONE; PLACENTAL GROWTH FACTOR; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SOLUBLE FMS LIKE TYROSINE KINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN; COBALT; FLT1 PROTEIN, HUMAN; PHENAZONE; PHENYLMETHYLPYRAZOLONE; PLACENTA PROTEIN; SCAVENGER; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; MTT ASSAY; OXIDATIVE STRESS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; TROPHOBLAST; UMBILICAL VEIN ENDOTHELIAL CELL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; CELL LINE; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PRE-ECLAMPSIA; PREGNANCY;

ANTIPYRINE; CELL HYPOXIA; CELL LINE; COBALT; FEMALE; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY PROTEINS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TROPHOBLASTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84902127135     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2014.04.002     Document Type: Article

References (42)

1. R. Pijnenborg, L. Vercruysse, and M. Hanssens The uterine spiral arteries in human pregnancy: facts and controversies Placenta 27 9-10 2006 Sep-Oct 939 958
2. C. Munaut, S. Lorquet, C. Pequeux, S. Blacher, S. Berndt, and F. Frankenne et al. Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast Hum Reprod 23 6 2008 Jun 1407 1415
3. J.J. Brosens, R. Pijnenborg, and I.A. Brosens The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature Am J Obstet Gynecol 187 5 2002 Nov 1416 1423
4. T. Nagamatsu, T. Fujii, M. Kusumi, L. Zou, T. Yamashita, and Y. Osuga et al. Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia Endocrinology 145 11 2004 Nov 4838 4845
5. R. Tal The role of hypoxia and hypoxia-inducible factor-1Alpha in preeclampsia pathogenesis Biol Reprod 87 6 2012 134
6. S. Sela, A. Itin, S. Natanson-Yaron, C. Greenfield, D. Goldman-Wohl, and S. Yagel et al. A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia Circ Res 102 12 2008 Jun 20 1566 1574
7. T.E. Society Hypoxia and sFlt-1 in preeclampsia: the "Chicken-and- Egg" question Endocrinology 145 11 2004 4835 4837 3
8. H. Li, B. Gu, Y. Zhang, D.F. Lewis, and Y. Wang Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta Placenta 26 2-3 2005 Feb-Mar 210 217
9. A. Makris, C. Thornton, J. Thompson, S. Thomson, R. Martin, and R. Ogle et al. Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1 Kidney Int 71 10 2007 May 977 984
10. Y. Zhao, K. Koga, Y. Osuga, M. Nagai, G. Izumi, and M. Takamura et al. Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the patgenesis of preeclampsia Fertil Steril 98 4 2012 Oct 917 921
11. Q.T. Huang, S.S. Wang, M. Zhang, L.P. Huang, J.W. Tian, and Y.H. Yu et al. Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia Placenta 34 10 2013 Oct 949 952
12. R. Thadhani, T. Kisner, H. Hagmann, V. Bossung, S. Noack, and W. Schaarschmidt et al. Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia Circulation 124 8 2011 Aug 23 940 950
13. J.S. Gilbert, J. Verzwyvelt, D. Colson, M. Arany, S.A. Karumanchi, and J.P. Granger Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia- induced hypertension Hypertension 55 2 2010 Feb 380 385
14. P.W.H. Bahjat Al-Ani, Melissa J. Cudmore, Takeshi Fujisawa, Mahmoud Saifeddine, Hannah Williams, and Wenda Ramma et al. Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells Hypertension 2010 55 2010
15. J.X. Chen, T. Zhao, and D.X. Huang Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells Neurosci Bull 25 2 2009 Apr 67 74
16. Y.H. Pan, Y.C. Wang, L.M. Zhang, and S.R. Duan Protective effect of edaravone against PrP106-126-induced PC12 cell death J Biochem Mol Toxicol 24 4 2010 Jul-Aug 235 241
17. H. Xi, M. Akishita, K. Nagai, W. Yu, H. Hasegawa, and M. Eto et al. Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis Atherosclerosis 191 2 2007 Apr 281 289
18. N. Nakamoto, S. Tada, K. Kameyama, K. Kitamura, S. Kurita, and Y. Saito et al. A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury Free Radic Res 37 8 2003 Aug 849 859
19. Y. Inokuchi, S. Imai, Y. Nakajima, M. Shimazawa, M. Aihara, and M. Araie et al. Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo J Pharmacol Exp Ther 329 2 2009 May 687 698
20. M.A. Goldberg, S.P. Dunning, and H.F. Bunn Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein Science 242 4884 1988 Dec 9 1412 1415
21. K.R. Li, Z.Q. Zhang, J. Yao, Y.X. Zhao, J. Duan, and C. Cao et al. Ginsenoside Rg-1 protects retinal pigment epithelium (RPE) cells from cobalt chloride (CoCl2) and hypoxia assaults PLoS One 8 12 2013 e84171
22. C.H. Yeh, H.C. Peng, and T.F. Huang Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis Blood 92 9 1998 Nov 1 3268 3276
23. G.C. McKeeman, J.E. Ardill, C.M. Caldwell, A.J. Hunter, and N. McClure Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop Am J Obstet Gynecol 191 4 2004 Oct 1240 1246
24. S.E. Maynard, J.Y. Min, J. Merchan, K.H. Lim, J. Li, and S. Mondal et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J Clin Invest 111 5 2003 Mar 649 658
25. G.L. Wang, and G.L. Semenza Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction Blood 82 12 1993 Dec 15 3610 3615
26. J.K. Park, J.W. Jeong, M.Y. Kang, J.C. Baek, J.K. Shin, and S.A. Lee et al. Inhibition of the PI3K-Akt pathway suppresses sFlt1 expression in human placental hypoxia models in vitro Placenta 31 7 2010 Jul 621 629
27. M. Hayashi, M. Sakata, T. Takeda, T. Yamamoto, Y. Okamoto, and K. Sawada et al. Induction of glucose transporter 1 expression through hypoxia-inducible factor 1alpha under hypoxic conditions in trophoblast-derived cells J Endocrinol 183 1 2004 Oct 145 154
28. K.S. Kim, V. Rajagopal, C. Gonsalves, C. Johnson, and V.K. Kalra A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells J Immunol 177 10 2006 Nov 15 7211 7224
29. Y. Yuan, G. Hilliard, T. Ferguson, and D.E. Millhorn Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha J Biol Chem 278 18 2003 May 2 15911 15916
30. T. Aoki, M. Nishimura, H. Kataoka, R. Ishibashi, K. Nozaki, and N. Hashimoto Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice Lab Invest 89 7 2009 Jul 730 741
31. M. Tosaka, Y. Hashiba, N. Saito, H. Imai, T. Shimizu, and T. Sasaki Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger Acta Neurochir (Wien) 144 12 2002 Dec 1305 1310 (discussion 10)
32. T. Nakamura, Y. Kuroda, S. Yamashita, X. Zhang, O. Miyamoto, and T. Tamiya et al. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage Stroke 39 2 2008 Feb 463 469
33. K. Kikuchi, H. Uchikado, N. Miyagi, Y. Morimoto, T. Ito, and S. Tancharoen et al. Beyond neurological disease: new targets for edaravone (Review) Int J Mol Med 28 6 2011 Dec 899 906
34. M. Yamawaki, N. Sasaki, M. Shimoyama, J. Miake, K. Ogino, and O. Igawa et al. Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes Br J Pharmacol 142 3 2004 Jun 618 626
35. R. Sukmawan, T. Yada, E. Toyota, Y. Neishi, T. Kume, and Y. Shinozaki et al. Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo J Pharmacol Sci 104 4 2007 Aug 341 348
36. S. Tajima, M. Soda, M. Bando, M. Enomoto, H. Yamasawa, and S. Ohno et al. Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice Respirology 13 5 2008 Sep 646 653
37. S. Tada, N. Nakamoto, K. Kameyama, S. Tsunematsu, N. Kumagai, and H. Saito et al. Clinical usefulness of edaravone for acute liver injury J Gastroenterol Hepatol 18 7 2003 Jul 851 857
38. T. Miyasou, A.H. Kwon, K. Tsuji, Z. Qiu, T. Okumura, and Y. Kamiyama Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax Shock 30 2 2008 Aug 212 216
39. K. Yagi, K.T. Kitazato, M. Uno, Y. Tada, T. Kinouchi, and K. Shimada et al. Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator Stroke 40 2 2009 Feb 626 631
40. R.J. Levine, C. Lam, C. Qian, K.F. Yu, S.E. Maynard, and B.P. Sachs et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia N Engl J Med 355 10 2006 Sep 7 992 1005
41. C.H. Acevedo, and A. Ahmed Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy J Clin Invest 101 5 1998 Mar 1 949 955
42. A. Ahmed, M. Rahman, X. Zhang, C.H. Acevedo, S. Nijjar, and I. Rushton et al. Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation Mol Med 6 5 2000 May 391 409