Continuous reporting of new cases in Spain supports the relationship between Herbalife® products and liver injury

Pharmacoepidemiology and Drug Safety

Volumn 20, Issue 10, 2011, Pages 1080-1087

  Manso, Gloria ^a   López Rivas, Laureano ^b   Salgueiro, M Esther ^a   Duque, Jose M ^b   Jimeno, Francisco J ^a   Andrade, Raúl J ^c,d   Lucena, M Isabel ^c,d  

^a UNIVERSIDAD DE OVIEDO   (Spain)

^b HOSPITAL SAN AGUSTÍN   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Adverse reactions; Dietary supplements; Hepatotoxicity; Herbal medicines; Herbalife

Indexed keywords

ALPRAZOLAM; AMOXICILLIN PLUS CLAVULANIC ACID; BILIRUBIN; CLONAZEPAM; EBASTINE; ENALAPRIL; ETAFEDRINE; HERBACEOUS AGENT; HERBALIFE; NYSTATIN; PARACETAMOL; TIBOLONE; UNCLASSIFIED DRUG; VENLAFAXINE; VITAMIN;

ACUTE HEPATITIS; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALGORITHM; ALKALINE PHOSPHATASE BLOOD LEVEL; ANOREXIA; ANOREXIA NERVOSA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTASIS; CHOLESTATIC HEPATITIS; CLINICAL ARTICLE; DIET SUPPLEMENTATION; DRUG CONTAMINATION; DRUG PACKAGING; DRUG SURVEILLANCE PROGRAM; FEMALE; GALACTORRHEA; HEPATITIS; HERBAL MEDICINE; HOSPITALIZATION; HUMAN; HYPERTENSION; JAUNDICE; KARCH AND LASAGNA ALGORITHM; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER TOXICITY; MALE; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SIDE EFFECT; SPAIN; VOMITING;

ADULT; BILIRUBIN; DIETARY SUPPLEMENTS; DRUG TOXICITY; DRUG-INDUCED LIVER INJURY; EPHEDRA; FEMALE; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PHARMACOVIGILANCE; SPAIN;

EID: 80053269081     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.2180     Document Type: Article

References (32)

1. Hoffmann M, Marbet UA, Hurni A, Bianchi L, Goldie H. Rezidiv medikamentös-toxischen einer Hepatitis. Schweiz Med Forum 2005; 5: 147-8.
2. Schoepfer AM, Engel A, Fattinger K, et al. Herbal does not mean innocuous: ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife products. J Hepatol 2007; 47: 521-6.
3. Elinav E, Pinsker G, Safadi R, et al. Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity. J Hepatol 2007; 47: 514-20.
4. Stickel F. Slimming at all costs: Herbalife-induced liver injury. J Hepatol 2007; 47: 444-6.
5. Duque JM, Ferreiro J, Salgueiro E, Manso G. Hepatotoxicity associated with the consumption of herbal slimming products. Med Clin (Barc) 2007; 128: 238-9.
6. Manso G, López-Rivas L, Duque JM, Salgueiro E. Spanish reports of hepatotoxicity associated with Herbalife products. J Hepatol 2008; 49: 289-90.
7. Chao S, Anders M, Turbay M, Olaiz E, Mc Cormack L, Mastai R. Toxic hepatitis by consumption Herbalife products: a case report. Acta Gastroenterol Latinoam 2008; 38: 274-7.
8. Stickel F, Droz S, Patsenker E, Bögli-Stuber K, Aebi B, Leib SL. Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis. J Hepatol 2009; 50: 111-7.
9. Seeff LB. Are herbals as safe as their advocates believe?. J Hepatol 2009; 50: 13-6.
10. Jóhannsson M, Ormarsdóttir S, Olafsson S. Hepatotoxicity associated with the use of Herbalife. Laeknabladid 2010; 96: 167-72.
11. Benichou C. Criteria of drug-induced liver disorders. J Hepatol 1990; 11: 272-6.
12. Web page of Herbalife [accessed 27 June 2011].
13. Temple R. Hy's law: predicting serious hepatotoxicity. Pharmacoepidemiol Drug Saf 2006; 15: 241-3.
14. Andrade RJ, Lucena MI, Fernández MC, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 2005; 129: 512-21.
15. Lucena MI, Andrade RJ, Fernández MC, et al. Determinants of liver expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain. Hepatology 2006; 44: 850-6.
16. Pedrós C, Cereza G, Garcia N, Laporte JR. Liver toxicity of Camellia sinensis dried extract etanolic. Med Clin (Barc) 2003; 121: 598-9.
17. Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 2006; 144: 68-71.
18. García-Cortés M, Borraz Y, Lucena MI, et al. Liver injury induced by "natural remedies": an analysis of cases submitted to the Spanish Liver Toxicity Registry. Rev Esp Enferm Dig 2008; 100: 688-95.
19. Sarma DN, Barrett ML, Chavez ML, et al. Safety of green tea extracts: a systematic review by the U.S. pharmacopeia. Drug Saf 2008; 31: 469-84.
20. Rabe C, Musch A, Schirmacher P, Kruis W, Hoffmann R. Acute hepatitis induced by an aloe vera preparation: a case report. World J Gastroenterol 2005; 11: 303-4.
21. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Intern Med 2006; 17: 589.
22. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007; 41: 1740-3.
23. Borghi-Scoazec G, Vial T, Bobin JY, Trepo C. Phytosya(R)-induced cytolytic hepatitis. Gastroenterol Clin Biol 2002; 26: 181-3.
24. Kotimchenko YS, Khozhaenko EV, Khotimchenko MY, Kolenchenko EA, Kovalev VV. Carrageenans as a source of new drugs with metal binding properties. Drugs 2010; 8: 1106-21
25. Ernst E. Toxic heavy metals and undeclared drugs in Asian herbal medicines. Trend Pharmacol Sci 2002; 23: 136-9.
26. Stedmann C. Herbal hepatotoxicity. Semin Liver Dis 2002; 22: 195-206.
27. De Smet PA. Health risks of herbal remedies: an update. Clin Pharmacol Ther 2004; 76: 1-17.
28. Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol 2005; 43: 901-10.
29. Seef LB. Herbal hepatotoxicity. Clin Liver Dis 2007; 11: 577-96.
30. Chan TY. Potential risks associated with the use of herbal anti-obesity products. Drug Saf 2009; 32: 453-6.
31. Stickel F, Kessebohm K, Weimann R, Seitz HK. Review of liver injury associated with dietary supplements. Liver Int 2011; 31: 595-605.
32. Cohen PA. American roulette-contaminated dietary supplements. N Engl J Med 2009; 361: 1523-5.