-
1
-
-
0036124965
-
Neuroprotective effect of flupirtine in prion disease
-
Schroder HC, Muller WE. Neuroprotective effect of flupirtine in prion disease. Drugs Today 2002;38:49-58.
-
(2002)
Drugs Today
, vol.38
, pp. 49-58
-
-
Schroder, H.C.1
Muller, W.E.2
-
3
-
-
33847663385
-
Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury
-
Watanabe K, Ma M, Wen J. Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury. Biol Pharm Bull 2007;30:460-464.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 460-464
-
-
Watanabe, K.1
Ma, M.2
Wen, J.3
-
4
-
-
33846217424
-
Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
-
Dohi K, Satoh K, Nakamachi T, Yofu S, Hiratsuka K, Nakamura S, Ohtaki H, Yoshikawa T, Shioda S, Aruga T. Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury? Antiox Redox Signal 2007;9:281-287.
-
(2007)
Antiox Redox Signal
, vol.9
, pp. 281-287
-
-
Dohi, K.1
Satoh, K.2
Nakamachi, T.3
Yofu, S.4
Hiratsuka, K.5
Nakamura, S.6
Ohtaki, H.7
Yoshikawa, T.8
Shioda, S.9
Aruga, T.10
-
5
-
-
56049121173
-
Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling
-
Anantharam V, Kanthasamy A, Choi CJ, Martin DP, Latchoumycandane C, Richt JA, Kanthasamy AG. Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling. Free Rad Biol Med 2008;45:1530-1541.
-
(2008)
Free Rad Biol Med
, vol.45
, pp. 1530-1541
-
-
Anantharam, V.1
Kanthasamy, A.2
Choi, C.J.3
Martin, D.P.4
Latchoumycandane, C.5
Richt, J.A.6
Kanthasamy, A.G.7
-
6
-
-
33747164172
-
Interaction of metals with prion protein: Possible role of divalent cations in the pathogenesis of prion diseases
-
Choi CJ, Kanthasamy A, Anantharam V, Kanthasamy AG. Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicol 2006;27:777-787.
-
(2006)
Neurotoxicol
, vol.27
, pp. 777-787
-
-
Choi, C.J.1
Kanthasamy, A.2
Anantharam, V.3
Kanthasamy, A.G.4
-
7
-
-
44649107650
-
Manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease
-
Brazier MW, Doctrow SR, Masters CL, Collins SJA. manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease. Free Rad Biol Med 2008;45:184-192.
-
(2008)
Free Rad Biol Med
, vol.45
, pp. 184-192
-
-
Brazier, M.W.1
Doctrow, S.R.2
Masters, C.L.3
Collins, S.J.A.4
-
8
-
-
33747195017
-
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
-
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM. An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol Dis 2006;23:669-678.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 669-678
-
-
Ferreiro, E.1
Resende, R.2
Costa, R.3
Oliveira, C.R.4
Pereira, C.M.5
-
9
-
-
0142218370
-
Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126
-
Turnbull S, Tabner BJ, Brown DR, Allsop D. Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126. Neuroreport 2003;14:1743-1745.
-
(2003)
Neuroreport
, vol.14
, pp. 1743-1745
-
-
Turnbull, S.1
Tabner, B.J.2
Brown, D.R.3
Allsop, D.4
-
10
-
-
0021745705
-
In vitro replication of scrapie agent in a neuronal model: Infection of PC12 cells
-
Rubenstein R, Carp RI, Callahan SM. In vitro replication of scrapie agent in a neuronal model: infection of PC12 cells. J Gen Virol 1984;65:2191-2198.
-
(1984)
J Gen Virol
, vol.65
, pp. 2191-2198
-
-
Rubenstein, R.1
Carp, R.I.2
Callahan, S.M.3
-
11
-
-
0025896969
-
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells
-
Rubenstein R, Deng H, Scalica C, Papini MC. Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells. J Gen Virol 1991;72:1279-1285.
-
(1991)
J Gen Virol
, vol.72
, pp. 1279-1285
-
-
Rubenstein, R.1
Deng, H.2
Scalica, C.3
Papini, M.C.4
-
12
-
-
2342477648
-
Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microglia
-
Ciesielski-Treska J, Grant NJ, Ulrich G, Corrotte M, Bailly Y, Haeberle AM, Chasserot-Golaz S, Bader MF. Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microglia. Glia 2004;46:101-115.
-
(2004)
Glia
, vol.46
, pp. 101-115
-
-
Ciesielski-Treska, J.1
Grant, N.J.2
Ulrich, G.3
Corrotte, M.4
Bailly, Y.5
Haeberle, A.M.6
Chasserot-Golaz, S.7
Bader, M.F.8
-
13
-
-
1242316262
-
Human in rescues cortical neurons from prion-peptide-induced apoptosis
-
Sponne I, Fifre A, Koziel V, Kriem B, Oster T, Pillot T. Human in rescues cortical neurons from prion-peptide-induced apoptosis. Mol Cell Neurosci 2004;25:95-102.
-
(2004)
Mol Cell Neurosci
, vol.25
, pp. 95-102
-
-
Sponne, I.1
Fifre, A.2
Koziel, V.3
Kriem, B.4
Oster, T.5
Pillot, T.6
-
14
-
-
50849115138
-
+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway
-
+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway. J Neurochem 2008;106:2345-2352.
-
(2008)
J Neurochem
, vol.106
, pp. 2345-2352
-
-
Chen, H.1
Wang, S.2
Ding, J.H.3
Hu, G.4
-
15
-
-
60749097825
-
Antioxidants and neuroprotection in the adult and developing central nervous system
-
Kaur C, Ling EA. Antioxidants and neuroprotection in the adult and developing central nervous system. Curr Med Chem 2008;15:3068-3080.
-
(2008)
Curr Med Chem
, vol.15
, pp. 3068-3080
-
-
Kaur, C.1
Ling, E.A.2
-
16
-
-
67349160568
-
Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells
-
Feb 18. (Epub ahead of print)
-
Liu XY, Yao LL, Chen YJ, Tao BB, Yu YC, Bian WH, Yu J, Wang YG. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells. Mol Cell Biochem 2009; Feb 18. (Epub ahead of print)
-
(2009)
Mol Cell Biochem
-
-
Liu, X.Y.1
Yao, L.L.2
Chen, Y.J.3
Tao, B.B.4
Yu, Y.C.5
Bian, W.H.6
Yu, J.7
Wang, Y.G.8
-
17
-
-
33750599225
-
Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria
-
Song Y, Zli M, Li JC, Wei EQ. Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria. J Zhejiang Univ Sci B 2006;7:749-756.
-
(2006)
J Zhejiang Univ Sci B
, vol.7
, pp. 749-756
-
-
Song, Y.1
Zli, M.2
Li, J.C.3
Wei, E.Q.4
-
18
-
-
12244303263
-
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver
-
Okatani Y, Wakatsuki A, Enzan H, Miyahara Y. Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 2003;465:163-170.
-
(2003)
Eur J Pharmacol
, vol.465
, pp. 163-170
-
-
Okatani, Y.1
Wakatsuki, A.2
Enzan, H.3
Miyahara, Y.4
-
19
-
-
33746495023
-
Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs
-
Akao T, Takeyoshi I, Totsuka O, Arakawa K, Muraoka M, Kobayashi K, Konno K, Matsumoto K, Morishita Y. Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs. J Heart Lung Transplant 2006;25:965-971.
-
(2006)
J Heart Lung Transplant
, vol.25
, pp. 965-971
-
-
Akao, T.1
Takeyoshi, I.2
Totsuka, O.3
Arakawa, K.4
Muraoka, M.5
Kobayashi, K.6
Konno, K.7
Matsumoto, K.8
Morishita, Y.9
-
20
-
-
20444417507
-
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats
-
Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, Shimazaki K, Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol 2005;516:125-130.
-
(2005)
Eur J Pharmacol
, vol.516
, pp. 125-130
-
-
Amemiya, S.1
Kamiya, T.2
Nito, C.3
Inaba, T.4
Kato, K.5
Ueda, M.6
Shimazaki, K.7
Katayama, Y.8
-
21
-
-
27944485677
-
Experimental study on the protective effects of edaravone against ischemic spinal cord injury
-
Suzuki K, Kazui T, Terada H, Umemura K, Ikeda Y, Bashar AH, Yamashita K, Washiyama N, Suzuki T, Ohkura K, Yasuike J. Experimental study on the protective effects of edaravone against ischemic spinal cord injury. J Thorac Cardiovasc Surg 2005;130:1586-1592.
-
(2005)
J Thorac Cardiovasc Surg
, vol.130
, pp. 1586-1592
-
-
Suzuki, K.1
Kazui, T.2
Terada, H.3
Umemura, K.4
Ikeda, Y.5
Bashar, A.H.6
Yamashita, K.7
Washiyama, N.8
Suzuki, T.9
Ohkura, K.10
Yasuike, J.11
-
22
-
-
0020490156
-
Identification of a protein that purifies with the scrapie prion
-
Bolton DC, McKinley MP, Prusiner SB. Identification of a protein that purifies with the scrapie prion. Science 1982;218:1309-1311.
-
(1982)
Science
, vol.218
, pp. 1309-1311
-
-
Bolton, D.C.1
McKinley, M.P.2
Prusiner, S.B.3
-
23
-
-
0025971881
-
Chemoprophylaxis of scrapie in mice
-
Diringer H, Ehlers B. Chemoprophylaxis of scrapie in mice. J Gen Virol 1991;72:457-460.
-
(1991)
J Gen Virol
, vol.72
, pp. 457-460
-
-
Diringer, H.1
Ehlers, B.2
-
24
-
-
33644542740
-
Conformational polymorphism of the PrP106-126 peptide in different environments: A molecular dynamics study
-
Villa A, Mark AE, Saracino GA, Cosentino U, Pitea D, Moro G, Salmona M, Cosentino U, Pitea D, Moro G, Salmona M. Conformational polymorphism of the PrP106-126 peptide in different environments: a molecular dynamics study. J Phys Chem B 2006;110:1423-1428.
-
(2006)
J Phys Chem B
, vol.110
, pp. 1423-1428
-
-
Villa, A.1
Mark, A.E.2
Saracino, G.A.3
Cosentino, U.4
Pitea, D.5
Moro, G.6
Salmona, M.7
Cosentino, U.8
Pitea, D.9
Moro, G.10
Salmona, M.11
-
25
-
-
0029997484
-
Role of microglia and host prion protein in neurotoxicity of a prion protein fragment
-
Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 1996;380:345-347.
-
(1996)
Nature
, vol.380
, pp. 345-347
-
-
Brown, D.R.1
Schmidt, B.2
Kretzschmar, H.A.3
-
26
-
-
0031194455
-
Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity
-
Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Exper Neurol 1997;146:104-112.
-
(1997)
Exper Neurol
, vol.146
, pp. 104-112
-
-
Brown, D.R.1
Schulz-Schaeffer, W.J.2
Schmidt, B.3
Kretzschmar, H.A.4
-
27
-
-
4444298682
-
Recent developments in prion immunotherapy
-
Heppner FL, Aguzzi A. Recent developments in prion immunotherapy. Curr Opin Immunol 2004;16:594-598.
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 594-598
-
-
Heppner, F.L.1
Aguzzi, A.2
-
28
-
-
30944453898
-
Neurodegeneration and oxidative stress: Prion disease results from loss of antioxidant defence
-
Brown DR. Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence. Folia Neuropathol 2005;43:229-243.
-
(2005)
Folia Neuropathol
, vol.43
, pp. 229-243
-
-
Brown, D.R.1
-
29
-
-
18344403931
-
Effects of oxidative stress on prion protein expression in PC12 cells
-
Brown DR, Schmidt B, Kretzschmar HA. Effects of oxidative stress on prion protein expression in PC12 cells. J Dev Neurosci 1997;15:961-972.
-
(1997)
J Dev Neurosci
, vol.15
, pp. 961-972
-
-
Brown, D.R.1
Schmidt, B.2
Kretzschmar, H.A.3
-
30
-
-
39049108315
-
A review of agents patented for their neuroprotective properties
-
Brimble MA, Levi MS. A review of agents patented for their neuroprotective properties. Recent Pat. CNS Drug Discov 2006;1:139-146.
-
(2006)
Recent Pat. CNS Drug Discov
, vol.1
, pp. 139-146
-
-
Brimble, M.A.1
Levi, M.S.2
-
31
-
-
0037229213
-
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
-
The Edaravone Acute Infarction Study Group
-
The Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003;15:222-229.
-
(2003)
Cerebrovasc Dis
, vol.15
, pp. 222-229
-
-
-
32
-
-
77956414915
-
Clinical trial for amyotrophic lateral sclerosis with free radical scavenger, edaravone
-
Noseworthy JH, editor. London: Martin Dunitz
-
Yoshinoya H, Kimura A. Clinical trial for amyotrophic lateral sclerosis with free radical scavenger, edaravone. In: Noseworthy JH, editor. Neurological therapeutics. London: Martin Dunitz; 2003. Vol 2, pp 557-564.
-
(2003)
Neurological Therapeutics
, vol.2
, pp. 557-564
-
-
Yoshinoya, H.1
Kimura, A.2
-
33
-
-
33847119443
-
Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (phase II study)
-
Yoshino H, Kimura A. Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (phase II study). Amyotroph Lateral Scler 2006;7:241-245.
-
(2006)
Amyotroph Lateral Scler
, vol.7
, pp. 241-245
-
-
Yoshino, H.1
Kimura, A.2
-
34
-
-
3042697180
-
Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes
-
Yamawaki M, Sasaki N, Shimoyama M, Miake J, Ogino K, Igawa O, Tajima F, Shigemasa C. Hisatome, I. Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes. Br J Pharmacol 2004;142:618-626.
-
(2004)
Br J Pharmacol
, vol.142
, pp. 618-626
-
-
Yamawaki, M.1
Sasaki, N.2
Shimoyama, M.3
Miake, J.4
Ogino, K.5
Igawa, O.6
Tajima, F.7
Shigemasa, C.8
Hisatome, I.9
-
35
-
-
33744788665
-
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage
-
Kono H, Woods CG, Maki A, Connor HD, Mason RP, Rusyn I, Fujii H. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Rad Res 2006;40:579-588.
-
(2006)
Free Rad Res
, vol.40
, pp. 579-588
-
-
Kono, H.1
Woods, C.G.2
Maki, A.3
Connor, H.D.4
Mason, R.P.5
Rusyn, I.6
Fujii, H.7
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