No difference in 5-httlpr and stin2 polymorphisms frequency between premature ejaculation patients and controls

Journal of Sexual Medicine

Volumn 9, Issue 6, 2012, Pages 1659-1668

  Zuccarello, Daniela ^a   Ghezzi, Marco ^a   Pengo, Manuel ^a   Forzan, Monica ^a   Frigo, Anna Chiara ^a   Ferlin, Alberto ^a   Foresta, Carlo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

5 HTTLPR; Premature Ejaculation; Serotonin transporter; SERT; SLC6A4; Stin2

Indexed keywords

5 HYDROXYTRYPTAMINE LINKED POLYMORPHIC REGION PROTEIN; FOLLITROPIN; GLUCOSE; LIOTHYRONINE; LUTEINIZING HORMONE; PROSTATE SPECIFIC ANTIGEN; SEROTONIN TRANSPORTER; STIN2 PROTEIN; TESTOSTERONE; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; EJACULATION; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INTRAVAGINAL EJACULATORY LATENCY TIME; LATENT PERIOD; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMISSION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREMATURE EJACULATION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

EID: 84861834203     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02715.x     Document Type: Article

References (29)

1. Waldinger MD. Lifelong premature ejaculation: Current debate on definition and treatment. J Mens Health Gend 2005;2:333-8.
2. Montorsi F. Prevalence of premature ejaculation: A global and regional perspective. J Sex Med 2005;2:96-102.
3. Waldinger MD. Toward evidence-based genetic research on lifelong premature ejaculation: A critical evaluation of methodology. Korean J Urol 2011;52:1-8.
4. Althof SE, Abdo CH, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger M, Becher E, Broderick GA, Buvat J, Goldstein I, El-Meliegy AI, Giuliano F, Hellstrom WJ, Incrocci L, Jannini EA, Park K, Parish S, Porst H, Rowland D, Segraves R, Sharlip I, Simonelli C, Tan HM; International Society for Sexual Medicine. International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 2010;7:2947-69.
5. Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002;168:2359-67.
6. Corona G, Jannini EA, Mannucci E, Fisher AD, Lotti F, Petrone L, Balercia G, Bandini E, Chiarini V, Forti G, Maggi M. Different testosterone levels are associated with ejaculatory dysfunction. J Sex Med 2008;5:1991-8.
7. Jern P, Santtila P, Witting K, Alanko K, Harlaar N, Johansson A, Von Der Pahlen B, Varjonen M, Vikström N, Ålgars M, Sandnabba K. Premature and delayed ejaculation: Genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med 2007;4:1739-49.
8. Jern P, Santtila P, Johansson A, Varjonen M, Witting K, von der Pahlen B, Sandnabba NK. Evidence for a genetic etiology to ejaculatory dysfunction. Int J Impot Res 2009;21:62-7.
9. Patel K, Hellstrom WJ. Central regulation of ejaculation and the therapeutic role of serotonergic agents in premature ejaculation. Curr Opin Investig Drugs 2009;10:681-90.
10. Waldinger MD, Berendsen HH, Blok BF, Olivier B, Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: The involvement of the serotonergic system. Behav Brain Res 1998;92:111-8.
11. Hull EM, Dominguez JM. Sexual behavior in male rodents. Horm Behav 2007;52:45-55.
12. Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP. A novel functional polymorphism within the promoter of the serotonin transporter gene: Possible role in susceptibility to affective disorders. Mol Psychiatry 1996;1:453-60.
13. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31.
14. Gunthert KC, Conner TS, Armeli S, Tennen H, Covault J, Kranzler HR. Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction. Psychosom Med 2007;69:762-8.
15. Lesch KP. Variation of serotonergic gene expression: Neurodevelopment and the complexity of response to psychopharmacologic drugs. Eur Neuropsychopharmacol 2001;11:457-74.
16. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, Schuckit MA. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 2005;29:8-16.
17. Zalsman G, Huang YY, Oquendo MA, Burke AK, Hu XZ, Brent DA, Ellis SP, Goldman D, Mann JJ. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 2006;163:1588-93.
18. Safarinejad MR. Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation. BJU Int 2010;105:73-8.
19. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-62.
20. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 1999;458:171-4.
21. Janssen PK, Bakker SC, Réthelyi J, Zwinderman AH, Touw DJ, Olivier B, Waldinger MD. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 2009;6:276-84.
22. Safarinejad MR. Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. J Urol 2009;181:2656-61.
23. Ozbek E, Tasci AI, Tugcu V, Ilbey YO, Simsek A, Ozcan L, Polat EC, Koksal V. Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population. Asian J Androl 2009;11:351-5.
24. Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A, Morris M. Development and validation of a premature ejaculation diagnostic tool. Eur Urol 2007;52:565-73.
25. Waldinger MD, Janssen PK, Schweitzer DH. Re: Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. M. R. Safarinejad. J Urol 2009;181:2656-61.
26. Comings DE. Behaviour genetics-Human. eLS. 2002.
27. Klenova E, Scott AC, Roberts J, Shamsuddin S, Lovejoy EA, Bergmann S, Bubb VJ, Royer HD, Quinn JP. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci 2004;24:5966-73.
28. Luo S, Lu Y, Wang F, Xie Z, Huang X, Dong Q, Zhang S. Association between polymorphisms in the serotonin 2C receptor gene and premature ejaculation in Han Chinese subjects. Urol Int 2010;85:204-8.
29. Santtila P, Jern P, Westberg L, Walum H, Pedersen CT, Eriksson E, Kenneth Sandnabba N. The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation. J Sex Med 2010;7:1538-46.