Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry

Diabetologia

Volumn 48, Issue 3, 2005, Pages 477-485

  Ahmed, M ^a,b,c   Bergsten, P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Ibrahim Medical College   (Bangladesh)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Cytokeratin; Glucose; Heat shock protein; Insulin biosynthesis; Islet; Proteomic; Secretory granule; Stress response; Two dimensional gel electrophoresis

Indexed keywords

ACTIN; ALPHA ENOLASE; CYTOKERATIN 8; ENDOPLASMIN; ENOLASE; GLUCOSE; GLUCOSE REGULATED PROTEIN; HEAT SHOCK PROTEIN; ISOENZYME; PEROXIREDOXIN; PROPROTEIN CONVERTASE 2; PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SECRETAGOGIN; SUPEROXIDE DISMUTASE; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL LEVEL; CELL MATURATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; GENE EXPRESSION PROFILING; GENE MAPPING; INSULIN SYNTHESIS; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STRESS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

ANIMALS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYMES; GLUCOSE; ISLETS OF LANGERHANS; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PROTEINS;

EID: 16844382825     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1661-7     Document Type: Article

References (32)

1. Rorsman P (1997) The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40:487-495
2. Scheen AJ (2004) Pathophysiology of insulin secretion. Ann Endocrinol (Paris) 65:29-36
3. Bruttomesso D, Pianta A, Mari A et al (1999) Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes 48:99-105
4. Wolf G (2001) Insulin resistance associated with leptin deficiency in mice: a possible model for noninsulin-dependent diabetes mellitus. Nutr Rev 59:177-179
5. Diani AR, Sawada GA, Hannah BA et al (1987) Analysis of pancreatic islet cells and hormone content in the spontaneously diabetic KKAy mouse by morphometry, immunocytochemistry and radioimmunoassay. Virchows Arch A Pathol Anal Histopathol 412:53-61
6. 2+ in pancreatic islets correspond to pulsatile insulin release. Am J Physiol 268:E282-E287
7. Sundsten T, Orsäter H, Bergsten P (2003) Prolonged culturing increases early and late insulin release in KKAy-mouse islets which correlates with changes in islet protein profiles. Diabetologia 46:A157
8. Svensson C, Sandler S, Hellerstrom C (1993) Lack of long-term beta-cell glucotoxicity in vitro in pancreatic islets isolated from two mouse strains (C57BL/6J; C57BL/KsJ) with different sensitivities of the beta-cells to hyperglycaemia in vivo. J Endocrinol 136:289-296
9. Heimberg H, De Vos A, Pipeleers D, Thorens B, Schuit F (1995) Differences in glucose transporter gene expression between rat pancreatic α- and β-cells are correlated to differences in glucose transport but not in glucose utilization. J Biol Chem 270:8971-8975
10. Liang Y, Najafi H, Smith RM et al (1992) Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41:792-806
11. Chan CB, Saleh MC, Koshkin V, Wheeler MB (2004) Uncoupling protein 2 and islet function. Diabetes 53(Suppl 1): S136-S142
12. Gorg A, Obermaier C, Boguth G et al (2000) The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 21:1037-1053
13. Shevchenko A, WiIm M, Vorm O, Mann M (1996) Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68:850-858
14. Rabilloud T (2000) Detecting proteins separated by 2-D gel electrophoresis. Anal Chem 72:48A-55A
15. Sanchez JC, Chiappe D, Converset V et al (2001) The mouse SWISS-2D PAGE database: a tool for proteomics study of diabetes and obesity. Proteomics 1:136-163
16. Sanchez JC, Converset V, Nolan A et al (2002) Effect of rosiglitazone on the differential expression of diabetes-associated proteins in pancreatic islets of C57B1/6 lep/lep mice. Mol Cell Proteomics 1:509-516
17. Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW (2003) Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. J Proteome Res 2:199-205
18. Andersson A (1976) Tissue culture of isolated pancreatic islets. Acta Endocrinol Suppl (Copenh) 205:283-294
19. Ling Z, Hannaert JC, Pipeleers D (1994) Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 37:15-21
20. Sparre T, Christensen UB, Mose Larsen P et al (2002) IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis. Diabetologia 45:1550-1561
21. Itoh N, Okamoto H (1980) Translational control of proinsulin synthesis by glucose. Nature 283:100-102
22. Ellgaard L, Helenius A (2003) Quality control in the endoplasmic reticulum. Nat Rev Mol Cell Biol 4:181-191
23. Varadi A, Ainscow EK, Allan VJ, Rutter GA (2002) Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in β-cells. Biochem Soc Trans 30:328-332
24. Howell SL, Tyhurst M (1982) Microtubules, microfilaments and insulin-secretion. Diabetologia 22:301-308
25. Goldstein LS, Philp AV (1999) The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol 15:141-183
26. Davidson HW, Rhodes CJ, Hutton JC (1988) Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases. Nature 333:93-96
27. - uptake and acidification. J Cell Sci 114:2145-2154
28. Oliveira HR, Curi R, Carpinelli AR (1999) Glucose induces an acute increase of superoxide dismutase activity in incubated rat pancreatic islets. Am J Physiol 276:C507-C510
29. Bast A, Wolf G, Oberbaumer I, Walther R (2002) Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells. Diabetologia 45:867-876
30. Kaneto H, Kajimoto Y, Miyagawa J et al (1999) Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β-cells against glucose toxicity. Diabetes 48:2398-2406
31. Fink AL (1999) Chaperone-mediated protein folding. Physiol Rev 79:425-449
32. Kessler L, Jesser C, Belcourt A, Pinget M (1997) Influence of acinar tissue contamination on encapsulated pancreatic islets: morphological and functional studies. Transplantation 63:1537-1540