Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome

Diabetologia

Volumn 53, Issue 2, 2010, Pages 309-320

  Dreja, T ^a   Jovanovic, Z ^b   Rasche, A ^c   Kluge, R ^a   Herwig, R ^c   Tung, Y C L ^b   Joost, H G ^a   Yeo, G S H ^b   Al Hasani, H ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Expression profiling; Genome wide association study; Glucotoxicity; Laser capture microdissection Lipotoxicity; NewZealand obesemouse; Obesity; Oxidative phosphorylation; Pancreas

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DIET; DOMINANT GENE; GENE EXPRESSION; GENE ISOLATION; GENETIC IDENTIFICATION; GENETICS; GENOME; IMPAIRED GLUCOSE TOLERANCE; LASER CAPTURE MICRODISSECTION; LASER MICRODISSECTION; LIPID DIET; MALE; METABOLIC SYNDROME X; MOUSE; NEW ZEALAND BLACK MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; TRANSCRIPTOMICS; UPREGULATION;

ANIMALS; CELL CYCLE; CELL DIVISION; DIABETIC DIET; DIET; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; ISLETS OF LANGERHANS; KINETICS; MALE; METABOLIC SYNDROME X; MICE; MULTIFACTORIAL INHERITANCE; POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION, GENETIC;

EID: 77949281428     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1576-4     Document Type: Article

References (40)

1. Doria A, Patti ME, Kahn CR (2008) The emerging genetic architecture of type 2 diabetes. Cell Metab 8:186-200
2. Schmidt C, Gonzaludo NP, Strunk S et al (2008) A meta-analysis of QTL for diabetes-related traits in rodents. Physiol Genomics 34:42-53
3. Wuschke S, Dahm S, Schmidt C, Joost HG, Al-Hasani H (2007) A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice. Int J Obes (Lond) 31:829-841
4. Yki-Jarvinen H (1992) Glucose toxicity. Endocr Rev 13:415-431
5. Poitout V, Robertson RP (2008) Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 29:351-366
6. Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333-1346
7. Ahn YB, Xu G, Marselli L et al (2007) Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia 50:334-342
8. Marselli L, Thorne J, Ahn YB et al (2008) Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab 93:1046-1053
9. Ruan H, Zarnowski MJ, Cushman SW, Lodish HF (2003) Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes. J Biol Chem 278:47585-47593
10. Jurgens HS, Neschen S, Ortmann S et al (2007) Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction. Diabetologia 50:1481-1489
11. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods: 25:402-408
12. Gentleman RC, Carey VJ, Bates DM et al (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5:R80
13. Wu Z, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F (2004) A model based background adjustment for oligonucleotide expression arrays. JASA 99:909-917
14. Dai M, Wang P, Boyd AD et al (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33:e175
15. Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27-30
16. Ashburner M, Ball CA, Blake JA et al (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25:25-29
17. HR KE, Kowald A, Wierling C, Lehrach H (2005) Systems biology in practice. Wiley-VCH, Weinheim
18. Cameron DP, Opat F, Insch S (1974) Studies of immunoreactive insulin secretion in NZO mice in vivo. Diabetologia 10(Suppl):649-654
19. Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
20. Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341
21. Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
22. Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
23. Namkung Y, Skrypnyk N, Jeong MJ et al (2001) Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest 108:1015-1022
24. Postic C, Dentin R, Denechaud PD, Girard J (2007) ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 27:179-192
25. Leiter EH, Coleman DL, Ingram DK, Reynolds MA (1983) Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J Nutr 113:184-195
26. Plum L, Giesen K, Kluge R et al (2002) Characterisation of the mouse diabetes susceptibility locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 45:823-830
27. Plum L, Kluge R, Giesen K, Altmuller J, Ortlepp JR, Joost HG (2000) Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity. Diabetes 49:1590-1596
28. Lavine JA, Raess PW, Davis DB et al (2008) Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. Mol Endocrinol 22:2716-2728
29. Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M (2005) Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2:385-397
30. Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A (2008) Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 57:938-944
31. Sparks LM, Xie H, Koza RA et al (2005) A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54:1926-1933
32. Misu H, Takamura T, Matsuzawa N et al (2007) Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Diabetologia 50:268-277
33. Takamura T, Misu H, Matsuzawa-Nagata N et al (2008) Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Obesity (Silver Spring) 16:2601-2609
34. Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 5:265-277
35. Houstis N, Rosen ED, Lander ES (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944-948
36. Osmundsen H, Bremer J, Pedersen JI (1991) Metabolic aspects of peroxisomal beta-oxidation. Biochim Biophys Acta 1085:141-158
37. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820
38. Furukawa S, Fujita T, Shimabukuro M et al (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752-1761
39. Urakawa H, Katsuki A, Sumida Y et al (2003) Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab 88:4673-4676
40. Cha-Molstad H, Saxena G, Chen J, Shalev A (2009) Glucosestimulated expression of TXNIP is mediated by CHREBP, p300 and histone H4 acetylation in pancreatic beta cells. J Biol Chem 284:16898-16905