Hepatotoxicity induced by herbal and dietary supplements

Seminars in Liver Disease

Volumn 34, Issue 2, 2014, Pages 172-193

  Navarro, Victor J ^a   Lucena, M Isabel ^b  

^a EINSTEIN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

drug induced liver injury; hepatotoxicity; herbal and dietary supplements

Indexed keywords

ANABOLIC AGENT; CAFFEINE; CAMPHOR; CASCARA SAGRADA; DIIODOTHYRONINE; GREEN TEA EXTRACT; HEAVY METAL; HERBACEOUS AGENT; PHENYLPROPANOLAMINE; PYRROLIZIDINE ALKALOID; RETINOL; YOHIMBINE; PLANT MEDICINAL PRODUCT;

ACACIA CATECHU; ACTAEA RACEMOSA; ACUTE LIVER FAILURE; ALOE; ALTERNATIVE MEDICINE; ARNICA; ARTICLE; ATRACTYLIS; AZADIRACHTA INDICA; BODY BUILDING; CAMELLIA SINENSIS; CASSIA; CENTELLA ASIATICA; CHINESE HERB; CHRONIC HEPATITIS; CLINICAL FEATURE; DIET SUPPLEMENTATION; ECHINACEA PURPUREA; EPHEDRA SINICA; FOOD SAFETY; GERMANDER; GLYCYRRHIZA; GLYCYRRHIZA URALENSIS; HERBAL MEDICINE; HUMAN; LIVER CIRRHOSIS; LIVER HISTOLOGY; LIVER INJURY; LIVER NECROSIS; ORGAN INJURY; PIPER METHYSTICUM; POLYGONUM; PRIORITY JOURNAL; SASSAFRAS; TOXIC HEPATITIS; TUSSILAGO; UNITED STATES; VISCUM ALBUM; WEIGHT REDUCTION; DRUG LEGISLATION; DRUG-INDUCED LIVER INJURY; EUROPE;

DIETARY SUPPLEMENTS; DRUG-INDUCED LIVER INJURY; EUROPE; HUMANS; LEGISLATION, DRUG; PLANT PREPARATIONS; UNITED STATES;

EID: 84901746055     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0034-1375958     Document Type: Article

References (155)

1. Navarro V. J. Herbal and dietary supplement hepatotoxicity. Semin Liver Dis: 2009; 29 4 373 382
2. Commission on Dietary Supplement Labels. Chapter I Dietary Supplement Health And Education Act of 1994. Available at: http://www.health.gov/dietsupp/ ch1.htm. Accessed January 13,: 2014
3. Hatch Leads Efforts to Prevent Overregulation of Dietary Supplements. Available at: http://www.hatch.senate.gov/public/index.cfm/2012/5/hatch-leads- efforts-to-prevent-overregulation-of-dietary-supplements. Accessed January 13,: 2014
4. US Food and Drug Administration Uprizing 2.0: Recall - Undeclared Drug Ingredient: Synthetic Steroid. Available at: http://www.fda.gov/Safety/MedWatch/ SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm274746.htm. Accessed January 13,: 2014
5. US Food and Drug Administration OxyElite Pro Supplements Recalled. Available at: http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm374742.htm. Accessed January 14,: 2014
6. US Food and Drug Administration Medical Foods Guidance Documents & Regulatory Information. Available at: http://www.fda.gov/Food/ GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/MedicalFoods/default. htm. Accessed April 9, 2014
7. Chalasani N., Vuppalanchi R., Navarro V., et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med: 2012; 156 12 857 860, W297-300
8. European Commission Herbal Medicinal Products. Available at: http://ec.europa.eu/health/human-use/herbal-medicines/index-en.htm. Accessed January 14,: 2014
9. European Medicines Agency Committee on Herbal Medicinal Products (HMPC). Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/about-us/ general/general-content-000264.jsp. Accessed January 13,: 2014
10. European Medicines Agency Herbal Medicines for Human Use. Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/ herbal-medicines-search-landing-page.jsp&mid=. Accessed January 13,: 2014
11. Medicines and Healthcare Products Regulatory Agency (MRHA). Herbal Medicines Advisory Committee. Available at: http://www.mhra.gov.uk/Committees/ Medicinesadvisorybodies/HerbalMedicinesAdvisoryCommittee/index.htm. Accessed January 13,: 2014
12. The WHO Essential Medicines and Health Products Information Portal. Available at: http://apps.who.int/medicinedocs/en. Accessed January 13,: 2014
13. World Health Organization International Regulatory Cooperation for Herbal Medicines (IRCH). Available at: http://www.who.int/medicines/areas/traditional/ irch/en/. Accessed January 13,: 2014
14. World Health Organization General Information on IRCH. Available at: http://www.who.int/medicines/areas/traditional/geninfo/en/. Accessed January 13,: 2014
15. Eisenberg D. M., Kessler R. C., Foster C., Norlock F. E., Calkins D. R., Delbanco T. L. Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med: 1993; 328 4 246 252 (Pubitemid 23035311)
16. Bailey R. L., Gahche J. J., Lentino C. V., et al. Dietary supplement use in the United States, 2003-2006. J Nutr: 2011; 141 2 261 266
17. Picciano M. F., Dwyer J. T., Radimer K. L., et al. Dietary supplement use among infants, children, and adolescents in the United States, 1999-2002. Arch Pediatr Adolesc Med: 2007; 161 10 978 985 (Pubitemid 47529415)
18. Bailey R. L., Gahche J. J., Miller P. E., Thomas P. R., Dwyer J. T. Why US adults use dietary supplements. JAMA Intern Med: 2013; 173 5 355 361
19. World Health Organization WHO traditional medicine strategy 2002-2005. Geneva WHO: 2002
20. Skeie G., Braaten T., Hjartåker A., et al. Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study. Eur J Clin Nutr: 2009; 63 04 S226 S238
21. Lindstrom A., Ooyen C., Lynch M. E., Blumenthal M. Herb supplement sales increase 5.5% in 2012: herbal supplement sales rise for 9th consecutive year. Herbal Gram: 2013; 99 60 65
22. PRWeb Focus. Global Herbal Supplements and Remedies Market to Reach US$107 Billion by 2017, According to New Report by Global Industry Analysts, Inc. Available at: http://www.prweb.com/releases/herbal-supplements/ herbal-remedies/prweb9260421.htm. Accessed January 13,: 2014
23. Björnsson E. S., Bergmann O. M., Björnsson H. K., Kvaran R. B., Olafsson S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology: 2013; 144 7 1419 1425, e1-e3, quiz e19-e20
24. Chalasani N., Fontana R. J., Bonkovsky H. L., et al. Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology: 2008; 135 6 1924 1934, e1-e4
25. Medina-Cáliz I., González-Jiménez A., Bessone F., et al. Variations in drug-induced liver injury (DILI) between different prospective DILI registries. Clin Ther: 2013; 35 (8 Suppl): S24
26. Bessone F., Hernandez N., Sanchez A., et al. The Spanish-Latin American DILI Network: preliminary results from a collaborative strategic initiative. J Hepatol: 2013; 58 01 212 213
27. Suk K. T., Kim D. J., Kim C. H., et al. A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol: 2012; 107 9 1380 1387
28. Wai C. T., Tan B. H., Chan C. L., et al. Drug-induced liver injury at an Asian center: a prospective study. Liver Int: 2007; 27 4 465 474
29. Wang Y. P., Shi B., Chen Y. X., Xu J., Jiang C. F., Xie W. F. Drug-induced liver disease: an 8-year study of patients from one gastroenterological department. J Dig Dis: 2009; 10 3 195 200
30. Devarbhavi H., Dierkhising R., Kremers W. K., Sandeep M. S., Karanth D., Adarsh C. K. Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol: 2010; 105 11 2396 2404
31. Navarro V. J., Barnhart H. X., Bonkovsky H. L., et al. The rising burden of herbal and dietary supplement induced hepatotoxicity in the U.S.A. Abstract presented at: 64th Annual Meeting of the American Association for the Study of Liver Diseases.; November 1-5,: 2013;; Washington, DC
32. Reuben A., Koch D. G., Lee W. M.; Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology: 2010; 52 6 2065 2076
33. Wu C. H., Wang C. C., Kennedy J. Changes in herb and dietary supplement use in the U.S. adult population: a comparison of the 2002 and 2007 National Health Interview Surveys. Clin Ther: 2011; 33 11 1749 1758
34. Andrade R. J., Lucena M. I., Fernández M. C., et al. Spanish Group for the Study of Drug-Induced Liver Disease. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology: 2005; 129 2 512 521 (Pubitemid 41096639)
35. Björnsson E., Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. Hepatology: 2005; 42 2 481 489 (Pubitemid 41061102)
36. Russo M. W., Galanko J. A., Shrestha R., Fried M. W., Watkins P. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl: 2004; 10 8 1018 1023 (Pubitemid 39232756)
37. Estes J. D., Stolpman D., Olyaei A., et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg: 2003; 138 8 852 858 (Pubitemid 36960946)
38. Fernández-Castañer A., García-Cortés M., Lucena M. I., et al. [An analysis of the causes, characteristics, and consequences of reexposure to a drug or compound responsible for a hepatotoxicity event]. Rev Esp Enferm Dig: 2008; 100 5 278 284 (Pubitemid 351966966)
39. Blendon R. J., DesRoches C. M., Benson J. M., Brodie M., Altman D. E. Americans' views on the use and regulation of dietary supplements. Arch Intern Med: 2001; 161 6 805 810 (Pubitemid 32225388)
40. Robinson A., McGrail M. R. Disclosure of CAM use to medical practitioners: a review of qualitative and quantitative studies. Complement Ther Med: 2004; 12 2-3 90 98 (Pubitemid 39618835)
41. Eisenberg D. M., Davis R. B., Ettner S. L., et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA: 1998; 280 18 1569 1575 (Pubitemid 28520643)
42. LiverTox® Clinical and Research Information on Drug Induced Liver Injury. Available at: http://livertox.nih.gov/. Accessed January 13,: 2014
43. lsharkawy A. M., McPherson S., Masson S., et al. Cholestasis secondary to anabolic steroid use in young men. BMJ: 2012; 344 468
44. Turani H., Levi J., Zevin D., Kessler E. Hepatic lesions in patients on anabolic androgenic therapy. Isr J Med Sci: 1983; 19 4 332 337 (Pubitemid 13042620)
45. Timcheh-Hariri A., Balali-Mood M., Aryan E., Sadeghi M., Riahi-Zanjani B. Toxic hepatitis in a group of 20 male body-builders taking dietary supplements. Food Chem Toxicol: 2012; 50 10 3826 3832
46. Singh V., Rudraraju M., Carey E. J., et al. Severe hepatotoxicity caused by a methasteron-containing performance-enhancing supplement. J Clin Gastroenterol: 2009; 43 3 287
47. Tandon B. N., Tandon H. D., Tandon R. K., Narndranathan M., Joshi Y. K. An epidemic of veno-occlusive disease of liver in central India. Lancet: 1976; 2 7980 271 272
48. Weston C. FM, Cooper B. T., Davies J. D., Levine D. F. Veno-occlusive disease of the liver secondary to ingestion of comfrey. Br Med J (Clin Res Ed): 1987; 295 6591 183 (Pubitemid 17101024)
49. Bras G., Jelliffe D. B., Stuart K. L. Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica. AMA Arch Pathol: 1954; 57 4 285 300
50. Stillman A. S., Huxtable R., Consroe P., Kohnen P., Smith S. Hepatic veno-occlusive disease due to pyrrolizidine (Senecio) poisoning in Arizona. Gastroenterology: 1977; 73 2 349 352 (Pubitemid 8152455)
51. US Food and Drug Administration Federal Food, Drug, and Cosmetic Act (FD&C Act). Available at: http://www.fda.gov/RegulatoryInformation/ Legislation/FederalFoodDrugandCosmeticActFDCAct/default.htm. Accessed January 13,: 2014
52. Kneifel W., Czech E., Kopp B. Microbial contamination of medicinal plants-a review. Planta Med: 2002; 68 1 5 15 (Pubitemid 34113580)
53. Stickel F., Droz S., Patsenker E., et al. Severe hepatotoxicity following ingestion of Herbalife contaminated with Bacillus subtilis. J Hepatol: 2009; 50 111 117
54. Saper R. B., Phillips R. S., Sehgal A., et al. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA: 2008; 300 8 915 923
55. Wong M. K., Tan P., Wee Y. C. Heavy metals in some Chinese herbal plants. Biol Trace Elem Res: 1993; 36 2 135 142 (Pubitemid 23069648)
56. Ernst E. Heavy metals in traditional Indian remedies. Eur J Clin Pharmacol: 2002; 57 12 891 896 (Pubitemid 34185560)
57. Miller G. M., Stripp R. A study of western pharmaceuticals contained within samples of Chinese herbal/patent medicines collected from New York City's Chinatown. Leg Med (Tokyo): 2007; 9 5 258 264 (Pubitemid 47089057)
58. Fleshner N., Harvey M., Adomat H., et al. Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors. J Urol: 2005; 174 2 636 641, discussion 641, quiz 801 (Pubitemid 40981620)
59. Komes D., Belščak-Cvitanović A., HorŽić D., Rusak G., Likić S., Berendika M. Phenolic composition and antioxidant properties of some traditionally used medicinal plants affected by the extraction time and hydrolysis. Phytochem Anal: 2011; 22 2 172 180
60. Harkey M. R., Henderson G. L., Gershwin M. E., Stern J. S., Hackman R. M. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr: 2001; 73 6 1101 1106 (Pubitemid 32496951)
61. Ye F., Wang H., Jiang S., et al. Quality evaluation of commercial extracts of Scutellaria baicalensis. Nutr Cancer: 2004; 49 2 217 222 (Pubitemid 39487882)
62. Navarro V. J., Bonkovsky H. L., Hwang S. I., Vega M., Barnhart H., Serrano J. Catechins in dietary supplements and hepatotoxicity. Dig Dis Sci: 2013; 58 9 2682 2690
63. Newmaster S. G., Grguric M., Shanmughanandhan D., Ramalingam S., Ragupathy S. DINA barcoding detects contamination and substitution in North American herbal products. BMC Med: 2013; 11 2 13
64. Danan G., Benichou C. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol: 1993; 46 11 1323 1330 (Pubitemid 23333873)
65. Benichou C., Danan G., Flahault A. Causality assessment of adverse reactions to drugs-II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol: 1993; 46 11 1331 1336 (Pubitemid 23333874)
66. Maria V. AJ, Victorino R. MM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology: 1997; 26 3 664 669 (Pubitemid 27392358)
67. Aithal G. P., Rawlins M. D., Day C. P. Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions. J Hepatol: 2000; 33 6 949 952
68. Naranjo C. A., Busto U., Sellers E. M., et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther: 1981; 30 2 239 245 (Pubitemid 12149145)
69. Sarma D. N., Barrett M. L., Chavez M. L., et al. Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf: 2008; 31 6 469 484 (Pubitemid 351693681)
70. Bénichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol: 1990; 11 2 272 276
71. Lucena M. I., Camargo R., Andrade R. J., Pérez-Sanchez C. J., Sánchez De La Cuesta F. Comparison of two clinical scales for causality assessment in hepatotoxicity. Hepatology: 2001; 33 1 123 130 (Pubitemid 32016894)
72. Fontana R. J., Watkins P. B., Bonkovsky H. L., et al. Rationale, design and conduct of the Drug Induced Liver Injury Network prospective study. Drug Saf: 2009; 32 55 68
73. Navarro V. J., Barnhart H. X., Bonkovsky H. L., et al. Diagnosing hepatotoxicity attributable to herbal and dietary supplements: test-retest reliability of novel causality assessment tool. J Hepatol: 2012; 55 02 S536
74. Teschke R., Schwarzenboeck A., Eickhoff A., Frenzel C., Wolff A., Schulze J. Clinical and causality assessment in herbal hepatotoxicity. Expert Opin Drug Saf: 2013; 12 3 339 366
75. Stickel F., Kessebohm K., Weimann R., Seitz H. K. Review of liver injury associated with dietary supplements. Liver Int: 2011; 31 5 595 605
76. Strader D. B., Navarro V. J., Seeff L. B. Hepatotoxicity of herbal preparations. In: Boyer T. D., Manns M. P., Sanyal A. J., eds. Zakim and Boyer's Hepatology: A Textbook of Liver Disease. 6th ed. Philadelphia, PA Saunders: 2012; 462 475
77. Bunchorntavakul C., Reddy K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther: 2013; 37 1 3 17
78. Ishak K. G. Hepatic lesions caused by anabolic and contraceptive steroids. Semin Liver Dis: 1981; 1 2 116 128
79. Haupt H. A., Rovere G. D. Anabolic steroids: a review of the literature. Am J Sports Med: 1984; 12 6 469 484 (Pubitemid 15177210)
80. DesJardins M. Supplement use in the adolescent athlete. Curr Sports Med Rep: 2002; 1 6 369 373
81. Martin D. J., Partridge B. J., Shields W. Hepatotoxicity associated with the dietary supplement N.O.-XPLODE. Ann Intern Med: 2013; 159 7 503 504
82. Vitetta l., Thomsen M., Sali A. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust: 2003; 21 411 412 (Pubitemid 36531611)
83. Nisbet B. C., O'Connor R. E. Black cohosh-induced hepatitis. Del Med J: 2007; 79 11 441 444
84. Whiting P. W., Clouston A., Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust: 2002; 177 8 440 443 (Pubitemid 35396365)
85. Vannacci A., Lapi F., Gallo E., et al. A case of hepatitis associated with long-term use of Cimicifuga racemosa. Altern Ther Health Med: 2009; 15 3 62 63
86. Pierard S., Coche J. C., Lanthier P., et al. Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution. Eur J Gastroenterol Hepatol: 2009; 21 8 941 945
87. Cohen S. M., O'Connor A. M., Hart J., Merel N. H., Te H. S. Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause: 2004; 11 5 575 577 (Pubitemid 40362157)
88. Mahady G. B., Low Dog T., Barrett M. L., et al. United States pharmacopeia review of the black cohosh case reports of hepatotoxicity. Menopause: 2008; 15 628 638
89. Verbitski S. M., Gourdin G. T., Ikenouye L. M., McChesney J. D., Hildreth J. Detection of Actaea racemosa adulteration by thin-layer chromatography and combined thin-layer chromatography-bioluminescence. J AOAC Int: 2008; 91 2 268 275 (Pubitemid 351667393)
90. Lontos S., Jones R. M., Angus P. W., Gow P. J. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust: 2003; 179 7 390 391 (Pubitemid 37265139)
91. Levitsky J., Alli T. A., Wisecarver J., Sorrell M. F. Fulminant liver failure associated with the use of black cohosh. Dig Dis Sci: 2005; 50 3 538 539 (Pubitemid 40543744)
92. Lynch C. R., Folkers M. E., Hutson W. R. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl: 2006; 12 6 989 992 (Pubitemid 43960376)
93. Sheikh N. M., Philen R. M., Love L. A. Chaparral-associated hepatotoxicity. Arch Intern Med: 1997; 157 8 913 919 (Pubitemid 28337043)
94. Lambert J. D., Kennett M. J., Sang S., Reuhl K. R., Ju J., Yang C. S. Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food Chem Toxicol: 2010; 48 1 409 416
95. García-Cortés M., Borraz Y., Lucena M. I., et al. [Liver injury induced by natural remedies: an analysis of cases submitted to the Spanish Liver Toxicity Registry]. Rev Esp Enferm Dig: 2008; 100 11 688 695
96. Bonkovsky H. L. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med: 2006; 144 1 68 71
97. Skoulidis F., Alexander G. JM, Davies S. E. Ma huang associated acute liver failure requiring liver transplantation. Eur J Gastroenterol Hepatol: 2005; 17 5 581 584 (Pubitemid 40592718)
98. Neff G. W., Reddy K. R., Durazo F. A., Meyer D., Marrero R., Kaplowitz N. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol: 2004; 41 6 1062 1064 (Pubitemid 39575679)
99. Nadir A., Agrawal S., King P. D., Marshall J. B. Acute hepatitis associated with the use of a Chinese herbal product, ma-huang. Am J Gastroenterol: 1996; 91 7 1436 1438
100. MacGregor F. B., Abernethy V. E., Dahabra S., Cobden I., Hayes P. C. Hepatotoxicity of herbal remedies. BMJ: 1989; 299 6708 1156 1157 (Pubitemid 19266434)
101. Elinav E., Pinsker G., Safadi R., et al. Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity. J Hepatol: 2007; 47 4 514 520 (Pubitemid 47331750)
102. Schoepfer A. M., Engel A., Fattinger K., et al. Herbal does not mean innocuous: ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife products. J Hepatol: 2007; 47 4 521 526 (Pubitemid 47331751)
103. Manso G., López-Rivas L., Salgueiro M. E., et al. Continuous reporting of new cases in Spain supports the relationship between Herbalife® products and liver injury. Pharmacoepidemiol Drug Saf: 2011; 20 10 1080 1087
104. Halegoua-De Marzio D., Vega M., Schifter-Weber J., et al. An International Effort to Assess Hepatotoxicity Associated with Some Herbalife® Products. Hepatology: 2013; 58 01 383
105. Dara L., Hewett J., Lim J. K. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol: 2008; 14 45 6999 7004
106. Fong T. L., Klontz K. C., Canas-Coto A., et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol: 2010; 105 7 1561 1566
107. Strahl S., Ehret V., Dahm H. H., Maier K. P. [Necrotizing hepatitis after taking herbal remedies]. Dtsch Med Wochenschr: 1998; 123 47 1410 1414 (Pubitemid 28545594)
108. Escher M., Desmeules J., Giostra E., Mentha G. Hepatitis associated with Kava, a herbal remedy for anxiety. BMJ: 2001; 322 7279 139 (Pubitemid 32116192)
109. Bujanda L., Palacios A., Silvariño R., Sánchez A., Muñoz C. [Kava-induced acute icteric hepatitis]. Gastroenterol Hepatol: 2002; 25 6 434 435
110. Stickel F., Baumüller H. M., Seitz K., et al. Hepatitis induced by Kava (Piper methysticum rhizoma). J Hepatol: 2003; 39 1 62 67 (Pubitemid 36724109)
111. Kraft M., Spahn T. W., Menzel J., et al. [Fulminant liver failure after administration of the herbal antidepressant Kava-Kava]. Dtsch Med Wochenschr: 2001; 126 36 970 972 (Pubitemid 32835490)
112. Thomsen M., Vitetta L., Schmidt M., Sali A. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Med J Aust: 2004; 180 4 198 199, author reply 199 (Pubitemid 38247959)
113. Ulbricht C., Basch E., Boon H., et al. Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration. Expert Opin Drug Saf: 2005; 4 4 779 794 (Pubitemid 40946072)
114. Han D., Matsumaru K., Rettori D., Kaplowitz N. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol: 2004; 67 3 439 451 (Pubitemid 38232884)
115. Durazo F. A., Lassman C., Han S. H., et al. Fulminant liver failure due to usnic acid for weight loss. Am J Gastroenterol: 2004; 99 5 950 952 (Pubitemid 39090229)
116. Favreau J. T., Ryu M. L., Braunstein G., et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med: 2002; 136 8 590 595 (Pubitemid 34407043)
117. Yellapu R. K., Mittal V., Grewal P., Fiel M., Schiano T. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can J Gastroenterol: 2011; 25 3 157 160
118. Fallon M. B., Boyer J. L. Hepatic toxicity of vitamin A and synthetic retinoids. J Gastroenterol Hepatol: 1990; 5 3 334 342 (Pubitemid 20375195)
119. Geubel A. P., De Galocsy C., Alves N., Rahier J., Dive C. Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology: 1991; 100 6 1701 1709
120. Lucena M. I., Molokhia M., Shen Y., et al. Spanish DILI Registry; EUDRAGENE; DILIN; DILIGEN; International SAEC. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology: 2011; 141 1 338 347
121. Daly A. K., Donaldson P. T., Bhatnagar P., et al. DILIGEN Study; International SAE Consortium. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet: 2009; 41 7 816 819
122. Lin G., Wang J. Y., Li N., et al. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol: 2011; 54 4 666 673
123. De Berardinis V., Moulis C., Maurice M., et al. Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. Mol Pharmacol: 2000; 58 3 542 551
124. Yang H. N., Kim D. J., Kim Y. M., et al. Aloe-induced toxic hepatitis. J Korean Med Sci: 2010; 25 3 492 495
125. AEMPS Retirada de los productos episdrol y epistane. In: SANITARIOS) AAEDMYP ed. Ministerio de sanidad, servicios sociales e igualdad; 2013;. Available at: http://www.aemps.gob.es/informa/notasInformativas/ medicamentosUsoHumano/medIlegales/2013/docs/ICM-MI-09-2013-episdrol-epistane. pdf. Accessed January 14, 2014
126. Nadir A., Reddy D., Van Thiel D. H. Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol: 2000; 95 12 3634 3637
127. Kao W. F., Hung D. Z., Tsai W. J., Lin K. P., Deng J. F. Podophyllotoxin intoxication: toxic effect of Bajiaolian in herbal therapeutics. Hum Exp Toxicol: 1992; 11 6 480 487
128. European Medicines Agency Assessment Report on Cimicifuga racemosa (L.) Nutt. Available at: http://www.ema.europa.eu/docs/en-GB/document-library/Herbal- HMPC-assessment-report/2011/05/WC500106358.pdf. Accessed January 14,: 2014
129. de Sanidad M., Sociales e Igualdad S. AEMPS. Extracto de la raíz de Cimicifuga racemosa y lesiones hepaticas. Available at: http://www.aemps.gob. es/informa/notasInformativas/medicamentosUsoHumano/seguridad/2006/docs/ NI-2006-06-cimicifuga.pdf. Accessed January 14,: 2014
130. European Medicines Agency Assessment report on Peumus boldus Molina, folium. Available at: http://www.ema.europa.eu/docs/en-GB/document-library/ Herbal-HMPC-assessment-report/2009/12/WC500018102.pdf. Accessed January 14,: 2014
131. Piscaglia F., Leoni S., Venturi A., Graziella F., Donati G., Bolondi L. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol: 2005; 40 2 236 239 (Pubitemid 40189006)
132. Sohni Y. R. The toxicity of Callilepis laureola, a South African traditional herbal medicine. Clin Biochem: 2002; 35 6 499 (Pubitemid 35284549)
133. AEMPS Suspension de comercialización de la especialidad farmacéutica Exolise®: Extracto etanolico de camelia sinensis (te verde). Available at: http://www.aemps.gob.es/informa/notasInformativas/ medicamentosUsoHumano/seguridad/2003/NI-2003-03-exolise.htm. Accessed January 13,: 2014
134. Jimenez J. F., Brown A. L., Arnold W. C., Byrne W. J. Chronic camphor ingestion mimicking Reye's syndrome. Gastroenterology: 1983; 84 2 394 398 (Pubitemid 13224282)
135. Uc A., Bishop W. P., Sanders K. D. Camphor hepatotoxicity. South Med J: 2000; 93 6 596 598 (Pubitemid 34263233)
136. Jorge O. A., Jorge A. D. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig: 2005; 97 2 115 124 (Pubitemid 40522135)
137. Benninger J., Schneider H. T., Schuppan D., Kirchner T., Hahn E. G. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology: 1999; 117 5 1234 1237 (Pubitemid 29512684)
138. Adachi M., Saito H., Kobayashi H., et al. Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido. Ann Intern Med: 2003; 139 6 488 492
139. Yuen M. F., Tam S., Fung J., Wong D. K., Wong B. C., Lai C. L. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study. Aliment Pharmacol Ther: 2006; 24 8 1179 1186 (Pubitemid 44427505)
140. Shah M., Williams C., Aggarwal A., Choudhry W. M. Licorice-related rhabdomyolysis: a big price for a sweet tooth. Clin Nephrol: 2012; 77 6 491 495
141. Bruguera M., Herrera S., Lázaro E., Madurga M., Navarro M., de Abajo F. J. [Acute hepatitis associated with Colpachi intake. Apropros of 5 cases]. Gastroenterol Hepatol: 2007; 30 2 66 68 (Pubitemid 46432856)
142. Abraham K., Wöhrlin F., Lindtner O., Heinemeyer G., Lampen A. Toxicology and risk assessment of coumarin: focus on human data. Mol Nutr Food Res: 2010; 54 2 228 239
143. Hernández S., di Pace F., Bessone M., et al. Espectro de la Hepatotoxicidad en Latinoamérica: Fundación y Resultados iniciales del Registro Español-. Latinoamericano de Hepatotoxicidad. Gastroenterol Hepatol: 2013; 36 01 27 97
144. Jacobsson I., Jönsson A. K., Gerdén B., Hägg S. Spontaneously reported adverse reactions in association with complementary and alternative medicine substances in Sweden. Pharmacoepidemiol Drug Saf: 2009; 18 11 1039 1047
145. Werneke U., Earl J., Seydel C., Horn O., Crichton P., Fannon D. Potential health risks of complementary alternative medicines in cancer patients. Br J Cancer: 2004; 90 2 408 413 (Pubitemid 38250637)
146. Gori L., Galluzzi P., Mascherini V., et al. Two contemporary cases of hepatitis associated with Teucrium chamaedrys L. decoction use: case reports and review of literature. Basic Clin Pharmacol Toxicol: 2011; 109 6 521 526
147. Anderson I. B., Mullen W. H., Meeker J. E., et al. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med: 1996; 124 8 726 734 (Pubitemid 26117921)
148. De Smet P. A., Van den Eertwegh A. J., Lesterhuis W., Stricker B. H. Hepatotoxicity associated with herbal tablets. BMJ: 1996; 313 7049 92
149. Stadlbauer V., Weiss S., Payer F., Stauber R. E. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol: 2008; 103 9 2406 2407
150. Ueng Y. F., Hsieh C. H., Don M. J. Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole. Food Chem Toxicol: 2005; 43 5 707 712
151. Hamid S., Rojter S., Vierling J. Protracted cholestatic hepatitis after the use of prostata. Ann Intern Med: 1997; 127 2 169 170 (Pubitemid 27337412)
152. Wiwanitkit V. Excessive consumption of soybean milk and unexplained hepatitis. J Postgrad Med: 2012; 58 3 226 227
153. Secretaria de Salud de Mexico. COFEPRIS. Comunicado a los consumidores del producto CAPSLIM. Available at: http://www.cofepris.gob.mx/AZ/Documents/ COMUNICADOCAPSLIM.pdf. Accessed January 14,: 2014
154. Harvey J., Colin-Jones D. G. Mistletoe hepatitis. Br Med J (Clin Res Ed): 1981; 282 6259 186 187 (Pubitemid 11188566)
155. Soares MdoC. Would Sacaca, Croton cajucara Benth (Euphorbiaceae) be an hepatotoxic plant like Germander, Teucrium chamaedrys L. (Labiatae)? Rev Soc Bras Med Trop: 2004; 37 02 96 97 (Pubitemid 40254584)