Lactone pathway to statins utilizing the wittig reaction. the synthesis of rosuvastatin

Journal of Organic Chemistry

Volumn 75, Issue 19, 2010, Pages 6681-6684

  Časar, Zdenko ^a   Steinbücher, Miha ^b   Košmrlj, Janez ^b  

^a Lek Pharmaceuticals dd a Sandoz company   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

DEPROTECTION; FUNCTIONALIZED; HIGH YIELD; ONE POT; PHOSPHONIUM SALTS; SIDE CHAINS; STATINS; WITTIG REACTION;

SYNTHESIS (CHEMICAL);

4 (TERT BUTYLDIMETHYLSILYLOXY) 6 OXOTETRAHYDRO 2H PYRAN 2 CARBALDEHYDE; ALDEHYDE; CALCIUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTONE; PHOSPHONIUM DERIVATIVE; ROSUVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; OLEFINATION; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; WITTIG REACTION;

FLUOROBENZENES; LACTONES; MOLECULAR STRUCTURE; PYRIMIDINES; STEREOISOMERISM; SULFONAMIDES;

EID: 77957123606     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101050z     Document Type: Article

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