Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation

Journal of Sexual Medicine

Volumn 7, Issue 8, 2010, Pages 2860-2867

  Alghobary, Moheiddin ^a   El Bayoumy, Youssef ^a   Mostafa, Yosry ^a   Mahmoud, El Hassanin Mohamed ^a   Amr, Mostafa ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

Paroxetine; Premature Ejaculation; Selective Serotonin Reuptake Inhibitor; Tramadol

Indexed keywords

PAROXETINE; TRAMADOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; HUMAN; LATENT PERIOD; LIBIDO; LONG TERM CARE; MALE; PENIS ERECTION; PREMATURE EJACULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; SINGLE DRUG DOSE; STOMACH DISCOMFORT;

EID: 77955236668     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01789.x     Document Type: Article

References (26)

1. Kaplan HI, Saddock BJ. Human sexuality. Synopsis of psychiatry 1998, 689-97. Cancaro R, Edmondson JGabbard GOManley MPatacki CSSaddock V. eds., 8th, edition, Baltimore, MD, Lippincott Williams & Wilkins
2. Godpodinoff ML. Premature ejaculation: Clinical subgroups and etiology. J Sex Marital Ther 1989, 15:130-4.
3. Masters WH, Johnson VE. Human sexual inadequacy 1970, 92-115. Boston, MA, Little Brown
4. International classification of diseases and related health problems 1994, World Health Organization, 10th, edition, Geneva, world Health Organization
5. Diagnostic and Statistical manual of Mental Disorders, DSM-IV-TR 2000, American Psychiatric association, 4th edition Revised, Washington, DC, American Psychiatric Association
6. Arafa M, Shamloul R. Development and evaluation of the Arab Index of Premature ejaculation (AIPE). J Sex Med 2007, 4:1750-6.
7. An evidence-based definition of lifelong premature ejaculation: Report of the International Society for Sexual Medicine (ISSM) Ad Hoc committee for the definition of premature ejaculation. J Sex Med 2008, 5:1590-606.
8. Sadeghi-Nejad H, Watson R. Premature ejaculation: Current medical treatment and new directions. J Sex Med 2008, 5:1037-50.
9. Waldinger MD, Berendson HH, Blok BF, Olivier B, Holstege G. Premature ejaculation and serotonergic antidepressant- induced delayed ejaculation: The involvement of serotonergic system. Behav Brain Res 1998, 92:111-8.
10. Lue T, Broderick G. Evaluation and non-surgical management of erectile dysfunction and premature ejaculation. Campell-Walsh urology 2007, 750-87. Walsh PC, Retik ABVaughan EDWein AJKavoussi LRNovick ACPartin AWPeters CA. eds., 9th, edition, Vol. 1, Pheladelphia, PA, Saunders-Elsevier
11. Donatucci CF. Etiology of ejaculation and pathophysiology of premature ejaculation. J Sex Med 2006, 3:303-8. suppl
12. Screponi E, Carosa E, Di Stasi SM, Pepe M, Carruba J, Jannin EA. Prevalence of chronic prostatitis in men with premature ejaculation. Urology 2001, 58:198-202.
13. Richardson D, Goldmeier D. Premature ejaculation-does country of origin tell us anything about etiology? J Sex Med 2005, 2:508-12.
14. Rosen RC, Althof S. Impact of premature ejaculation: The psychological, quality of life and sexual relationship consequences. J Sex Med 2008, 5:1296-307.
15. Waldinger MD. Premature ejaculation definition and drug treatment. Drugs 2007, 67:547-68.
16. Waldinger MD, Schweitzer DH, Olivier B. On demand SSRI treatment of premature ejaculation: Pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2005, 2:120-30.
17. Blier P, de Montigny C. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci 1983, 3:1270-8.
18. Chaput Y, Blier P, de Montigny C. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J Neurosci 1986, 6:2796-801.
19. Blier P, Chaput Y, de Montigny C. Long-term 5-HT reuptake blockade but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: An electrophysiological study in the rat brain. Naunyn Schmiedeberg's Arch Pharmacol 1988, 337:246-54.
20. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: A randomized, double-blind fixed-dose study with stop watch assessment. Eur Urol 2004, 46:510-5. discussion 516
21. Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 2006, 26:27-31.
22. Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med 2008, 5:188-93.
23. Frink MC, Hennies HH, Engelberger W, Haurand M, Willfert B. Infeunce of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung 1996, 46:1029-36.
24. Raffa RB. Basic pharmacology relevant to drug abuse assessment: Tramadol as example. J Clin Pharmacol Ther 2008, 33:101-8.
25. Waldinger MD, Zwinderman AH, Olivier B, Schwietzer DH. The majority of men with lifelong premature ejaculation prefer daily treatment. An observation study in a consecutive group of Dutch men. J Sex Med 2007, 4:1028-37.
26. Salonia A, Rocchini L, Sacca A, Pelluchi F, Ferrari M, Carro U, Ribotto P, Gallina A, Zanni G, Deho F, Rigatti P, Montorsi F. Acceptance of and discontinuation rate from paroxetine treatment in patient with lifelong premature ejaculation. J Sex Med 2009, 6:2868-77.