Inhibition of the PI3K-Akt Pathway Suppresses sFlt1 Expression in Human Placental Hypoxia Models In Vitro

Placenta

Volumn 31, Issue 7, 2010, Pages 621-629

  Park, J K ^a   Jeong, J W ^a   Kang, M Y ^a   Baek, J C ^a   Shin, J K ^a   Lee, S A ^a   Choi, W S ^a   Lee, J H ^a   Paik, W Y ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

PI3K inhibitor; Placental hypoxia model; sFlt1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTAL GROWTH FACTOR; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; COBALT; MORPHOLINE DERIVATIVE; PLACENTA PROTEIN; VASCULOTROPIN A;

ADULT; ARTICLE; BLOOD PRESSURE; CHORIOCARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; PLACENTA; PLACENTA HYPOXIA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TROPHOBLAST; WESTERN BLOTTING; ANOXIA; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PREGNANCY; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; COBALT; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MORPHOLINES; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 77953958165     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2010.04.009     Document Type: Article

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