Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation

Asian Journal of Andrology

Volumn 15, Issue 1, 2013, Pages 138-142

  Eassa, Bayoumy I ^a   El Shazly, Mohamed A ^b  

^a AL AZHAR UNIVERSITY   (Egypt)

^b MENOUFIA UNIVERSITY   (Egypt)

Author keywords

early ejaculation; erectile dysfunction; intravaginal ejaculation latency time; PE; premature climax; premature ejaculation; rapid ejaculation; tramadol

Indexed keywords

PLACEBO; TRAMADOL;

ADULT; ARTICLE; DIZZINESS; DRUG CAPSULE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; PENIS ERECTION; PREMATURE EJACULATION; PRURITUS; SEXUAL INTERCOURSE; SEXUAL SATISFACTION; SIDE EFFECT; SOMNOLENCE; VOMITING; XEROSTOMIA;

ADULT; COITUS; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT SATISFACTION; PREMATURE EJACULATION; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TRAMADOL; TREATMENT OUTCOME;

EID: 84872177778     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2012.96     Document Type: Article

References (61)

1. Barazani Y, Stahl JP, Nagler HM, Stember DS. Management of ejaculatory disorders in infertile men. Asian J Androl 2012; 12: 1-5.
2. Rosen R, Porst H, Montorsi F. The premature ejaculation prevalence and attitudes (PEPA) survey: A multi-national survey [abstract]. Proceedings of the 11th World Congress of the International Society of Sexual and Impotence Research 2004;17-21 October 2004.
3. Masters WH, Johnson VE. Human Sexual Inadequacy. Boston: Little, Brown and company; 1970. p29-115.
4. Rowland DL, Cooper SE, Schneider M. Defining early ejaculation for experimental and clinical investigations. Arch Sex Behav 2001; 30: 235.
5. Althof SE, Abdo CH, Dean J, Hackett G, McCabe M et al. International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 2010; 7: 2947-69.
6. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: A double-Blind, randomized, placebo-controlled study. Am J Psychiatry 1994; 151: 1377-9. (Pubitemid 24281766)
7. Waldinger MD. Four measures of investigating ejaculatory performance. J Sex Med 2007; 4: 520. (Pubitemid 46394728)
8. Schover LR, Friedman JM, Weiler SJ, Heiman Jr. LoPiccolo J. Multiaxial problemoriented system for sexual dysfunctions. Arch Gen Psychiat 1982; 39: 614.
9. Olivier B. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatry Clin Pract 1998; 2: 287-93. (Pubitemid 29023494)
10. Jannini EA, Lenzi A. Ejaculatory disorders: Epidemiology and current approaches to definition, classification and subtyping. World J Urol 2005; 23: 68-75. (Pubitemid 41051494)
11. McMahon CG. Long term results of treatment of premature ejaculation with selective serotonin re-Uptake inhibitors. Int J Impot Res 2002; 14: S19.
12. Godpodinoff ML. Premature ejaculation: Clinical subgroups and etiology. J Sex Marital Ther 1989; 15: 130-4. (Pubitemid 19213787)
13. El-Nashaar A, Shamloul R. Antibiotic treatment can delay ejaculation in patients with premature ejaculation and chronic bacterial prostatitis. J Sex Med 2007; 4: 491-6. (Pubitemid 46394723)
14. Cihan A, Demir O, Demir T, Aslan G, Comlekci A et al. The relationship between premature ejaculation and hyperthyroidism. J Urol 2009; 181: 1273-80.
15. Goldstein I. Premature to early ejaculation: A sampling of manuscripts regarding the most common male sexual dysfunction published in the IJIR. J Sex Med 2003; 15: 307-8. (Pubitemid 37376932)
16. Flick K, Frankus E. 1-(m-Substituted Phenyl)-2-Aminomethyl Cyclohexanols, issued 28 March 1972.
17. Gobbi M, Moia M, Pirona L, Ceglia I, Reyes-ParadaMet al. P-Methylthioamphetamine and 1-(m-chlorophenyl) piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. J Neurochem 2002; 82: 1435-43.
18. Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B. Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung 1996; 46: 1029-36. (Pubitemid 26391736)
19. Dayer P, Desmeules J, Collart L. Pharmacology of tramadol. Drugs 1997; 53: SUPPL2: 18-24.
20. Choi1 HK, Xin ZC, Choi YD, Lee WH, Mah SY et al. Safety and efficacy study with various doses of SS-cream in patients with premature ejaculation in a double-Blind, randomized, placebo controlled clinical study. Int J Impot Res 1999; 11: 261-4 (Pubitemid 29505065)
21. Xin ZC, Chung WS, Choi YD, Seong DH, Choi YJ et al. Penile sensitivity in patients with primary premature ejaculation. J Urol 1996; 156: 979-81. (Pubitemid 26269813)
22. Park HJ, Park JK, Park K, Lee SW, Kim SW et al. Prevalence of premature ejaculation in young and middle-Aged men in Korea: A multicenter internet-Based survey from the Korean Andrological Society. Asian J Androl 2010; 12: 880-9.
23. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JP et al. AUA Erectile Dysfunction Guideline Update Panel. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 2004; 172: 290-4.
24. Kaplan HS. The New Sex Therapy: Active Treatment of Sexual Dysfunctions. NewYork: Brunner/Mazel; 1974.
25. Waldinger M, Quinn P, Dilleen M, Mundayat R, Schweitzer D et al. A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005; 2: 292-7.
26. Morales A, Barada J, Wyllie MG. A review of the current status of topical treatments for premature ejaculation. BJU Int 2007; 100: 493-501. (Pubitemid 47205483)
27. Ashton K, Hamer R, Rosen R. Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: A large-Scale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther 1997; 23: 165.
28. Gitlin MJ. Treatment of sexual side effects with dopaminergic agents. J Clin Psychiatry 1995; 56: 124.
29. Palmer NR, Stuckey BG. Premature ejaculation: A clinical update. Med J Aust 2008; 188: 662-6.
30. Shindel A, Nelson C, Brandes S. Urologist practice patterns in the management of premature ejaculation: A nationwide survey. J Sex Med 2008; 5: 199-205.
31. Bettocchi C, Verze P, Palumbo F, Arcaniolo D, Mirone V. Ejaculatory disorders: Pathophysiology and management. Nat Clin Pract Urol 2008; 5: 93-103. (Pubitemid 351248098)
32. Althof SE, Levine SB, Corty EW, Risen CB, Stern EB et al. A double-Blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J Clin Psychiatry 1995; 56: 402-7.
33. Kim SC, Seo KK. Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: A double blind placebo controlled study. J Urol 1998; 159: 425-7. (Pubitemid 28049248)
34. Girgis SM, EL Haggar S, EL Hermouzy S. A double blind trial of clomipramine in premature ejaculation. Andrologia 1982; 14: 364-8. (Pubitemid 12067626)
35. Fein RL. Intracavernous medication for treatment of premature ejaculation. Urology 1990; 35: 301-3. (Pubitemid 20136957)
36. Haensel SM, Rowland DL, Kallan KT. Clomipramine and sexual function in men with premature ejaculation and controls. J Urol 1996; 156: 1310-5. (Pubitemid 26307601)
37. Kim SW, Paick JS. Short-Term analysis of the effects of as needed use of sertraline at 5 pm for the treatment of premature ejaculation. Urology 1999; 54: 544-7. (Pubitemid 29407036)
38. Basar MM, Yilmaz E, Ferhat M, Basar H, Batislam E. Terazosin in the treatment of premature ejaculation: A short-Term follow-Up. Int Urol Nephrol 2005; 37: 773-7. (Pubitemid 43124245)
39. Alghobary M, El-Bayoumy Y, Mostafa Y, Mahmoud EH, Amr M. Evaluation of tramadol on demand vs. daily paroxetine as a long-Term treatment of lifelong premature ejaculation. J Sex Med 2010; 7: 2860-7.
40. Gurkan L, Oommen M, Hellstrom WJ. Premature ejaculation: Current and future treatments. Asian J Androl 2008; 10: 102-9.
41. Melnik T, Althof S, Atallah AN, Puga ME, Glina S et al. Psychosocial interventions for premature ejaculation. Cochrane Database Syst Rev 2011; 10: CD008195.
42. Salem EA, Wilson SK, Bissada NK, Delk II JR, Hellstrom WJ et al. Tramadol HCL has promise in on-Demand use to treat premature ejaculation. J Sex Med 2008; 5: 188-93.
43. McMahon C, Kim SW, Park NC, Chang CP, Rivas D et al. Dapoxetine 3003 Study Investigators. Treatment of premature ejaculation in the Asia-Pacific region: Results from a phase III double-Blind, parallel-Group study of dapoxetine. J Sex Med 2010; 7: 256-68.
44. Lintz W, Erlacin S, Frankus E, Uragg H. [Biotransformation of tramadol in man and animal (author's transl)]. Arzneimittelforschung 1981; 31: 1932-43. German (Pubitemid 12228508)
45. Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation. J Clin Psychopharmacol 2006; 26: 27-31.
46. Hellstrom WJ. Update on treatments for premature ejaculation. Int J Clin Pract 2011; 65: 16-26.
47. Bar-Or D, Salottolo KM, Orlando A, Winkler JV. A randomized double-Blind, placebocontrolled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol 2012; 61: 736-43.
48. Xiong GG, Wu FH, Chen SH, Yao WL. Safety and efficacy of tramadol hydrochloride with behavioral modification in the treatment of premature ejaculation. Zhonghua Nan Ke Xue. 2011; 17: 538-41.
49. Kaynar M, Kilic O, Yurdakul T. On-Demand tramadol hydrochloride use in premature ejaculation treatment. Urology 2012; 79: 145-9.
50. Cicero TJ, Adams EH, Geller A, Inciardi JA, Munoz A et al. A post marketing surveillance program to monitor Ultram (tramadol hydrochloride) abuse in the United States. Drug Alcohol Depend 1999; 57: 7-22. (Pubitemid 29452951)
51. Na?slund S, Dahlqvist R. Treatment with tramadol can give rise to dependence and abuse (Article in Swedish). Lakartidningen 2003; 100: 712-4. (Pubitemid 37463679)
52. Adams EH, Breiner S, Cicero TJ, Geller A, Inciardi JA et al. A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain. J Pain Symptom Manage 2006; 31: 465-76. (Pubitemid 43744403)
53. Hara K, Minami K, Sata T. The effects of tramadol and its metabolite on glycine, gamma-Amino butyric acid A, and N-methyl-D-Aspartate receptors expressed in Xenopus oocytes. Anesth Analg 2005; 100: 1400-5. (Pubitemid 40577394)
54. Ogata J, Minami K, Uezono Y, Okamoto T, Shiraishi M et al. The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg 2004; 98: 1401-6. (Pubitemid 38525599)
55. Shiraishi M, Minami K, Uezono Y, Yanagihara N, Shigematsu A et al. Inhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha 7 receptors. Br J Pharmacol 2002; 136: 207-16. (Pubitemid 34587667)
56. Shiga Y, Minami K, Shiraishi M, Uezono Y, Murasaki O et al. The inhibitory effects of tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M (3) receptors. Anesth Analg 2002; 95: 1269-73. (Pubitemid 35239123)
57. Paick J-S, Jeong H, Park M-S. Penile sensitivity in men with premature ejaculation. Int J Impot Res 1998; 10: 247-50. (Pubitemid 29020781)
58. Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinetic 2004; 43: 879-923. (Pubitemid 39447033)
59. Sadeghi-Nejad H, Watson R. Premature ejaculation, Current medical treatment and new directions. J Sex Med 2008; 5: 1037-50. (Pubitemid 351606695)
60. Xin ZC, Zhu YC, Yuan YM, Cui WS, Jin Z et al. Current therapeutic strategies for premature ejaculation and future perspectives. Asian J Androl 2011; 13: 550-7.
61. Mulhall JP. Current and future pharmacotherapeutic strategies in treatment of premature ejaculation. Urology 2006; 67: 9-16. (Pubitemid 43069246)