Severe hepatitis associated with the use of black cohosh: A report of two cases and an advice for caution

European Journal of Gastroenterology and Hepatology

Volumn 21, Issue 8, 2009, Pages 941-945

  Pierard, Sophie ^a   Coche, Jean Charles ^a   Lanthier, Philippe ^b   Dekoninck, Xavier ^a   Lanthier, Nicolas ^c   Rahier, Jacques ^c   Geubel, André P ^c  

^a Clinique Saint Pierre of Ottignies   (Belgium)

^b Clinique Saint Joseph   (Belgium)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Black cohosh; Drug induced; Hepatitis

Indexed keywords

ANGELICA EXTRACT; CALCIUM PHOSPHATE; CIMICIFUGA RACEMOSA EXTRACT; FEMONE; HYPERICUM PERFORATUM EXTRACT; ISOFLAVONE; PLANT EXTRACT; PUERARIA EXTRACT; RED CLOVER EXTRACT; UNCLASSIFIED DRUG; YAM EXTRACT; NON PRESCRIPTION DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANAMNESIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; CHRONIC HEPATITIS; CLINICAL EXAMINATION; DRUG INDICATION; EPIGASTRIC DISCOMFORT; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LETHARGY; LIVER BIOPSY; LIVER FUNCTION TEST; LIVER NECROSIS; MENOPAUSAL SYNDROME; MENSTRUATION DISORDER; PRIORITY JOURNAL; SIDE EFFECT; SOYBEAN; ACTAEA; MIDDLE AGED; PATHOLOGY; PHYTOTHERAPY; TOXIC HEPATITIS;

CIMICIFUGA; DRUG-INDUCED LIVER INJURY, CHRONIC; FEMALE; HUMANS; MIDDLE AGED; NONPRESCRIPTION DRUGS; PHYTOTHERAPY;

EID: 67651024194     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3283155451     Document Type: Article

References (22)

1. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML. Writing Group for the Women's Health Initiative Register. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. J Am Med Assoc 2002; 288:321-333. (Pubitemid 34761611)
2. Whiting PW, Clouston A, Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. MJA 2002; 177:432-435. (Pubitemid 35396365)
3. Cohen SM, O'Connor AM, Hart J, Merel NH, Te HS. Automimmune hepatitis associated with the use of black cohosh: a case study. Menopause 2004; 11:575-577. (Pubitemid 40362157)
4. De Semdt PAGM, Keller K, Hansel R, Chandler RF, editors. Adverse effects of herbal drugs (2 and 3). Berlin: Springer-Verlag; 1993.
5. Vitetta L, Thomsen M, Sali A. Black cohosh and other herbal remedies associated with acute hepatitis. MJA 2002; 178:411-412.
6. Lontos S, Jones RM, Angus PW, Gow PJ. Acute liver failure associated with the use of herbal preparation containing black cohosh. MJA 2002; 179:390-391. (Pubitemid 37265139)
7. Thomsen M, Vitetta L, Sali A, Schmidt M. Acute liver failure associated with the use of herbal preparation containing black cohosh. MJA 2002; 180:598-599.
8. Levitsk J, Alli TA, Wisecarver J, Sorrell MF. Fulminant liver failure associated with the use of black cohosh. Dig Dis Sci 2004; 50:538-539.
9. Lynch CR, Milan EF, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl 2006; 12:989-992. (Pubitemid 43960376)
10. Andrade RJ, Lucena MI, Fernandez MC, Vega JL, Garcia-Cortes M, Casado M, et al. Cholestatic hepatitis related to the use of irbesartan: a case report and a literature review of angiotensin II antagonist-associated hepatotoxicity. Eur J Gastroenterol Hepatol 2002; 14:887-890. (Pubitemid 34913590)
11. Foruny Olcina JR, Moreira Vincente VF, Gomez Garcia M, Morell Hita JL. Irbesartan-induced acute hepatitis. Gastroenterol Hepatol 2004; 27:71-72.
12. Annicchiarico BE, Siciliano M. Could irbesartan trigger auto-immune cholestatic hepatitis? Eur J Gastroenterol Hepatol 2005; 17:247-248.
13. Peron JM, Robic MA, Bureau C, Vinel JP. Irbesartan induced acute hepatitis: one case. Gastroenterol Clin Biol 2005; 29:747-748. (Pubitemid 40957287)
14. Huntley A, Ernst E. A systemic review of the safety of black cohosh. Menopause 2003; 10:58-64. (Pubitemid 36706323)
15. Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001; 19:2739-2745. (Pubitemid 32441380)
16. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003; 44 (Suppl 1):S67-S77. (Pubitemid 36263037)
17. Hernandez Munoz G, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003; 44 (Suppl 1): S59-S65. (Pubitemid 36263036)
18. Verhoeven MO, van der Mooren MJ, van de Weijer PH, Verdegem PJ, van der Burgt LM, Kenemans P, Curatrial Research Group. Effect of a combination of osoflavones and Actaea racemosa linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. Menopause 2005; 12:412-420.
19. American College of Obstetricians and Gynecologists Committee on Practice Bulletins. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001; 97 (Suppl 1-11):5-11.
20. Huntley A. The safety of black cohosh (Actaea racemosa, Cimifuga racemosa). Expert Opin Drug Saf 2004; 3:615-623. (Pubitemid 39530214)
21. Nisbet BC, O'Connor RE. Black-cohosh-induced hepatitis. Del Med J 2007; 79:441-444.
22. Tsukamoto S, Aburatani M, Ohta T. Isolation of CYP 3A4 inhibitors from the black cohosh (Cimifuga racemosa). Evid Based Complement Alternat Med 2005; 2:223-226. (Pubitemid 41399496)