Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress

Toxicology and Applied Pharmacology

Volumn 265, Issue 1, 2012, Pages 73-82

  Mohammad, Mohammad K ^a,b   Avila, Diana ^a,b   Zhang, Jingwen ^a,b   Barve, Shirish ^a,b   Arteel, Gavin ^a,b   McClain, Craig ^a,b,c   Joshi Barve, Swati ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; ER stress; Liver; Mitochondria; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ACROLEIN; ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE TRIPHOSPHATE; CASPASE INHIBITOR; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; LIVER NECROSIS; LIVER TOXICITY; MOLECULAR PATHOLOGY; OXIDATIVE STRESS; PROTEIN SECRETION; UPREGULATION;

ACROLEIN; ADENOSINE TRIPHOSPHATE; ANTIOXIDANTS; CASPASE INHIBITORS; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HEPATOCYTES; HUMANS; INDICATORS AND REAGENTS; MAP KINASE KINASE 4; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PERMEABILITY; PHOSPHOTRANSFERASES;

EID: 84867748150     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.09.021     Document Type: Article

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