Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury

Toxicological Sciences

Volumn 137, Issue 1, 2014, Pages 234-248

  Laifenfeld, Daphna ^a   Qiu, Luping ^b   Swiss, Rachel ^b   Park, Jennifer ^a   Macoritto, Michael ^a   Will, Yvonne ^b   Younis, Husam S ^c   Lawton, Michael ^b  

^a Selventa   (United States)

^b PFIZER INC   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

Biological modeling; Liver; Risk assessment; Safety evaluation; Systems biology; Systems toxicology; Toxicogenomics

Indexed keywords

BUSPIRONE; ENTACAPONE; FINASTERIDE; FLUTAMIDE; GLAFENINE; LEFLUNOMIDE; LEVOFLOXACIN; METFORMIN; METHOTREXATE; NEFAZODONE; NIMESULIDE; ROSIGLITAZONE; SULINDAC; TOLCAPONE; TROVAFLOXACIN; VALDECOXIB; AUTACOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IDIOSYNCRATIC DRUG INDUCED LIVER INJURY; IN VITRO STUDY; INFLAMMATION; MALE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; NONHUMAN; RAT; TOXIC HEPATITIS; ANIMAL; ARTIFICIAL INTELLIGENCE; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; HEPG2 CELL LINE; LIVER; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY; PROCEDURES; RISK ASSESSMENT; RISK FACTOR; SPRAGUE DAWLEY RAT; SYSTEMS BIOLOGY; TIME; TOXICOGENETICS;

ANIMALIA; RATTUS;

ANIMALS; ARTIFICIAL INTELLIGENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HEP G2 CELLS; HUMANS; INFLAMMATION MEDIATORS; LIVER; MALE; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; RISK FACTORS; SYSTEMS BIOLOGY; TIME FACTORS; TOXICOGENETICS;

EID: 84891306505     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft232     Document Type: Article

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