The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin

Synthesis (Germany)

Volumn 44, Issue 11, 2012, Pages 1700-1710

  Fabris, Jan ^a,b   Časar, Zdenko ^b,c   Smilović, Ivanagazi ^b  

^a Cadonic Consultancy Services LLC   (Slovenia)

^b Lek Pharmaceuticals dd   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

drugs; heterocycles; lactones; quinolines; Wittig reactions

Indexed keywords

DRUGS; HETEROCYCLES; LACTONES; QUINOLINES; WITTIG REACTION;

BROMINE COMPOUNDS; METHANOL;

CHEMICAL REACTIONS;

2 CYCLOPROPYL 3 [(DIETHYLPHOSPHORYL)METHY] 4 (4 FLUOROPHENYL)QUINOLINE; 2 CYCLOPROPYL 3 [(DIPHENYLPHOSPHORYL)METHY] 4 (4 FLUOROPHENYL)QUINOLINE; 2 CYCLOPROPYL 4 (4 FLUOROPHENYL) 3 METHYLQUINOLINE; 4 [[TERT BUTYL(DIMETHYL)SILYL]OXY] 6 [2 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]VINYL]TETRAHYDRO 2H PYRAN 2 ONE; 6 [2 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]VINYL] 4 HYDROXYTETRAHYDRO 2H PYRAN 2 ONE; 6 [2 [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]VINYL] 5,6 DIHYDRO 2H PYRAN 2 ONE; 7 [2 CYCLOPROPYL 4 (4 FLUORPHENYL)QUINOLIN 3 YL] 3,5 DIHYDROXYHEPT 6 ENOATE; [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHANOL; [2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL TRIFLUOROACETATE; [[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHY](TRIPHENYL)PHOSPHONIUM BROMIDE; [[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHY](TRIPHENYL)PHOSPHONIUM TRIFLUOROACETATE; BROMINE DERIVATIVE; DIETHYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONATE; METHANOL; PHOSPHONIUM DERIVATIVE; PITAVASTATIN; QUINOLINE DERIVATIVE; TRI TERT BUTYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONIUM BROMIDE TOLUENE SOLVATE; TRIBUTYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONIUM BROMIDE; TRIBUTYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONIUM TRIFLUOROACETATE; TRICYCLOHEXYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONIUM BROMIDE; TRICYCLOHEXYL[[2 CYCLOPROPYL 4 (4 FLUOROPHENYL)QUINOLIN 3 YL]METHYL]PHOSPHONIUM TRIFLUOROACETATE; TRIPHENYLPHOSPHONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATION EXCHANGE; CRYSTALLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; LACTONIZATION; OLEFINATION; STEREOCHEMISTRY; WITTIG REACTION;

EID: 84861341314     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1290916     Document Type: Article

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