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Volumn 8, Issue 8, 2011, Pages 2135-2143

The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation

Author keywords

Ejaculation; PDE5 Inhibitor; Premature Ejaculation; Sildenafil; SSRI; Tadalafil; Vardenfil

Indexed keywords

FLUOXETINE; NITRIC OXIDE; PAROXETINE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SILDENAFIL; TADALAFIL; VARDENAFIL;

EID: 79960802998     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02401.x     Document Type: Article
Times cited : (66)

References (58)
  • 4
    • 79960773027 scopus 로고    scopus 로고
    • Evaluation of premature ejaculation
    • May 6 [Epub ahead of print] doi: 10.1111/j.1743-6109.2011.02289.x.
    • Jannini EA, Maggi M, Lenzi A. Evaluation of premature ejaculation. J Sex Med 2011 May 6 [Epub ahead of print] doi: 10.1111/j.1743-6109.2011.02289.x.
    • (2011) J Sex Med
    • Jannini, E.A.1    Maggi, M.2    Lenzi, A.3
  • 5
    • 74049101562 scopus 로고    scopus 로고
    • Treatment of premature ejaculation in the Asia-Pacific region: Results from a phase III double-blind, parallel-group study of dapoxetine
    • McMahon C, Kim SW, Park NC, Chang CP, Rivas D, Tesfaye F, Rothman M, Aquilina J. Treatment of premature ejaculation in the Asia-Pacific region: Results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 2010;7:256-68.
    • (2010) J Sex Med , vol.7 , pp. 256-268
    • McMahon, C.1    Kim, S.W.2    Park, N.C.3    Chang, C.P.4    Rivas, D.5    Tesfaye, F.6    Rothman, M.7    Aquilina, J.8
  • 6
    • 22944450037 scopus 로고    scopus 로고
    • Ejaculatory disorders: Epidemiology and current approaches to definition, classification and subtyping
    • Jannini EA, Lenzi A. Ejaculatory disorders: Epidemiology and current approaches to definition, classification and subtyping. World J Urol 2005;23:68-75.
    • (2005) World J Urol , vol.23 , pp. 68-75
    • Jannini, E.A.1    Lenzi, A.2
  • 9
    • 33644867580 scopus 로고    scopus 로고
    • Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
    • Uckert S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P. Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate. Eur Urol 2006;49:740-5.
    • (2006) Eur Urol , vol.49 , pp. 740-745
    • Uckert, S.1    Oelke, M.2    Stief, C.G.3    Andersson, K.E.4    Jonas, U.5    Hedlund, P.6
  • 11
    • 34447528681 scopus 로고    scopus 로고
    • Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors
    • Uckert S, Bazrafshan S, Scheller F, Mayer ME, Jonas U, Stief CG. Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors. Urology 2007;70:185-9.
    • (2007) Urology , vol.70 , pp. 185-189
    • Uckert, S.1    Bazrafshan, S.2    Scheller, F.3    Mayer, M.E.4    Jonas, U.5    Stief, C.G.6
  • 12
    • 0032856960 scopus 로고    scopus 로고
    • Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-)
    • Kriegsfeld LJ, Demas GE, Huang PL, Burnett AL, Nelson RJ. Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-). Physiol Behav 1999;67:561-6.
    • (1999) Physiol Behav , vol.67 , pp. 561-566
    • Kriegsfeld, L.J.1    Demas, G.E.2    Huang, P.L.3    Burnett, A.L.4    Nelson, R.J.5
  • 14
    • 33745712565 scopus 로고    scopus 로고
    • Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: A systematic review
    • McMahon CG, McMahon CN, Leow LJ, Winestock CG. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: A systematic review. BJU Int 2006;98:259-72.
    • (2006) BJU Int , vol.98 , pp. 259-272
    • McMahon, C.G.1    McMahon, C.N.2    Leow, L.J.3    Winestock, C.G.4
  • 16
    • 0025215385 scopus 로고
    • Intracavernous medication for treatment of premature ejaculation
    • Fein RL. Intracavernous medication for treatment of premature ejaculation. Urology 1990;35:301-3.
    • (1990) Urology , vol.35 , pp. 301-303
    • Fein, R.L.1
  • 17
    • 0035066010 scopus 로고    scopus 로고
    • Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation
    • Abdel-Hamid IA, El Naggar EA, El Gilany AH. Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res 2001;13:41-5.
    • (2001) Int J Impot Res , vol.13 , pp. 41-45
    • Abdel-Hamid, I.A.1    El Naggar, E.A.2    El Gilany, A.H.3
  • 19
    • 0037253661 scopus 로고    scopus 로고
    • Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation
    • Chen J, Mabjeesh NJ, Matzkin H, Greenstein A. Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation. Urology 2003;61:197-200.
    • (2003) Urology , vol.61 , pp. 197-200
    • Chen, J.1    Mabjeesh, N.J.2    Matzkin, H.3    Greenstein, A.4
  • 20
    • 28344455471 scopus 로고    scopus 로고
    • Correlation between ejaculatory and erectile dysfunction
    • Jannini EA, Lombardo F, Lenzi A. Correlation between ejaculatory and erectile dysfunction. Int J Androl 2005;28(2 suppl):40-5.
    • (2005) Int J Androl , vol.28 , Issue.2 SUPPL. , pp. 40-45
    • Jannini, E.A.1    Lombardo, F.2    Lenzi, A.3
  • 22
    • 33747697070 scopus 로고    scopus 로고
    • Subclinical erectile dysfunction: Proposal for a novel taxonomic category in sexual medicine
    • Jannini EA, Lenzi A, Isidori A, Fabbri A. Subclinical erectile dysfunction: Proposal for a novel taxonomic category in sexual medicine. J Sex Med 2006;3:787-93.
    • (2006) J Sex Med , vol.3 , pp. 787-793
    • Jannini, E.A.1    Lenzi, A.2    Isidori, A.3    Fabbri, A.4
  • 23
    • 22644445043 scopus 로고    scopus 로고
    • The Sexual Health Inventory for Men (SHIM): A 5-year review of research and clinical experience
    • Cappelleri JC, Rosen RC. The Sexual Health Inventory for Men (SHIM): A 5-year review of research and clinical experience. Int J Impot Res 2005;17:307-19.
    • (2005) Int J Impot Res , vol.17 , pp. 307-319
    • Cappelleri, J.C.1    Rosen, R.C.2
  • 24
    • 59349091131 scopus 로고    scopus 로고
    • Screening for erectile dysfunction in men with lifelong premature ejaculation-Is the Sexual Health Inventory for Men (SHIM) reliable?
    • McMahon CG. Screening for erectile dysfunction in men with lifelong premature ejaculation-Is the Sexual Health Inventory for Men (SHIM) reliable? J Sex Med 2009;6:567-73.
    • (2009) J Sex Med , vol.6 , pp. 567-573
    • McMahon, C.G.1
  • 25
    • 1642492864 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors in rapid ejaculation: Potential use and possible mechanisms of action
    • Abdel-Hamid IA. Phosphodiesterase 5 inhibitors in rapid ejaculation: Potential use and possible mechanisms of action. Drugs 2004;64:13-26.
    • (2004) Drugs , vol.64 , pp. 13-26
    • Abdel-Hamid, I.A.1
  • 28
    • 0031903722 scopus 로고    scopus 로고
    • Effect of SSRI antidepressants on ejaculation: A double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline
    • Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: A double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 1998;18:274-81.
    • (1998) J Clin Psychopharmacol , vol.18 , pp. 274-281
    • Waldinger, M.D.1    Hengeveld, M.W.2    Zwinderman, A.H.3    Olivier, B.4
  • 29
    • 0037940276 scopus 로고    scopus 로고
    • Nitric oxide and the lower urinary tract: Current concepts, future prospects
    • Mamas MA, Reynard JM, Brading AF. Nitric oxide and the lower urinary tract: Current concepts, future prospects. Urology 2003;61:1079-85.
    • (2003) Urology , vol.61 , pp. 1079-1085
    • Mamas, M.A.1    Reynard, J.M.2    Brading, A.F.3
  • 30
    • 48749096829 scopus 로고    scopus 로고
    • Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies-Part I-Defining and selecting the study population
    • McMahon CG. Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies-Part I-Defining and selecting the study population. J Sex Med 2008;5:1805-16.
    • (2008) J Sex Med , vol.5 , pp. 1805-1816
    • McMahon, C.G.1
  • 31
    • 48749110142 scopus 로고    scopus 로고
    • Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies-Part II-Study design, outcome measures, data analysis, and reporting
    • McMahon CG. Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies-Part II-Study design, outcome measures, data analysis, and reporting. J Sex Med 2008;5:1817-33.
    • (2008) J Sex Med , vol.5 , pp. 1817-1833
    • McMahon, C.G.1
  • 32
    • 68149148161 scopus 로고    scopus 로고
    • Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation
    • Aversa A, Pili M, Francomano D, Bruzziches R, Spera E, La Pera G, Spera G. Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 2009;21:221-7.
    • (2009) Int J Impot Res , vol.21 , pp. 221-227
    • Aversa, A.1    Pili, M.2    Francomano, D.3    Bruzziches, R.4    Spera, E.5    La Pera, G.6    Spera, G.7
  • 34
    • 14544281524 scopus 로고    scopus 로고
    • Sexual problems among women and men aged 40-80y: Prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors
    • Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E, Wang T. Sexual problems among women and men aged 40-80y: Prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17:39-57.
    • (2005) Int J Impot Res , vol.17 , pp. 39-57
    • Laumann, E.O.1    Nicolosi, A.2    Glasser, D.B.3    Paik, A.4    Gingell, C.5    Moreira, E.6    Wang, T.7
  • 35
    • 0036378116 scopus 로고    scopus 로고
    • Management of premature ejaculation-A comparison of treatment outcome in patients with and without erectile dysfunction
    • Chia S. Management of premature ejaculation-A comparison of treatment outcome in patients with and without erectile dysfunction. Int J Androl 2002;25:301-5.
    • (2002) Int J Androl , vol.25 , pp. 301-305
    • Chia, S.1
  • 36
    • 65349133562 scopus 로고    scopus 로고
    • Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: A randomised, prospective and crossover study
    • Mathers MJ, Klotz T, Roth S, Lummen G, Sommer F. Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: A randomised, prospective and crossover study. Andrologia 2009;41:169-75.
    • (2009) Andrologia , vol.41 , pp. 169-175
    • Mathers, M.J.1    Klotz, T.2    Roth, S.3    Lummen, G.4    Sommer, F.5
  • 37
    • 0032702452 scopus 로고    scopus 로고
    • The effects of alterations in nitric oxide levels in the paraventricular nucleus on copulatory behavior and reflexive erections in male rats
    • Sato Y, Christ GJ, Horita H, Adachi H, Suzuki N, Tsukamoto T. The effects of alterations in nitric oxide levels in the paraventricular nucleus on copulatory behavior and reflexive erections in male rats. J Urol 1999;162:2182-5.
    • (1999) J Urol , vol.162 , pp. 2182-2185
    • Sato, Y.1    Christ, G.J.2    Horita, H.3    Adachi, H.4    Suzuki, N.5    Tsukamoto, T.6
  • 38
    • 0034804237 scopus 로고    scopus 로고
    • Central modulation of the NO/cGMP pathway affects the MPOA-induced intracavernous pressure response
    • Sato Y, Zhao W, Christ GJ. Central modulation of the NO/cGMP pathway affects the MPOA-induced intracavernous pressure response. Am J Physiol Regul Integr Comp Physiol 2001;281:R269-78.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Sato, Y.1    Zhao, W.2    Christ, G.J.3
  • 39
    • 0031401238 scopus 로고    scopus 로고
    • Co-localization of nitric oxide synthase, neuropeptides and tyrosine hydroxylase in nerves supplying the human post-natal vas deferens and seminal vesicle
    • Jen PY, Dixon JS, Gosling JA. Co-localization of nitric oxide synthase, neuropeptides and tyrosine hydroxylase in nerves supplying the human post-natal vas deferens and seminal vesicle. Br J Urol 1997;80:291-9.
    • (1997) Br J Urol , vol.80 , pp. 291-299
    • Jen, P.Y.1    Dixon, J.S.2    Gosling, J.A.3
  • 40
    • 0035800627 scopus 로고    scopus 로고
    • Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway
    • Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Brain Res 2001;909:170-8.
    • (2001) Brain Res , vol.909 , pp. 170-178
    • Jain, N.K.1    Patil, C.S.2    Singh, A.3    Kulkarni, S.K.4
  • 41
    • 31944433246 scopus 로고    scopus 로고
    • Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation
    • Atan A, Basar MM, Tuncel A, Ferhat M, Agras K, Tekdogan U. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology 2006;67:388-91.
    • (2006) Urology , vol.67 , pp. 388-391
    • Atan, A.1    Basar, M.M.2    Tuncel, A.3    Ferhat, M.4    Agras, K.5    Tekdogan, U.6
  • 42
    • 34247578775 scopus 로고    scopus 로고
    • Can sildenafil treat primary premature ejaculation? A prospective clinical study
    • Wang WF, Wang Y, Minhas S, Ralph DJ. Can sildenafil treat primary premature ejaculation? A prospective clinical study. Int J Urol 2007;14:331-5.
    • (2007) Int J Urol , vol.14 , pp. 331-335
    • Wang, W.F.1    Wang, Y.2    Minhas, S.3    Ralph, D.J.4
  • 43
    • 27344431918 scopus 로고    scopus 로고
    • Epidemiology of premature ejaculation
    • Jannini EA, Lenzi A. Epidemiology of premature ejaculation. Curr Opin Urol 2005;15:399-403.
    • (2005) Curr Opin Urol , vol.15 , pp. 399-403
    • Jannini, E.A.1    Lenzi, A.2
  • 44
    • 33846223486 scopus 로고    scopus 로고
    • The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: Prevalence, comorbidities, and professional help-seeking
    • discussion 824.
    • Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: Prevalence, comorbidities, and professional help-seeking. Eur Urol 2007;51:816-23; discussion 824.
    • (2007) Eur Urol , vol.51 , pp. 816-823
    • Porst, H.1    Montorsi, F.2    Rosen, R.C.3    Gaynor, L.4    Grupe, S.5    Alexander, J.6
  • 46
    • 0036468626 scopus 로고    scopus 로고
    • Nucleotide-evoked relaxation of rat vas deferens: Possible mechanisms
    • Bultmann R, Klebroff W, Starke K. Nucleotide-evoked relaxation of rat vas deferens: Possible mechanisms. Eur J Pharmacol 2002;436:135-43.
    • (2002) Eur J Pharmacol , vol.436 , pp. 135-143
    • Bultmann, R.1    Klebroff, W.2    Starke, K.3
  • 47
    • 59349099338 scopus 로고    scopus 로고
    • Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation
    • Uckert S, Bazrafshan S, Sonnenberg JE, Kuczyk MA. Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation. J Sex Med 2009;6:408-14.
    • (2009) J Sex Med , vol.6 , pp. 408-414
    • Uckert, S.1    Bazrafshan, S.2    Sonnenberg, J.E.3    Kuczyk, M.A.4
  • 49
    • 79951954522 scopus 로고    scopus 로고
    • Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?
    • Aversa A, Francomano D, Bruzziches R, Natali M, Spera G, Lenzi A. Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation? Int J Impot Res 2011;23:17-23.
    • (2011) Int J Impot Res , vol.23 , pp. 17-23
    • Aversa, A.1    Francomano, D.2    Bruzziches, R.3    Natali, M.4    Spera, G.5    Lenzi, A.6
  • 50
    • 0033963474 scopus 로고    scopus 로고
    • Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males
    • Aversa A, Mazzilli F, Rossi T, Delfino M, Isidori AM, Fabbri A. Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. Hum Reprod 2000;15:131-4.
    • (2000) Hum Reprod , vol.15 , pp. 131-134
    • Aversa, A.1    Mazzilli, F.2    Rossi, T.3    Delfino, M.4    Isidori, A.M.5    Fabbri, A.6
  • 51
    • 78751644211 scopus 로고    scopus 로고
    • In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: Placebo-controlled, double-blind, cross-over laboratory setting
    • Gokce A, Demirtas A, Halis F, Ekmekcioglu O. In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: Placebo-controlled, double-blind, cross-over laboratory setting. Int Urol Nephrol 2010;42:881-7.
    • (2010) Int Urol Nephrol , vol.42 , pp. 881-887
    • Gokce, A.1    Demirtas, A.2    Halis, F.3    Ekmekcioglu, O.4
  • 52
    • 41149130086 scopus 로고    scopus 로고
    • Tadalafil and fluoxetine in premature ejaculation: Prospective, randomized, double-blind, placebo-controlled study
    • Mattos RM, Marmo Lucon A, Srougi M. Tadalafil and fluoxetine in premature ejaculation: Prospective, randomized, double-blind, placebo-controlled study. Urol Int 2008;80:162-5.
    • (2008) Urol Int , vol.80 , pp. 162-165
    • Mattos, R.M.1    Marmo Lucon, A.2    Srougi, M.3
  • 53
    • 0036430071 scopus 로고    scopus 로고
    • Sexological approach to ejaculatory dysfunction
    • Jannini EA, Simonelli C, Lenzi A. Sexological approach to ejaculatory dysfunction. Int J Androl 2002;25:317-23.
    • (2002) Int J Androl , vol.25 , pp. 317-323
    • Jannini, E.A.1    Simonelli, C.2    Lenzi, A.3
  • 55
    • 61549096908 scopus 로고    scopus 로고
    • The sexual tipping point: A mind/body model for sexual medicine
    • Perelman MA. The sexual tipping point: A mind/body model for sexual medicine. J Sex Med 2009;6:629-32.
    • (2009) J Sex Med , vol.6 , pp. 629-632
    • Perelman, M.A.1
  • 57
    • 47949097219 scopus 로고    scopus 로고
    • Identifying constructs and criteria for the diagnosis of premature ejaculation: Implication for making errors of classification
    • Althof SE, Rowland DL. Identifying constructs and criteria for the diagnosis of premature ejaculation: Implication for making errors of classification. BJU Int 2008;102:708-12.
    • (2008) BJU Int , vol.102 , pp. 708-712
    • Althof, S.E.1    Rowland, D.L.2
  • 58
    • 85031231458 scopus 로고    scopus 로고
    • Development JJPRa. A prospective randomized, double-blind, placebo-controlled, parallel group, multicenter study of the efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with phosphodiesterase-5 inhibitor. In: Clinicaltrialsgov.
    • Development JJPRa. 2010 A prospective randomized, double-blind, placebo-controlled, parallel group, multicenter study of the efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with phosphodiesterase-5 inhibitor. In: Clinicaltrialsgov.
    • (2010)


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