Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 16, 2004, Pages 5788-5793

  Greenberg, William A ^a   Varvak, Alexander ^a   Hanson, Sarah R ^a   Wong, Kelvin ^a   Huang, Hongjun ^a   Chen, Pei ^a   Burk, Mark J ^a  

^a DIVERSA CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CARBON; DEOXYRIBOSEPHOSPHATE ALDOLASE; DNA; FRUCTOSE BISPHOSPHATE ALDOLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; ISOENZYME; ROSUVASTATIN; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CATALYSIS; CATALYST; COMMERCIAL PHENOMENA; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; PRIORITY JOURNAL; SCALE UP; STEREOCHEMISTRY; STEREOISOMERISM; VOLUMETRY;

AMINO ACID SEQUENCE; CATALYSIS; FLUOROBENZENES; FRUCTOSE-BISPHOSPHATE ALDOLASE; HEPTANOIC ACIDS; MOLECULAR SEQUENCE DATA; PYRIMIDINES; PYRROLES; STEREOISOMERISM; SULFONAMIDES;

EID: 1942469509     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0307563101     Document Type: Article

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