Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation

Journal of Sexual Medicine

Volumn 6, Issue 10, 2009, Pages 2868-2877

  Salonia, Andrea ^a   Rocchini, Lorenzo ^a   Sacca', Antonino ^a   Pellucchi, Federico ^a   Ferrari, Matteo ^a   Carro, Ubaldo Del ^a   Ribotto, Paolo ^a   Gallina, Andrea ^a   Zanni, Giuseppe ^a   Deho', Federico ^a   Rigatti, Patrizio ^a   Montorsi, Francesco ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Acceptance; Discontinuation; Paroxetine; Premature ejaculation; Therapy; Treatment

Indexed keywords

PAROXETINE; ANTIDEPRESSANT AGENT; SEROTONIN UPTAKE INHIBITOR;

ADULT; ALLERGIC ASTHMA; ARTICLE; CHRONIC BRONCHITIS; CLINICAL TRIAL; COMORBIDITY; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; EJACULATION; ERECTILE DYSFUNCTION; GASTROINTESTINAL SYMPTOM; HEART INFARCTION; HUMAN; IRRITABILITY; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT ATTITUDE; PEPTIC ULCER; PERIPHERAL VASCULAR DISEASE; PHYSICAL EXAMINATION; PREMATURE EJACULATION; PRIORITY JOURNAL; SEXUAL BEHAVIOR; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESPONSE; ADOLESCENT; AGE; ATTITUDE TO HEALTH; DRUG EFFECTS; HEALTH STATUS INDICATOR; ITALY; MEDICATION COMPLIANCE; MIDDLE AGED; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; STATISTICS AND NUMERICAL DATA; TIME FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; EJACULATION; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HEALTH STATUS INDICATORS; HUMANS; ITALY; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PAROXETINE; SEROTONIN UPTAKE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TIME FACTORS; YOUNG ADULT;

EID: 70649113739     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01404.x     Document Type: Article

References (52)

1. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, Adaikan PG, Becher E, Broderick GA, Buvat J, Dabees K, Giraldi A, Giuliano F, Hellstrom WJ, Incrocci L, Laan E, Meuleman E, Perelman MA, Rosen RC, Rowland DL, Segraves R. An evidence-based definition of lifelong premature ejaculation: Report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008, 5:1590-606.
2. Waldinger MD, Schweitzer DH. The use of old and recent DSM definitions of premature ejaculation in observational studies: A contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med 2008, 5:1079-87.
3. Giuliano F, Patrick DL, Porst H, La Pera G, Kokoszka A, Merchant S, Rothman M, Gagnon DD, Polverejan E. Premature ejaculation: Results from a five-country European observational study. Eur Urol 2008, 53:1048-57.
4. Waldinger MD, Berendsen HHG, Blok BFM, Olivier B, Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: The involvement of the serotonergic system. Behav Brain Res 1998, 92:111-8.
5. de Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B. Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 2006, 30:893-907.
6. Giuliano F, Clement P. Serotonin and premature ejaculation: From physiology to patient management. Eur Urol 2006, 50:454-66.
7. Giuliano F. Interview with Dr François Giuliano (by Christine McKillop): New avenues in the pharmacological treatment of premature ejaculation. Eur Urol 2007, 52:1254-7.
8. Waldinger MD, Rietschel M, Nothen MM, Hengeveld MW, Olivier B. Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998, 8:37-40.
9. Jern P, Santtila P, Witting K, Alanko K, Harlaar N, Johansson A, von der Pahlen B, Varjonen M, Vikstrom N, Algars M, Sandnabba NK. Premature and delayed ejaculation: Genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med 2007, 4:1739-49.
10. Janssen PK, Bakker SC, Réthelyi J, Zwinderman AH, Touw DJ, Olivier B, Waldinger MD. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 2009, 6:276-84.
11. Waldinger MD. Premature ejaculation: Definition and drug treatment. Drugs 2007, 67:1-23.
12. Giuliano F, Hellstrom WJ. The pharmacological treatment of premature ejaculation. BJU Int 2008, 102:668-75.
13. Waldinger MD, Zwinderman AH, Schweitzer DH, Oliver B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis. Int J Impot Res 2004, 16:369-81.
14. Waldinger MD, Schweitzer DH, Olivier B. On-demand SSRI treatment of premature ejaculation: Pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2005, 2:121-31.
15. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. The majority of men with lifelong premature ejaculation prefer daily drug treatment: An observation study in a consecutive group of Dutch men. J Sex Med 2007, 4:1028-37.
16. McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 1999, 161:1826-30.
17. Sadeghi-Nejad H, Watson R. Premature ejaculation: Current medical treatment and new directions. J Sex Med 2008, 5:1037-50.
18. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: A critical review. J Clin Psychopharmacol 1999, 19:67-85.
19. Taman L, Ozpoyraz N. Selective serotonin reuptake inhibitor discontinuation syndrome: A review. Adv Ther 2002, 19:17-26.
20. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987, 40:373-83.
21. The ICD-9-CM version of the International classification of Diseases. http://www.cdc.gov/nchs/about/otheract/icd9/abticd9.htm, [No author listed, Available at:, accessed August 23, 2008
22. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49:822-30.
23. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: A double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994, 151:1377-9.
24. Meares EM, Stamey TA. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol 1968, 5:492-518.
25. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999, 54:346-51.
26. Rowland DL, Haensel SM, Blom JH, Slob AK. Penile sensitivity in men with premature ejaculation and erectile dysfunction. J Sex Marital Ther 1993, 19:189-97.
27. Xin ZC, Chung WS, Choi YD, Seong DH, Choi YJ, Choi HK. Penile sensitivity in patients with lifelong premature ejaculation. J Urol 1996, 156:979-81.
28. Paick JS, Jeong H, Park MS. Penile sensitivity in men with premature ejaculation. Int J Impot Res 1998, 10:247-50.
29. Colpi GM, Fanciullacci F, Beretta G, Negri L, Zanollo A. Evoked sacral potentials in subjects with true premature ejaculation. Andrologia 1986, 18:583-6.
30. Fanciullacci F, Colpi GM, Beretta G, Zanollo A. Cortical evoked potentials in subjects with true premature ejaculation. Andrologia 1988, 20:326-30.
31. Ozcan C, Ozbek E, Soylu A, Yilmaz U, Guzelipek M, Balbay MD. Auditory event-related potentials in patients with premature ejaculation. Urology 2001, 58:1025-9.
32. Son H, Park H, Kim SW, Paick JS. Reasons for discontinuation of sildenafil citrate after successful restoration of erectile function. Asian J Androl 2004, 6:117-20.
33. Klotz T, Mathers M, Klotz R, Sommer F. Why do patients with erectile dysfunction abandon effective therapy with sildenafil (Viagra®)?. Int J Impot Res 2005, 17:2-4.
34. Eardley I. Optimisation of PDE5 inhibitor therapy in men with erectile dysfunction: Converting " non-responders" into " responders. Eur Urol 2006, 50:31-3.
35. Gruenwald I, Shenfeld O, Chen J, Raviv G, Richter S, Cohen A, Vardi Y. Positive effect of counselling and dose adjustment in patients with erectile dysfunction who failed treatment with sildenafil. Eur Urol 2006, 50:134-40.
36. Salonia A, Abdollah F, Gallina A, Pellucchi F, Molina RA, Maccagnano C, Rocchini L, Zanni G, Rigatti P, Montorsi F. Does educational status affect a patient's behavior toward erectile dysfunction?. J Sex Med 2008, 5:1941-8.
37. Salonia A, Gallina A, Zanni G, Briganti A, Dehò F, Saccà A, Suardi N, Barbieri L, Guazzoni G, Rigatti P, Montorsi F. Acceptance of and discontinuation rate from erectile dysfunction oral treatment in patients following bilateral nerve-sparing radical prostatectomy. Eur Urol 2008, 53:564-70.
38. Moreira ED, Brock G, Glasser DB, Nicolosi A, Laumann EO, Paik A, Wang T, Gingell C. Help-seeking behaviour for sexual problems: The global study of sexual attitudes and behaviors. Int J Clin Pract 2005, 59:6-16.
39. Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: Prevalence, comorbidities, and professional help-seeking. Eur Urol 2007, 51:816-23.
40. Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: A double-blind, randomized, placebo-controlled study. BJU Int 2004, 93:1018-21.
41. Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, Callander M, Wylie K, Novak C, Keywood C, Heath P, Wyllie M. Topical eutectic mixture for premature ejaculation (TEMPE): A novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 2007, 99:369-75.
42. Kim SW, Paick JS. Short-term analysis of the effects of as needed use of sertraline at 5 pm for the treatment of premature ejaculation. Urology 1999, 54:544-7.
43. Akgül T, Karakan T, Ayyildiz A, Germiyanǒlu C. Comparison of sertraline and citalopram for treatment of premature ejaculation. Urol J 2008, 5:41-5.
44. Buvat J, Tesfaye F, Rothman M, Rivas DA, Giuliano F. Dapoxetine for the treatment of premature ejaculation: Results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 2009, 55:957-68.
45. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatr Clin Pract 1998, 2:287-93.
46. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: A randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004, 46:510-6.
47. Nicolosi A, Buvat J, Glasser DB, Hartmann U, Laumann EO, Gingell C. Sexual behaviour, sexual dysfunctions and related help-seeking patterns in middle-aged and elderly Europeans: The global study of sexual attitudes and behaviors. World J Urol 2006, 24:423-8.
48. McMahon CG. Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies-part II-study design, outcome measures, data analysis, and reporting. J Sex Med 2008, 5:1817-33.
49. Kaufman JM, Rosen RC, Mudumbi RV, Tesfaye F, Hashmonay R, Rivas D. Treatment benefit of dapoxetine for premature ejaculation: Results from a placebo-controlled phase III trial. BJU Int 2009, 103:651-8.
50. Waldinger MD, Schweitzer DH. Premature ejaculation and pharmaceutical company-based medicine: The dapoxetine case. J Sex Med 2008, 5:966-97.
51. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: An integrated analysis of two double-blind, randomised controlled trials. Lancet 2006, 368:929-37.
52. Shabsigh R, Patrick DL, Rowland DL, Bull SA, Tesfaye F, Rothman M. Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: Results from phase III trials with dapoxetine. BJU Int 2008, 102:824-8.