An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

Journal of Sexual Medicine

Volumn 11, Issue 6, 2014, Pages 1392-1422

  Althof, Stanley E ^a   Mcmahon, Chris G ^b   Waldinger, Marcel D ^c   Serefoglu, Ege Can ^d   Shindel, Alan W ^e   Adaikan, P Ganesan ^f   Becher, Edgardo ^g   Dean, John ^h   Giuliano, Francois ⁱ   Hellstrom, Wayne J G ^j   Giraldi, Annamaria ^k   Glina, Sidney ^l   Incrocci, Luca ^m   Jannini, Emmanuele ⁿ   Mccabe, Marita ^o   Parish, Sharon ^p   Rowland, David ^q   Segraves, R Taylor ^a   Sharlip, Ira ^r   Torres, Luiz Otavio ^s  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Australian Centre for Sexual Health   (Australia)

^c UTRECHT UNIVERSITY   (Netherlands)

^d BAGCILAR TRAINING AND RESEARCH HOSPITAL   (Turkey)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^g UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^h London Clinic Cancer Centre   (United Kingdom)

ⁱ RAYMOND POINCARÉ HOSPITAL   (France)

^j TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^k Rigshospitalet   (Denmark)

^l Instituto H Ellis   (Brazil)

^m ERASMUS MEDICAL CENTER   (Netherlands)

ⁿ UNIVERSITY OF L'AQUILA   (Italy)

^o DEAKIN UNIVERSITY   (Australia)

^p ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^q VALPARAISO UNIVERSITY   (United States)

^r UNIVERSITY OF CALIFORNIA   (United States)

^s Clinica de Urologia e Andrologia   (Brazil)

more..

Author keywords

Definition of PE; Diagnosis of PE; Etiology of PE; Pharmacotherapy of PE; Premature ejaculation; Prevalence of PE; Psychotherapy of PE

Indexed keywords

DAPOXETINE; LOCAL ANESTHETIC AGENT; OXYTOCIN; PHOSPHODIESTERASE V INHIBITOR; PROLACTIN; SEROTONIN UPTAKE INHIBITOR; TESTOSTERONE; THYROID HORMONE; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; VASOACTIVE AGENT;

ACUPUNCTURE; ARTICLE; BEHAVIOR THERAPY; CLINICAL ASSESSMENT; CRYOABLATION; ERECTILE DYSFUNCTION; EVIDENCE BASED PRACTICE; GENERAL PRACTICE; GENERAL PRACTITIONER; GENETIC VARIABILITY; HUMAN; HYPERTHYROIDISM; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MALE; MEDICAL SOCIETY; MEN WHO HAVE SEX WITH MEN; META ANALYSIS (TOPIC); NEUROBIOLOGY; NEUROMODULATION; PATIENT EDUCATION; PATIENT PREFERENCE; PERFORMANCE ANXIETY; PHASE 3 CLINICAL TRIAL (TOPIC); PHYSICAL EXAMINATION; PRACTICE GUIDELINE; PREMATURE EJACULATION; PREVALENCE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROSTATITIS; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL THEORY; PSYCHOTHERAPY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEXUAL BEHAVIOR; SEXUAL EDUCATION; SEXUAL FUNCTION; SYSTEMATIC REVIEW (TOPIC);

DEFINITION OF PE; DIAGNOSIS OF PE; ETIOLOGY OF PE; PHARMACOTHERAPY OF PE; PREMATURE EJACULATION; PREVALENCE OF PE; PSYCHOTHERAPY OF PE;

ABLATION TECHNIQUES; ACUPUNCTURE THERAPY; COMBINED MODALITY THERAPY; DRUG EVALUATION; EJACULATION; HUMANS; MALE; MEDICAL HISTORY TAKING; OFF-LABEL USE; PATIENT EDUCATION AS TOPIC; PHYSICAL EXAMINATION; PHYSICIAN'S ROLE; PREMATURE EJACULATION; PRIMARY HEALTH CARE; PSYCHOTHERAPY; SEXUAL PARTNERS;

EID: 84901978777     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12504     Document Type: Article

References (255)

1. Althof S, Abdo C, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger MD, Becher E, Broderick G, Buvat J, Goldstein I, El-Meliegy A, Giuliano F, Hellstrom W, Incrocci L, Jannini EA, Park K, Parish S, Porst H, Rowland D, Segraves R, Sharlip I, Simonelli C, Tan HM. International Society for Sexual Medicine's Guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 2010;7:2947-2969.
2. Centre for Evidence Based Medicine. Oxford Centre for Evidence Based Medicine levels of evidence. 2001. Available at: http://www.cebm.net (accessed August 5, 2013).
3. Jannini E, Eardley I, Sand M, Hackett G. Clinical and basic science research in sexual medicine must rely, in part, on pharmaceutical funding? J Sex Med 2010;7:2331-2337.
4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edition, text revision. Washington, DC: American Psychiatric Association; 2000.
5. Colpi G, Weidner W, Jungwirth A, Pomerol J, Papp G, Hargreave T, Dohle G. EAU guidelines on ejaculatory dysfunction. Eur Urol 2004;46:555-558.
6. Masters W, Johnson V. Human sexual inadequacy. Boston: Little, Brown; 1970.
7. Metz M, McCarthy B. Coping with premature ejaculation: How to overcome PE, please your partner & have great sex. Oakland: New Harbinger Publications; 2003.
8. Waldinger M, Quinn P, Dilleen M, Mundayat R, Schweitzer D, Boolell M. A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005;2:292-297.
9. World Health Organization. International classification of diseases and related health problems. 10th edition. Geneva: WHO; 1994.
10. Waldinger M. Premature ejaculation: Different pathophysiologies and etiologies determine its treatment. J Sex Marital Ther 2008;34:1-13.
11. Jannini E, Lenzi A. Ejaculatory disorders: Epidemiology and current approaches to definition, classification and subtyping. World J Urol 2005;23:68-75.
12. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip I, Adaikan PG, Becher E, Broderick GA, Buvat J, Dabees K, Giraldi A, Giuliano F, Hellstrom WJ, Incrocci L, Laan E, Meuleman E, Perelman MA, Rosen RC, Rowland DL, Segraves R. An evidence-based definition of lifelong premature ejaculation: Report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008;5:1590-1606.
13. American Psychiatric Association. The diagnostic and statistical manual of mental disorders, 5th edition. Washington, DC: American Psychiatric Association; 2013.
14. Pagani E, Rodrigues O, Torselli M, Genari D. Characterization of 305 men with complaints of premature ejaculation. Int J Impot Res 1996;8:172.
15. Waldinger M. Pathophysiology of lifelong premature ejaculation. In: Jannini EA, McMahon CM, Waldinger MD, eds. Premature ejaculation from etiology to diagnosis and treatment. Italia: Springer-Verlag; 2013:71-80.
16. Gross S. Practical treatise on impotence and sterility and allied disorders of the male sexual organs. Edinburg: YJ Pentland; 1887.
17. Carson C, Gunn K. Premature ejaculation: Definition and prevalence. Int J Impot Res 2006;18:S5-13.
18. Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E. Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation. Eur Urol 2010;57:804-814.
19. Waldinger M. The neurobiological approach to premature ejaculation. J Urol 1998;168:2359-2367.
20. Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E, Wang T. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17:39-57.
21. Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The premature ejaculation prevalence and attitudes (PEPA) survey: Prevalence, comorbidities and professional help-seeking. Eur Urol 2007;51:816-824.
22. Laumann E, Paik A, Rosen R. Sexual dysfunction in the United States: Prevalence and predictors. J Am Med Assoc 1999;281:537-544.
23. Waldinger M, Schweitzer D. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part II- proposals for DSM-V and ICD-11. J Sex Med 2006;3:693-705.
24. Dunn KM, Croft PR, Hackett GI. Sexual problems: A study of the prevalence and need for health care in the general population. Fam Pract 1998;15:519-524.
25. Fugl-Meyer K, Fugl-Meyer AR. Sexual disabilities are not singularities. Int J Impot Res 2002;14:487-493.
26. Rowland D, Perelman M, Althof S, Barada J, McCullough A, Bull S, Jamieson C, Ho KF. Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med 2004;1:225-232.
27. Nolazco C, Bellora O, Lopez M, Surur D, Vazquez J, Rosenfeld C, Becher E, Mazza O. Prevalence of sexual dysfunctions in Argentina. Int J Impot Res 2004;16:69-72.
28. Basile Fasolo C, Mirone V, Gentile V, Parazzini F, Ricci E. Premature ejaculation: Prevalence and associated conditions in a sample of 12, 558 men attending the andrology prevention week 2001-A study of the Italian Society of Andrology (SIA). J Sex Med 2005;2:376-382.
29. Stulhofer A, Bajic Z. Prevalence of erectile and ejaculatory difficulties among men in Croatia. Croat Med J 2006;47:114-124.
30. Shindel AW, Nelson CJ, Naughton CK, Mulhall JP. Premature ejaculation in infertile couples: Prevalence and correlates. J Sex Med 2008;5:485-491.
31. Brock GB, Benard F, Casey R, Elliott SL, Gajewski JB, Lee JC. Canadian male sexual health council survey to assess prevalence and treatment of premature ejaculation in Canada. J Sex Med 2009;6:2115-2123.
32. Traeen B, Stigum H. Sexual problems in 18-67-year-old Norwegians. Scand J Public Health 2010;38:445-456.
33. Son H, Song SH, Kim SW, Paick JS. Self-reported premature ejaculation prevalence and characteristics in Korean young males: Community-based data from an internet survey. J Androl 2010;31:540-546.
34. Amidu N, Owiredu WK, Woode E, Addai-Mensah O, Gyasi-Sarpong KC, Alhassan A. Prevalence of male sexual dysfunction among Ghanaian populace: Myth or reality? Int J Impot Res 2010;22:337-342.
35. Liang CZ, Hao ZY, Li HJ, Wang ZP, Xing JP, Hu WL, Zhang TF, Ge WW, Zhang XS, Zhou J, Li Y, Zhou ZX, Tang ZG, Tai S. Prevalence of premature ejaculation and its correlation with chronic prostatitis in Chinese men. Urology 2010;76:962-966.
36. Park HJ, Park JK, Park K, Lee SW, Kim SW, Yang DY, Moon du G, Min KS, Moon KH, Yang SK, Hyun JS, Park NC. Prevalence of premature ejaculation in young and middle-aged men in Korea: A multicenter internet-based survey from the Korean Andrological Society. Asian J Androl 2010;12:880-889.
37. Vakalopoulos I, Dimitriadis G, Varnava C, Herodotou Y, Gkotsos G, Radopoulos D. Prevalence of ejaculatory disorders in urban men: Results of a random-sample survey. Andrologia 2011;43:327-333.
38. Hirshfield S, Chiasson MA, Wagmiller RL Jr, Remien RH, Humberstone M, Scheinmann R, Grov C. Sexual dysfunction in an Internet sample of U.S. men who have sex with men. J Sex Med 2010;7:3104-3114.
39. Christensen BS, Gronbaek M, Osler M, Pedersen BV, Graugaard C, Frisch M. Sexual dysfunctions and difficulties in Denmark: Prevalence and associated sociodemographic factors. Arch Sex Behav 2011;40:121-132.
40. Serefoglu EC, Yaman O, Cayan S, Asci R, Orhan I, Usta MF, Ekmekcioglu O, Kendirci M, Semerci B, Kadioglu A. Prevalence of the complaint of ejaculating prematurely and the four premature ejaculation syndromes: Results from the Turkish Society of Andrology Sexual Health Survey. J Sex Med 2011;8:540-548.
41. Tang WS, Khoo EM. Prevalence and correlates of premature ejaculation in a primary care setting: A preliminary cross-sectional study. J Sex Med 2011;8:2071-2078.
42. Mialon A, Berchtold A, Michaud PA, Gmel G, Suris JC. Sexual dysfunctions among young men: Prevalence and associated factors. J Adolesc Health 2012;51:25-31.
43. Shaeer O, Shaeer K. The Global Online Sexuality Survey (GOSS): Ejaculatory function, penile anatomy, and contraceptive usage among Arabic-speaking Internet users in the Middle East. J Sex Med 2012;9:425-433.
44. Shindel AW, Vittinghoff E, Breyer BN. Erectile dysfunction and premature ejaculation in men who have sex with men. J Sex Med 2012;9:576-584.
45. McMahon CG, Lee G, Park JK, Adaikan PG. Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region. J Sex Med 2012;9:454-465.
46. Lotti F, Corona G, Rastrelli G, Forti G, Jannini EA, Maggi M. Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility. J Sex Med 2012;9:2698-2707.
47. Zhang H, Yip AW, Fan S, Yip PS. Sexual dysfunction among Chinese married men aged 30-60 years: A population-based study in Hong Kong. Urology 2013;81:334-339.
48. Lee SW, Lee JH, Sung HH, Park HJ, Park JK, Choi SK, Kam SC. The prevalence of premature ejaculation and its clinical characteristics in Korean men according to different definitions. Int J Impot Res 2013;25:12-17.
49. Shaeer O. The Global Online Sexuality Survey (GOSS): The United States of America in 2011 chapter III-premature ejaculation among English-speaking male internet users. J Sex Med 2013;10:1882-1888.
50. Gao J, Zhang X, Su P, Liu J, Xia L, Yang J, Shi K, Tang D, Hao Z, Zhou J, Liang C. Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: A large observational study in china. J Sex Med 2013;10:1874-1881.
51. Hwang I, Yang DO, Park K. Self-reported prevalence of and attitudes toward premature ejaculation in a community-based study of married couples. World J Mens Health 2013;31:70-75.
52. Vansintejan J, Janssen J, Van De Vijver E, Vandevoorde J, Devroey D. The gay men sex studies: prevalence of sexual dysfunctions in Belgian HIV(+) gay men. HIV AIDS (Auckl) 2013;5:89-96.
53. Zhang X, Gao J, Liu J, Yip PS. Distribution and factors associated with four premature ejaculation syndromes in outpatients complaining of ejaculating prematurely. J Sex Med 2013;10:1603-1611.
54. Simons JS, Carey MP. Prevalence of sexual dysfunctions: results from a decade of research. Arch Sex Behav 2001;30:177-219.
55. Waldinger M. History of premature ejaculation. In: Jannini EA, McMahon C, Waldinger M, eds. Premature ejaculation: From etiology to diagnosis and treatment. Italia: Springer-Verlag; 2013:5-24.
56. Waldinger M, McIntosh J, Schweitzer DH. A five-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population. J Sex Med 2009;6:2888-2895.
57. Waldinger MD. Recent advances in the classification, neurobiology and treatment of premature ejaculation. Adv Psychosom Med 2008;29:50-69.
58. Serefoglu EC, Cimen HI, Atmaca AF, Balbay MD. The distribution of patients who seek treatment for the complaint of ejaculating prematurely according to the four premature ejaculation syndromes. J Sex Med 2010;7:810-815.
59. Serefoglu EC, Yaman O, Cayan S, Asci R, Orhan I, Usta MF, Ekmekcioglu O, Kendirci M, Semerci B, Kadioglu A. The comparison of premature ejaculation assessment questionnaires and their sensitivity for the four premature ejaculation syndromes: results from the Turkish society of andrology sexual health survey. J Sex Med 2011;8:1177-1185.
60. Schapiro B. Premature ejaculation, a review of 1130 cases. J Urol 1943;50:374-379.
61. Xin ZC, Choi YD, Rha KH, Choi HK. Somatosensory evoked potentials in patients with primary premature ejaculation. J Urol 1997;158:451-455.
62. Fanciullacci F, Colpi G, Beretta G. Cortical evoked potentials in subjects with true premature ejaculation. Andrologia 1988;20:326-330.
63. Waldinger M, Berendsen HH, Blok BF, Olivier B, Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: The involvement of the serotonergic system. Behav Brain Res 1998;92:111-118.
64. Giuliano F. 5-Hydroxytryptamine in premature ejaculation: Opportunities for therapeutic intervention. Trends Neurosci 2007;30:79-84.
65. Chia S. Management of premature ejaculation-A comparison of treatment outcome in patients with and without erectile dysfunction. Int J Androl 2002;25:301-305.
66. Jannini EA, Lombardo F, Lenzi A. Correlation between ejaculatory and erectile dysfunction. Int J Androl 2005;28(suppl 2):40-45.
67. Screponi E, Carosa E, Di Stasi SM, Pepe M, Carruba G, Jannini EA. Prevalence of chronic prostatitis in men with premature ejaculation. Urology 2001;58:198-202.
68. Adson DE, Kotlyar M. Premature ejaculation associated with citalopram withdrawal. Ann Pharmacother 2003;37:1804-1806.
69. O'Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry 2000;177:567-568.
70. Peugh J, Belenko S. Alcohol, drugs and sexual function: A review. J Psychoactive Drugs 2001;33:223-232.
71. Gonen M, Kalkan M, Cenker A, Ozkardes H. Prevalence of premature ejaculation in Turkish men with chronic pelvic pain syndrome. J Androl 2005;26:601-603.
72. Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, Jannini EA. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. JCEM 2005;90:6472-6479.
73. Corona G, Petrone L, Mannucci E, Jannini E, Mansani R, Magini A, Giommi R, Forti G, Maggi M. Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur Urol 2004;46:615-622.
74. Waldinger M, Schweitzer DH. The use of old and recent DSM definitions of premature ejaculation in observational studies: A contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med 2008;5:1079-1087.
75. Clement P, Bernabe J, Compagnie S, Alexandre L, McCallum S, Giuliano F. Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: A multi-level site of action. Br J Pharmacol 2013;169:1477-1485.
76. Clement P, Pozzato C, Heidbreder C, Alexandre L, Giuliano F, Melotto S. Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat. J Sex Med 2009;6:980-988.
77. Borgdorff AJ, Bernabe J, Denys P, Alexandre L, Giuliano F. Ejaculation elicited by microstimulation of lumbar spinothalamic neurons. Eur Urol 2008;54:449-456.
78. Borgdorff AJ, Rossler AS, Clement P, Bernabe J, Alexandre L, Giuliano F. Differences in the spinal command of ejaculation in rapid ejaculating rats. J Sex Med 2009;6:2197-2205.
79. Truitt W, Coolen L. Identification of a potential ejaculation generator in the spinal cord. Science 2002;297:1566-1569.
80. Coolen L, Allard J, Truitt W, McKenna K. Central regulation of ejaculation. Physiol Behav 2004;83:203-215.
81. Staudt MD, Truitt WA, McKenna KE, de Oliveira CV, Lehman MN, Coolen LM. A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections. J Sex Med 2012;9:2256-2265.
82. Chehensse C, Bahrami S, Denys P, Clement P, Bernabe J, Guiliano F. The spinal control of ejaculation revisited. A systematic review and meta-analysis of anejaculation in spinal cord injured patients. Hum Reprod Update 2013;19:507-526.
83. Waldinger M, Rietschel M, Nothen N, Hengeveld MW, Olivier B. Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998;8:37-40.
84. Jern P, Santtila P, Alanko K, Harlaar N, Johansson A, von der Pahlen B, Araojen M, Vilstrom N, Algars M, Sandnabba K. Premature and delayed ejaculation: Genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med 2007;4:1739-1749.
85. Janssen P, Bakker S, Rethelyi J, Zwinderman AH, Touw DJ. Olivier B, Waldinger, MD. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 2009;6:276-284.
86. Zuccarello D, Ghezzi M, Pengo M, Forzan M, Frigo AC, Ferlin A, Foresta C. No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls. J Sex Med 2012;9:1659-1668.
87. Jern P, Eriksson E, Westberg L. A reassessment of the possible effects of the serotonin transporter gene linked polymorphism 5-HTTLPR on premature ejaculation. Arch Sex Behav 2013;42:45-49.
88. Ozbek E, Tasci A, Tugcu V, Ilbey YO, Simsek A, Ozcan L, Polat EC, Koksal V. Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with PE in a Turkish population. Asian J Androl 2009;11:1-5.
89. Santtila P, Jern P, Westberg L, Walum H, Pedersen CT, Eriksson E, Sandnabba N. The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation. J Sex Med 2010;7:1538-1546.
90. Van Dyck C, Malison R, Jacobson L, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J Nucl Med 2005;46:745-751.
91. Van Ness S, Owens M, Kilts C. The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet 2005;6:55.
92. Jern P, Westberg L, Johansson A, Jonsson L, Corander J, Sandnabba NK, Santtila P. Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function? BJU Int 2012;110:E1173-1180.
93. Jern P, Westberg L, Johansson A, Gunst A, Eriksson E, Sandnabba K, Santtila P. A study of possible associations between single nucleotide polymorphisms in the serotonin receptor 1A, 1B, and 2C genes and self-reported ejaculation latency time. J Sex Med 2012;9:866-872.
94. Luo S, Lu Y, Wang F, Xie Z, Huang X, Dong Q, Zhang S. Association between polymorphisms in the serotonin 2C receptor gene and premature ejaculation in Han Chinese subjects. Urol Int 2010;85:204-208.
95. Carosa E, Di Sante S, Rossi S, Castri A, D'Adamo F, Gravina GL, Ronchi P, Kostrouch Z, Dolci S, Lenzi A, Jannini EA. Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis. J Sex Med 2010;7:1381-1390.
96. Kulikov AV, Maksyutova AV, Ivanova EA, Khvorostov IB, Popova NK. The effect of thyroidectomy on the expression of the mRNA of 5-HT2A serotonin receptors in the rat frontal cortex. Dokl Biochem Biophys 2002;383:116-118.
97. Kulikov AV, Zubkov EA. Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain. Neurosci Lett 2007;416:307-309.
98. Cihan A, Demir O, Demir T, Aslan G, Comlekci A, Esen A. The relationship between premature ejaculation and hyperthyroidism. J Urol 2009;181:1273-1280.
99. Cihan A, Murat N, Demir O, Aslan G, Comlekci A, Esen A. An experimental approach to the interrelationship between hyperthyroidism and ejaculation latency time in male rats. J Urol 2009;181:907-912.
100. Corona G, Jannini EA, Lotti F, Boddi V, De Vita G, Forti G, Lenzi A, Mannucci E, Maggi M. Premature and delayed ejaculation: Two ends of a single continuum influenced by hormonal milieu. Int J Androl 2011;34:41-48.
101. Ozturk MI, Koca O, Tuken M, Keles MO, Ilktac A, Karaman MI. Hormonal evaluation in premature ejaculation. Urol Int 2012;88:454-458.
102. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Thyroid-stimulating hormone assessments in a Dutch cohort of 620 men with lifelong premature ejaculation without erectile dysfunction. J Sex Med 2005;2:865-870.
103. Corona G, Jannini EA, Vignozzi L, Rastrelli G, Maggi M. The hormonal control of ejaculation. Nat Rev Urol 2012;9:508-519.
104. Corona G, Mannucci E, Jannini E, Lotti F, Ricca V, Monami M, Boddi V, Bandini E, Balercia G, Forti G, Maggi M. Hypoprolactinemia: A new clinical syndrome in patients with sexual dysfunction. J Sex Med 2009;6:1457-1466.
105. Corona G, Jannini E, Mannucci E, Fisher AD, Lotti F, Petrone L, Balercia G, Bandini E, Chiarini V, Forti G, Maggi M. Different testosterone levels are associated with ejaculatory dysfunction. J Sex Med 2008;5:1991-1998.
106. Liang CZ, Zhang XJ, Hao ZY, Shi HQ, Wang KX. Prevalence of sexual dysfunction in Chinese men with chronic prostatitis. BJU Int 2004;93:568-570.
107. Trinchieri A, Magri V, Cariani L, Bonamore R, Restelli A, Garlaschi MC, Perletti G. Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome. Arch Ital Urol Androl 2007;79:67-70.
108. Shamloul R, el-Nashaar A. Chronic prostatitis in premature ejaculation: A cohort study in 153 men. J Sex Med 2006;3:150-154.
109. Lotti F, Corona G, Mancini M, Biagini C, Colpi G, Innocenti SD, Filmberti E, Gacci M, Krausz C, Sforza A, Forti G, Mannucci E, Maggi M. The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. J Sex Med 2009;6:2878-2887.
110. el-Sakka AI. Efficacy of sildenafil citrate in treatment of erectile dysfunction: impact of associated premature ejaculation and low desire. Urology 2006;68:642-647.
111. Malavige LS, Jayaratne SD, Kathriarachchi ST, Sivayogan S, Fernando DJ, Levy JC. Erectile dysfunction among men with diabetes is strongly associated with premature ejaculation and reduced libido. J Sex Med 2008;5:2125-2134.
112. Shaeer O, Shaeer K. The Global Online Sexuality Survey (GOSS): The United States of America in 2011. Chapter I: Erectile dysfunction among English-speakers. J Sex Med 2012;9:3018-3027.
113. Hwa JS, Kam SC, Choi JH, Do JM, Seo DH, Hyun JS. Impact of erectile function and age in men with lower urinary tract symptoms on ejaculatory dysfunction and premature ejaculation. Int J Impot Res 2012;24:101-105.
114. Porst H, McMahon C, Althof S, Sharlip I, Bull S, Rivas DA. Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: Integrated analysis of two phase III dapoxetine trials. J Sex Med 2010;7:2231-2242.
115. McMahon CG. Screening for erectile dysfunction in men with lifelong premature ejaculation-Is the Sexual Health Inventory for Men (SHIM) reliable? J Sex Med 2009;6:567-573.
116. Cahangirov A, Cihan A, Murat N, Demir O, Aslan G, Gidener S, Esen, AA. Investigation of the neural target level of hyperthyroidism in premature ejaculation in a rat model of pharmacologically induced ejaculation. J Sex Med 2011;8:90-96.
117. Cooper AJ, Cernovsky ZZ, Colussi K. Some clinical and psychometric characteristics of primary and secondary premature ejaculators. J Sex Marital Ther 1993;19:276-288.
118. Jannini EA, Porst H. A practical approach to premature ejaculation. J Sex Med 2011;8(suppl 4):301-303.
119. Ozturk B, Cetinkaya M, Saglam H, Adsan O, Akin O, Memis A. Erectile dysfunction in premature ejaculation. Arch Ital Urol Androl 1997;69:133-136.
120. Lau J, Kim J, Tsui H. Prevalence and sociocultural predictors of sexual dysfunction among Chinese men who have sex with men in Hong Kong. J Sex Med 2008;5:2766-2779.
121. Bancroft J, Carnes L, Janssen E, Goodrich D, Long JS. Erectile and ejaculatory problems in gay and heterosexual men. Arch Sex Behav 2005;34:285-297.
122. Jern P, Santtila P, Johansson A, Alanko K, Salo B, Sandnabba NK. Is there an association between same-sex sexual experience and ejaculatory dysfunction? J Sex Marital Ther 2010;36:303-312.
123. Althof S, McCabe M, Assalian P, Chevret-Measson M, Leiblum S, Simonelli C, Wylie K. Psychological and interpersonal dimensions of sexual function and dysfunction. In: Montorsi F, Basson R, Adaikan G, Becher E, Clayton A, Giuliano F, Khory S, Sharlip I, eds. Sexual Medicine: Sexual dysfunctions in men and women. Editions 21. Paris: Editions 21; 2010:121-182.
124. McCabe M. The development and maintenance of sexual dysfunction: An explanation based on cognitive theory. Sex Marital Ther 1991;6:254-260.
125. Michetti P, Rossi R, Bonanno D, DeDominicis C, Lori F, Simonelli C. Dysregulation of emotions and premature ejaculation (PE): Alexithymia in 100 outpatients. J Sex Med 2007;17:18-23.
126. Graziottin A, Althof S. What does premature ejaculation mean to the man, the woman, and the couple? J Sex Med 2011;8(suppl 4):304-309.
127. Mohr D, Bentler L. Erectile dysfunction: A review of diagnostic and treatment procedures. Clin Psychol Rev 1990;10:123-150.
128. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, McNulty P, Rothman M, Jamieson C. Premature ejaculation: An observational study of men and their partners. J Sex Med 2005;2:358-367.
129. Giuliano F, Patrick DL, Porst H, La Pera G, Kokoszka A, Merchant S, Rothman M, Gagnon DD, Polverejan E. Premature ejaculation: Results from a five-country European observational study. Eur Urol 2008;53:1048-1057.
130. Rosen R, Althof S. Impact of premature ejaculation: The psychological quality of life and sexual relationship consequences. J Sex Med 2008;5:1296-1307.
131. Rowland D, Patrick D, Rothman M, Gagnon D. The psychological burden of premature ejaculation. J Urol 2007;177:1065-1070.
132. Symonds T, Roblin D, Hart K, Althof S. How does premature ejaculation effect a man's life. J Sex Marital Ther 2003;29:361-370.
133. Escajadillo-Vargas N, Mezones-Holguin E, Castro-Castro J, Cordova-Marcelo W, Blumel JE, Perez-Lopez FR, Chedraui P. Sexual dysfunction risk and associated factors in young Peruvian university women. J Sex Med 2011;8:1701-1709.
134. Hobbs K, Symonds T, Abraham L, May K, Morris MF. Sexual dysfunction in partners of men with premature ejaculation. Int J Impot Res 2008;20:512-517.
135. Limoncin E, Tomassetti M, Gravina GL, Ciocca G, Carosa E, Di Sante S, Gentile V, Mirone V, Montorsi F, Lenzi A, Jannini EA. Premature ejaculation results in female sexual distress: Standardization and validation of a new diagnostic tool for sexual distress. J Urol 2013;189:1830-1835.
136. Oberg K, Sjogren Fugl-Meyer K. On Swedish women's distressing sexual dysfunctions: Some concomitant conditions and life satisfaction. J Sex Med 2005;2:169-180.
137. Riley A, Riley E. Premature ejaculation: Presentation and associations. An audit of patients attending a sexual problems clinic. Int J Clin Pract 2005;59:1482-1487.
138. Shaeer O, Shaeer K, Shaeer E. The Global Online Sexuality Survey (GOSS): Female sexual dysfunction among Internet users in the reproductive age group in the Middle East. J Sex Med 2012;9:411-424.
139. Zhang H, Yip PS. Female sexual dysfunction among young and middle-aged women in Hong Kong: Prevalence and risk factors. J Sex Med 2012;9:2911-2918.
140. Dogan S, Dogan M. The frequency of sexual dysfunctions in male partners of women with vaginismus in a Turkish sample. Int J Impot Res 2008;20:218-221.
141. Schein M, Zyzanski SJ, Levine S, Medalie JH, Dickman RL, Alemagno SA. The frequency of sexual problems among family practice patients. Fam Pract Res J 1988;7:122-134.
142. Humphrey S, Nazareth I. GP's view on their management of sexual dysfunction. Fam Pract 2001;18:516-518.
143. Rowland D, McMahon C, Abdo C, Chen J, Jannini E, Waldinger MD, Ahn TY. Disorders of orgasm and ejaculation in men. J Sex Med 2010;7:1668-1686.
144. Jannini E, Maggi M, Lenzi A. Evaluation of premature ejaculation. J Sex Med 2011;8:328-334.
145. Serefoglu EC, Cimen HI, Ozdemir AT, Symonds T, Berktas M, Balbay MD. Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. Int J Impot Res 2009;21:139-144.
146. Althof SE. Evidence based assessment of rapid ejaculation. Int J Impot Res 1998;10(suppl 2):S74-76, discussion S77-9.
147. Pryor JL, Broderick GA, Ho KF, Jamieson C, Gagnon D. Comparison of estimated versus measured intravaginal ejaculatory latency time in men with and without premature ejaculation. J Sex Med 2005;3:54.
148. Rosen R, McMahon C, Niederberger C, Broderick G, Jamieson C, Gagnon DD. Correlates to the clinical diagnosis of premature ejaculation: Results from a large observational study of men and their partners. J Urol 2007;177:1059-1064.
149. Corona G, Jannini E, Maggi M. Inventories for male and female sexual dysfunctions. Int J Impot Res 2006;18:236-250.
150. Althof S, Rosen R, Symonds T, Mundayat R, May K, Abraham L. Development and validation of a new questionnaire to assess sexual satisfaction, control and distress associated with premature ejaculation. J Sex Med 2006;3:465-475.
151. Arafa M, Shamloul R. Development and validation of the Arabic Index of Premature Ejaculation (AIPE). J Sex Med 2007;4:1750-1756.
152. Patrick DL, Giuliano F, Ho KF, Gagnon DD, McNulty P, Rothman M. The premature ejaculation profile: Validation of self-reported outcome measures for research and practice. BJU Int 2008;103:358-367.
153. Symonds T, Perelman M, Althof S, Giuliano F, Martin M, Abraham L, Crossland A, Morris M, May K. Further evidence of the reliability and validity of the premature ejaculation diagnostic tool. Int J Impot Res 2007;19:521-525.
154. Symonds T, Perelman M, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A, Morris M. Development and validation of a premature ejaculation diagnostic tool. Eur Urol 2007;52:565-573.
155. Yuan Y, Xin ZC, Jiang J, Guo YJ, Liu WJ, Tian L, Zhu JC. Sexual function of premature ejaculation patients assayed with the Chinese Index of Premature Ejaculation. Asian J Androl 2004;6:121-126.
156. Althof S. Psychological approaches to the treatment of rapid ejaculation. J Mens Health Gend 2006;3:180-186.
157. Althof S. Treatment of rapid ejaculation: Psychotherapy, pharmacotherapy, and combined therapy. In: Leiblum S, ed. Principles and practice of sex therapy. 4th edition. New York: Guilford Press; 2007:212-240.
158. Jannini E, Simonelli C, Lenzi A. Sexological approach to ejaculatory dysfunction. Int J Androl 2002;25:317-323.
159. Kaplan HS. The new sex therapy. New York: Bruner Mazel; 1974.
160. Levine SB. Sexual life: A clinician's guide. New York: Plenum; 1992.
161. McCarthy B. Cognitive behavioral strategies and techniques in the treatment of early ejaculation. In: Leiblum S, Rosen R, eds. Principles and practice of sex therapy: Update for the 1990s. New York: Guilford Press; 1990:141-167.
162. Semans J. Premature ejaculation. South Med J 1956;49:352-358.
163. Hawton K. Treatment of sexual dysfunctions by sex therapy and other approaches. Br J Psychiatry 1995;167:307-314.
164. De Carufel F, Trudel G. Effects of a new functional sexological treatment for premature ejaculation. J Sex Marital Ther 2006;32:97-114.
165. Trudel G, Proulx S. Treatment of premature ejaculation by bibliotherapy: An experimental study. Sex Marital Ther 1987;2:163-167.
166. Fruhauf S, Gerger H, Schmidt HM, Munder T, Barth J. Efficacy of psychological interventions for sexual dysfunction: A systematic review and meta-analysis. Arch Sex Behav 2013;42:915-933.
167. Melnik T, Althof S, Atallah Á, Puga MS, Glina S, Riera R. Psychosocial interventions for premature ejaculation. Cochrane Database Syst Rev 2010;1:CD008195.
168. Berner M, Gunzler C. Efficacy of psychosocial interventions in men and women with sexual dysfunctions-A systematic review of controlled clinical trials: Part 1-the efficacy of psychosocial interventions for male sexual dysfunction. J Sex Med 2012;9:3089-3107.
169. McCabe M, Price E, Piterman L, Lording D. Evaluation of a internet based psychological intervention for the treatment of erectile dysfunction. Int J Impot Res 2008;20:324-330.
170. Jones L, McCabe M. The effectiveness of an internet-based psychological treatment program for female sexual dysfunction. J Sex Med 2011;8:2781-2792.
171. Giuliano F, Clement P. Pharmacology for the treatment of premature ejaculation. Pharmacol Rev 2012;64:621-644.
172. Dinsmore W, Wylie M. PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 minutes before intercourse in men with premature ejaculation: Results of a phase III, multicentre, double-blind, placebo-controlled study. BJU Int 2009;103:940-949.
173. Carson C, Wylie M. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: Results of a phase III, double-blind, placebo-controlled study. J Sex Med 2010;7:3179-3189.
174. McMahon C. Clinical trial methodology in premature ejaculation observational, interventional and treatment preference studies- Part 1- Defining and selecting the study population. J Sex Med 2008;6:1805-1816.
175. Kaynar M, Kilic O, Yurdakul T. On-demand tramadol hydrochloride use in premature ejaculation treatment. Urology 2012;79:145-149.
176. Aversa A, Pili M, Francomano D, Bruzziches R, Spera E, La Pera G, Spera G. Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 2009;21:221-227.
177. Cavallini G. Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur Urol 1995;28:126-130.
178. Althof S, Levine S, Corty E, Risen C, Stern E, Kurit D. Clomipramine as a treatment for rapid ejaculation: A double-blind crossover trial of fifteen couples. J Clin Psychiatry 1995;56:402-407.
179. Atmaca M, Kuloglu M, Tezcan E, Semercioz A. The efficacy of citalopram in the treatment of premature ejaculation: A placebo-controlled study. Int J Impot Res 2002;14:502-505.
180. Goodman RE. An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation. J Int Med Res 1980;8:53-59.
181. Hellstrom WJ, Althof S, Gittelman M, Streidle C, Ho KF, Kell S, Nilson-Beijber A. Dapoxetine for the treatment of men with premature ejaculation (PE): Dose-finding analysis. J Urol 2005;173:238. abstract 877.
182. McMahon C, Kim S, Park N, Chang C, Rivas D, Tesfaye F, Rothman M, Aquilina J. Treatment of premature ejaculation in the Asia-Pacific region: Results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 2009;7:256-268.
183. McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: A single-blind placebo controlled crossover study. J Urol 1998;159:1935-1938.
184. McMahon CG, Althof SE, Kaufman JM, Buvat J, Levine SB, Aquilina JW, Tesfaye F, Rothman M, Rivas DA, Porst H. Efficacy and safety of dapoxetine for the treatment of premature ejaculation: Integrated analysis of results from five phase 3 trials. J Sex Med 2011;8:524-539.
185. McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 1999;161:1826-1830.
186. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: A double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994;151:1377-1379.
187. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: A randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004;46:510-515.
188. Buvat J, Tesfaye F, Rothman M, Rivas DA, Giuliano F. Dapoxetine for the treatment of premature ejaculation: Results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 2009;55:957-967.
189. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: An integrated analysis of two double-blind, randomised controlled trials. Lancet 2006;368:929-937.
190. Dresser MJ, Desai D, Gidwani S, Seftel AD, Modi NB. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Int J Impot Res 2006;18:104-110.
191. Jannini EA. Editorial comment on: Dapoxetine for the treatment of premature ejaculation: Results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 2009;55:967-968.
192. McMahon CG, Giuliano F, Dean J, Hellstrom WJ, Bull S, Tesfaye F, Sharma O, Rivas D, Aquilina J. Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: Randomized, placebo-controlled, phase III study. J Sex Med 2013;10:2312-2325.
193. Levine L Evaluation of Withdrawal Effects with Dapoxetine in the Treatment of Premature Ejaculation (PE). Poster presented at SMSNA 2006.
194. Kara H, Aydin S, Yucel M, Agargun MY, Odabas O, Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: A double-blind placebo controlled study. J Urol 1996;156:1631-1632.
195. Waldinger M, Zwinderman A, Schweitzer D, Oliver B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and metaanalysis. Int J Impot Res 2004;16:1-13.
196. McMahon CG. Long term results of treatment of premature ejaculation with selective serotonin re-uptake inhibitors. Int J Impot Res 2002;14:S19.
197. Waldinger MD. Premature ejaculation: Definition and drug treatment. Drugs 2007;67:547-568.
198. Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN. Adverse effect of paroxetine on sperm. Fertil Steril 2010;94:1021-1026.
199. Marangell L, Dennehy E, Wisniewski S, Bauer MS, Miyahara S, Allen MH, Martinez M, Al Jurdi RK, Thase ME. Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD. J Clin Psychiatry 2008;69:916-922.
200. Khan A, Khan S, Kolts R, Brown WA. Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: Analysis of FDA reports. Am J Psychiatry 2003;160:790-792.
201. Mann J, Emslie G, Baldessarini R, Beardslee W, Fawcett J, Goodwin FK, Leon AC, Meltzer HY, Ryan ND, Shaffer D, Wagner KD. ACNP Task Force report on SSRIs and suicidal behavior in youth. Neuropsychopharmacology 2006;31:473-492.
202. Stone M, Laughren T, Jones ML, Levenson M, Holland PC, Hughes A, Hammad TA, Temple R, Rochester G. Risk of suicidality in clinical trials of antidepressants in adults: Analysis of proprietary data submitted to US Food and Drug Administration. Br Med J 2009;339:2880-2890.
203. Black K, Shea CA, Dursun S, Kutcher S. Selective serotonin reuptake inhibitor discontinuation syndrome: Proposed diagnostic criteria. J Psychiatry Neurosci 2000;25:255-261.
204. Kim SW, Paick JS. Short-term analysis of the effects of as needed use of sertraline at 5 PM for the treatment of premature ejaculation. Urology 1999;54:544-547.
205. Strassberg DS, de Gouveia Brazao CA, Rowland DL, Tan P, Slob AK. Clomipramine in the treatment of rapid (premature) ejaculation. J Sex Marital Ther 1999;25:89-101.
206. Salonia A, Rocchini L, Sacca A, Pellucchi F, Ferrari M, Del Carro U, Ribotto P, Gallina A, Zanni G, Deho F, Regatti P, Montorsi F. Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation. J Sex Med 2009;6:2868-2877.
207. Mondaini N, Fusco F, Cai T, Benemei S, Mirone V, Bartoletti R. Dapoxetine treatment in patients with lifelong premature ejaculation: The reasons of a "waterloo". Urology 2013;82:620-624.
208. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. The majority of men with lifelong premature ejaculation prefer daily drug treatment: An observation study in a consecutive group of Dutch men. J Sex Med 2007;4:1028-1037.
209. Berkovitch M, Keresteci AG, Koren G. Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol 1995;154:1360-1361.
210. Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: A double-blind, randomized, placebo-controlled study. BJU Int 2004;93:1018-1021.
211. Pu C, Yang L, Liu L, Yuan H, Wei Q, Han P. Topical anesthetic agents for premature ejaculation: A systematic review and meta-analysis. Urology 2013;81:799-804.
212. Wieder JA, Brackett NL, Lynne CM, Green JT, Aballa TC. Anesthetic block of the dorsal penile nerve inhibits vibratory-induced ejaculation in men with spinal cord injuries. Urology 2000;55:915-917.
213. Jannini EA, McMahon C, Chen J, Aversa A, Perelman M. The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation. J Sex Med 2011;8:2135-2143.
214. McMahon CG, Stuckey B, Andersen ML. Efficacy of Viagra: Sildenafil citrate in men with premature ejaculation. J Sex Med 2005;2:368-375.
215. Salonia A, Maga T, Colombo R, Scattoni V, Briganti A, Cestari A, Guazzoni G, Rigatti P, Montorsi F. A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. J Urol 2002;168:2486-2489.
216. Asimakopoulos AD, Miano R, Finazzi Agro E, Vespasiani G, Spera E. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? A systematic review and meta-analysis. J Sex Med 2012;9:2404-2416.
217. McMahon CG, McMahon CN, Leow LJ, Winestock CG. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: A systematic review. BJU Int 2006;98:259-272.
218. Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B. Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung 1996;46:1029-1036.
219. Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 2006;26:27-31.
220. Szkutnik-Fiedler D, Kus K, Balcerkiewicz M, Grzeskowiak E, Nowakowska E, Burda K, Ratajczak P, Sadowski C. Concomitant use of tramadol and venlafaxine-Evaluation of antidepressant-like activity and other behavioral effects in rats. Pharmacol Rep 2012;64:1350-1358.
221. Alghobary M, El-Bayoumy Y, Mostafa Y, Mahmoud HM, Amr M. Evaluation of tramadol on demand versus daily paroxetine as a long-term treatment of lifelong premature ejaculation. J Sex Med 2010;7:2860-2867.
222. Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med 2008;5:188-193.
223. Bar-Or D, Salottolo KM, Orlando A, Winkler JV. A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol 2011;61:736-743.
224. Eassa BI, El-Shazly MA. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl 2013;15:138-142.
225. Takeshita J, Litzinger M. Serotonin syndrome associated with tramadol. Prim Care Companion J Clin Psychiatry 2009;11:273.
226. Arletti R, Bazzani C, Castelli M, Bertolini A. Oxytocin improves male copulatory performance in rats. Horm Behav 1985;19:14-20.
227. Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K. Oxytocin and sexual behaviour in the male rat and rabbit. J Endocrinol 1985;107:97-106.
228. Argiolas A, Collu M, D'Aquila P, Gessa GL, Melis MR, Serra G. Apomorphine stimulation of male copulatory behavior is prevented by the oxytocin antagonist d(CH2)5 Tyr(Me)-Orn8-vasotocin in rats. Pharmacol Biochem Behav 1989;33:81-83.
229. Clement P, Peeters M, Bernabe J, Denys P, Alexandre L, Giuliano F. Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats. Br J Pharmacol 2008;154:1150-1159.
230. Shinghal R, Barnes A, Mahar K, Stier B, Giancaterino L, Condreay LD, Black L, McCallum SW. Safety and efficacy of epelsiban in the treatment of men with premature ejaculation: A randomized, double-blind, placebo-controlled, fixed-dose study. J Sex Med 2013;10:2506-2517.
231. Yang CC, Bradley WE. Peripheral distribution of the human dorsal nerve of the penis. J Urol 1998;159:1912-1916, discussion 16-7.
232. David Prologo J, Snyder LL, Cherullo E, Passalacqua M, Pirasteh A, Corn D. Percutaneous CT-guided cryoablation of the dorsal penile nerve for treatment of symptomatic premature ejaculation. J Vasc Interv Radiol 2013;24:214-219.
233. Basal S, Goktas S, Ergin A, Yildirim I, Atim A, Tahmaz L, Dayanc M. A novel treatment modality in patients with premature ejaculation resistant to conventional methods: The neuromodulation of dorsal penile nerves by pulsed radiofrequency. J Androl 2010;31:126-130.
234. Fein RL. Intracavernous medication for treatment of premature ejaculation. Urology 1990;35:301-303.
235. Sunay D, Sunay M, Aydogmus Y, Bagbanci S, Arslan H, Karabulut A, Emir L. Acupuncture versus paroxetine for the treatment of premature ejaculation: A randomized, placebo-controlled clinical trial. Eur Urol 2011;59:765-771.
236. Jeon HJ, Kim HS, Lee CH, Lee YG, Choi SM, Sohn YS, Shin CY, Kim J, Shim HJ, Kang KK, Ahn BO, Kim SH. Candidate molecule for premature ejaculation, DA-8031: In vivo and in vitro characterization of DA-8031. Urology 2011;77:e17-21.
237. Kang KK, Ahn GJ, Sung JH, Kim SH, Kim H, Lee S. Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation. Urology 2013;81:e13-18.
238. Marson L, Yu G, Farber NM. The effects of oral administration of d-modafinil on male rat ejaculatory behavior. J Sex Med 2010;7:70-78.
239. Serefoglu EC, Silay MS. Botulinum toxin-A injection may be beneficial in the treatment of life-long premature ejaculation. Med Hypotheses 2010;74:83-84.
240. Serefoglu ECHW, Lesker GF, Grissom EM, Sikka SC, Dohanich GP, Hellstrom WJG. Effect of botulinum-A toxin injection into Bulbospongiosus muscle on ejaculatory latency time in male rats. In: Goldstein I, ed. World meeting on sexual medicine. Chicago: Wiley-Blackwell; 2012:331.
241. Althof S. Sex therapy in the age of pharmacotherapy. Annu Rev Sex Res 2006;116-132.
242. Perelman M. A new combination treatment for premature ejaculation. A sex therapist's perspective. J Sex Med 2006;3:1004-1012.
243. Li P, Zhy G, Xu P, Sun J, Wang P. Interventional effect of behavioral psychotherapy on patients with premature ejaculation [Chinese]. Zhonghua nan ke xue=Natl J Androl 2006;12:717-719.
244. Tang W, Ma L, Zhao L, Liu Y, Chen Z. Clinical efficacy of viagra with behavior therapy against premature ejaculation [Chinese]. Zhonghua nan ke xue=Natl J Androl 2004;10:366-367.
245. Yuan P, Dai J, Yang Y, Guo J, Liang R. A comparative study on treatment for premature ejaculation: citalopram used in combination with behavioral therapy versus either citalopram or behavioral therapy alone [Chinese]. Chin J Androl 2008;22:35-38.
246. Steggall M, Fowler C, Pryce A. Combination therapy for PE: Results of a small-scale study. Sex Relat Ther 2008;23:365-376.
247. Abdo CH, Afif-Abdo J, Otani F, Machado AC. Sexual satisfaction among patients with erectile dysfunction treated with counseling, sildenafil, or both. J Sex Med 2008;5:1720-1726.
248. Aubin S, Heiman J, Berger R, Murallo A, Yung-Wen L. Comparing sildenafil alone versus sildenafil plus brief couple sex therapy on erectile dysfunction and couples' sexual and marital quality of life: A pilot study. J Sex Marital Ther 2009;35:122-143.
249. Perelman M. Sex coaching for physicians: Combination treatment for patient and partner. Int J Impot Res 2003;15:S67-74.
250. McMahon C, Abdo C, Incrocci L, Perelman M, Rowland D, Stuckey B, Waldinger M, Xin ZC. Disorders of orgasm and ejaculation in men. In: Lue T, Basson R, Rosen R, eds. Sexual medicine: Sexual dysfunctions in men and women (2nd International Consultation on Sexual Dysfunctions). Paris: Health Publications; 2004:409-468.
251. Jannini E, Isidori A, Aversa A, Lenzi A, Althof SE. Which first? The controversial issue of precedence in the treatment of male sexual dysfunctions. J Sex Med 2013;10:2359-2369.
252. American Academy of Family Physicians. Definition of Primary Care. Available at: http://www.aafp.org/online/en/home/policy/policies/p/primarycare.html (accessed November 11, 2009).
253. Annon J. Behavioral treatment of sexual problems: Brief therapy. Hagerstown, MD: Harper & Row; 1976.
254. Sadowsky R. The role of the primary care clinician in the management of erectile dysfunction. Rev Urol 2002;4:S54-63.
255. Murray M. Reducing waits and delays in the referral process. Fam Pract Manag 2002;9:39-42.