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Volumn 74, Issue 7, 2014, Pages 719-728

Defining phenotypes in asthma: A step towards personalized medicine

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; AZITHROMYCIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; BRODALUMAB; BRONCHODILATING AGENT; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; CORTICOSTEROID; CYTOKINE; DUPILUMAB; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 5; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MACROLIDE; MEPOLIZUMAB; MONOCLONAL ANTIBODY; NAVARIXIN; OMALIZUMAB; RESLIZUMAB; TRALOKINUMAB;

EID: 84901848274     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-014-0213-9     Document Type: Review
Times cited : (59)

References (88)
  • 1
    • 0346334385 scopus 로고    scopus 로고
    • Clinical phenotypes of asthma
    • 10.1097/00063198-200401000-00008
    • Bel EH. Clinical phenotypes of asthma. Curr Opin Pulmonary Med. 2004;10(1):44-50.
    • (2004) Curr Opin Pulmonary Med , vol.10 , Issue.1 , pp. 44-50
    • Bel, E.H.1
  • 2
    • 0033025989 scopus 로고    scopus 로고
    • Difficult/therapy-resistant asthma: The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma European Respiratory Society
    • 1:STN:280:DyaK1MzktFektQ%3D%3D 10414427
    • Chung KF, Godard P, Adelroth E, Ayres J, Barnes N, Barnes P, et al. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma European Respiratory Society. Eur Respir J. 1999;13(5):1198-208.
    • (1999) Eur Respir J , vol.13 , Issue.5 , pp. 1198-1208
    • Chung, K.F.1    Godard, P.2    Adelroth, E.3    Ayres, J.4    Barnes, N.5    Barnes, P.6
  • 3
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions
    • American Thoracic Society
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med. 2000;162(6):2341-51.
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.6 , pp. 2341-2351
  • 4
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • 10.1016/S0140-6736(08)61452-X 18805339
    • Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008;372(9643):1107-19.
    • (2008) Lancet , vol.372 , Issue.9643 , pp. 1107-1119
    • Anderson, G.P.1
  • 5
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
    • 10.1016/j.jaci.2010.11.037 21281866
    • Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127(2):355-60.
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.2 , pp. 355-360
    • Lotvall, J.1    Akdis, C.A.2    Bacharier, L.B.3    Bjermer, L.4    Casale, T.B.5    Custovic, A.6
  • 6
    • 84890083503 scopus 로고    scopus 로고
    • Challenges in identifying asthma subgroups using unsupervised statistical learning techniques
    • 10.1164/rccm.201304-0694OC 24180417
    • Prosperi MC, Sahiner UM, Belgrave D, Sackesen C, Buchan IE, Simpson A, et al. Challenges in identifying asthma subgroups using unsupervised statistical learning techniques. Am J Respir Crit Care Med. 2013;188(11):1303-12.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.11 , pp. 1303-1312
    • Prosperi, M.C.1    Sahiner, U.M.2    Belgrave, D.3    Sackesen, C.4    Buchan, I.E.5    Simpson, A.6
  • 7
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    • 2822971 10.1164/rccm.200906-0896OC 19892860
    • Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315-23.
    • (2010) Am J Respir Crit Care Med , vol.181 , Issue.4 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3    Teague, W.G.4    Li, H.5    Li, X.6
  • 8
    • 79551500941 scopus 로고    scopus 로고
    • Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    • 3060668 10.1016/j.jaci.2010.11.015 21195471
    • Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127(2):382-389.e1-13.
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.2
    • Fitzpatrick, A.M.1    Teague, W.G.2    Meyers, D.A.3    Peters, S.P.4    Li, X.5    Li, H.6
  • 10
    • 80051537670 scopus 로고    scopus 로고
    • Identifying adult asthma phenotypes using a clustering approach
    • 1:STN:280:DC%2BC3Mjit1WltA%3D%3D 10.1183/09031936.00120810 21233270
    • Siroux V, Basagana X, Boudier A, Pin I, Garcia-Aymerich J, Vesin A, et al. Identifying adult asthma phenotypes using a clustering approach. Eur Respir J. 2011;38(2):310-7.
    • (2011) Eur Respir J , vol.38 , Issue.2 , pp. 310-317
    • Siroux, V.1    Basagana, X.2    Boudier, A.3    Pin, I.4    Garcia-Aymerich, J.5    Vesin, A.6
  • 11
    • 84878772362 scopus 로고    scopus 로고
    • Identification of asthma clusters in two independent Korean adult asthma cohorts
    • 10.1183/09031936.00100811 23060627
    • Kim TB, Jang AS, Kwon HS, Park JS, Chang YS, Cho SH, et al. Identification of asthma clusters in two independent Korean adult asthma cohorts. Eur Respir J. 2013;41(6):1308-14.
    • (2013) Eur Respir J , vol.41 , Issue.6 , pp. 1308-1314
    • Kim, T.B.1    Jang, A.S.2    Kwon, H.S.3    Park, J.S.4    Chang, Y.S.5    Cho, S.H.6
  • 12
    • 84875173354 scopus 로고    scopus 로고
    • Asthma phenotypes in Japanese adults - Their associations with the CCL5 and ADRB2 genotypes
    • 1:CAS:528:DC%2BC3sXltFCgsrs%3D 10.2332/allergolint.12-OA-0467 23267209
    • Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Yatagai Y, et al. Asthma phenotypes in Japanese adults - their associations with the CCL5 and ADRB2 genotypes. Allergol Int. 2013;62(1):113-21.
    • (2013) Allergol Int , vol.62 , Issue.1 , pp. 113-121
    • Kaneko, Y.1    Masuko, H.2    Sakamoto, T.3    Iijima, H.4    Naito, T.5    Yatagai, Y.6
  • 13
    • 84866371606 scopus 로고    scopus 로고
    • Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population
    • 1:CAS:528:DC%2BC38XhsVSjt7fE 3441500 10.1371/journal.pone.0044540 23028556
    • Patrawalla P, Kazeros A, Rogers L, Shao Y, Liu M, Fernandez-Beros ME, Shang S, Reibman J. Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population. PLoS ONE. 2012;7(9):e44540.
    • (2012) PLoS ONE , vol.7 , Issue.9 , pp. 44540
    • Patrawalla, P.1    Kazeros, A.2    Rogers, L.3    Shao, Y.4    Liu, M.5    Fernandez-Beros, M.E.6    Shang, S.7    Reibman, J.8
  • 15
  • 16
    • 84873083832 scopus 로고    scopus 로고
    • Identification of subtypes of refractory asthma in Korean patients by cluster analysis
    • 10.1007/s00408-012-9430-8 23143671
    • Jang AS, Kwon HS, Cho YS, Bae YJ, Kim TB, Park JS, et al. Identification of subtypes of refractory asthma in Korean patients by cluster analysis. Lung. 2013;191(1):87-93.
    • (2013) Lung , vol.191 , Issue.1 , pp. 87-93
    • Jang, A.S.1    Kwon, H.S.2    Cho, Y.S.3    Bae, Y.J.4    Kim, T.B.5    Park, J.S.6
  • 17
    • 84861008611 scopus 로고    scopus 로고
    • Cluster analysis of obesity and asthma phenotypes
    • 1:CAS:528:DC%2BC38XnslOqs74%3D 3350517 10.1371/journal.pone.0036631 22606276
    • Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, et al. Cluster analysis of obesity and asthma phenotypes. PLoS ONE. 2012;7(5):e36631.
    • (2012) PLoS ONE , vol.7 , Issue.5 , pp. 36631
    • Sutherland, E.R.1    Goleva, E.2    King, T.S.3    Lehman, E.4    Stevens, A.D.5    Jackson, L.P.6
  • 18
    • 84874063346 scopus 로고    scopus 로고
    • Obesity-associated severe asthma represents a distinct clinical phenotype: Analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI
    • 1:CAS:528:DC%2BC3sXjvVamurY%3D 10.1378/chest.12-0872 23064546
    • Gibeon D, Batuwita K, Osmond M, Heaney LG, Brightling CE, Niven R, et al. Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI. Chest. 2013;143(2):406-14.
    • (2013) Chest , vol.143 , Issue.2 , pp. 406-414
    • Gibeon, D.1    Batuwita, K.2    Osmond, M.3    Heaney, L.G.4    Brightling, C.E.5    Niven, R.6
  • 20
    • 84883546289 scopus 로고    scopus 로고
    • Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts
    • 10.1164/rccm.201301-0156OC 23777340
    • Boudier A, Curjuric I, Basagana X, Hazgui H, Anto JM, Bousquet J, et al. Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts. Am J Respir Crit Care Med. 2013;188(5):550-60.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.5 , pp. 550-560
    • Boudier, A.1    Curjuric, I.2    Basagana, X.3    Hazgui, H.4    Anto, J.M.5    Bousquet, J.6
  • 21
    • 5144221336 scopus 로고    scopus 로고
    • Can guideline-defined asthma control be achieved? the Gaining Optimal Asthma ControL study
    • 10.1164/rccm.200401-033OC 15256389
    • Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med. 2004;170(8):836-44.
    • (2004) Am J Respir Crit Care Med , vol.170 , Issue.8 , pp. 836-844
    • Bateman, E.D.1    Boushey, H.A.2    Bousquet, J.3    Busse, W.W.4    Clark, T.J.5    Pauwels, R.A.6
  • 22
    • 69249222635 scopus 로고    scopus 로고
    • Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: Present and future
    • 1:CAS:528:DC%2BD1MXhtVehu77O 10.1007/s00228-009-0682-z 19557399
    • Chung KF, Caramori G, Adcock IM. Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. Eur J Clin Pharmacol. 2009;65(9):853-71.
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.9 , pp. 853-871
    • Chung, K.F.1    Caramori, G.2    Adcock, I.M.3
  • 23
    • 84893513577 scopus 로고    scopus 로고
    • International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
    • 1:CAS:528:DC%2BC2cXls1Ggsb4%3D 10.1183/09031936.00202013 24337046
    • Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343-73.
    • (2014) Eur Respir J , vol.43 , pp. 343-373
    • Chung, K.F.1    Wenzel, S.E.2    Brozek, J.L.3    Bush, A.4    Castro, M.5    Sterk, P.J.6
  • 24
    • 20144386778 scopus 로고    scopus 로고
    • Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    • 1:CAS:528:DC%2BD2MXivV2ju7c%3D 10.1016/j.jaci.2004.12.1129 15805990
    • Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, et al. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005;115(4):720-7.
    • (2005) J Allergy Clin Immunol , vol.115 , Issue.4 , pp. 720-727
    • Deykin, A.1    Lazarus, S.C.2    Fahy, J.V.3    Wechsler, M.E.4    Boushey, H.A.5    Chinchilli, V.M.6
  • 25
    • 77951979415 scopus 로고    scopus 로고
    • Effects of steroid therapy on inflammatory cell subtypes in asthma
    • 10.1136/thx.2009.126722 19996343
    • Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax. 2010;65(5):384-90.
    • (2010) Thorax , vol.65 , Issue.5 , pp. 384-390
    • Cowan, D.C.1    Cowan, J.O.2    Palmay, R.3    Williamson, A.4    Taylor, D.R.5
  • 26
    • 77953141236 scopus 로고    scopus 로고
    • Effects of oral prednisone on sputum eosinophils and cytokines in patients with severe refractory asthma
    • 1:CAS:528:DC%2BC3cXovFCntLw%3D 10.1016/j.anai.2010.04.003 20568377
    • Dente FL, Bacci E, Bartoli ML, Cianchetti S, Costa F, Di Franco A, et al. Effects of oral prednisone on sputum eosinophils and cytokines in patients with severe refractory asthma. Ann Allergy Asthma Immunol. 2010;104(6):464-70.
    • (2010) Ann Allergy Asthma Immunol , vol.104 , Issue.6 , pp. 464-470
    • Dente, F.L.1    Bacci, E.2    Bartoli, M.L.3    Cianchetti, S.4    Costa, F.5    Di Franco, A.6
  • 27
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
    • 10.1016/S0140-6736(02)11679-5 12480423
    • Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002;360(9347):1715-21.
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6
  • 28
    • 84901761120 scopus 로고    scopus 로고
    • Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
    • Dec 8 [Epub ahead of print]
    • Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2013 Dec 8 [Epub ahead of print].
    • (2013) J Allergy Clin Immunol
    • Moore, W.C.1    Hastie, A.T.2    Li, X.3    Li, H.4    Busse, W.W.5    Jarjour, N.N.6
  • 29
    • 0036907604 scopus 로고    scopus 로고
    • Effects of montelukast and beclomethasone on airway function and asthma control
    • 1:CAS:528:DC%2BD3sXlvFegtw%3D%3D 10.1067/mai.2002.129413 12464949
    • Israel E, Chervinsky PS, Friedman B, van Bavel J, Skalky CS, Ghannam AF, et al. Effects of montelukast and beclomethasone on airway function and asthma control. J Allergy Clin Immunol. 2002;110(6):847-54.
    • (2002) J Allergy Clin Immunol , vol.110 , Issue.6 , pp. 847-854
    • Israel, E.1    Chervinsky, P.S.2    Friedman, B.3    Van Bavel, J.4    Skalky, C.S.5    Ghannam, A.F.6
  • 30
    • 0032698182 scopus 로고    scopus 로고
    • Neutrophilic inflammation in severe persistent asthma
    • 1:STN:280:DC%2BD3c%2FislKksQ%3D%3D 10.1164/ajrccm.160.5.9806170 10556116
    • Jatakanon A, Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1532-9.
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.5 PART 1 , pp. 1532-1539
    • Jatakanon, A.1    Uasuf, C.2    Maziak, W.3    Lim, S.4    Chung, K.F.5    Barnes, P.J.6
  • 31
    • 0242537115 scopus 로고    scopus 로고
    • Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma
    • 10.1164/rccm.200304-503OC 12893649
    • Chaudhuri R, Livingston E, McMahon AD, Thomson L, Borland W, Thomson NC. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med. 2003;168(11):1308-11.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.11 , pp. 1308-1311
    • Chaudhuri, R.1    Livingston, E.2    McMahon, A.D.3    Thomson, L.4    Borland, W.5    Thomson, N.C.6
  • 33
    • 84896725213 scopus 로고    scopus 로고
    • Characterization of factors associated with systemic corticosteroid use in severe asthma: Data from the Severe Asthma Research Program
    • 1:CAS:528:DC%2BC3sXitVWjsb3M 10.1016/j.jaci.2013.10.031 24332222
    • Wysocki K, Park SY, Bleecker E, Busse W, Castro M, Chung KF, et al. Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2014;133:915-8.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 915-918
    • Wysocki, K.1    Park, S.Y.2    Bleecker, E.3    Busse, W.4    Castro, M.5    Chung, K.F.6
  • 34
    • 84869119470 scopus 로고    scopus 로고
    • Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma
    • 1:CAS:528:DC%2BC38XhtlSgu73L 3578224 10.1016/j.jaci.2012.07.017 22947346
    • Chang PJ, Bhavsar PK, Michaeloudes C, Khorasani N, Chung KF. Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma. J Allergy Clin Immunol. 2012;130(4):877-885.e5.
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.4
    • Chang, P.J.1    Bhavsar, P.K.2    Michaeloudes, C.3    Khorasani, N.4    Chung, K.F.5
  • 35
    • 77951196142 scopus 로고    scopus 로고
    • Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
    • 1:CAS:528:DC%2BC3cXlvVWjsbY%3D 10.1183/09031936.00071309 19840967
    • Bhavsar P, Khorasani N, Hew M, Johnson M, Chung KF. Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma. Eur Respir J. 2010;35(4):750-6.
    • (2010) Eur Respir J , vol.35 , Issue.4 , pp. 750-756
    • Bhavsar, P.1    Khorasani, N.2    Hew, M.3    Johnson, M.4    Chung, K.F.5
  • 36
    • 0035315925 scopus 로고    scopus 로고
    • Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages
    • 1:CAS:528:DC%2BD3MXivFOrurc%3D 11292684
    • Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 2001;15(6):1110-2.
    • (2001) FASEB J , vol.15 , Issue.6 , pp. 1110-1112
    • Ito, K.1    Lim, S.2    Caramori, G.3    Chung, K.F.4    Barnes, P.J.5    Adcock, I.M.6
  • 37
    • 0036231010 scopus 로고    scopus 로고
    • P38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
    • 1:CAS:528:DC%2BD38XjslCrsrg%3D 10.1067/mai.2002.122465 11941315
    • Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol. 2002;109(4):649-57.
    • (2002) J Allergy Clin Immunol , vol.109 , Issue.4 , pp. 649-657
    • Irusen, E.1    Matthews, J.G.2    Takahashi, A.3    Barnes, P.J.4    Chung, K.F.5    Adcock, I.M.6
  • 38
    • 0030702823 scopus 로고    scopus 로고
    • Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
    • 1:CAS:528:DyaK2sXntFertbc%3D 2199113 10.1084/jem.186.9.1567 9348314
    • Leung DYM, Hamid Q, Vottero A, Szefler SJ, Surs W, Minshall E, et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med. 1997;186(9):1567-74.
    • (1997) J Exp Med , vol.186 , Issue.9 , pp. 1567-1574
    • Leung, D.Y.M.1    Hamid, Q.2    Vottero, A.3    Szefler, S.J.4    Surs, W.5    Minshall, E.6
  • 40
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • 1:STN:280:DyaK1Mvgtlanuw%3D%3D 10.1164/ajrccm.160.3.9812110 10471631
    • Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160(3):1001-8.
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.3 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6
  • 41
    • 78650864775 scopus 로고    scopus 로고
    • Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    • 1:CAS:528:DC%2BC3MXjs1ehtg%3D%3D 10.1016/j.jaci.2010.10.024 21211650
    • Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol. 2011;127(1):153-160.e1-9.
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.1
    • Baines, K.J.1    Simpson, J.L.2    Wood, L.G.3    Scott, R.J.4    Gibson, P.G.5
  • 42
    • 77951665424 scopus 로고    scopus 로고
    • Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    • 1:CAS:528:DC%2BC3cXlvVWmtb4%3D 2878277 10.1016/j.jaci.2010.02.008 20398920
    • Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010;125(5):1028- 1036.e13.
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.5
    • Hastie, A.T.1    Moore, W.C.2    Meyers, D.A.3    Vestal, P.L.4    Li, H.5    Peters, S.P.6
  • 43
    • 84859793554 scopus 로고    scopus 로고
    • Bacteria in sputum of stable severe asthma and increased airway wall thickness
    • 3351013 10.1186/1465-9921-13-35 22513083
    • Zhang Q, Illing R, Hui CK, Downey K, Carr D, Stearn M, et al. Bacteria in sputum of stable severe asthma and increased airway wall thickness. Respir Res. 2012;13:35.
    • (2012) Respir Res , vol.13 , pp. 35
    • Zhang, Q.1    Illing, R.2    Hui, C.K.3    Downey, K.4    Carr, D.5    Stearn, M.6
  • 44
    • 74549186515 scopus 로고    scopus 로고
    • Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    • 1:CAS:528:DC%2BC3cXlvFahsw%3D%3D 10.3109/10715760903362576 19922242
    • Wood LG, Simpson JL, Hansbro PM, Gibson PG. Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res. 2010;44(2):146-54.
    • (2010) Free Radic Res , vol.44 , Issue.2 , pp. 146-154
    • Wood, L.G.1    Simpson, J.L.2    Hansbro, P.M.3    Gibson, P.G.4
  • 45
    • 44649183243 scopus 로고    scopus 로고
    • Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    • 1:CAS:528:DC%2BD1cXmvV2ktb0%3D 2442216 10.1016/j.jaci.2008.03.008 18417198
    • Fitzpatrick AM, Holguin F, Teague WG, Brown LA. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol. 2008;121(6):1372-8.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.6 , pp. 1372-1378
    • Fitzpatrick, A.M.1    Holguin, F.2    Teague, W.G.3    Brown, L.A.4
  • 46
    • 26944476623 scopus 로고    scopus 로고
    • Defective apoptotic cell phagocytosis attenuates PGE2 and 15-HETE in severe asthma alveolar macrophages
    • 10.1164/rccm.200501-035OC 16040786
    • Huynh ML, Malcolm KC, Kotaru C, Tilstra JA, Westcott JY, Fadok VA, et al. Defective apoptotic cell phagocytosis attenuates PGE2 and 15-HETE in severe asthma alveolar macrophages. Am J Respir Crit Care Med. 2005;172:972-9.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 972-979
    • Huynh, M.L.1    Malcolm, K.C.2    Kotaru, C.3    Tilstra, J.A.4    Westcott, J.Y.5    Fadok, V.A.6
  • 47
    • 12144261115 scopus 로고    scopus 로고
    • Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma
    • 10.1016/j.rmed.2004.06.007 15715187
    • Nguyen LT, Lim S, Oates T, Chung KF. Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. Respir Med. 2005;99(2):200-7.
    • (2005) Respir Med , vol.99 , Issue.2 , pp. 200-207
    • Nguyen, L.T.1    Lim, S.2    Oates, T.3    Chung, K.F.4
  • 48
    • 39449123817 scopus 로고    scopus 로고
    • Differences in airway cytokine profile in severe asthma compared to moderate asthma
    • 1:CAS:528:DC%2BD1cXjtFemsL8%3D 10.1378/chest.07-1881 18071017
    • Shannon J, Ernst P, Yamauchi Y, Olivenstein R, Lemiere C, Foley S, et al. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest. 2008;133(2):420-6.
    • (2008) Chest , vol.133 , Issue.2 , pp. 420-426
    • Shannon, J.1    Ernst, P.2    Yamauchi, Y.3    Olivenstein, R.4    Lemiere, C.5    Foley, S.6
  • 50
    • 35649028488 scopus 로고    scopus 로고
    • Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    • 1:CAS:528:DC%2BD2sXhtFGitbjI 2000427 10.1073/pnas.0707413104 17898169
    • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA. 2007;104(40):15858-63.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.40 , pp. 15858-15863
    • Woodruff, P.G.1    Boushey, H.A.2    Dolganov, G.M.3    Barker, C.S.4    Yang, Y.H.5    Donnelly, S.6
  • 51
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • 1:CAS:528:DC%2BD1MXhtFOju7vI 2742757 10.1164/rccm.200903-0392OC 19483109
    • Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180(5):388-95.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.5 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3    Jia, G.4    Abbas, A.R.5    Ellwanger, A.6
  • 52
    • 84895064176 scopus 로고    scopus 로고
    • Measures of gene expression in sputum cells can identify T2-high and T2-low subtypes of asthma
    • 1:CAS:528:DC%2BC3sXhsFemtr7J 3981552 10.1016/j.jaci.2013.07.036 24075231
    • Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify T2-high and T2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133:388-94.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 388-394
    • Peters, M.C.1    Mekonnen, Z.K.2    Yuan, S.3    Bhakta, N.R.4    Woodruff, P.G.5    Fahy, J.V.6
  • 53
    • 52049113214 scopus 로고    scopus 로고
    • New targets for drug development in asthma
    • 1:CAS:528:DC%2BD1cXhtFektrfK 10.1016/S0140-6736(08)61449-X 18805336
    • Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma. Lancet. 2008;372(9643):1073-87.
    • (2008) Lancet , vol.372 , Issue.9643 , pp. 1073-1087
    • Adcock, I.M.1    Caramori, G.2    Chung, K.F.3
  • 54
    • 84860655039 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in asthma
    • 1:CAS:528:DC%2BC38XmsFOqtbY%3D 10.1038/nm.2731 22561831
    • Holgate ST. Innate and adaptive immune responses in asthma. Nat Med. 2012;18(5):673-83.
    • (2012) Nat Med , vol.18 , Issue.5 , pp. 673-683
    • Holgate, S.T.1
  • 55
    • 84885037157 scopus 로고    scopus 로고
    • New treatments for severe treatment-resistant asthma: Targeting the right patient
    • 1:CAS:528:DC%2BC2cXotFClsg%3D%3D 10.1016/S2213-2600(13)70128-0 24461667
    • Chung KF. New treatments for severe treatment-resistant asthma: targeting the right patient. Lancet Respir Med. 2013;1:639-52.
    • (2013) Lancet Respir Med , vol.1 , pp. 639-652
    • Chung, K.F.1
  • 56
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • 1:CAS:528:DC%2BD2MXivVOgurc%3D 10.1111/j.1398-9995.2004.00772.x 15679715
    • Humbert M, Beasley R, Ayres J, Slavin R, Hebert J, Bousquet J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309-16.
    • (2005) Allergy , vol.60 , Issue.3 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3    Slavin, R.4    Hebert, J.5    Bousquet, J.6
  • 57
    • 79952795093 scopus 로고    scopus 로고
    • Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
    • 1:CAS:528:DC%2BC3MXjtlSlsbs%3D 3093964 10.1056/NEJMoa1009705 21410369
    • Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011;364(11):1005-15.
    • (2011) N Engl J Med , vol.364 , Issue.11 , pp. 1005-1015
    • Busse, W.W.1    Morgan, W.J.2    Gergen, P.J.3    Mitchell, H.E.4    Gern, J.E.5    Liu, A.H.6
  • 58
    • 79955751312 scopus 로고    scopus 로고
    • Omalizumab in severe allergic asthma inadequately controlled with standard therapy: A randomized trial
    • 10.7326/0003-4819-154-9-201105030-00002 21536936
    • Hanania NA, Alpan O, Hamilos DL, Condemi JJ, Reyes-Rivera I, Zhu J, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med. 2011;154(9):573-82.
    • (2011) Ann Intern Med , vol.154 , Issue.9 , pp. 573-582
    • Hanania, N.A.1    Alpan, O.2    Hamilos, D.L.3    Condemi, J.J.4    Reyes-Rivera, I.5    Zhu, J.6
  • 59
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
    • 1:CAS:528:DC%2BC3sXnsVGhsrk%3D 10.1164/rccm.201208-1414OC 23471469
    • Hanania NA, Wenzel S, Rosen K, Hsieh HJ, Mosesova S, Choy DF, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med. 2013;187(8):804-11.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.8 , pp. 804-811
    • Hanania, N.A.1    Wenzel, S.2    Rosen, K.3    Hsieh, H.J.4    Mosesova, S.5    Choy, D.F.6
  • 60
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • 1:CAS:528:DC%2BD1cXhvFSgtQ%3D%3D 10.1164/rccm.200701-085OC 17872493
    • Flood-Page P, Swenson C, Faiferman I, Matthews J, Williams M, Brannick L, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med. 2007;176(11):1062-71.
    • (2007) Am J Respir Crit Care Med , vol.176 , Issue.11 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3    Matthews, J.4    Williams, M.5    Brannick, L.6
  • 61
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • 1:CAS:528:DC%2BD1MXislOlsLs%3D 3992367 10.1056/NEJMoa0808991 19264686
    • Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360(10):973-84.
    • (2009) N Engl J Med , vol.360 , Issue.10 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3    Gupta, S.4    Monteiro, W.5    Sousa, A.6
  • 62
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • 1:CAS:528:DC%2BC3MXhs1ejsLnL 10.1164/rccm.201103-0396OC 21852542
    • Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011;184(10):1125-32.
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.10 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Boulet, L.P.4    Xie, F.5    Young, J.6
  • 63
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • 1:CAS:528:DC%2BD1MXislOlsLg%3D 10.1056/NEJMoa0805435 19264687
    • Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360(10):985-93.
    • (2009) N Engl J Med , vol.360 , Issue.10 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3    Inman, M.D.4    Efthimiadis, A.5    Pizzichini, E.6
  • 64
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • 1:CAS:528:DC%2BC38Xht1aksLfE 10.1016/S0140-6736(12)60988-X 22901886
    • Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651-9.
    • (2012) Lancet , vol.380 , Issue.9842 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 65
    • 84864292663 scopus 로고    scopus 로고
    • Targeting interleukin-4 in asthma: Lost in translation?
    • 1:CAS:528:DC%2BC38XhtlCjsrrI 10.1165/rcmb.2012-0080TR 22538865
    • Maes T, Joos GF, Brusselle GG. Targeting interleukin-4 in asthma: lost in translation? Am J Respir Cell Mol Biol. 2012;47(3):261-70.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , Issue.3 , pp. 261-270
    • Maes, T.1    Joos, G.F.2    Brusselle, G.G.3
  • 66
    • 77953039047 scopus 로고    scopus 로고
    • A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
    • 1:CAS:528:DC%2BC3cXhtFahsb7O 10.1164/rccm.200909-1448OC 20056900
    • Corren J, Busse W, Meltzer EO, Mansfield L, Bensch G, Fahrenholz J, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med. 2010;181(8):788-96.
    • (2010) Am J Respir Crit Care Med , vol.181 , Issue.8 , pp. 788-796
    • Corren, J.1    Busse, W.2    Meltzer, E.O.3    Mansfield, L.4    Bensch, G.5    Fahrenholz, J.6
  • 67
    • 84879401471 scopus 로고    scopus 로고
    • Dupilumab in persistent asthma with elevated eosinophil levels
    • 1:CAS:528:DC%2BC3sXhtFajsLfN 10.1056/NEJMoa1304048 23688323
    • Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013;368:2455-66.
    • (2013) N Engl J Med , vol.368 , pp. 2455-2466
    • Wenzel, S.1    Ford, L.2    Pearlman, D.3    Spector, S.4    Sher, L.5    Skobieranda, F.6
  • 69
    • 84873389433 scopus 로고    scopus 로고
    • A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
    • 1:CAS:528:DC%2BC3sXjsVKitrw%3D 3561510 10.1183/09031936.00223411 22743678
    • Piper E, Brightling C, Niven R, Oh C, Faggioni R, Poon K, et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma. Eur Respir J. 2013;41(2):330-8.
    • (2013) Eur Respir J , vol.41 , Issue.2 , pp. 330-338
    • Piper, E.1    Brightling, C.2    Niven, R.3    Oh, C.4    Faggioni, R.5    Poon, K.6
  • 70
    • 84862519263 scopus 로고    scopus 로고
    • Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: A randomized, placebo-controlled clinical trial
    • 1:CAS:528:DC%2BC38Xht1Kkt7nJ 10.1111/j.1365-2222.2012.04014.x 22702508
    • Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O'Byrne PM, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2012;42(7):1097-103.
    • (2012) Clin Exp Allergy , vol.42 , Issue.7 , pp. 1097-1103
    • Nair, P.1    Gaga, M.2    Zervas, E.3    Alagha, K.4    Hargreave, F.E.5    O'Byrne, P.M.6
  • 71
    • 38348998987 scopus 로고    scopus 로고
    • Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    • 1:CAS:528:DC%2BD1cXhvFGgt70%3D 10.1164/rccm.200707-1134OC 17947611
    • Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med. 2008;177(2):148-55.
    • (2008) Am J Respir Crit Care Med , vol.177 , Issue.2 , pp. 148-155
    • Simpson, J.L.1    Powell, H.2    Boyle, M.J.3    Scott, R.J.4    Gibson, P.G.5
  • 72
    • 84875219719 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations in severe asthma (AZISAST): A multicentre randomised double-blind placebo-controlled trial
    • 10.1136/thoraxjnl-2012-202698 23291349
    • Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013;68(4):322-9.
    • (2013) Thorax , vol.68 , Issue.4 , pp. 322-329
    • Brusselle, G.G.1    Vanderstichele, C.2    Jordens, P.3    Deman, R.4    Slabbynck, H.5    Ringoet, V.6
  • 73
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
    • 1:CAS:528:DC%2BC2cXhtVKqs7c%3D 10.1164/rccm.201212-2318OC 24200404
    • Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med. 2013;188(11):1294-302.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.11 , pp. 1294-1302
    • Busse, W.W.1    Holgate, S.2    Kerwin, E.3    Chon, Y.4    Feng, J.5    Lin, J.6
  • 74
    • 84860011737 scopus 로고    scopus 로고
    • The investigation of severe asthma to define phenotypes
    • 1:STN:280:DC%2BC38rmt1Oluw%3D%3D 10.1111/j.1365-2222.2012.03959.x 22515390
    • Gibeon D, Chung KF. The investigation of severe asthma to define phenotypes. Clin Exp Allergy. 2012;42(5):678-92.
    • (2012) Clin Exp Allergy , vol.42 , Issue.5 , pp. 678-692
    • Gibeon, D.1    Chung, K.F.2
  • 75
    • 83155181425 scopus 로고    scopus 로고
    • Inflammatory biomarkers in severe asthma
    • 1:CAS:528:DC%2BC3MXhsFOgt7fE 10.1097/MCP.0b013e32834d09a5
    • Chung KF. Inflammatory biomarkers in severe asthma. Curr Opin Pulmonary Med. 2012;18(1):35-41.
    • (2012) Curr Opin Pulmonary Med , vol.18 , Issue.1 , pp. 35-41
    • Chung, K.F.1
  • 76
    • 80052438246 scopus 로고    scopus 로고
    • An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications
    • 1:CAS:528:DC%2BC3MXhtlWqtrfM 10.1164/rccm.9120-11ST 21885636
    • Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602-15.
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.5 , pp. 602-615
    • Dweik, R.A.1    Boggs, P.B.2    Erzurum, S.C.3    Irvin, C.G.4    Leigh, M.W.5    Lundberg, J.O.6
  • 77
    • 84865696394 scopus 로고    scopus 로고
    • Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
    • 1:CAS:528:DC%2BC38XhtFeitLbK 3626285 10.1016/j.jaci.2012.06.025 22857879
    • Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012;130(3):647-654.e10.
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.3
    • Jia, G.1    Erickson, R.W.2    Choy, D.F.3    Mosesova, S.4    Wu, L.C.5    Solberg, O.D.6
  • 78
    • 84881180798 scopus 로고    scopus 로고
    • Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
    • 1:CAS:528:DC%2BC3sXpvVyks7g%3D 10.1016/j.jaci.2013.04.050 23791506
    • Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013;132(2):305-312. e3.
    • (2013) J Allergy Clin Immunol , vol.132 , Issue.2
    • Kanemitsu, Y.1    Matsumoto, H.2    Izuhara, K.3    Tohda, Y.4    Kita, H.5    Horiguchi, T.6
  • 79
    • 84871722995 scopus 로고    scopus 로고
    • Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma
    • 1:CAS:528:DC%2BC38Xhs1KqsLzM 10.1016/j.jaci.2012.10.005 23146380
    • Saito J, Zhang Q, Hui C, Macedo P, Gibeon D, Menzies-Gow A, et al. Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma. J Allergy Clin Immunol. 2013;131(1):232-234.e1-3.
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.1
    • Saito, J.1    Zhang, Q.2    Hui, C.3    MacEdo, P.4    Gibeon, D.5    Menzies-Gow, A.6
  • 80
    • 84867404390 scopus 로고    scopus 로고
    • Epigenetics in asthma and COPD
    • 1:CAS:528:DC%2BC38XhtFKit7vN 10.1016/j.biochi.2012.07.017 22874820
    • Kabesch M, Adcock IM. Epigenetics in asthma and COPD. Biochimie. 2012;94(11):2231-41.
    • (2012) Biochimie , vol.94 , Issue.11 , pp. 2231-2241
    • Kabesch, M.1    Adcock, I.M.2
  • 81
    • 84455191835 scopus 로고    scopus 로고
    • Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma
    • 1:CAS:528:DC%2BC3MXhs1yrsb7K 10.1016/j.jaci.2011.08.011 21917308
    • Tsitsiou E, Williams AE, Moschos SA, Patel K, Rossios C, Jiang X, et al. Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. J Allergy Clin Immunol. 2012;129(1):95-103.
    • (2012) J Allergy Clin Immunol , vol.129 , Issue.1 , pp. 95-103
    • Tsitsiou, E.1    Williams, A.E.2    Moschos, S.A.3    Patel, K.4    Rossios, C.5    Jiang, X.6
  • 82
    • 80053173026 scopus 로고    scopus 로고
    • Network analysis of quantitative proteomics on asthmatic bronchi: Effects of inhaled glucocorticoid treatment
    • 3206435 10.1186/1465-9921-12-124 21939520
    • O'Neil SE, Sitkauskiene B, Babusyte A, Krisiukeniene A, Stravinskaite-Bieksiene K, Sakalauskas R, et al. Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment. Respir Res. 2011;12:124.
    • (2011) Respir Res , vol.12 , pp. 124
    • O'Neil, S.E.1    Sitkauskiene, B.2    Babusyte, A.3    Krisiukeniene, A.4    Stravinskaite-Bieksiene, K.5    Sakalauskas, R.6
  • 83
    • 44449119819 scopus 로고    scopus 로고
    • A protein interaction network associated with asthma
    • 1:CAS:528:DC%2BD1cXms1ajs7k%3D 10.1016/j.jtbi.2008.02.011 18395227
    • Hwang S, Son SW, Kim SC, Kim YJ, Jeong H, Lee D. A protein interaction network associated with asthma. J Theor Biol. 2008;252(4):722-31.
    • (2008) J Theor Biol , vol.252 , Issue.4 , pp. 722-731
    • Hwang, S.1    Son, S.W.2    Kim, S.C.3    Kim, Y.J.4    Jeong, H.5    Lee, D.6
  • 84
    • 77953303583 scopus 로고    scopus 로고
    • An integrative systems biology approach to understanding pulmonary diseases
    • 10.1378/chest.09-1850 20525651
    • Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010;137(6):1410-6.
    • (2010) Chest , vol.137 , Issue.6 , pp. 1410-1416
    • Auffray, C.1    Adcock, I.M.2    Chung, K.F.3    Djukanovic, R.4    Pison, C.5    Sterk, P.J.6
  • 85
    • 84867331897 scopus 로고    scopus 로고
    • Systems biology: Personalized medicine for the future?
    • 1:CAS:528:DC%2BC38XhsVKrtbvJ 10.1016/j.coph.2012.07.011 22858243
    • Chen R, Snyder M. Systems biology: personalized medicine for the future? Curr Opin Pharmacol. 2012;12(5):623-8.
    • (2012) Curr Opin Pharmacol , vol.12 , Issue.5 , pp. 623-628
    • Chen, R.1    Snyder, M.2
  • 86
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • 1:CAS:528:DC%2BC3sXis1Okt7k%3D 3575604 10.1016/j.cell.2013.01.019 23415222
    • Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013;152(4):714-26.
    • (2013) Cell , vol.152 , Issue.4 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3    McKenna, A.4    Stevenson, K.5    Lawrence, M.S.6
  • 87
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • 1:CAS:528:DC%2BC3cXptFajt7Y%3D 10.1056/NEJMp1006304 20551152
    • Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med. 2010;363(4):301-4.
    • (2010) N Engl J Med , vol.363 , Issue.4 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 88
    • 67649805319 scopus 로고    scopus 로고
    • An official American Thoracic Society/European Respiratory Society statement: Asthma control and exacerbations: Standardizing endpoints for clinical asthma trials and clinical practice
    • 10.1164/rccm.200801-060ST 19535666
    • Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009;180(1):59-99.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.1 , pp. 59-99
    • Reddel, H.K.1    Taylor, D.R.2    Bateman, E.D.3    Boulet, L.P.4    Boushey, H.A.5    Busse, W.W.6


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