Severe hepatotoxicity following ingestion of Herbalife® nutritional supplements contaminated with Bacillus subtilis

Journal of Hepatology

Volumn 50, Issue 1, 2009, Pages 111-117

  Stickel, Felix ^a   Droz, Sara ^a   Patsenker, Eleonora ^a   Bögli Stuber, Katja ^a   Aebi, Beat ^a   Leib, Stephen L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Drug induced hepatitis; Food supplement; Hepatotoxicity; Herbal medicine; Herbalife; Weight reduction

Indexed keywords

CORTICOSTEROID; URSODEOXYCHOLIC ACID;

ADULT; AGED; ARTICLE; BACILLUS SUBTILIS; BACTERIUM CONTAMINATION; BACTERIUM IDENTIFICATION; CASE REPORT; CHOLESTATIC HEPATITIS; DIET SUPPLEMENTATION; DISEASE SEVERITY; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; LABORATORY TEST; LIVER CIRRHOSIS; LIVER TOXICITY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PRURITUS;

AGED; BACILLUS SUBTILIS; DIETARY SUPPLEMENTS; FEMALE; FOOD CONTAMINATION; GRAM-POSITIVE BACTERIAL INFECTIONS; HEPATITIS; HERBAL MEDICINE; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 56949108345     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.08.017     Document Type: Article

References (47)

1. Radimer K., Bindewald B., Hughes J., Ervin B., Swanson C., and Picciano M.F. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey 1999-2000. Am J Epidemiol 160 (2004) 339-349
2. Landström E., Hursti U.K., Becker W., and Magnusson M. Use of functional food among Swedish consumers is related to health-consciousness and perceived effect. Br J Nutr 98 (2007) 1058-1069
3. Reinert A., Rohrmann S., Becker N., and Linseisen J. Lifestyle and diet in people using dietary supplements. Eur J Nutr 46 (2007) 165-173
4. Dorsch K.D., and Bell A. Dietary supplement use in adolescents. Curr Opin Pediatr 17 (2005) 653-657
5. Mokdad A.H., Serdula M.K., Dietz W.H., Bowman B.A., Marks J.S., and Koplan J.P. The spread of the obesity epidemic in the United States, 1991-1998. JAMA 282 (1999) 1519-1522
6. European Association for the study of Obesity. Guidelines for the management of obesity in adults. European Project for Primary Care, 2002. Available from: www.iotf.org/oonet/easo.
7. National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases. Obesity education initiative. Clinical guidelines on the identification, education, and treatment of overweight and obesity in adults: the evidence report. NIH Publication No. 98-4083. Bethesda, MD, 1998.
8. Michels Blanck H., Serdula M.K., Gillespie C., Galuska D.A., Sharpe P.A., Conway J.M., et al. Use of nonprescription dietary supplements for weight loss is common among Americans. J Am Diet Assoc 107 (2007) 441-447
9. Pittler M.H., and Ernst E. Dietary supplements for body weight reduction: a systematic review. Am J Clin Nutr 79 (2004) 529-536
10. Tsai A.G., and Wadden T.A. Systematic review: an evaluation of major commercial weight loss programmes in the United States. Ann Intern Med 142 (2005) 56-66
11. Favreau J.T., Ryu M.L., Braunstein G., Orshansky G., Park S.S., Coody G.L., et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 136 (2002) 590-595
12. Stevens T., Qadri A., and Zein N.N. Two patients with acute liver injury associated with use of the herbal weight-loss supplement Hydroxycut. Ann Intern Med 142 (2005) 477-478
13. Bjornsson E., and Olsson R. Serious adverse liver reactions associated with herbal weight-loss supplements. J Hepatol 47 (2007) 295-297
14. Bonkovsky H.L. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 144 (2006) 68-71
15. ® nutritional supplements and acute hepatotoxicity. J Hepatol 47 (2007) 514-520
16. ® products. J Hepatol 47 (2007) 521-526
17. Duque J.M., Ferreiro J., Salgueiro E., and Manso G. Hepatotoxicity associated with the consumption of herbal slimming products. Med Clin (Barc) 128 (2007) 238-239
18. Benichou C., and Uclaf R. Criteria of drug-induced liver disorders: report of an international consensus meeting. J Hepatol 11 (1990) 272-276
19. Available from: http://www.who-umc.org/DynPage,aspx?id=22682.
20. Aebi B., and Bernhard W. Gas Chromatography with dual mass spectrometric and nitrogen-phosphorus specific detection: a new and powerful tool for forensic analyses. For Sci Int 102 (1999) 91-101
21. Aebi B., and Bernhard W. Advances in the use of mass spectral libraries. J Anal Toxicol 26 (2002) 149-156
22. Pichler W.J., and Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 59 (2004) 809-820
23. Yamamoto S., and Harayama S. PCR amplification and direct sequencing of gyrB genes with universal primers and their application to the detection and taxonomic analysis of Pseudomonas putida strains. Appl Environ Microbiol 61 (1995) 1104-1109
24. Altschul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J. Basic local alignment search tool. J Mol Biol 215 (1990) 403-410
25. Jordan M.A., and Haywood T. Evaluation of internet websites marketing herbal weight loss supplements to consumers. J Altern Complement Med 13 (2007) 1035-1044
26. Stickel F., Patsenker E., and Schuppan D. Herbal hepatotoxicity. J Hepatol 43 (2005) 901-910
27. Saker M.L., Welker M., and Vasconcelos V.M. Multiplex PCR for the detection of toxigenic cyanobacteria in dietary supplements produced for human consumption. Appl Microbiol Biotechnol 73 (2007) 1136-1142
28. De Smet P.A.G.M. Herbal medicine. N Engl J Med 347 (2002) 2046-2056
29. Tournas V.H., Katsoudas E., and Miracco E.J. Moulds, yeasts and aerobic plate counts in ginseng supplements. Int J Food Microbiol 108 (2006) 178-181
30. Kramer J.M., and Gilbert R.J. Bacillus cereus and other Bacillus species. In: Doyle M.P. (Ed). Foodborne bacterial pathogens (1989), Decker, New York 21-70
31. Wallet F., Crunelle V., Roussel-Delvallez M., Fruchart A., Saunier P., and Courcol R.J. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 91 (1996) 1477-1478
32. Mahler H., Pasi A., Kramer J.M., Schulte P., Scoging A.C., Bär W., et al. Fulminant liver failure in association with the emetic toxin of Bacillus cereus. N Engl J Med 336 (1997) 1142-1148
33. Striegel H., Vollkommer G., Horstmann T., and Niess A.M. Contaminated nutritional supplements - legal protection for elite athletes who tested positive: a case report from Germany. J Sport Sci 23 (2005) 723-726
34. Raman P., Patino L.C., and Nair N.G. Evaluation of metal and microbial contamination in botanical supplements. J Agric Food Chem 52 (2004) 7822-7827
35. Aithal P.G., and Day C.P. The natural history of histologically proved drug induced liver disease. Gut 44 (1999) 731-735
36. Andrade R.J., Lucena M.I., Kaplowitz N., Garcia-Munoz B., Borraz Y., Pachkoria K., et al. Outcome of acute idiosyncratic drug-induced liver injury: long-term follow-up in a hepatotoxicity registry. Hepatology 44 (2006) 1581-1588
37. Björnsson E., Kalaitzakis E., av Klinteberg V., Alem N., and Olsson R. Long-term follow-up of patients with mild to moderate drug-induced liver injury. Aliment Pharmacol Ther 26 (2007) 79-85
38. Hennes E.M., Zeniya M., Czaja A.J., Pares A., Dalekos G.N., Krawitt E.L., et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 48 (2008) 169-176
39. Liu Z.X., and Kaplowitz N. Immune-mediated drug-induced liver disease. Clin Liver Dis 6 (2002) 755-774
40. Benninger J., Schneider H.T., Schuppan D., Kirchner T., and Hahn E.G. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology 117 (1999) 1234-1237
41. Stickel F., Baumüller H.M., Seitz K.H., Vasilakis D., Seitz G., Seitz H.K., et al. Hepatitis induced by Kava-Kava (Piper methysticum rhizoma). J Hepatol 39 (2003) 62-67
42. Adkinson N.F., Essayan D., Gruchalla R., Haggerty H., Kawabata T., Sandler J.D., et al. Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions. J Allergy Clin Immunol 109 (2002) S461-S478
43. Berg P.A., and Becker E.W. The lymphocyte transformation test - a debated method for the evaluation of drug allergic hepatic injury. J Hepatol 22 (1995) 115-118
44. Maria V.A., and Victorino R.M. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury. Gut 41 (1997) 534-540
45. Coppens P., da Silva M.F., and Pettman S. European regulations on neutraceuticals, dietary supplements and functional foods: a framework based on safety. Toxicology 221 (2006) 59-74
46. Gulati O.P., and Berry Ottaway P. Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicology 221 (2006) 75-87
47. Ashar B.H., Rice T.N., and Sisson S.D. Physician's understanding of the regulation of dietary supplements. Arch Intern Med 167 (2007) 966-969