Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage

Stroke

Volumn 39, Issue 2, 2008, Pages 463-469

  Nakamura, Takehiro ^a   Kuroda, Yasuhiro ^a   Yamashita, Susumu ^a   Zhang, Xia ^a   Miyamoto, Osamu ^a   Tamiya, Takashi ^a   Nagao, Seigo ^a   Xi, Guohua ^b   Keep, Richard F ^b   Itano, Toshifumi ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Behavior; Cerebral hemorrhage; Edema; Oxidative stress; Rat

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; FERRIC CHLORIDE; IRON; NORPHENAZONE; PENTOBARBITAL; THROMBIN; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; BLOOD; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN WATER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; NEUROLOGIC DISEASE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; WATER CONTENT; ACUTE DISEASE; ANIMAL; BRAIN CORTEX; DISEASE MODEL; METABOLISM;

ACUTE DISEASE; ANIMALS; ANTIPYRINE; BASAL GANGLIA; BRAIN EDEMA; CEREBRAL CORTEX; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; WATER;

EID: 39349091206     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.486654     Document Type: Article

References (35)

1. Fayad PB, Awad IA. Surgery for intracerebral hemorrhage. Neurology. 1998;51(suppl 3):69-73.
2. Lee KR, Colon GP, Betz AL, Keep RF, Kim S, Hoff JT. Edema from intracerebral hemorrhage: the role of thrombin. J Neurosurg. 1996;84:91-96.
3. Xi G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM, Broderick JP, Brott TG, Hoff JT, Muizeloaar JP. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke. 1998;29:2580-2586.
4. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab. 2003;23:629-652.
5. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res. 2005;1039:30-36.
6. Peeling J, Yan HJ, Chen SG, Campbell M, Del Bigio MR. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat. Brain Res. 1998;795:63-70.
7. Peeling J, Del Bigio MR, Corbett D, Gree AR, Jackson DM. Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology. 2001;40:433-439.
8. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg. 2004;100:672-678.
9. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998;89:991-996.
10. Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke. 2002;33:2478-2484.
11. Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP, Chen J. Introduction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia. J Neurochem. 2000;75:1716-1728.
12. Saito S, Yamauchi H, Hasui Y, Kurashige J, Ochi H, Yoshida K. Quantitative determination of urinary 8-hydroxydeoxyguanosine(8-OHdG) by using ELISA. Res Commun Mol Pathol Pharmacol. 2000;107:39-44.
13. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther. 1994;268:1597-1604.
14. Watanabe T, Tanaka M, Watanabe K, Takamatsu Y, Tobe A. Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi. 2004;124:99-111.
15. Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, Shimazaki K, Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol. 2005;516:125-130.
16. Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH. Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis. 2001;8:380-390.
17. Fujimura M, Morita-Fujimura Y, Kawase M, Chan PH. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 1999;19:495-501.
18. Kasai H, Nishimura S. Hydrooxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical forming agent. Environ Health Perspect. 1986;67:111-116.
19. Miyamoto O, Tamae K, Kasai H, Hirakawa H, Hayashida Y, Konishi R, Itano T. Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. Eur J Pharmacol. 2003;459:179-186.
20. Lan J, Henshall DC, Simon RP, Chen J. Formation of the base modification 8-hydroxyl-2′-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat. J Neurochem. 2000;74:302-309.
21. Stadtman ER. Metal ion catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic Biol Med. 1990;9:315-325.
22. Stadtman ER, Berlett BS. Fenton chemistry: amino acids oxidation. J Biol Chem. 1991;266:17201-17211.
23. Keller RJ, Christine Halmes N, Hinson JA, Pumford NR. Immunochemical detection of oxidized proteins. Chem Res. 1993;6:430-433.
24. Nagasawa T, Hatayama T, Watanabe Y, Tanaka M, Niisato Y, Kitts DD. Free radical-mediated effects on skeletal muscle protein in rats treated with Fe-nitrilotriacetate. Biochem Biophys Res Commun. 1997;231:37-41.
25. Chavko M, Harabin AL. Regional lipid peroxidation and protein oxidation in rat brain after hyperbaric oxygen exposure. Free Radic Biol Med. 1996;20:973-978.
26. Korolainen MA, Goldsteins G, Alafuzoff I, Koistinaho J, Pirttila T. Proteomic analysis of protein oxidation in Alzheimer's disease brain. Electrophoresis. 2002;23:3428-3433.
27. Heo HH, Han SW, Lee SK. Free radicals as triggers of brain edema formation after stroke. Free Radic Biol Med. 2005;39:51-70.
28. Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci. 1997;17:4180-4189.
29. Siesjo BK, Agardh CD, Bengtsson F. Free radicals and brain damage. Cerebrovasc Brain Metab Rev. 1989;1:165-211.
30. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. Iron and iron handling proteins in the brain after intracerebral hemorrhage. Stroke. 2003;34:2964-2969.
31. Marlet JM, Barreto Fonseca J de P. Experimental determination of time of intracranial hemorrhage by spectrophotometric analysis of cerebrospinal fluid. J Forensic Sci. 1982;27:880-888.
32. Bradley WG Jr. MR appearance of hemorrhage in the brain. Radiology. 1993;189:15-26.
33. Zhang Z, Wei T, Hou J, Li G, Yu S, Xin W. Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid. Eur J Pharmacol. 2003;467:41-47.
34. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg. 2002;96:287-293.
35. Kozlov AB, Ostrachovitch EA, Afanas'ev IB. Mechanism of inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates. Biochem Pharmacol. 1994;47:795-799.