Paradoxical effect of TrkA inhibition in alzheimer's disease models

Journal of Alzheimer's Disease

Volumn 40, Issue 3, 2014, Pages 605-617

  Zhang, Qiang ^a   Descamps, Olivier ^a   Hart, Matthew J ^a,c   Poksay, Karen S ^a   Spilman, Patricia ^a   Kane, Darci J ^a   Gorostiza, Olivia ^a   John, Varghese ^a   Bredesen, Dale E ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Alzheimer's disease; amyloid protein precursor; A PPneo; GW441756; nerve growth factor; transcriptional activation; TrkA receptor

Indexed keywords

ADDN 1351; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GW 441756; PROTEIN TYROSINE KINASE A; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; DANUSERTIB; NERVE GROWTH FACTOR; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DEATH; CHEMISTRY; CHO CELL LINE; CRICETULUS; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MUTATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BENZAMIDES; CELL DEATH; CHO CELLS; CRICETULUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NERVE GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PYRAZOLES; RECEPTOR, TRKA; TRANSFECTION;

EID: 84901950701     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130017     Document Type: Article

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