Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca2+ release leading to catecholaminergic polymorphic ventricular tachycardia

Circulation

Volumn 124, Issue 6, 2011, Pages 682-694

  Suetomi, Takeshi ^a   Yano, Masafumi ^a   Uchinoumi, Hitoshi ^a   Fukuda, Masakazu ^a   Hino, Akihiro ^a   Ono, Makoto ^a   Xu, Xiaojuan ^a   Tateishi, Hiroki ^a   Okuda, Shinichi ^a   Doi, Masahiro ^a   Kobayashi, Shigeki ^a   Ikeda, Yasuhiro ^a   Yamamoto, Takeshi ^a   Ikemoto, Noriaki ^b,c   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

calcium; CPVT; ion channels; sarcoplasmic reticulum; ventricular tachycardia

Indexed keywords

CALCIUM; CYCLIC AMP; DANTROLENE; RYANODINE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONTROLLED STUDY; FLUORESCENCE; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; TREADMILL EXERCISE;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM; DANTROLENE; DIASTOLE; EPINEPHRINE; GENE KNOCK-IN TECHNIQUES; HUMANS; ION CHANNEL GATING; MICE; MICE, TRANSGENIC; MODELS, CARDIOVASCULAR; MOLECULAR SEQUENCE DATA; MUSCLE RELAXANTS, CENTRAL; MUTATION, MISSENSE; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RUNNING; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TACHYCARDIA, VENTRICULAR;

EID: 80051798088     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.023259     Document Type: Article

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